Buscopan

Lub npe dav: N-butylscopolammonium bromide txhaj tshuaj
Dosage form: RAU NTAUB NTAWV SIV nkaus xwb

Ntawm nplooj ntawv no

• Kev piav qhia
• Dosage thiab Administration
• Contraindications
• Ceeb toom
• Cov kev ceev faj
• Cov Kev Phem Tsis Zoo/Sib Phem
• Clinical Pharmacology
• Kev tshawb fawb soj ntsuam
• Yuav Ua Li Cas Muab / Cia thiab tuav
• Cov ntaub ntawv

NADA 141-228, Pom zoo los ntawm FDA

Antispasmodic (spasmolytic) thiab tshuaj anticholinergic rau kev siv cov hlab ntsha hauv cov nees nkaus xwb

tus nqi hydrocodone ib ntsiav tshuaj

Ceev faj

Tsoom Fwv Teb Chaws txoj cai txwv cov tshuaj no siv los ntawm lossis raws li kev txiav txim ntawm tus kws kho tsiaj muaj ntawv tso cai.

Kev piav qhia

Buscopan yog ib qho tshuaj antispasmodic (spasmolytic) thiab tshuaj anticholinergic uas inhibits spasms ntawm digestive system.

Lub npe tshuaj rau cov khoom tseem ceeb ntawm Buscopan Injectable Solution yog N-butylscopolammonium bromide. Nws yog ib qho dej soluble, dawb crystalline khoom nrog ib qho hnyav molecular ntawm 440.40. Txhua mL ntawm Buscopan Injectable Solution muaj 20 mg N-butylscopolammonium bromide, 1.8 mg methylparaben, 0.2 mg propylparaben, 6.0 mg sodium chloride, thiab dej rau kev txhaj tshuaj. Cov qauv tshuaj lom neeg yog:

Cov lus qhia

Buscopan yog qhia rau kev tswj mob plab (colic) cuam tshuam nrog spasmodic colic, flatulent colic, thiab yooj yim cuam tshuam rau nees.

tshuaj dawb tsis muaj 4

Dosage thiab Administration

Muab ib qho kev txhaj tshuaj ntawm 0.3 mg / kg lub cev hnyav (0.14 mg / lb), maj mam IV. Qhov no yog sib npaug rau 30 mg N-butylscopolammonium bromide ib 100 kg (220 phaus) lub cev hnyav lossis 1.5 mL ntawm Buscopan Injectable Solution rau 100 kg (220 phaus) lub cev hnyav.

Contraindications

Buscopan yuav tsum tsis txhob siv nyob rau hauv impaction colic txuam nrog ileus, los yog nyob rau hauv nees nrog glaucoma.

Ceeb toom

Tsis yog rau nees npaj rau tib neeg noj. Tsis siv rau tib neeg. Khaws kom deb ntawm cov menyuam yaus. Yog tias noj, hu rau tus kws kho mob tam sim ntawd.

Cov kev ceev faj

Buscopan tsis pom zoo siv rau hauv cov laus foals lossis hauv cev xeeb tub lossis lactating mares, vim tsis tau tsim kev nyab xeeb. Cov teebmeem ntawm Buscopan tuaj yeem ua rau muaj zog los ntawm kev siv lwm yam tshuaj anticholinergic. Kev tshawb fawb ntawm kev tswj hwm ntawm Buscopan nrog lwm cov tshuaj tsis tau ua. Tshuaj compatibility yuav tsum tau saib xyuas zoo nyob rau hauv cov neeg mob xav tau kev kho adjunctive. Kev nyab xeeb ntawm Buscopan tsis tau tsim los rau kev tswj hwm intramuscular (IM). Kev tswj hwm ntawm Buscopan ua rau lub plawv dhia nce siab. Lub plawv dhia tsis tuaj yeem siv los ua qhov qhia tau tseeb ntawm qhov mob hnyav rau 30 feeb tom qab txhaj tshuaj IV.

Kev Phem Tsis Zoo

Kev hloov pauv tachycardia thiab txo qis borborygmal suab tau siv sijhawm li 30 feeb tom qab tswj hwm. Tej zaum yuav raug soj ntsuam ntawm cov menyuam yaus dilation.

Txhawm rau tshaj tawm cov kev xav tsis zoo, kom tau txais Daim Ntawv Qhia Txog Kev Nyab Xeeb Khoom Siv (MSDS), lossis rau kev pab cuam, hu rau 1 800-821-7467.

Clinical Pharmacology

Buscopan's spasmolytic action yog ua raws li cov tshuaj anticholinergic uas tshwm sim los ntawm kev sib tw inhibition ntawm parasympathetic activation (ntawm muscarinic receptors) ntawm cov leeg nqaij leeg.ibCov kev mob tshwm sim loj yog qhov mob me me, lub plawv dhia siab.

Pharmacokinetics

Tom qab ib leeg IV kev tswj hwm ntawm14C-Buscopan (0.4 mg / kg, sab saw sau) hauv 3 tus nees, txoj hauv kev tseem ceeb ntawm kev tshem tawm tag nrho cov xov tooj cua yog los ntawm cov zis thiab quav yuav luag sib npaug. Feem ntau ntawm cov xov tooj cua (> 96%) uas sawv cev rau tag nrho14C-labeled moieties muab los ntawm cov14C-Buscopan koob tshuaj raug tshem tawm ( tso zis thiab quav) hauv thawj 48 teev tom qab noj. Kev tshem tawm ib nrab-lub neej ntawm tag nrho cov ntshav plasma14C tau kwv yees kwv yees li 6 teev. Yog li, kev tshem tawm ib nrab-lub neej ntawm niam txiv tshuaj hauv ntshav ntshav yog sib npaug lossis luv dua 6 teev. Cov khoom siv hluav taws xob tseem ceeb hauv cov zis, uas sib koom ua ke nrog Buscopan siv nyias txheej chromatography (TLC), suav txog kwv yees li 85% ntawm cov khoom siv hluav taws xob pom.

Kev ua tau zoo

Kev tshawb fawb ntau qhov chaw, kev tshawb fawb tau ua los tsim kom muaj kev kho mob zoo ntawm Buscopan (0.3 mg / kg lub cev qhov hnyav) rau kev tswj cov mob plab (colic) cuam tshuam nrog spasmodic, flatulent thiab yooj yim cuam tshuam colic hauv cov nees. Tag nrho ntawm 217 tus neeg mob tau muab tso rau hauv pawg Buscopan lossis placebo; cov kws tshawb nrhiav tau npog qhov ncauj nrog kev saib xyuas.

Dab tsi yog boric acid siv rau

Nees tau txais kev kuaj mob pretreatment colic, nrog rov kuaj dua ntawm 5, 15, thiab 30 feeb tom qab kuaj kab lus. Tag nrho cov qhab nia colic tau muab rau txhua kis raws li 5 tus neeg ua haujlwm (hws tawm hws, pawing, lub taub hau thiab lub cev txav, ncaws, thiab xav pw). Ib qho kev xav pom dav dav tau ua nyob rau ntawm 30-feeb tom qab kev kho mob. Tsis muaj kev ntsuam xyuas ntxiv tom qab 30 feeb.

Quarter Nees, Arabians, thiab Thoroughbreds suav rau feem ntau ntawm cov xwm txheej. Tsib caug-peb feem pua ​​​​ntawm cov nees yog geldings, 39% yog mares thiab 8% yog stallions. Lub cev hnyav li ntawm 300-1700 lb (136-772 kg), nrog rau qhov nruab nrab ntawm 968 lb (440 kg). Cov hnub nyoog nyob nruab nrab ntawm 4 lub hlis thiab 35 xyoo, nrog qhov nruab nrab ntawm 10.6 xyoo.

Tag nrho cov qhab nia colic tau txo qis thoob plaws hauv 30-feeb tom qab kev soj ntsuam kev kho mob rau ob qho tib si Buscopan thiab placebo. Cov qhab nia qis dua (p≦0.001) rau Buscopan kho nees. Tsis tas li ntawd, 88% ntawm cov neeg mob Buscopan raug ntsuas raws li 'kev ua tiav' (zoo heev, zoo, lossis nruab nrab). Qhov no tau loj dua (p≦0.0001) ntau dua li 42% kev vam meej rau cov placebo pawg.

cov kev mob tshwm sim ntawm boniva

Kev ua tau zoo ntawm Buscopan kuj tau txais kev txhawb nqa los ntawm kev txhim kho tag nrho hauv kev coj tus cwj pwm ntawm cov nees. Qhov feem pua ​​​​siab dua ntawm Buscopan kho cov nees tau raug ntsuas raws li 'kev ceeb toom / kev thaj yeeb' ntawm 15 thiab 30 feeb tom qab kev kho mob (p≦0.005 thiab 0.0058, raws li), thiab qhov tseem ceeb (p≦0.006) ntau dua ntawm cov placebo kho nees yog ' ntxhov siab / tsis xis nyob.' Ib qho piv txwv ntawm cov xwm txheej rau ob pawg Buscopan thiab cov placebo tau muab cais ua 'hnyav' lossis 'drowsy / ntxhov siab' txhua lub sijhawm. Kev kho mob tom qab lub plawv dhia tau nce siab (p≦0.0001) rau Buscopan kho nees ntawm 5 thiab 15 feeb, piv rau cov placebo kho nees, raws li xav tau vim Buscopan's parasympatholytic cuam tshuam. Los ntawm 30 feeb tom qab kev kho mob, lub plawv dhia rau pawg Buscopan tsis txawv txav ntawm lawv cov kev kho mob ua ntej lub plawv dhia. Qhov kev siv thiab zaus ntawm borborygmi nyob rau hauv tag nrho plaub lub plab quadrants tau txo qis rau pawg Buscopan ntawm feem ntau cov ntsiab lus tom qab kev kho mob (p≦0.02).

Kev Nyab Xeeb Tsiaj

Lub hom phiaj kev nyab xeeb tsiaj raug soj ntsuam nyob rau hauv ntau qhov kev tshawb fawb, suav nrog kev siv tshuaj ntev, lub hom phiaj kev nyab xeeb tsiaj, hemodynamics, thiab kev nyab xeeb teb. Tsis muaj cov tsos mob ntawm toxicity los yog kev phiv tshwm sim. Cov teebmeem pharmacological pom hauv cov kev tshawb fawb no tau ua raws li cov tshuaj anticholinergic (saib saum toj).

Hauv kev tshawb fawb txog kev nyab xeeb ntawm tsiaj, Buscopan tau soj ntsuam hauv ob theem. Hauv thawj theem, cov tshuaj tau txhaj tshuaj intravenously ntawm ntau npaum li cas ntawm 1, 3, thiab 5 npaug ntawm qib pom zoo (30, 90 thiab 150 mg rau 100 kg lub cev hnyav) ib hnub rau peb hnub sib law liag. Nyob rau theem ob nws tau muab rau ntawm qhov pom zoo siv tshuaj (30 mg rau ib kg lub cev qhov hnyav) ntawm ib teev twg rau peb teev sib law liag. Nees tau txais Buscopan zoo li muaj kev ncua ntev, txo qis ntawm auscultated borborygmi, uas tuaj yeem raug ntaus nqi los ntawm kev npaj kho mob ntawm cov tshuaj. Tsis muaj pov thawj ntawm plab stasis lossis colic. Tsis pom muaj lwm cov teebmeem tseem ceeb hauv kev kho mob. Txawm hais tias muaj kev cuam tshuam ib ntus ntawm lub plawv dhia tau raug sau tseg hauv lwm cov kev tshawb fawb, kev soj ntsuam hauv qhov kev tshawb fawb no (1-4 teev tom qab kev tswj hwm tshuaj) tau ua tom qab thawj cov tshuaj pharmacological rau cov tshuaj no dhau lawm. Tsis yog qhov tseem ceeb ntawm kev noj tshuaj nrog cov menyuam kawm ntawv / menyuam kawm ntawv lub teeb teb raws li tau sau tseg hauv lwm cov kev tshawb fawb. Pupillary dilation yog qhov xav tau tshuaj teb rau cov tshuaj no (anticholinergic). Qhov tsis muaj qhov chaw kho mob hauv qhov kev tshawb fawb no kuj tseem muaj feem cuam tshuam nrog lub sijhawm ntev tom qab kev kho mob uas qhov kev soj ntsuam thawj zaug tau ua. Nyob rau hauv txhua rooj plaub, qhov kev tshawb fawb no qhia tau hais tias ib qho kev cuam tshuam ntawm cov lus teb ntawm cov tub ntxhais hluas lub teeb yog qhov tseeb. Tsis muaj tshuaj cuam tshuam txog kev tshawb pom txog kev soj ntsuam ntshav, thiab tsis muaj qhov cuam tshuam tshwm sim ntawm necropsy thiab histopathology.

Hauv kev tshawb nrhiav kev ua siab ntev, plaub tus nees tau muab 10 npaug ntawm cov tshuaj Buscopan pom zoo (300 mg / 100 kg) thiab tau tshuaj xyuas ntawm 10 feeb thiab tom qab ntawd tom qab 1, 2, 3, 4, 24, thiab 72 teev tom qab txhaj tshuaj. Txhua tus nees tau ntsib ib ntus ntawm cov menyuam kawm ntawv uas tsis muaj zog thiab ruaj khov ntawm 10 feeb tom qab txhaj tshuaj. Lub teeb pom kev zoo li qub tau rov qab los ntawm ob tus nees ntawm 4 teev thiab lwm tus nees ntawm 24 teev. Lub plawv dhia tau nce ntawm 10 thiab 60 feeb, tab sis tau rov qab mus rau qhov qub ntawm 2 teev. Qhov ncauj mucous daim nyias nyias tau qhuav ntawm 10 feeb, tab sis zoo li qub ntawm 2 teev. Lub plab motility, raws li tau txiav txim los ntawm auscultated borborygmi, tsis tuaj ntawm 10 feeb tom qab txhaj tshuaj, tab sis tau rov qab mus rau lub hauv paus zaus thiab siv los ntawm 3 teev nyob rau hauv 2 nees thiab 4 teev nyob rau hauv cov nees ntxiv. Muaj ob qhov tshwm sim ntawm colic, nrog rau ib tus nees uas pom tias mob me me ntawm 1 teev, thiab lwm qhov mob me me ntawm 11 teev. Ob qho kev mob colic yog ib ntus thiab tsis xav tau tshuaj. Tsis muaj cov tshuaj cuam tshuam txog kev hloov pauv hauv CBC, ntshav coagulation, lossis ntshav chemistry. Tsis muaj leej twg muaj cov tshuaj cuam tshuam txog tag nrho lossis kev hloov pauv histopathological.

Hauv kev tshawb fawb txog hemodynamic tsis, Buscopan txo txoj cai atrial siab, thaum lub plawv tso zis tau khaws cia. Cov kev hloov pauv hemodynamic uas tshwm sim tom qab kev tswj hwm Buscopan yog qhov tseem ceeb ntawm kev kho mob me me, ua tau zoo zoo ib yam li cov uas tau tshaj tawm rau cov tshuaj qis ntawm lwm cov tshuaj anticholinergics xws li atropine.

Cia

Khaws ntawm chav tsev kub tswj, 59-86 ° F (15-30 ° C).

Yuav Ua Li Cas

Buscopan Injectable Solution yog muab rau hauv 50 mL multi-dose vials uas muaj 20 mg N-butylscopolammonium bromide ib mL.

Kuv yuav coj zyrtec thiab dayquil

Cov ntaub ntawv

ibRoelvinck, M.E.J., et al. 1991. Analgesic thiab spasmolytic teebmeem ntawm dipyrone, hyoscine-N-butylbromide thiab kev sib xyaw ntawm ob qho tib si hauv ponies.Veterinary Record129:379-380

Manufactured rau:
Boehringer Ingelheim Vetmedica, Inc.
St. Joseph, MO 64506

BuscopanTMyog lub cim lag luam ntawm Boehringer Ingelheim Pharma GmbH & Co. KG thiab siv raws li daim ntawv tso cai.

Kho tshiab 08/2008

81313157 ib
81312800 R.0

mL Ntim Label

mL thawv