Cov teebmeem ntawm Clopidogrel

Rau Cov Neeg Siv Khoom

Siv rau clopidogrel : ntsiav tshuaj

Ceeb toom

Qhov ncauj (Tablet)



Qhov ua tau zoo ntawm clopidogrel hydrogen sulfate tau tshwm sim los ntawm nws cov kev ua haujlwm antiplatelet, uas yog nyob ntawm nws qhov kev hloov pauv mus rau cov metabolite nquag los ntawm cytochrome P450 (CYP) system, feem ntau CYP2C19. Clopidogrel hydrogen sulfate ntawm koob tshuaj pom zoo tsim tsawg dua ntawm cov nquag metabolite thiab yog li muaj kev txo qis ntawm platelet kev ua haujlwm hauv cov neeg mob uas homozygous rau nonfunctional alleles ntawm CYP2C19 noob, (lub npe hu ua CYP2C19 pluag metabolizers). Kev ntsuam xyuas muaj los txheeb xyuas cov neeg mob uas yog CYP2C19 cov metabolizers tsis zoo. Xav txog kev siv lwm cov platelet P2Y12 inhibitor hauv cov neeg mob uas pom tias yog CYP2C19 cov metabolizers tsis zoo..

diclofenac sodium ec 75

Kev mob tshwm sim yuav tsum tau mus kho mob tam sim

Nrog rau nws cov teebmeem xav tau, clopidogrel tuaj yeem ua rau qee qhov tsis xav tau. Txawm hais tias tsis yog tag nrho cov kev mob tshwm sim no tuaj yeem tshwm sim, yog tias lawv tshwm sim lawv yuav xav tau kev kho mob.

Nrog koj tus kws kho mob tham tam sim ntawd Yog tias ib qho ntawm cov kev mob tshwm sim hauv qab no tshwm sim thaum noj clopidogrel:

Feem ntau

  • Kev sau cov ntshav hauv qab ntawm daim tawv nqaij
  • tob, tsaus liab doog bruise
  • khaus, mob, liab, los yog o

Tsawg dua

  • Ntshav ntswg
  • ntshav, dub, los yog quav quav
  • ntuav ntawm cov ntshav los yog cov khoom uas zoo li kas fes hauv av

Tsis tshua muaj

Qhov xwm txheej tsis paub

  • Kev ntxhov siab
  • blistering, peeling, loosening ntawm daim tawv nqaij
  • mob plab
  • qhov muag tsis pom kev
  • kub siab mob plab
  • hloov hauv kev puas siab puas ntsws
  • mob hauv siab los yog nruj
  • txias sweats
  • nrog rau
  • cem quav
  • txias, tawv nqaij
  • hnoos los yog hoarseness
  • tsaus nti los yog ntshav tso zis
  • ua pa nyuaj los yog nqos
  • nyuaj hais lus
  • kiv taub hau , faintness, los yog lightheadedness thaum sawv tam sim ntawd los ntawm ib tug dag los yog zaum
  • lub plawv dhia ceev
  • kev tsis xis nyob
  • ua npaws nrog los yog tsis txias
  • kev xav ntawm nkees lossis qaug zog
  • khaus khaus , khaus, daim tawv nqaij ua pob
  • nce kev tshaib kev nqhis
  • plab zom mov
  • o ntawm cov pob qij txha
  • pob qij txha los yog mob leeg
  • loj, Hive-zoo li o ntawm lub ntsej muag, daim tawv muag, daim di ncauj, tus nplaig, caj pas, tes, ceg, taw, lub cev nqaij daim tawv
  • cov quav daj
  • poob qab los noj mov
  • sab nraub qaum lossis sab mob
  • mob mob
  • ntxhov siab
  • npau suav phem
  • ua pa nrov
  • mob los yog tso zis nyuaj
  • mob nyob rau sab, tejzaum nws radiating rau sab nraum qab
  • pinpoint liab me ntsis ntawm daim tawv nqaij
  • puffiness los yog o ntawm daim tawv muag los yog ib ncig ntawm lub qhov muag, ntsej muag, daim di ncauj, los yog tus nplaig
  • ua pob khaus nrog cov kab mob tiaj tus los yog cov kab mob me me ntawm daim tawv nqaij
  • qhov quav los ntshav
  • liab khaus qhov muag
  • liab ntawm daim tawv nqaij, feem ntau nrog ib tug liab doog chaw
  • reddening ntawm daim tawv nqaij, tshwj xeeb tshaj yog nyob ib ncig ntawm pob ntseg
  • qaug dab peg
  • shakiness
  • daim tawv nqaij hlwv
  • lus slur
  • mob caj pas
  • mob, rwj, lossis pob dawb ntawm daim di ncauj lossis hauv qhov ncauj
  • mob plab, mob plab, lossis mob
  • tawm hws
  • o ntawm qhov muag, ntsej muag, lossis sab hauv ntawm lub qhov ntswg
  • o los yog o ntawm qhov ncauj
  • o lossis mob qog
  • ua tsis taus pa
  • los ntshav los yog bruising txawv txawv
  • dej los yog ntshav raws plab
  • qhov muag daj lossis tawv nqaij

Kev mob tshwm sim tsis tas yuav tsum tau kho mob tam sim

Qee qhov kev mob tshwm sim ntawm clopidogrel tuaj yeem tshwm sim uas feem ntau tsis xav tau kev kho mob . Cov kev mob tshwm sim no yuav ploj mus thaum kho raws li koj lub cev hloov kho rau cov tshuaj. Tsis tas li ntawd, koj tus kws kho mob yuav tuaj yeem qhia koj txog txoj hauv kev los tiv thaiv lossis txo qee qhov kev mob tshwm sim.

Tshawb xyuas nrog koj tus kws kho mob yog tias muaj cov kev mob tshwm sim hauv qab no txuas ntxiv los yog thab plaub los yog koj muaj lus nug txog lawv:

Qhov xwm txheej tsis paub

  • Hloov hauv saj tsis zoo los yog tsis kaj siab (tom qab) saj
  • nyuaj txav
  • poob ntawm kev xav ntawm saj
  • mob ib ce, cramps, los yog txhav
  • liab los yog o pob qij txha
  • pom, hnov, lossis hnov ​​tej yam uas tsis nyob ntawd

Rau Cov Kws Kho Mob

Siv rau clopidogrel: ntsiav tshuaj ntawm qhov ncauj

General

Feem ntau tshaj tawm qhov tshwm sim tsis zoo yog los ntshav, nrog rau kev ua rau lub neej hem thiab los ntshav tuag.[ Ref ]

Hematology

Tsis tshua muaj (0.1% mus rau 1%): los ntshav tuag, eosinophilia leukopenia, lub sijhawm los ntshav, thrombocytopenia

Tsis tshua muaj (0.01% rau 0.1%): Neutropenia

Tsawg heev (tsawg dua 0.01%): Txo cov platelet suav

Postmarketing qhia : Mob hnyav los ntshav (feem ntau ntawm daim tawv nqaij), hemarthrosis, hematoma, hemorrhage ntawm lub qhov txhab operative, tuag hemorrhage (intracranial, gastrointestinal, thiab retroperitoneal), thrombotic thrombocytopenic purpura (TTP), tau hemophilia A, aplastic anemia , pancytopenia , agranulocytosis , granulocytopenia , mob ntshav qab zib[ Ref ]

Hauv kev tshawb fawb COMMIT (n = 45,852), qhov tshwm sim ntawm qhov tsis zoo ntawm lub hlwb lossis lub hlwb los ntshav yog 0.6% hauv clopidogrel ntxiv. tshuaj aspirin kho cov neeg mob, nrog 0.4% cais raws li loj tsis-cerebral (0.2% tuag) thiab 0.2% raws li hemorrhagic stroke (0.2% tuag). Cov los ntshav uas tsis yog tseem ceeb lossis cov ntshav tsis muaj hlwb tshwm sim hauv 3.6% thiab 3.9% ntawm cov neeg mob tau txais cov tshuaj no ntxiv rau cov tshuaj aspirin, feem. Cov ntshav loj tau txhais tias yog ntshav los ntshav los yog cov ntshav uas tsis yog lub hlwb xav tias tau ua rau tuag lossis qhov yuav tsum tau txhaj tshuaj.

cognium ntsiav tshuaj phiv

Hauv txoj kev tshawb fawb CURE (n = 12,562), qhov tshwm sim ntawm kev tuag los ntshav (0.2%) thiab intracranial hemorrhage (0.1%) yog tib yam ntawm clopidogrel nrog cov tshuaj aspirin thiab cov placebo nrog cov tshuaj aspirin.[ Ref ]

plab hnyuv

Feem ntau (1% mus rau 10%): Mob plab , gastrointestinal hemorrhage , dyspepsia , mob plab, xeev siab , mob plab

Tsis tshua muaj (0.1% mus rau 1%): ntuav, flatulence , cem quav, plab, peptic, los yog duodenal rwj

Tsis tshua muaj (0.01% mus rau 0.1%): Retroperitoneal hemorrhage

Postmarketing qhia : Colitis ulcerative los yog lymphocytic, pancreatitis , stomatitis [ Ref ]

Hauv kev tshawb fawb CAPRIE (n = 19,185), plab hnyuv hemorrhage tshwm sim hauv 2% ntawm cov neeg mob noj clopidogrel piv rau 2.7% noj tshuaj aspirin. Cov ntshav uas yuav tsum tau mus pw hauv tsev kho mob tshwm sim hauv 0.7% clopidogrel-kho thiab 1.1% cov neeg mob aspirin-kho.[ Ref ]

Mob siab heev

Postmarketing qhia : Angioedema , cov tshuaj tiv thaiv anaphylactic, cross reactive hypersensitivity ntawm thienopyridines (xws li ticlopidine, ua prasugrel ), cov tshuaj tiv thaiv hypersensitivity[ Ref ]

Mob plawv

Feem ntau (1% mus rau 10%): mob hauv siab, kub siab, mob angina pectoris , coronary artery disorder, peripheral ischemia

Tsawg heev (tsawg dua 0.01%): Hematoma

Postmarketing qhia : Hypotension , syncope , vasculitis [ Ref ]

Lub paj hlwb

Feem ntau (1% mus rau 10%): kiv taub hau, mob taub hau

Tsis tshua muaj (0.1% rau 1%): Paresthesia

Tsis tshua muaj (0.01% rau 0.1%): Vertigo , intracranial hemorrhage

Postmarketing qhia : Taste disruptions, ageusia[ Ref ]

Musculoskeletal

Feem ntau (1% mus rau 10%): Arthralgia, mob nraub qaum

Postmarketing qhia : Mob caj dab, myalgia, musculoskeletal los ntshav[ Ref ]

Kev puas siab puas ntsws

Feem ntau (1% mus rau 10%): Kev nyuaj siab

Postmarketing qhia : Hallucinations, tsis meej pem[ Ref ]

Ua pa

Feem ntau (1% mus rau 10%): Upper respiratory tract infection , ua tsis taus pa , rhinitis, hnoos, bronchitis, epistaxis

Postmarketing qhia Cov tsos mob: bronchospasm, interstitial pneumonitis , eosinophilic mob ntsws o los ntshav los ntshav (hemoptysis, pulmonary hemorrhage)[ Ref ]

Dermatology

Feem ntau (1% mus rau 10%): pob khaus, purpura, pruritus , nqaij tawv

Postmarketing qhia : Maculopapular, erythematous, lossis exfoliative pob, urticaria bullous dermatitis, erythema multiforme, Stevens-Johnson Syndrome , tshuaj lom epidermal necrolysis , mob heev generalized exanthematous pustulosis, tshuaj-induced hypersensitivity syndrome, tshuaj pob khaus nrog eosinophilia thiab cov tsos mob ntawm lub cev (DRESS), eczema , lichen planus [ Ref ]

Hauv CAPRIE (n = 19,185), 4.2% ntawm cov neeg mob tau txais clopidogrel tsim pob liab liab piv rau 3.5% hauv pawg tshuaj aspirin. Hauv CURE (n = 12,562), 1.3% kho nrog clopidogrel thiab tshuaj aspirin piv rau 1.1% cov placebo, nrog rau 0.7% ntawm cov neeg mob hauv CLARITY (n = 3491) qhia tawm pob. Kev siv tshuaj tsis tu ncua vim muaj kev puas tsuaj ntawm daim tawv nqaij hauv CAPRIE yog 0.8% thiab hauv CAPRIE 0.4% ntawm cov neeg mob.[ Ref ]

phiv los ntawm sodium bicarb

Mob siab

Postmarketing qhia : Kab mob siab (tsis muaj kab mob), mob siab tsis ua haujlwm, txawv txav kuaj lub siab ua haujlwm [ Ref ]

Metabolic

Feem ntau (1% mus rau 10%): Hypercholesterolemia[ Ref ]

Cov kab mob genitourinary

Feem ntau (1% mus rau 10%): Cov kab mob tso zis

Postmarketing qhia : Hematuria [ Ref ]

Ocular

Postmarketing qhia : Qhov muag los ntshav (conjunctival, ocular, retinal)[ Ref ]

Lwm yam

Feem ntau (1% mus rau 10%): Kev raug mob / raug mob, mob khaub thuas -zoo li cov tsos mob, mob, qaug zog, kis kab mob

5 htp thiab wellbutrin

Postmarketing qhia : Ua npaws[ Ref ]

Lub raum

Tsis tshua muaj (0.1% mus rau 1%): Hematuria

Postmarketing qhia : Glomerulopathy, ntshav creatinine nce[ Ref ]

Immunologic

Postmarketing qhia : Mob ntshav qab zib, insulin autoimmune syndrome[ Ref ]

Endocrine

Postmarketing qhia Cov tsos mob: Gynecomastia[ Ref ]

Hauv zos

Feem ntau (1% mus rau 10%): Qhov chaw los ntshav[ Ref ]

Cov ntaub ntawv

1. Cerner Multum, Inc. 'UK Summary of Product Characteristics.' O 0

2. Cerner Multum, Inc. 'Australian Product Information.' O 0

3. 'Cov ntaub ntawv khoom. Plavix (clopidogrel). Bristol-Myers Squibb, Princeton, NJ.

Cov ntaub ntawv ntxiv

Nco ntsoov sab laj nrog koj tus kws kho mob kom paub meej tias cov ntaub ntawv uas tshwm sim hauv nplooj ntawv no siv tau rau koj tus kheej.

Qee qhov kev mob tshwm sim yuav tsis qhia. Koj tuaj yeem qhia lawv mus rau lub FDA .