Ascorbic acid

Hais lus

(ib SKOR bik AS id)

Index Terms

  • Ascorbate Sodium
  • Ascorbic Acid / Ascorbate Sodium
  • Sodium Ascorbate
  • Vitamin C

Daim ntawv noj tshuaj

Excipient cov ntaub ntawv nthuav tawm thaum muaj (tsawg, tshwj xeeb tshaj yog rau cov khoom siv); sab laj tshwj xeeb cov khoom labeling. [DSC] = Cov khoom lag luam txiav tawm



Capsule Extended Release, Qhov ncauj:

C-time: 500 mg

Generic: 500 mg

Capsule Extended Release, Oral [preservative free]:

Generic: 500 mg

Crystals, Qhov ncauj:

Vita-C: (120 g, 480 g) [tsiaj khoom pub dawb, gelatin dawb, gluten dawb, tsis muaj lactose, tsis muaj xim xim, tsis muaj tsw tsw, tsis muaj hmoov txhuv nplej siab, tsis muaj suab thaj, tsis muaj poov xab]

Kua, qhov ncauj:

BProtected Vitamin C: 500 mg/5 mL (236 mL) [muaj propylene glycol, saccharin sodium, sodium benzoate; citrus tsw]

Generic: 500 mg / 5 mL (118 mL, 473 mL)

Pob ntawv, Qhov ncauj:

Generic: 500 mg (80 ea)

Hmoov, Qhov ncauj:

Ascocid (227g)

Qhov hnyav: (113g, 120g, 480g)

Hmoov Effervescent, Qhov ncauj:

Ascocid-ISO-pH: (150 g) [pob kws dawb, rye dawb, nplej dawb]

Kev daws, Txhaj Tshuaj:

Qauv: 500mg / mL (50 mL)

Kev daws, Txhaj [preservative free]:

Mega-C/A Plus: 500 mg/mL (50 mL [DSC])

Qauv: 500mg / mL (50 mL)

Kev daws, Intravenous [preservative free]:

Ascor: 500 mg / mL (50 mL) [muaj edetate disodium]

Tshuaj, Txhaj, raws li sodium ascorbate [preservative free]:

Ortho-CS 250: 250 mg/mL (100 mL [DSC]) [muaj edetate disodium, dej, sterile]

Generic: 250 mg / mL (30 mL [DSC])

Syrup, Qhov ncauj:

Generic: 500 mg / 5 mL (118 mL [DSC])

Tablet, Qhov ncauj:

Asco-Tabs-1000: 1000 mg [xim dawb, hmoov txhuv nplej siab, tsis muaj suab thaj]

mucinex 600 mg qhia

Generic: 100 mg, 250 mg, 500 mg, 1000 mg

Tablet, Oral [preservative free]:

Generic: 250 mg, 500 mg

Tablet Chewable, Qhov ncauj:

Chew-C: 500 mg

Txiv Hmab Txiv Ntoo C 500: 500 mg [tsiaj khoom pub dawb, gelatin dawb, gluten dawb, kosher ntawv pov thawj, tsis muaj lactose, tsis muaj xim cuav, tsis muaj tsw tsw, tsis muaj hmoov txhuv nplej siab, tsis muaj suab thaj, tsis muaj poov xab]

Txiv Hmab Txiv Ntoo C: 100 mg [tsiaj khoom pub dawb, gelatin dawb, gluten dawb, tsis muaj lactose, tsis muaj xim xim, tsis muaj tsw tsw, tsis muaj hmoov txhuv nplej siab, tsis muaj suab thaj, tsis muaj poov xab]

Fruity C: 250 mg

VitaChew Vit C Citrus Burst: 125 mg

Generic: 100 mg, 250 mg, 500 mg

Tablet Chewable, Qhov ncauj [preservative free]:

C-500: 500 mg [tsiaj khoom pub dawb, gluten dawb, soy dawb, hmoov txhuv nplej siab, tsis muaj poov xab]

Generic: 500 mg

Tablet Extended Release, Oral:

Cemill: 500 mg

Cemill SR: 1000 mg

Generic: 500 mg, 1000 mg [DSC], 1500 mg

Wafer, Qhov ncauj [preservative free]:

Acerola C 500: 500 mg (50 ea) [ pob kws dawb, tsis muaj xim xim, tsis muaj tsw tsw tsw), nplej dawb, tsis muaj poov xab; muaj acerola (malpighia glabra)]

Hom Lub Npe: U.S.

  • Acerola C 500 [OTC]
  • Disgust-Tabs-1000 [OTC]
  • Ascocid [OTC] Cov
  • Ascocid-ISO-pH [OTC]
  • Ascor
  • BProtected Vitamin C [OTC]
  • C-500 [OTC]
  • C-Lub Sijhawm [OTC]
  • Cemill SR [OTC]
  • Cemill [OTC]
  • Chew-C [OTC]
  • Txiv Hmab Txiv Ntoo C 500 [OTC]
  • Txiv Hmab Txiv Ntoo C [OTC]
  • Fruity C [OTC]
  • Mega-C/A Ntxiv [DSC]
  • Ortho-CS 250 [DSC]
  • Vita-C [OTC]
  • VitaChew Vit C Citrus tawg [OTC]

Pharmacologic qeb

  • Vitamin, dej soluble

Pharmacology

Ascorbic acid yog ib qho tseem ceeb dej soluble vitamin uas ua raws li cofactor thiab antioxidant. Ascorbic acid yog cov khoom siv hluav taws xob siv rau collagen hydroxylation, carnitine biosynthesis, thiab tshuaj hormone / amino acid biosynthesis. Nws yog tsim nyog rau kev sib txuas cov ntaub so ntswg nrog rau kev nqus hlau thiab cia (IOM 2000).

Kev nqus

Qhov ncauj: Yooj yim absorbed nyob rau hauv txoj hnyuv; Cov txheej txheem nquag xav tias yuav ua kom txaus thiab noj tshuaj nyob ntawm (30 txog 180 mg / hnub: 70% txog 90%;> 1,000 mg / hnub: ≤50%) (IOM 2000)

Kev faib tawm

pituitary thiab adrenal qog, leukocytes, cov ntaub so ntswg qhov muag thiab kev lom zem, thiab lub hlwb; Kev txo qis hauv plasma thiab qaub ncaug (IOM 2000)

Metabolism

Reversibly oxidized rau dehydroascorbic acid (DHA); ob qho tib si ascorbic acid thiab DHA yog active. Unabsorbed ascorbic acid yog degraded nyob rau hauv txoj hnyuv (IOM 2000)

Kev tso tawm

Cov zis (nrog cov ntshav siab ntau) (IOM 2000); muaj ib tus neeg lub raum pib rau ascorbic acid; Thaum cov ntshav siab siab, ascorbic acid raug tso tawm hauv cov zis, thaum cov qib qis qis (cov koob tshuaj txog li 80 mg / hnub) tsawg heev yog tias muaj ascorbic acid raug tso rau hauv cov zis.

Pib ntawm Kev Ua

Rov qab cov tsos mob scurvy: 2 hnub mus rau 3 lub lis piam

Ib nrab-Life Elimination

10 teev (Schwedhelm 2003). Biological ib nrab-lub neej: 8 mus rau 40 hnub (IOM 2000)

Protein Binding

25%

Siv: Cov ntawv cim npe

Ascorbic acid deficiency: Kev kho mob ntawm cov tsos mob me me tsis txaus; siv nyob rau hauv tej yam kev mob uas yuav tsum tau nce kom tsawg (piv txwv li, kub hnyiab, qhov txhab kho)

Khoom noj khoom haus ntxiv: Raws li kev noj haus vitamin C ntxiv

Parenteral khoom noj khoom haus, tu yuav tsum tau: Tiv thaiv thiab kho cov vitamin C tsis txaus ua ib qho ntxiv rau IV tag nrho cov khoom noj khoom haus parenteral

Scurvy: Kev tiv thaiv thiab kev kho mob ntawm scurvy

Off Label Siv

Methemoglobinemia

Cov ntaub ntawv los ntawm ntau cov ntaub ntawv qhia tau hais tias IV ascorbic acid (vitamin C) yuav ua tau zoo rau kev kho mob ntawm methemoglobinemia, thaum methylene xiav yog contraindicated los yog tsis muaj.[Dhibar 2018],[Faust 2018],[Park 2017],[Park 2014],[Reeves 2016],[Rehman 2018].

Mob hnyav sepsis lossis septic shock

Cov ntaub ntawv los ntawm ib qho me me, rov qab los, ua ntej-tom qab kev tshawb fawb qhia tias IV ascorbic acid (vitamin C) ua ke nrog IV hydrocortisone thiab IV thiamine nyob rau hauv cov neeg mob hnyav sepsis lossis septic shock tej zaum yuav ua rau txo qis kev tuag thiab tiv thaiv lub cev tsis ua haujlwm.[Marik 2017]. Txawm li cas los xij, cov ntaub ntawv los ntawm ntau lub zeem muag, randomized, tswj kev sim qhia IV ascorbic acid (vitamin C) (nrog lossis tsis muaj IV hydrocortisone thiab IV thiamine) piv rau cov placebo lossis hydrocortisone ib leeg hauv sepsis thiab mob ua pa nyuaj siab tsis muaj txiaj ntsig rau lub sijhawm ua haujlwm ntawm lub tshuab ua pa. , cov qhab nia ntawm lub cev tsis ua haujlwm, cov cim ntawm qhov mob thiab cov hlab ntsha raug mob, lub sijhawm muaj sia nyob thiab tsis muaj kev tswj hwm vasopressor, ICU, lossis tag nrho cov neeg tuag.[Fowler 2019],[Fujii 2020],[Nabil Habib 2017].

Contraindications

Tsis muaj contraindications tau teev nyob rau hauv lub khw muag khoom daim ntawv lo.

Dosing: Neeg laus

Ascorbic acid deficiency: IM, IV, SubQ: 70 mus rau 150 mg txhua hnub yog ib koob tshuaj tiv thaiv nruab nrab; koob tshuaj 3 mus rau 5 npaug ntawm qhov pom zoo pub noj zaub mov yuav tsim nyog rau cov xwm txheej uas yuav tsum tau nce ntxiv.

Hlawv: IM, IV, SubQ: 1 mus rau 2 g txhua hnub rau kev kub nyhiab heev; koob tshuaj yuav raug txiav txim los ntawm cov ntaub so ntswg raug mob.

Methemoglobinemia (kev siv tsis siv daim ntawv lo): Nco ntsoov: Xav txog thaum methylene xiav yog contraindicated (piv txwv li, xav tias yog los yog sau tseg G6PD deficiency) los yog tsis muaj; koob tshuaj raws li cov ntaub ntawv txwv, kev pom zoo koob tshuaj tsis tau txheeb xyuas.

Qhov ntau npaum li cas: IV: 1 mus rau 10 g txhua 6 teev kom txog thaum cov qib methemoglobin normalize (Dhibar 2018; Faust 2018; Park 2014; Park 2017; Reeves 2016; Rehman 2018).

Khoom noj khoom haus ntxiv: Qhov ncauj: 100 mus rau 1,500 mg txhua hnub; ntau npaum li cas yuav txawv nyob ntawm daim ntawv ntau npaum; sab laj tshwj xeeb cov khoom labeling.

Parenteral khoom noj khoom haus, tu yuav tsum tau: IV: 200 mg/day (American Society of Parenteral and Enteral Nutrition 2019).

Scurvy:

IM, IV, SubQ: 300 txog 1,000 mg ib hnub; koob tshuaj thiab lub sijhawm ntawm kev kho yuav tsum yog tus kheej; Cov koob tshuaj txog li 6 g ib hnub twg tau raug tswj hwm (ib lub chaw tsim khoom).

Ascor: IV: 200 mg ib hnub ib zaug rau qhov siab kawg ntawm 7 hnub. Yog tias tsis muaj kev txhim kho tom qab ib lub lim tiam ntawm kev kho mob, thim rov qab kom txog thaum pom cov tsos mob tshwm sim.

Qhov ncauj: 100 mus rau 300 mg txhua hnub kom txog thaum lub cev rov ua dua; koob tshuaj thiab lub sijhawm ntawm kev kho yuav tsum yog tus kheej; koob tshuaj tsawg li 10 mg yuav zoo (Hirschmann 1999; Popovich 2009; Weinstein 2001).

Mob hnyav sepsis lossis septic shock (tshwj tsis yog siv daim ntawv lo) : Nco tseg: Kev kho mob hnyav sepsis lossis septic shock nrog ascorbic acid (vitamin C), nrog lossis tsis muaj corticosteroids thiab thiamine, yuav raug txiav txim siab, tab sis qhov kev kho no yog tshawb nrhiav thiab tsis tau txhais zoo rau lub sijhawm no.

IV: 1.5 g tshaj 30 mus rau 60 feeb; rov ua dua txhua 6 teev rau 4 mus rau 10 hnub kom txog thaum kev daws teeb meem ntawm kev poob siab lossis txog thaum ICU tso tawm; Qee cov kws kho mob muab tshuaj ua ke nrog IV thiamine thiab IV hydrocortisone (Fujii 2020; Marik 2017; Nabil Habib 2017).

Kev kho mob: IM, IV, SubQ: 300 mus rau 500 mg ib hnub twg rau 7 mus rau 10 hnub ua ntej thiab tom qab ua haujlwm; Cov koob tshuaj loj dua kuj tau siv.

Dosing: Geriatric

Xa mus rau cov neeg laus noj.

Dosing: Pediatric

Parenteral khoom noj khoom haus additive, tu yuav tsum tau (ASPEN [Vanek 2012]; ESPGHAN/ESPEN/ESPR/CSPEN [Bronsky 2018]):

Cov me nyuam mos: IV: 15 mus rau 25 mg / kg / hnub; Cov koob tshuaj ntau tshaj txhua hnub: 80 mg / hnub .

Cov menyuam yaus thiab cov tub ntxhais hluas: IV: 80 mg ib hnub.

Scurvy, kev kho mob:

Cov menyuam mos, menyuam yaus, thiab cov tub ntxhais hluas: Cov ntaub ntawv txwv tsis pub muaj: Qhov ncauj, IM, IV: Pib: 100 mus rau 300 mg / hnub hauv cov koob tshuaj sib faib rau 1 lub lis piam ua raws li 100 mg / hnub kom txog thaum cov ntaub so ntswg saturation (~ 1 mus rau 3 lub hlis) ( Kleinman 2013; Kliegman 2016; Popovich 2009; Weinstein 2001).

Chaw tsim tshuaj paus lub npe: Ascor:

Cov me nyuam mos ≥5 lub hlis: IV: 50 mg ib hnub ib zaug rau 1 lub lis piam.

Me nyuam<11 years: IV: 100 mg once daily for 1 week.

Cov menyuam yaus ≥11 xyoos thiab Cov Hluas: IV: 200 mg ib hnub ib zaug rau 1 lub lis piam.

Kev kho dua tshiab

Ua ntej IV kev tswj hwm, dilute nyob rau hauv ib tug loj ntim parenteral tov (xws li, D5W, SWFI). Xa mus rau cov chaw tsim khoom daim ntawv lo rau cov lus qhia ntxiv txog kev npaj. Nco tseg: Lub siab tuaj yeem tsim nyob rau hauv lub vial thaum khaws cia.

Kev tswj hwm

Kev tswj qhov ncauj yog qhov nyiam tshwj tsis yog xav tias malabsorption. Kev tswj hwm IM yog qhov zoo dua thaum xav tau txoj hauv kev parenteral. Cov khoom siv hauv qhov ncauj tuaj yeem muab nrog zaub mov.

Kev phais Bariatric: Capsule thiab ntsiav tshuaj, ncua kev tso tawm: Qee lub tsev kawm ntawv yuav muaj cov txheej txheem tshwj xeeb uas cuam tshuam nrog cov lus pom zoo no; xa mus rau lub koom haum raws li txoj cai. Capsule tuaj yeem qhib thiab cov khoom ntim rau hauv cov khoom muag muag. ER ntsiav tshuaj yuav tsum tau hloov mus rau IR los yog chewable formulation.

Txhaj Tshuaj: Rau IM (xav tau), IV, lossis SubQ tswj hwm. Tsis txhob txhaj tshuaj IV sai; tej zaum yuav ua rau qaug zog ib ntus lossis kiv taub hau.

Ascor: Rau IV siv nkaus xwb. Tom qab dilution hauv cov tshuaj IV uas tsim nyog (piv txwv li, D5W, SWFI), ua haujlwm los ntawm qeeb IV infusion ntawm tus nqi ntawm 33 mg / feeb.

Kev xav txog kev noj haus

Qee cov khoom yuav muaj sodium.

Cov khoom noj muaj txiaj ntsig zoo ntawm ascorbic acid yog citrus txiv hmab txiv ntoo, txiv lws suav / txiv lws suav, thiab qos yaj ywm; kuj pom nyob rau hauv lwm cov txiv hmab txiv ntoo, zaub paj, zaub qhwv, zaub qhwv, spinach, thiab strawberries. Kev nqus los ntawm kev noj zaub mov thiab tshuaj ntxiv zoo ib yam (IOM 2000).

Kev noj zaub mov kom txaus noj (AI) (IOM 2000):

0 mus rau 6 lub hlis: 40 mg ib hnub twg

7 mus rau 12 lub hlis: 50 mg ib hnub twg

Kev noj haus pom zoo txhua hnub nyiaj pub dawb (RDA) (IOM 2000): Nco tseg: Cov neeg mob uas muaj hemochromatosis, G6PD tsis muaj peev xwm, thiab lub raum tsis zoo yuav muaj kev pheej hmoo ntau dua rau cov teebmeem tshwm sim thaum muaj ntau tshaj qhov txwv tsis pub noj.

1 mus rau 3 xyoos: 15 mg ib hnub twg; Kev txwv qis ntawm kev noj tshuaj yuav tsum tsis pub tshaj 400 mg ib hnub twg

4 mus rau 8 xyoo: 25 mg ib hnub twg; Kev txwv qis ntawm kev noj tshuaj yuav tsum tsis pub tshaj 650 mg ib hnub twg

9 mus rau 13 xyoos: 45 mg ib hnub twg; Kev txwv qis ntawm kev noj tshuaj yuav tsum tsis pub tshaj 1,200 mg ib hnub twg

14 mus rau 18 xyoo: Kev txwv siab ntawm kev noj tshuaj yuav tsum tsis pub tshaj 1,800 mg ib hnub twg

Txiv neej: 75 mg ib hnub twg

dawb puag ncig 5658

Poj niam: 65 mg ib hnub twg

Cov poj niam cev xeeb tub: 80 mg ib hnub; Kev txwv qis ntawm kev noj tshuaj yuav tsum tsis pub tshaj 1,800 mg ib hnub twg

Cov poj niam cev xeeb tub: 115 mg ib hnub; Kev txwv qis ntawm kev noj tshuaj yuav tsum tsis pub tshaj 1,800 mg ib hnub twg

> 18 xyoo: Kev txwv siab yuav tsum tsis pub tshaj 2,000 mg ib hnub twg

Txiv neej: 90 mg ib hnub twg

Poj niam: 75 mg ib hnub twg

Cov poj niam cev xeeb tub: 19 txog 50 xyoo: 85 mg ib hnub

Cov poj niam cev xeeb tub: 19 txog 50 xyoo: 120 mg ib hnub

Cov neeg laus haus luam yeeb: Ntxiv 35 mg ntxiv ib hnub

Cia

Txhaj tshuaj: Khaws hauv tub yees ntawm 2 ° C txog 8 ° C (36 ° txog 46 ° F); tiv thaiv los ntawm lub teeb. Siv tsis pub dhau 4 teev ntawm vial nkag; pov tseg qhov seem.

Qhov ncauj: Khaws ntawm chav tsev kub.

m.amphet ntsev 5 mg

Cov tshuaj sib cuam tshuam

Aluminium Hydroxide: Ascorbic Acid tuaj yeem ua rau kom nqus tau ntawm Aluminium Hydroxide. Kev tswj hwm: Hauv cov neeg mob uas lub raum tsis ua haujlwm hnyav, xav txog kev zam qhov kev sib xyaw ua ke no. Kev tswj xyuas cov neeg ua haujlwm tsawg kawg 2 teev sib nrug tuaj yeem pab txo qis. Saib xyuas cov tshuaj lom ntawm txhuas (los ntawm antacid) yog ascorbic acid coadministered. Xav txog kev hloov kho

Amphetamines: Ascorbic Acid tuaj yeem txo cov ntshav ntshav ntawm Amphetamines. Saib xyuas kev kho mob

Bortezomib: Ascorbic Acid tuaj yeem txo qis kev kho mob ntawm Bortezomib. Kev tswj hwm: Cov neeg mob yuav tsum tsis txhob noj cov tshuaj vitamin C thiab vitamin C-muaj cov vitamins thaum lawv kho bortezomib. Tej zaum nws yog qhov tsis tsim nyog los qhia cov neeg mob kom tsis txhob noj zaub mov / dej haus uas muaj vitamin C (xws li txiv hmab txiv ntoo citrus, thiab lwm yam). Xav txog kev hloov kho

Copper: Tej zaum yuav txo cov ntshav concentration ntawm ascorbic acid. Kev tswj hwm: Txhawm rau txo qis kev pheej hmoo rau ascorbic acid degradation, ntxiv cov khoom lag luam multivitamin rau TPN cov tshuaj tam sim ua ntej infusion lossis muab tshuaj multivitamin thiab tooj liab hauv cov thawv cais. Xav txog kev hloov kho

CycloSPORINE (Systemic): Ascorbic Acid tuaj yeem txo cov ntshav concentration ntawm CycloSPORINE (Systemic). Saib xyuas kev kho mob

Deferoxamine: Ascorbic Acid tuaj yeem txhim kho qhov tsis zoo / tshuaj lom ntawm Deferoxamine. Sab laug ventricular dysfunction yog ib qho kev txhawj xeeb tshwj xeeb. Kev tswj hwm: Tsis txhob noj tshuaj ascorbic acid ntau dua 200 mg / hnub. Cov koob tshuaj qis dua tuaj yeem muab rau cov neeg mob uas tsis muaj lub plawv tsis ua haujlwm, tom qab ib hlis ntawm kev kho mob tsis tu ncua nrog deferoxamine ib leeg, qhov zoo tshaj plaws tom qab teeb tsa lub twj tso kua mis. Saib xyuas lub plawv ua haujlwm. Xav txog kev hloov kho

Estrogen Derivatives: Ascorbic Acid tuaj yeem ua rau kom cov ntshav concentration ntawm Estrogen Derivatives. Saib xyuas kev kho mob

Ntsuam xyuas kev sib cuam tshuam

Cov quav tsis zoo-tsis zoo occult ntshav 48 mus rau 72 teev tom qab noj ascorbic acid.

Ascorbic acid tuaj yeem cuam tshuam nrog kev kuaj sim raws li oxidation-txo cov tshuaj tiv thaiv (piv txwv li, ntshav thiab zis kuaj ntshav, qib nitrite thiab bilirubin, leucocyte suav). Cov koob tshuaj ntau ascorbic acid tau cuam tshuam nrog kev ntsuas cov piam thaj tsis tseeb los ntawm kev saib xyuas glucometers. Kev siv cov tshuaj plasma kuaj lossis ib qho khoom siv uas tau pom zoo los ntawm FDA uas kho qhov cuam tshuam tau raug pom zoo (Hager 2019; Tran 2014; Vasudevan 2014). Xwb, kev kuaj sim raws li oxidation-txo cov tshuaj tiv thaiv yuav tsum ncua mus txog 24 teev tom qab noj tshuaj.

Kev Phem Tsis Zoo

Cov tshuaj tiv thaiv tsis zoo hauv qab no thiab qhov tshwm sim yog muab los ntawm cov khoom lag luam tshwj tsis yog tau teev tseg.

1% mus rau 10%: Endocrine & metabolic: Hyperoxaluria (nrog koob tshuaj loj)

Lus Ceeb Toom/Precautions

Kev txhawj xeeb txog cov teebmeem tsis zoo:

• Oxalate nephropathy/nephrolithiasis: Acidification ntawm cov zis los ntawm ascorbic acid yuav ua rau nag lossis daus ntawm cysteine, urate lossis oxalate pob zeb. Mob hnyav thiab mob ntev oxalate nephropathy tau raug tshaj tawm nrog kev siv sijhawm ntev ntawm cov koob tshuaj IV siab. Cov neeg mob lub raum nrog rau lub raum tsis ua haujlwm, keeb kwm ntawm oxalate raum pob zeb, cov neeg laus thiab cov neeg mob menyuam yaus<2 years of age may be at increased risk. Monitor renal function in patients at increased risk. Discontinue in patients who develop oxalate nephropathy.

Kev txhawj xeeb txog kab mob:

• Mob Ntshav Qab Zib: Cov neeg mob ntshav qab zib mellitus yuav tsum tsis txhob noj ntau dhau rau lub sijhawm ntev.

• Glucose-6-phosphatase dehydrogenase deficiency: Hemolysis tau tshaj tawm rau cov neeg mob uas muaj qabzib-6-phosphatase dehydrogenase (G6PD) tsis txaus thiab kev pheej hmoo rau hemolysis hnyav tuaj yeem nce ntxiv thaum kho ascorbic acid. Kev txo koob tshuaj yuav tsim nyog nrog rau kev saib xyuas kom tsim nyog (piv txwv li, hemoglobin, ntshav suav). Txiav kev kho yog tias xav tias hemolysis.

• Hemochromatosis: Siv ceev faj rau cov neeg mob hemochromatosis; Kev noj ntau dhau ntawm ascorbic acid tuaj yeem ua rau muaj kev pheej hmoo ntawm cov xwm txheej tsis zoo (IOM 2000).

• Lub raum tsis zoo: Siv ceev faj rau cov neeg mob lub raum tsis zoo lossis cov neeg mob uas ua rau lub raum rov qab; Tej zaum yuav muaj kev pheej hmoo ntawm kev tsim mob hnyav lossis mob ntev oxalate nephropathy.

Cov pejxeem tshwj xeeb:

• Cov Laus: Siv ceev faj rau cov neeg laus; Tej zaum yuav muaj kev pheej hmoo ntxiv rau oxalate nephropathy.

• Pediatric: Siv ceev faj rau cov menyuam yaus<2 years of age; may be at increased risk for oxalate nephropathy due to immature kidney function.

Dosage form cov teeb meem tshwj xeeb:

• Aluminium: Cov khoom parenteral tuaj yeem muaj txhuas; Cov tshuaj lom neeg muaj pes tsawg leeg tuaj yeem pom nrog cov koob tshuaj ntau, siv ntev, lossis lub raum tsis ua haujlwm. Cov me nyuam yug ntxov ntxov muaj kev pheej hmoo siab dua vim lub raum tsis ua haujlwm thiab kev noj tshuaj txhuas los ntawm lwm qhov chaw parenteral. Parenteral txhuas raug ntawm> 4 mus rau 5 mcg / kg / hnub yog txuam nrog CNS thiab pob txha toxicity; Kev thauj cov ntaub so ntswg tuaj yeem tshwm sim ntawm cov koob tshuaj qis dua (Federal Register 2002). Saib cov chaw tsim khoom lub npe.

• Benzyl cawv thiab derivatives: Qee cov ntawv siv tshuaj yuav muaj sodium benzoate/benzoic acid; benzoic acid (benzoate) yog ib qho metabolite ntawm benzyl cawv; benzyl cawv ntau ntau (≥99 mg / kg / hnub) tau cuam tshuam nrog qhov muaj peev xwm ua rau tuag taus (gasping syndrome) hauv cov menyuam mos; gasping syndrome muaj metabolic acidosis, ua pa nyuaj, pa pa pa, CNS tsis ua hauj lwm (xws li convulsions, intracranial hemorrhage), hypotension, thiab plawv plawv (AAP ['Inactive' 1997]; CDC 1982); Qee cov ntaub ntawv qhia tias benzoate tshem tawm bilirubin los ntawm cov chaw sib txuas protein (Ahlfors 2001); zam lossis siv cov ntawv ntau npaum uas muaj benzyl cawv derivative nrog ceev faj hauv cov menyuam mos. Saib cov chaw tsim khoom lub npe.

• Txhaj Tshuaj: Tsis txhob txhaj tshuaj IV sai; tej zaum yuav ua rau qaug zog ib ntus lossis kiv taub hau.

• Sodium: Qee cov khoom yuav muaj sodium; siv nrog ceev faj hauv cov neeg mob txwv sodium.

Saib xyuas Parameters

Lub raum ua haujlwm (cov neeg mob uas muaj feem yuav tsim oxalate nephropathy / nephrolithiasis); hemoglobin thiab ntshav suav (cov neeg mob uas tsis muaj G6PD).

Cov tsos mob tsis txaus: Tej zaum yuav tshwm sim hauv 1 lub hlis ntawm kev noj tsawg (<10 mg/day) (ASPEN 2017; Vitamin C 2018). Symptoms include fatigue, malaise, corkscrew hair, and inflammation of the gums progressing to petechia, ecchymosis, purpura, joint pain, and poor wound healing.

Scurvy: Cov tsos mob muaj xws li kev nyuaj siab; o, los ntshav cov pos hniav; loosening ntawm cov hniav; thiab hlau-deficiency anemia vim los ntshav thiab txo cov hlau tsis haum (Vitamin C 2018).

Kev soj ntsuam hauv chav kuaj: Plasma ascorbic acid yog txoj kev nyiam ntawm cov vitamin no (ASPEN 2017). Kev txhais cov qib plasma / ascorbic acid yog raws li nram no: txaus:> 23 mcmol / L (0.4 mg / dL); qis: 12 txog 23 mcmol / L (0.2 txog 0.4 mg / dL); Tsis txaus: ≤11 mcmol / L (0.2 mg / dL)

Pregnancy Risk Factor C Kev txiav txim siab xeeb menyuam

Kev tshawb fawb txog tsiaj yug tsiaj tsis tau ua. Maternal plasma concentrations ntawm ascorbic acid txo qis thaum cev xeeb tub tshwm sim vim hemodilution thiab nce hloov mus rau fetus. Qee cov poj niam cev xeeb tub (xws li, cov neeg haus luam yeeb) yuav xav tau kev pab ntxiv ntau dua li RDA (IOM 2000).

Kev Kawm Tus Neeg Mob

Cov tshuaj no siv rau dab tsi?

• Nws yog siv los kho lossis tiv thaiv tsis muaj vitamin C.

• Nws yog siv los kho scurvy.

• Tej zaum nws yuav muab rau koj rau lwm yam laj thawj. Tham nrog tus kws kho mob.

Txhua yam tshuaj yuav ua rau muaj kev phiv. Txawm li cas los xij, ntau tus neeg tsis muaj kev phiv los yog tsuas yog muaj kev phiv me me xwb. Hu rau koj tus kws kho mob lossis tau txais kev pab kho mob yog tias ib qho ntawm cov kev mob tshwm sim no lossis lwm yam kev mob tshwm sim cuam tshuam rau koj lossis tsis ploj mus:

• Mob plab

• xeev siab

• ntuav

• Qhov chaw txhaj tshuaj khaus khaus

CEEB TOOM/CEEB TOOM: Txawm hais tias nws yuav tsis tshua muaj, qee tus neeg yuav muaj qhov phem heev thiab qee zaum ua rau muaj kev phom sij thaum noj tshuaj. Qhia rau koj tus kws kho mob lossis tau txais kev pab kho mob tam sim yog tias koj muaj ib qho ntawm cov tsos mob hauv qab no lossis cov tsos mob uas yuav cuam tshuam rau qhov tshwm sim tsis zoo:

• Cov teeb meem hauv lub raum xws li tso zis tsis tau, cov ntshav tso zis, hloov cov zis ntau dhau, lossis hnyav nce.

• Lub raum pob zeb zoo li mob nraub qaum, mob plab, lossis cov ntshav tso zis.

• Tsis muaj zog thiab lub zog loj heev

• Cov zis tsaus

• Cov tawv nqaij daj

• Cov tsos mob ntawm kev ua xua, xws li pob liab liab; khaus khaus; khaus; liab, o, hlwv, lossis tawv nqaij nrog lossis tsis ua npaws; hawb pob; nruj ntawm lub hauv siab los yog caj pas; ua tsis taus pa, nqos, lossis hais lus; hoarseness txawv txawv; los yog o ntawm qhov ncauj, ntsej muag, daim di ncauj, tus nplaig, los yog caj pas.

Nco tseg: Qhov no tsis yog ib daim ntawv teev tag nrho cov kev mob tshwm sim. Tham nrog koj tus kws kho mob yog tias koj muaj lus nug.

Cov Ntaub Ntawv Cov Neeg Siv Khoom Siv thiab Tsis lees paub: Cov ntaub ntawv no yuav tsum tsis txhob siv los txiav txim seb puas yuav noj cov tshuaj no lossis lwm yam tshuaj. Tsuas yog tus kws kho mob muaj kev paub thiab kev cob qhia los txiav txim seb cov tshuaj twg tsim nyog rau tus neeg mob tshwj xeeb. Cov ntaub ntawv no tsis pom zoo rau cov tshuaj uas muaj kev nyab xeeb, muaj txiaj ntsig, lossis pom zoo rau kev kho tus neeg mob lossis kev noj qab haus huv. Qhov no tsuas yog cov ntsiab lus luv luv ntawm cov ntaub ntawv dav dav txog cov tshuaj siv los ntawm daim ntawv qhia kev kawm ntawm tus neeg mob thiab tsis yog tsim los ua kom dav. Cov ntsiab lus luv luv no TSIS suav nrog txhua cov ntaub ntawv muaj txog kev siv tau, cov lus qhia, lus ceeb toom, kev ceev faj, kev cuam tshuam, kev cuam tshuam, lossis kev pheej hmoo uas yuav siv tau rau cov tshuaj no. Cov ntaub ntawv no tsis yog tsim los muab cov lus qhia kho mob, kuaj mob lossis kev kho mob thiab tsis hloov cov ntaub ntawv koj tau txais los ntawm tus kws kho mob. Yog xav paub ntxiv txog cov lus qhia ntxaws ntxaws txog qhov txaus ntshai thiab cov txiaj ntsig ntawm kev siv cov tshuaj no, thov tham nrog koj tus kws kho mob thiab tshuaj xyuas tag nrho cov ntawv qhia txog tus neeg mob.

Cov ntaub ntawv ntxiv

Nco ntsoov sab laj nrog koj tus kws kho mob kom paub meej tias cov ntaub ntawv uas tshwm sim hauv nplooj ntawv no siv tau rau koj tus kheej.