Carbidopa / Levodopa Dosage

phentermine hci 30 mg

Siv rau cov hauv qab no muaj zog: 10 mg-100 mg; 25 mg-100 mg; 25 mg-250 mg; 50 mg-200 mg; 4.63 mg-20 mg / ml; 23.75 mg-95 mg; 36.25 mg-145 mg; 48.75 mg-195 mg; 61.25 mg-245 mg

Ib txwm Adult Dose rau:

Cov lus qhia txog kev noj tshuaj ntxiv:

Ib txwm siv rau cov neeg laus noj rau tus kab mob Parkinson

Qhov koob tshuaj zoo tshaj plaws yog txiav txim siab los ntawm kev ua tib zoo saib xyuas tus kheej: Txhua koob tshuaj qhia raws li CARBIDOPA-LEVODOPA

Tam sim no-tso nrog rau qhov ncauj disintegrating ntsiav tshuaj:
Thawj koob tshuaj: 25 mg-100 mg ntawm qhov ncauj peb zaug hauv ib hnub lossis 10 mg-100 mg ntawm qhov ncauj 3 lossis 4 zaug hauv ib hnub
- nce ntxiv los ntawm 1 ntsiav tshuaj txhua hnub lossis txhua hnub raws li xav tau kom txog rau thaum noj 8 ntsiav tshuaj; tuaj yeem siv cov ntsiav tshuaj sib xyaw ua ke los ntawm ob qho piv txwv (1: 4 lossis 1: 10) los muab cov koob tshuaj zoo tshaj.
Kev hloov pauv los ntawm LEVODOPA :
-Levodopa yuav tsum tau txiav tawm tsawg kawg 12 teev ua ntej pib carbidopa-levodopa; pib nrog kwv yees li 25% ntawm cov koob tshuaj levodopa yav dhau los.
-Cov koob tshuaj pom zoo rau cov neeg mob tau txais tsawg dua levodopa 1500 mg ib hnub: 25 mg-100 mg ntawm qhov ncauj 3 lossis 4 zaug hauv ib hnub.
-Cov koob tshuaj pom zoo rau cov neeg mob tau txais ntau dua levodopa 1500 mg ib hnub: 25 mg-250 mg ntawm qhov ncauj 3 lossis 4 zaug hauv ib hnub.

Sustained-Release Tablets (SINEMET CR):
-Cov koob tshuaj pib (levodopa-naive): 50 mg-200 mg ntawm qhov ncauj ob zaug ib hnub; Thawj koob tshuaj yuav tsum tau muab nyob rau ntawm lub sijhawm ntau dua 6 teev
-Cov koob tshuaj thiab koob tshuaj yuav nce lossis txo qis ntawm qhov tsawg kawg 3 hnub raws li cov lus teb kho
-Cov koob tshuaj ntau: Feem ntau cov neeg mob yuav tsum tau levodopa 400 mus rau 1600 mg / hnub hauv kev faib tshuaj txhua 4 mus rau 8 teev thaum sawv ntxov; koob tshuaj 2400 mg / hnub ntawm lub sijhawm tsawg dua 4 teev tau siv, tab sis feem ntau tsis pom zoo.
Kev hloov pauv los ntawm IMMEDIATE-RELEASE levodopa nrog lossis tsis muaj decarboxylase inhibitor:
-Rau cov neeg mob tau txais levodopa nrog decarboxylase inhibitor: Kev siv tshuaj nrog Sinemet CR yuav tsum yog kwv yees li 10% siab dua li yav dhau los levodopa noj; qhov no yuav tsum tau nce mus txog 30% siab dua nyob ntawm qhov chaw kho mob.
-Rau cov neeg mob tau txais levodopa yam tsis muaj decarboxylase inhibitor: Kev noj tshuaj nrog kev tso tawm yuav tsum yog kwv yees li 25% ntawm cov tshuaj levodopa yav dhau los; levodopa yuav tsum tau txiav tawm tsawg kawg 12 teev ua ntej pib carbidopa-levodopa

Extended-Release Capsules (RYTARY) :
-Cov koob tshuaj pib (levodopa-naive): 23.75 mg-95 mg ntawm qhov ncauj 3 zaug hauv ib hnub rau 3 hnub; Hnub plaub, tuaj yeem nce mus rau 36.25 mg-145 mg 3 zaug hauv ib hnub
-Dosing ncua sij hawm yuav nce mus txog qhov siab tshaj plaws ntawm 5 zaug hauv ib hnub, yog tias zam tau
-Cov koob tshuaj ntau tshaj txhua hnub: 612.5 mg-2450 mg
Kev hloov pauv los ntawm IMMEDIATE-RELEASE carbidopa-levodopa rau RYTARY: Cov koob tshuaj pom zoo no yuav tsum tau muab faib thiab muab 3 zaug hauv ib hnub:
-Rau cov neeg mob tau txais levodopa 400 txog 549 mg / hnub: RYTARY levodopa koob tshuaj yuav tsum yog 855 mg / hnub
-Rau cov neeg mob tau txais levodopa 550 txog 749 mg / hnub: RYTARY levodopa koob tshuaj yuav tsum yog 1140 mg / hnub
-Rau cov neeg mob tau txais levodopa 750 txog 949 mg / hnub: RYTARY levodopa koob tshuaj yuav tsum yog 1305 mg / hnub
-Rau cov neeg mob tau txais levodopa 950 txog 1249 mg / hnub: RYTARY levodopa koob tshuaj yuav tsum yog 1755 mg / hnub
-Rau cov neeg mob tau txais levodopa sib npaug lossis ntau dua 1250 mg / hnub: RYTARY levodopa koob tshuaj yuav tsum yog 2205 lossis 2340 mg / hnub

Cov lus pom:
-Peripheral dopa decarboxylase yog saturated los ntawm carbidopa ntawm kwv yees li 70 mus rau 100 mg / hnub; tus neeg mob tau txais tsawg dua li cov carbidopa no feem ntau yuav ua rau xeev siab thiab ntuav; Kev paub nrog cov koob tshuaj carbidopa ntau dua 200 mg / hnub yog txwv.
-RYTARY cov khoom tsis hloov pauv nrog lwm cov khoom carbidopa-levodopa; rau cov neeg mob tau txais carbidopa-levodopa ntxiv rau catechol-O-methyl transferase (COMT) inhibitors, thawj zaug pom zoo tag nrho cov koob tshuaj levodopa txhua hnub yuav tsum tau nce ntxiv.

Siv: Rau kev kho mob ntawm cov tsos mob ntawm idiopathic Parkinson tus kab mob, postencephalitic parkinsonism, thiab symptomatic parkinsonism uas yuav ua raws li kev raug mob rau lub paj hlwb los ntawm carbon monoxide intoxication thiab/los yog manganese intoxication.

DUOPA Enteral Suspension (carbidopa 4.63 mg-levodopa 20 mg per mL) yog qhia rau kev kho mob ntawm lub cev muaj zog hloov pauv hauv cov neeg mob uas muaj tus kab mob Parkinson siab heev.
-Tau rau hauv jejunum los ntawm PEG-J raj siv CADD-Legacy 1400 portable infusion twj; rau kev tswj xyuas lub sijhawm luv luv, lub raj naso-jejunal yuav siv tau.
-Tag nrho cov koob tshuaj yog tsim los ntawm 3 koob tshuaj kho ib tus zuj zus: koob tshuaj MORNING bolus, koob tshuaj txuas ntxiv mus, thiab EXTRA BOLUS koob tshuaj.

Kev pib: Hloov txhua hom levodopa rau qhov ncauj tam sim-tso carbidopa-levodopa ntsiav tshuaj siv 1: 4 ratio ntsiav tshuaj.
-Hnub 1 thaum sawv ntxov koob tshuaj: Muab ib koob tshuaj levodopa sib npaug rau hnub dhau los thawj koob tshuaj levodopa; xam los ntawm kev hloov cov koob tshuaj levodopa los ntawm mg rau milliliters thiab ntxiv 3 milliliters ntawm ntim rau prime lub plab hnyuv; muab ntau tshaj 10 mus rau 30 feeb.
-Hnub 1 koob tshuaj tas mus li: Muab cov tshuaj levodopa tsim nyog rau 16 teev sawv ntxov; xam los ntawm kev txiav txim siab npaum li cas ntawm levodopa tau txais hnub dhau los, tshem tawm cov koob tshuaj thaum sawv ntxov thiab hmo ntuj.
-Ntxiv bolus koob muaj nuj nqi muaj los tswj tus mob 'tawm' cov tsos mob; thawj zaug nws yuav tsum tau teem rau 20 mg (1 mL), titrate hauv 0.2 mL increments; Cov koob tshuaj ntxiv yuav tsum txwv rau ib zaug txhua 2 teev.
Kho koob tshuaj raws li kev soj ntsuam teb :
MORNING DOSE yog muab sai sai (tshaj li 10 mus rau 30 feeb) kom ua tiav qib kev kho mob; Cov koob tshuaj no yuav tsum tau hloov kho yog tias muaj cov lus teb tsis txaus nyob rau hauv 1 teev ntawm kev noj tshuaj thaum sawv ntxov hnub ua ntej :
-Rau cov koob tshuaj tsawg dua lossis sib npaug li 6 mL (tsis suav nrog 3 mL rau prime raj): nce 1 mL.
-Rau cov koob tshuaj ntau dua 6 mL (tsis suav nrog 3 mL rau prime raj): nce 2 mL.
-Yog hais tias dyskinesia los yog levodopa-txog kev phiv tshwm sim tshwm sim nyob rau hauv 1 teev sawv ntxov koob tshuaj nyob rau hnub ua ntej, txo cov koob tshuaj thaum sawv ntxov los ntawm 1 mL.
TSIS TAU TXAIS NTUJ:
-Xav txog kev nce koob tshuaj raws li tus naj npawb thiab ntim ntawm cov tshuaj ntxiv uas tau muab rau hnub dhau los thiab tus neeg mob cov lus teb.
-Xav txog txo cov koob tshuaj rau cov teeb meem dyskinesia lossis lwm yam kev phiv tshwm sim; rau cov tshuaj tiv thaiv kav ntev li 1 teev lossis ntau dua los ntawm 0.3 mL / hr; rau cov tshuaj tiv thaiv kav ntev li 2 teev lossis ntau dua los ntawm 0.6 mL / hr.
MAXIMUM DAIM NTAWV THOV: 1 ntsiav tshuaj (levodopa 2000 mg) tshaj 16 teev; Tus neeg mob yuav noj lawv cov koob tshuaj hmo ntuj ntawm qhov ncauj tam sim-tso carbidopa-levodopa.



Renal Dose Adjustments

Siv ceev faj.

Kev Kho Mob Siab

Siv ceev faj.

cov teebmeem ntev ntawm gabapentin

Kev Kho Tshuaj

Thaum pib cov tshuaj no, kev tswj hwm ntawm lwm cov tshuaj antiparkinsonian tus qauv yuav txuas ntxiv mus; Txawm li cas los xij, kev hloov kho koob tshuaj ntawm cov tshuaj no yuav xav tau.

RYTARY (carbidopa-levodopa ncua-tso capsule) tsis hloov pauv nrog lwm cov khoom carbidopa-levodopa.

Cov kev ceev faj

Kev nyab xeeb thiab kev ua tau zoo tsis tau tsim nyob rau hauv cov neeg mob hnub nyoog qis dua 18 xyoo.

Nrog rau WARNINGS seem rau kev ceev faj ntxiv.

Dialysis

Cov ntaub ntawv tsis muaj.

tshuaj tua kab mob puas ua rau koj lub sijhawm

Lwm Cov Lus Qhia

Cov lus qhia txog kev tswj hwm:
Qhov ncauj Disintegrating ntsiav tshuaj :
- Tshem cov ntsiav tshuaj ntawm lub raj mis nrog ob txhais tes qhuav ua ntej kev tswj hwm
- Muab tus nplaig, ces nqos qaub ncaug; kev tswj cov kua dej tsis tsim nyog

Sinemet CR (R) ntsiav tshuaj :
- Ncua tag nrho; tsis txhob zom los yog zom

Rytary(R) Extended-Release Capsules :
- Ncua tag nrho; kuj tseem tuaj yeem nchuav cov ntsiab lus ntawm cov tshuaj ntsiav mus rau 1 mus rau 2 tablespoons applesauce thiab noj tam sim ntawd.
-Xav txog kev noj thawj zaug ntawm 1 mus rau 2 teev ua ntej noj mov; Cov rog rog, cov zaub mov muaj calorie ntau tuaj yeem ncua kev nqus ntawm levodopa mus txog 2 mus rau 3 teev.

Txoj hnyuv plab (DUOPA):
-Cassettes yuav tsum tau coj mus rau chav tsev kub ua ntej siv; saib cov ntaub ntawv khoom kom tiav cov lus qhia ua haujlwm.
-Cassettes tshwj xeeb tsim los txuas nrog CADD(R) Legacy 1400 twj tso kua mis.
-Cassettes yog siv rau ib leeg xwb, tsis txhob siv ntev dua 16 teev

Cov cai cia khoom: DUOPA Cassettes :
- Khaws rau hauv lub freezer ntawm -20C (-4F) ua ntej muab tshuaj
-Thaum muab xa tawm, cov ntawv ntim yuav tsum tau muab tso rau hauv lub tub yees ntawm 2C txog 8C (36F txog 46F); nqa cov thawv tawm ntawm lub thawv thauj thiab sib cais los ntawm ib leeg kom tso cai txawm tias thawing (thawing yuav siv li 96 teev); ib zaug thawed, cartons tej zaum yuav repacked nyob rau hauv ib tug ze configuration.
-Siv siv 12 lub lis piam los ntawm hnub ib zaug muab tso rau hauv lub tub yees kom thaw.
-Cassettes yuav tsum tau tiv thaiv los ntawm lub teeb thiab khaws cia rau hauv thawv ua ntej siv.

Kev ruaj ntseg:
-Stable rau 24 lub hlis ntawm -20C thiab 15 lub lis piam ntawm 5C; 16 teev ib zaug sab nraum lub tub yees.

General:
-Cov tshuaj no yog qhia rau kev kho mob ntawm idiopathic parkinsonism, nws yog ib qho tseem ceeb rau relieving ntau cov tsos mob tshwj xeeb tshaj yog rigidity thiab bradykinesia; Nws feem ntau pab tau rau kev tswj kev tshee, dysphagia, sialorrhea, thiab postural instability.
-Qhov sib ntxiv ntawm carbidopa rau levodopa yuav txo cov teebmeem peripheral ntawm levodopa; Txawm li cas los xij, txij li thaum carbidopa tsis hla cov hlab ntsha hauv lub hlwb, cov kev cuam tshuam tsis zoo vim qhov cuam tshuam hauv nruab nrab tuaj yeem tshwm sim sai dua thiab qis dua li levodopa ib leeg.
-Tsis txhob tso tseg tam sim ntawd lossis txo koob tshuaj sai sai ntawm cov tshuaj no.
-Vim levodopa sib tw nrog qee cov amino acids rau kev thauj mus los ntawm lub plab phab ntsa, qhov nqus ntawm levodopa tuaj yeem txo qis hauv cov neeg mob noj cov zaub mov muaj protein ntau.

Saib xyuas :
-Cov hlab plawv: Saib xyuas cov tsos mob thiab cov tsos mob ntawm orthostatic hypotension, tshwj xeeb tshaj yog thaum noj tshuaj nce ntxiv; rau cov neeg mob uas muaj keeb kwm ntawm myocardial infarction nrog residual atrial, nodal, lossis ventricular arrhythmias, lub plawv ua haujlwm yuav tsum tau saib xyuas hauv qhov chaw kho mob plawv thaum pib siv tshuaj.
-Nervous System: Saib xyuas dyskinesia, somnolence thiab tsaug zog
-Dermatology: Saib xyuas melanomas; xav txog kev kuaj tawv nqaij raws sij hawm los ntawm dermatologists.
-Ocular: Saib xyuas lub siab intraocular nyob rau hauv cov neeg mob uas mob ntev glaucoma nyob ze thaum kho; blepharospasm yog ib qho txiaj ntsig ntxov ntawm kev siv tshuaj ntau dhau hauv qee cov neeg mob.
-Psychiatric: Nug cov neeg mob txog qhov kev xav tshiab lossis nce kev twv txiaj, xav txog kev sib deev, kev siv nyiaj tsis raug cai, binge lossis compulsive noj, lossis lwm yam kev yaum; saib xyuas cov xwm txheej tshiab lossis kev puas siab puas ntsws thiab kev hloov tus cwj pwm.
-Kev kuaj mob: Thaum lub sij hawm kho mob ntev, kev soj ntsuam ib ntus ntawm cov kab mob siab, hematopoietic, thiab lub raum ua haujlwm raug pom zoo.

Tus neeg mob cov lus qhia :
-Qhia rau cov neeg mob tias cov tshuaj no yuav ua rau cov kua txiv kab ntxwv xim av daj hauv cov qaub ncaug, zis, lossis hws; tuaj yeem hloov lawv cov khaub ncaws.
-Cov tshuaj no feem ntau ua rau qaug zog; Cov neeg mob yuav tsum tsis txhob tsav tsheb lossis ua haujlwm cov tshuab lossis lwm yam kev ua ub no uas yuav muaj kev phom sij txog thaum nws txiav txim siab tias cov tshuaj no cuam tshuam rau lawv lub hlwb thiab / lossis kev ua haujlwm ntawm lub cev muaj zog; rau cov neeg mob uas muaj kev qaug zog ntxiv, lawv yuav tsum tham nrog lawv tus kws kho mob txog kev nyab xeeb ntawm kev tsav tsheb.
-Cov neeg mob lossis cov neeg saib xyuas yuav tsum tau qhia kom qhia txog qhov tshwm sim ntawm qhov pib ntawm kev pw tsaug zog tam sim ntawd, tshiab lossis hnyav dua dyskinesia, kev coj tus cwj pwm tshiab lossis hnyav zuj zus ntxiv thiab / lossis kev xav tsis zoo, kev sim tua tus kheej lossis kev xav tua tus kheej.
-Cov neeg mob yuav tsum tau qhia kom qhia txog kev hloov pauv ntawm qhov loj, zoo li, lossis xim ntawm moles ntawm lawv daim tawv nqaij thiab yuav tsum tau kuaj xyuas lawv cov tawv nqaij tsis tu ncua rau melanomas.
-Cov neeg mob yuav tsum paub tias cov tshuaj no yuav ua rau cov ntshav siab hloov pauv xws li qaug zog thiab kiv taub hau thiab cov neeg mob tau qhia kom tsis txhob sawv sai sai tom qab zaum lossis pw.
-Cov neeg mob yuav tsum tham nrog lawv tus kws kho mob lossis tus kws kho mob yog tias lawv xeeb tub, xav xeeb tub, lossis pub niam mis.

Cov ntaub ntawv ntxiv

Nco ntsoov sab laj nrog koj tus kws kho mob kom paub meej tias cov ntaub ntawv uas tshwm sim hauv nplooj ntawv no siv tau rau koj tus kheej.