Diovan Sab Nraud

Lub npe dav: valsartan

Nco tseg: Cov ntaub ntawv no muaj cov ntaub ntawv cuam tshuam txog valsartan. Qee cov ntaub ntawv noj tshuaj uas tau teev tseg rau ntawm nplooj ntawv no yuav tsis thov rau lub npe nrov Diovan.



Hauv Summary

Cov kev mob tshwm sim ntawm Diovan muaj xws li: kiv taub hau thiab nce ntshav cov poov tshuaj. Lwm cov kev mob tshwm sim muaj xws li: hypotension. Saib hauv qab no kom paub cov npe ntawm cov teebmeem tsis zoo.

Rau Cov Neeg Siv Khoom

Siv rau valsartan : ntsiav tshuaj

Ceeb toom

Txoj kev ntawm qhov ncauj (Capsule; Tablet; Tshuaj)

Thaum kuaj pom cev xeeb tub, txiav tawm valsartan sai li sai tau. Cov tshuaj uas ua ncaj qha rau ntawm renin-angiotensin system tuaj yeem ua rau raug mob thiab tuag rau tus menyuam hauv plab.

Kev mob tshwm sim yuav tsum tau mus kho mob tam sim

Nrog rau nws cov teebmeem xav tau, valsartan (cov khoom muaj nyob hauv Diovan ) tej zaum yuav ua rau tej yam tsis xav tau. Txawm hais tias tsis yog tag nrho cov kev mob tshwm sim no tuaj yeem tshwm sim, yog tias lawv tshwm sim lawv yuav xav tau kev kho mob.

Nrog koj tus kws kho mob tham tam sim ntawd Yog tias ib qho ntawm cov kev mob tshwm sim hauv qab no tshwm sim thaum noj valsartan:

Tsawg dua

  • Ntshav tso zis
  • txias sweats
  • tsis meej pem
  • txo zaus los yog tso zis ntau
  • ua pa nyuaj
  • kiv taub hau , faintness, los yog lightheadedness thaum sawv los ntawm txoj hauj lwm dag
  • ua tsis taus pa
  • nce nqhis dej
  • lub plawv dhia tsis xwm yeem
  • poob qab los noj mov
  • sab nraub qaum lossis sab mob
  • xeev siab
  • ntxhov siab
  • ua tsis taus pa los yog tingling ntawm tes, ko taw, los yog daim di ncauj
  • o ntawm lub ntsej muag, ntiv tes, lossis ob txhais ceg
  • nkees nkees lossis qaug zog
  • ntuav
  • qaug zog ntawm heaviness ntawm ob txhais ceg
  • hnyav nce

Tsis tshua muaj

  • Ua daus no
  • ua npaws
  • hnov lus
  • mob caj pas
  • o ntawm qhov ncauj, tes, lossis ko taw
  • teeb meem nrog nqos lossis ua pa (dhau los)

Qhov xwm txheej tsis paub

  • Dub, tarry quav
  • cov pos hniav los ntshav
  • ntshav nyob rau hauv cov zis los yog cov quav
  • tso zis tsaus
  • general nkees thiab qaug zog
  • loj, ua pob zoo li o ntawm lub ntsej muag, daim tawv muag, daim di ncauj, tus nplaig, caj pas, tes, ceg, ko taw, lossis cov kab mob sib deev
  • cov quav daj
  • pinpoint liab me ntsis ntawm daim tawv nqaij
  • liab, mob, lossis khaus tawv nqaij
  • los ntshav los yog bruising txawv txawv
  • sab xis plab plab lossis mob plab
  • daj qhov muag thiab tawv nqaij

Kev mob tshwm sim tsis tas yuav tsum tau kho mob tam sim

Qee qhov kev mob tshwm sim ntawm valsartan tuaj yeem tshwm sim uas feem ntau tsis xav tau kev kho mob . Cov kev mob tshwm sim no yuav ploj mus thaum kho raws li koj lub cev hloov kho rau cov tshuaj. Tsis tas li ntawd, koj tus kws kho mob tuaj yeem qhia koj txog txoj hauv kev los tiv thaiv lossis txo qee qhov kev mob tshwm sim.

Tshawb xyuas nrog koj tus kws kho mob yog tias muaj cov kev mob tshwm sim hauv qab no txuas ntxiv los yog thab plaub los yog koj muaj lus nug txog lawv:

Tsawg dua

  • Mob nraub qaum
  • qhov muag tsis pom kev
  • mob khaub thuas lossis mob khaub thuas
  • hnoos
  • raws plab
  • nyuaj txav
  • mob taub hau
  • mob nqaij los yog txhav
  • mob, o, lossis liab ntawm pob qij txha
  • mob plab

Qhov xwm txheej tsis paub

Rau Cov Kws Kho Mob

Siv rau valsartan: qhov ncauj capsule, qhov ncauj ntsiav tshuaj

Lub paj hlwb

Feem ntau (10% lossis ntau dua): Mob taub hau (txog 14%), kiv taub hau (txog 14%)

Feem ntau (1% mus rau 10%): kiv taub hau

Advil vs tylenol rau qhov mob

Tsis tshua muaj (0.1% mus rau 1%): Vertigo [ Ref ]

Ua pa

Feem ntau (1% mus rau 10%): hnoos

Tsis tshua muaj (0.1% mus rau 1%): Ua tsis taus pa [ Ref ]

Mob siab heev

Ib tug poj niam muaj hnub nyoog 71 xyoo tau ntsib ib qho mob hnyav angioedema thiab photosensitive pruritic pob liab tom qab 3 lub hlis ntawm valsartan (cov khoom muaj nyob hauv Diovan) kho. Nws cov tsos mob tau ploj mus thiab cov pob khaus tau daws tom qab kev kho mob nrog subcutaneous epinephrine, tso rau hauv cov hlab ntsha Methylprednisolone , diphenhydramine , thiab emollient cream.

Ib qho xwm txheej tshwj xeeb ntawm kev siv tshuaj, valsartan-induced angioedema tau raug tshaj tawm. Ob teev tom qab pib txhaj koob tshuaj (160 mus rau 320 mg / hnub) ntawm valsartan, tus neeg mob tsim angioedema (piv txwv li, o ntawm daim di ncauj thiab tus nplaig). Cov tsos mob tau daws tau tom qab txo qhov koob tshuaj rau thawj koob tshuaj ntawm 160 mg / hnub.[ Ref ]

Tsawg heev (tsawg dua 0.01%): Angioedema[ Ref ]

Mob plawv

Feem ntau (1% mus rau 10%): Cov tsos mob hypotension hauv 5.5% ntawm plawv tsis ua hauj lwm cov neeg mob hauv kev sim tshuaj

Tsis tshua muaj (tsawg dua 0.1%): Mob plawv , mob hauv siab

Zaus tsis qhia : kiv taub hau ntsig txog orthostatic hypotension

Postmarketing qhia : Lub plawv tsis ua hauj lwm[ Ref ]

Metabolic

Feem ntau (1% mus rau 10%): Hyperkalemia , hyponatremia [ Ref ]

Lub raum

Zaus tsis qhia : Lub raum ua haujlwm tsis zoo, nce hauv cov ntshav creatinine concentration, ntshav urea nitrogen, thiab potassium

Postmarketing qhia : Lub raum tsis ua haujlwm[ Ref ]

Dermatology

Tsis tshua muaj (tsawg dua 0.1%): Pruritus , liab, alopecia

Postmarketing qhia : Bullous dermatitis[ Ref ]

plab hnyuv

Tsis tshua muaj (0.1% mus rau 1%): raws plab, cem quav , qhov ncauj qhuav, dyspepsia anorexia, xeev siab, ntuav, flatulence

Postmarketing qhia : Saj cuam tshuam (piv txwv li, hloov rhiab heev ntawm qhov pib saj) tau raug tshaj tawm tom qab rov muab tshuaj dua[ Ref ]

Musculoskeletal

Feem ntau (1% mus rau 10%): Mob nraub qaum, mob leeg, myalgias

Tsawg heev (tsawg dua 0.01%): Rhabdomyolysis[ Ref ]

c 74 paj liab

Kev puas siab puas ntsws

Zaus tsis qhia : Kev ntxhov siab , insomnia , paresthesia, somnolence[ Ref ]

Cov kab mob genitourinary

Tsawg heev (tsawg dua 0.01%): Impotence [ Ref ]

Hematology

Tsis tshua muaj (0.1% mus rau 1%): Hematocrit txo qis, hemoglobin txo, neutropenia

Postmarketing qhia : Thrombocytopenia , vasculitis [ Ref ]

Mob siab

Valsartan-associated hepatotoxicity nyob rau hauv tus neeg mob uas muaj kab mob siab B nto antigen (HBs-Ag) zoo (tsis muaj cov tsos mob thiab cov tsos mob) tau tshaj tawm. Tom qab 1 lub hlis ntawm kev kho mob nrog valsartan (cov khoom muaj nyob rau hauv Diovan) tus neeg mob no tau tsim pruritic erythematous ntawm daim tawv nqaij hloov, xeev siab, daj daj , txoj cai subcostal mob plab , nce siab enzymes , thiab mob hepatomegaly. Cov tsos mob thiab cov tsos mob ntawm hepatotoxicity daws tau nyob rau hauv 2 mus rau 3 lub lis piam tom qab txiav tawm ntawm valsartan thiab tus neeg mob tseem nyob asymptomatic tom qab 6 lub hlis ntawm kev soj ntsuam.[ Ref ]

Tsawg heev (tsawg dua 0.01%): Kab mob siab

Zaus tsis qhia : Hepatic enzymes nce[ Ref ]

Cov ntaub ntawv

1. Waeber B, Burnier M, Nussberger J, Brunner HR 'Kev paub nrog angiotensin II antagonists hauv cov neeg mob ntshav siab.' Clin Exp Pharmacol Physiol 23 (Suppl (1996): s142-6

2. 'Cov ntaub ntawv khoom. Diovan (valsartan).' Novartis Pharmaceuticals, East Hanover, NJ.

3. McInnes GT 'Clinical kom zoo dua ntawm valsartan.' Cardiology 91 (1999): 14-8

4. Oparil S, Dyke S, Harris F, et al. 'Kev ua tau zoo thiab kev nyab xeeb ntawm valsartan piv nrog cov placebo hauv kev kho mob ntawm cov neeg mob ntshav siab tseem ceeb.' Clin Ther 18 (1996): 797-810

5. Cerner Multum, Inc. 'UK Summary of Product Characteristics.' O 0

6. Holwerda NJ, Fogari R, Angeli P, et al. 'Valsartan, tus tshiab angiotensin II antagonist rau kev kho mob ntshav siab tseem ceeb: kev ua tau zoo thiab kev nyab xeeb piv nrog cov placebo thiab enalapril.' J Hypertens 14 (1996): 1147-115

7. Benz J, Oshrain C, Henry D, Avery C, Chiang YT, Gatlin M 'Valsartan, ib tug tshiab angiotensin II receptor antagonist: ib tug ob-dig muag txoj kev kawm piv qhov tshwm sim ntawm hnoos nrog lisinopril thiab hydrochlorothiazide. J Clin Pharmacol 37 (1997): 101-7

8. Irons BK, Kumar A 'Valsartan-induced angioedema.' Ann Pharmacother 37 (2003): 1024-7

9. Frye CB, Pettigrew TJ 'Angioedema thiab cov pob liab liab tshwm sim los ntawm valsartan.' Pharmacotherapy 18 (1998): 866-8

10. Burnier M, Roch-Ramel F, Brunner HR 'Lub raum cuam tshuam ntawm angiotensin II receptor blockade nyob rau hauv cov ntsiab lus normotensive.' Raum Int 49 (1996): 1787-90

11. Burnier M, Hagman M, Nussberger J, Biollaz J, Armagnac C, Brouard R, Weber B, Brunner HR 'Lub sij hawm luv luv thiab txhawb nqa lub raum cuam tshuam ntawm angiotensin II receptor blockade hauv cov khoom noj qab haus huv.' Ntshav siab 25 (1995): 602-9

12. Ziai F, Ots M, Provoost AP, Troy JL, Rennke HG, Brenner BM, Mackenzie HS 'Tus angiotensin receptor antagonist, irbesartan, txo lub raum raug mob hauv kev sim mob raum tsis ua haujlwm.' Raum Int Suppl 57 (1996): s132-6

13. Marquart-Elbaz C, Grosshans E, Lipsker D, Lipsker D 'Sartans, angiotensin II receptor antagonists, tuaj yeem ua rau psoriasis.' Br J Dermatol 147 (2002): 617-8

14. Tsuruoka S, Wakaumi M, Ioka T, et al. 'Angiotensin II receptor blocker-induces blunted saj rhiab heev: kev sib piv ntawm candesartan thiab valsartan.' Br J Clin Pharmacol 60 (2005): 204-7

15. Flores CA, Ardiles LG, Aros CA, et al. 'Valsartan-Induced Hematocrit Hloov hauv Cov Neeg Mob Raum Hloov.' Transplant Proc 37 (2005): 1586-1588

16. Kiykim A, Altintas E, Sezgin O, et al. 'Valsartan-induced hepatotoxicity hauv tus neeg mob HBs-Ag-Positive.' Am J Gastroenterol 98 (2003): 507

Cov ntaub ntawv ntxiv

Nco ntsoov sab laj nrog koj tus kws kho mob kom paub meej tias cov ntaub ntawv uas tshwm sim hauv nplooj ntawv no siv tau rau koj tus kheej.

Qee qhov kev mob tshwm sim yuav tsis raug qhia. Koj tuaj yeem qhia lawv mus rau lub vev xaib FDA .