Clindamycin Hydrochloride Capsules rau Tsiaj Siv - Drugs.com

Nplooj ntawv no muaj cov ntaub ntawv hais txog Clindamycin Hydrochloride Capsules rau kev siv kws kho tsiaj .
Cov ntaub ntawv muab feem ntau suav nrog cov hauv qab no:

Clindamycin Hydrochloride Capsules Indications
Cov lus ceeb toom thiab ceeb toom rau Clindamycin Hydrochloride Capsules
Cov lus qhia thiab ntau npaum li cas rau Clindamycin Hydrochloride Capsules

Clindamycin Hydrochloride Capsules

Txoj kev kho no siv rau cov hom hauv qab no:

Cov dev

Chaw tsim tshuaj paus: Clipper (Phoenix Pharm.)

Tshuaj tua kab mob

ANADA 200-298, Pom zoo los ntawm FDA

Kev piav qhia

Clindamycin Hydrochloride Capsules muaj clindamycin hydrochloride uas yog hydrated ntsev ntawm clindamycin. Clindamycin yog ib hom tshuaj tua kab mob semisynthetic uas tsim los ntawm 7(S)-chlorosubstitution ntawm 7(R)-hydroxyl pawg ntawm cov tshuaj tua kab mob uas tsim tawm los ntawm Streptomyces lincolnensis var. lincolnensis .

Clindamycin Hydrochloride Capsules

25 Mg Capsule, Txhua Lub Ncauj Daj thiab Tsis Muaj Xim Muaj Clindamycin Hydrochloride sib npaug rau 25 Mg ntawm Clindamycin.

75 mg tab , Txhua Ntsuab Thiab Tsis Muaj Xim Capsule muaj Clindamycin Hydrochloride sib npaug rau 75 Mg ntawm Clindamycin.

150 mg tab , Txhua lub Blue thiab Colorless Capsule muaj Clindamycin Hydrochloride sib npaug rau 150 Mg ntawm Clindamycin.

300 mg Capsule, Txhua Turquoise Thiab Tsis Muaj Xim Capsule muaj Clindamycin Hydrochloride sib npaug rau 300 mg ntawm Clindamycin.

kev nqis tes ua: Qhov Chaw Thiab Hom Kev Ua

Clindamycin yog ib qho inhibitor ntawm protein synthesis hauv cov kab mob ntawm tes. Qhov chaw ntawm kev khi zoo li nyob rau hauv 50S sub-unit ntawm ribosome. Kev khi tau tshwm sim rau cov dej soluble RNA feem ntawm qee cov ribosomes, yog li inhibiting kev khi ntawm cov amino acids rau cov ribosomes. Clindamycin txawv ntawm cell phab ntsa inhibitors nyob rau hauv uas nws ua rau irreversible hloov ntawm cov protein-synthesizing subcellular ntsiab nyob rau hauv ribosomal theem.

Microbiology

Clindamycin yog lincosaminide antimicrobial tus neeg sawv cev nrog kev ua haujlwm tawm tsam ntau yam kab mob aerobic thiab anaerobic kab mob. Clindamycin yog ib qho bacteriostatic compound uas inhibits cov kab mob protein synthesis los ntawm kev khi rau 50S ribosomal subunit. Yam tsawg kawg nkaus inhibitory concentrations (MICs) ntawm Gram-positive thiab obligate anaerobic pathogens cais los ntawm dev nyob rau hauv lub tebchaws United States yog nthuav tawm nyob rau hauv Table 1. Cov kab mob raug cais nyob rau hauv 1998-1999. Txhua MICs tau ua tiav raws li National Committee for Clinical Laboratory Standards (NCCLS).

Table 1. Clindamycin MIC Values (µg/mL) los ntawm Diagnostic Laboratory Survey Data Evaluating Canine Pathogens in the US thaum xyoo 1998-99 ^ib

Kab mob	Number of Isolates	Mic tsib caug	mic 85	mic 90	ntau
Soft Tissue/Qhov txhab^ob
Staphylococcus aureus	17	0.5	0.5	≥4.0	0.25-≥4.0
Staphylococcus intermediaus	28	0.25 ib	0.5	≥4.0	0.125-≥4.0
Staphylococcus ua spp.	18	0.5	0.5	≥4.0	0.25-≥4.0
Beta-hemolytic streptococci	46 lub sijhawm zoo tshaj los noj nexium	0.5	0.5	≥4.0	0.25-≥4.0
Streptococcus ua spp.	kaum ib	0.5	≥4.0	≥4.0	0.25-≥4.0
Osteomyelitis / Pob txha³
Staphylococcus aureus	nees nkaum	0.5	0.5	0.5	0.5⁴
Staphylococcus intermediaus	kaum tsib	0.5	≥4.0	≥4.0	0.25-≥4.0
Staphylococcus ua spp.	18	0.5	≥4.0	≥4.0	0.25-≥4.0
Beta-hemolytic streptococci	nees nkaum ib	0.5	2.0	2.0	0.25-≥4.0
Streptococcus ua spp.	nees nkaum ib	≥4.0	≥4.0	≥4.0	0.25-≥4.0
Dermal / tawv nqaij⁵
Staphylococcus aureus	25	0.5	≥4.0	≥4.0	0.25-≥4.0
Staphylococcus intermediaus	48	0.5	≥4.0	≥4.0	0.125-≥4.0
Staphylococcus ua spp.	32	0.5	≥4.0	≥4.0	0.25-≥4.0
Beta-hemolytic streptococci	17	0.5	0.5	0.5	0.25-0.5 hli

^ibKev sib raug zoo ntawm cov hauv vitro Cov ntaub ntawv susceptibility thiab kev kho mob teb tsis tau txiav txim siab.

^obCov ntaub so ntswg mos / qhov txhab: suav nrog cov qauv sau lub qhov txhab, abscess, aspirate, exudates, ntws dej, qhov txhab, thiab loj

³Osteomyelitis/pob txha: suav nrog cov qauv sau cov pob txha, pob txha, pob txha, leeg

⁴Tsis muaj ntau yam, tag nrho cov kev sib cais tawm tau tus nqi tib yam

⁵Dermal / Daim tawv nqaij: suav nrog cov qauv sau daim tawv nqaij, daim tawv nqaij swab, biopsy, incision, di ncauj

Pharmacology

Kev nqus

Clindamycin hydrochloride yog sai absorbed los ntawm lub plab zom mov.

Dog Serum Levels

Cov qib ntshav ntawm lossis siab dua 0.5 µg / mL tuaj yeem tswj hwm los ntawm kev noj tshuaj ntawm qhov ncauj ntawm tus nqi ntawm 2.5 mg / lb ntawm clindamycin hydrochloride txhua 12 teev. Tib txoj kev tshawb fawb no tau qhia tias qhov nruab nrab ntawm cov ntshav siab ntau ntawm clindamycin tshwm sim 1 teev thiab 15 feeb tom qab noj qhov ncauj. Kev tshem tawm ib nrab-lub neej rau clindamycin hauv dev ntshav yog kwv yees li 5 teev. Tsis muaj bioactivity tsub zuj zuj tom qab kev tswj hwm ntawm ntau qhov ncauj qhov ncauj hauv cov dev noj qab haus huv.

Clindamycin Serum Concentrations 2.5 mg/lb (5.5 mg/kg) Tom qab B.I.D. Qhov ncauj koob tshuaj Clindamycin Hydrochloride Capsules rau dev

Metabolism thiab Excretion

Cov kev tshawb fawb dav dav ntawm cov metabolism thiab excretion ntawm clindamycin hydrochloride tau siv qhov ncauj hauv cov tsiaj thiab tib neeg tau pom tias cov tshuaj tsis hloov pauv thiab cov tshuaj bioactive thiab bioinactive metabolites raug tawm hauv cov zis thiab quav. Yuav luag tag nrho cov bioactivity kuaj pom hauv cov ntshav tom qab clindamycin hydrochloride cov khoom siv yog vim niam txiv molecule (clindamycin). Cov zis bioactivity, txawm li cas los xij, qhia txog kev sib xyaw ntawm clindamycin thiab cov metabolites nquag, tshwj xeeb tshaj yog N-dimethyl clindamycin thiab clindamycin sulfoxide.

Tsiaj Kev Nyab Xeeb Summary

Rat Thiab Dog Data

Ib xyoos kev tshawb fawb txog kev ua xua rau ntawm qhov ncauj hauv cov nas thiab dev ntawm koob tshuaj 30, 100 thiab 300 mg / kg / hnub (13.6, 45.5 thiab 136.4 mg / lb / hnub) tau pom tias clindamycin hydrochloride capsules yuav tsum zam kom zoo. Qhov sib txawv tsis tau tshwm sim nyob rau hauv cov kev ntsuas ntsuas los ntsuas toxicity thaum sib piv pab pawg ntawm cov tsiaj kho nrog kev tswj xyuas niaj hnub no. Cov nas tsuag tau muab tshuaj clindamycin hydrochloride ntawm 600 mg / kg / hnub (272.7 mg / lb / hnub) rau rau lub hlis zam cov tshuaj zoo; Txawm li cas los xij, cov dev noj ntawm qhov ncauj ntawm 600 mg / kg / hnub (272.7 mg / lb / hnub) ntuav, muaj anorexia, thiab tom qab poob phaus. Nyob rau ntawm necropsy cov dev no muaj erosive gastritis thiab focal thaj chaw ntawm necrosis ntawm mucosa ntawm lub gall zais zis.

Kev nyab xeeb nyob rau hauv gestating bitches los yog yug me nyuam txiv neej tsis tau tsim.

Clindamycin Hydrochloride Capsules Indications clindamycin Hydrochloride Capsules yog qhia rau kev kho mob ntawm cov kab mob tshwm sim los ntawm raug kab mob ntawm cov kab mob tsim nyob rau hauv cov xwm txheej tshwj xeeb hauv qab no:

dev: Kab mob ntawm daim tawv nqaij (qhov txhab thiab abscesses) vim Coagulase Positive Staphylococci ( Staphylococcus aureus Los yog Staphylococcus Intermediaus ). Qhov mob tob tob thiab abscesses vim Bacteroides Fragilis, Prevotella Melaninogenicus, Fusobacterium Necrophorum Thiab Clostridium Perfringens . Cov kab mob hniav vim Staphylococcus aureus, Bacteroides Fragilis, Prevotella Melaninogenicus, Fusobacterium Necrophorum Thiab Clostridium Perfringens . mob osteomyelitis vim Staphylococcus aureus, Bacteroides Fragilis, Prevotella Melaninogenicus, Fusobacterium Necrophorum Thiab Clostridium Perfringens .

contraindications

Clindamycin Hydrochloride Capsules yog contraindicated nyob rau hauv cov tsiaj nrog keeb kwm ntawm hypersensitivity rau kev npaj muaj clindamycin los yog lincomycin.

Vim tias muaj feem cuam tshuam rau plab hnyuv, tsis txhob noj rau luav, hamsters, guinea npua, nees, chinchillas lossis ruminating tsiaj.

Ceeb toom

Khaws kom deb ntawm cov menyuam yaus. Tsis yog siv rau tib neeg.

Cov kev ceev faj

Thaum lub sij hawm kev kho mob ntev ntev ntawm ib lub hlis lossis ntau dua, kev kuaj lub siab thiab lub raum ua haujlwm thiab ntsuas ntshav yuav tsum tau ua. Kev siv clindamycin hydrochloride qee zaus ua rau muaj kev loj hlob ntawm cov kab mob uas tsis muaj kab mob xws li clostridia thiab poov xab. Yog li ntawd, kev tswj hwm ntawm Clindamycin Hydrochloride Capsules yuav tsum raug zam nyob rau hauv cov tsiaj uas nkag siab rau lub plab zom mov ntawm clindamycin (saib CONTRAINDICATIONS). Yog tias superinfections tshwm sim, kev ntsuas tsim nyog yuav tsum tau ua raws li qhia los ntawm qhov chaw kho mob. Cov neeg mob uas mob raum mob hnyav heev thiab/los yog kab mob siab heev nrog rau cov metabolic aberrations hnyav yuav tsum tau txhaj tshuaj nrog ceev faj, thiab cov qib ntshav clindamycin tau soj ntsuam thaum lub sij hawm kho mob siab.

Clindamycin hydrochloride tau pom tias muaj cov tshuaj tiv thaiv neuromuscular uas tuaj yeem txhim kho kev ua haujlwm ntawm lwm cov tshuaj tiv thaiv neuromuscular. Yog li ntawd, Clindamycin Hydrochloride Capsules yuav tsum tau siv nrog ceev faj hauv cov tsiaj uas tau txais cov tshuaj no.

Kev nyab xeeb nyob rau hauv gestating bitches los yog yug me nyuam txiv neej dev tsis tau tsim.

Kev Phem Tsis Zoo

Cov kev mob tshwm sim qee zaus pom hauv kev sim tshuaj lossis thaum siv tshuaj kho mob yog ntuav thiab raws plab.

Clindamycin Hydrochloride Capsules Dosage Thiab Administration

Cov dev: Kab mob kis kab mob, Abscesses thiab kab mob hniav.

Qhov ncauj

2.5-15.0 mg / lb lub cev hnyav txhua 12 teev.

Duration

Kev kho mob nrog Clindamycin Hydrochloride cov khoom tuaj yeem txuas ntxiv mus txog qhov siab kawg ntawm 28 hnub yog tias qhov kev txiav txim kho mob qhia tau hais tias. Kev kho mob ntawm tus kab mob yuav tsum tsis txhob txuas ntxiv rau ntau tshaj peb lossis plaub hnub yog tias tsis pom cov lus teb rau kev kho.

Lub sij hawm noj tshuaj

Capsules

Clindamycin Hydrochloride 25 mg, muab 1-6 ntsiav tshuaj txhua 12 teev rau txhua 10 phaus ntawm lub cev hnyav.

Clindamycin Hydrochloride 75 mg, muab 1-6 ntsiav tshuaj txhua 12 teev rau txhua 30 phaus ntawm lub cev hnyav.

Clindamycin Hydrochloride 150 mg, muab 1-6 ntsiav tshuaj txhua 12 teev rau txhua 60 phaus ntawm lub cev hnyav.

Clindamycin Hydrochloride 300 mg, muab 1-6 ntsiav tshuaj txhua 12 teev rau txhua 120 phaus ntawm lub cev hnyav.

Cov dev: Osteomyelitis

Qhov ncauj

5.0-15.0 mg / lb lub cev hnyav txhua 12 teev.

Duration

Kev kho mob nrog Clindamycin Hydrochloride raug pom zoo rau tsawg kawg 28 hnub. Kev kho mob yuav tsum tsis txhob txuas ntxiv ntev dua 28 hnub yog tias tsis pom cov lus teb rau kev kho.

Lub sij hawm noj tshuaj

Capsules

Clindamycin Hydrochloride 25 mg, muab 2-6 ntsiav tshuaj txhua 12 teev rau txhua 10 phaus ntawm lub cev hnyav.

Clindamycin Hydrochloride 75 mg, muab 2-6 ntsiav tshuaj txhua 12 teev rau txhua 30 phaus ntawm lub cev hnyav.

Clindamycin Hydrochloride 150 mg, muab 2-6 ntsiav tshuaj txhua 12 teev rau txhua 60 phaus ntawm lub cev hnyav.

Clindamycin Hydrochloride 300 mg, muab 2-6 ntsiav tshuaj txhua 12 teev rau txhua 120 phaus ntawm lub cev hnyav.

Yuav Ua Li Cas

Clindamycin Hydrochloride Capsules muaj xws li:

25 mg capsules muab rau hauv lub raj mis ntawm 600

75 mg capsules muab rau hauv lub raj mis ntawm 200

150 mg capsules muab rau hauv lub raj mis ntawm 100

300 mg capsules muab rau hauv lub raj mis ntawm 100

Khaws ntawm Chav Ua Haujlwm Kub Kub 20°-25°c (68°-77°f).

Txhawm rau tshaj tawm qhov xav tias muaj kev cuam tshuam tsis zoo lossis thov daim ntawv qhia txog kev nyab xeeb ntawm cov khoom siv (MSDS), hu rau 1-800-759-3664.

Clindamycin Hydrochloride Capsules Ceev faj

Tsoom Fwv Teb Chaws txoj cai txwv cov tshuaj no siv los ntawm lossis raws li kev txiav txim ntawm tus kws kho tsiaj muaj ntawv tso cai.

Khaws lub thawv kaw kom nruj.

Khaws Tsis Tau Cov Me Nyuam

Rau Tsiaj siv xwb

Tsim los ntawm IVX Animal Health, Inc., St. Joseph, MO 64503

Phoenix ™ Pharmaceutical, Inc.

Tsim Rau: Clipper Distributing Company, Llc, St. Joseph, Mo 64507

Cov cim lag luam yog cov cuab yeej ntawm Clipper Distributing Company, LLC.

	Net Cov ntsiab lus:	NDC
25 mg ib	600 Capsules	57319-467-48	801022 Rev. 2-04
75mg ib	200 Capsules	57319-468-46	801023 Rev0506 ib
150 mg	100 Capsules	57319-469-13	801024 Rev 0706 ib
300 mg	100 Capsules	57319-469-13	801037 Rev0607 Ib

yug tsis muaj.

12561225 ib CLIPPER DISTRIBUTING CO., LLC
PHOENIX PharmaceUTICAL INC.
1302 SOUTH 59 Street, ST. JOSEPH, MO, 64507

Xov tooj:		816-364-5777 ib
Order Desk:		800-759-3644 Ib
Fax:		816-364-4969 ib
Lub Vev Xaib:		www.clipperdist.net

Txhua qhov kev siv zog tau ua los xyuas kom meej qhov tseeb ntawm Clindamycin Hydrochloride Capsules cov ntaub ntawv luam tawm saum toj no. Txawm li cas los xij, nws tseem yog lub luag haujlwm ntawm cov neeg nyeem kom paub txog lawv tus kheej nrog cov ntaub ntawv cov khoom lag luam uas muaj nyob rau hauv US cov khoom lag luam daim ntawv lo lossis pob ntim.