Hnub Tuesday, Peb Hlis 23, 2021 - Rau cov tib neeg uas muaj hom 2 ntshav qab zib mellitus (T2DM), ib zaug ib lub lim tiam, ua haujlwm ntev, basal insulin Fc (BIF) tsis zoo rau insulin degludec rau kev tswj glycemic, raws li kev tshawb fawb tau nthuav tawm ntawm lub rooj sib tham txhua xyoo ntawm Lub Koom Haum Endocrine, tau tuav zoo txij lub Peb Hlis 20 txog rau 23.
Juan Pablo Frias, MD, Ph.D., los ntawm National Research Institute hauv San Diego, thiab cov npoj yaig tau tshuaj xyuas kev nyab xeeb thiab kev ua tau zoo ntawm BIF piv rau insulin degludec tshaj 32 lub lis piam hauv 399 tus neeg mob T2DM. Ob qhov sib txawv ntawm kev siv tshuaj rau BIF tau suav nrog, nrog lub hom phiaj yoo mov (FG) ntawm ≦140 mg / dL (BIF-A1) thiab ≦120 mg / dL (BIF-A2). Insulin degludec tau titrated rau FG lub hom phiaj ntawm ≦100 mg / dL.
Cov kws tshawb fawb pom tau hais tias rau lub ntsiab lus kawg ntawm hemoglobin A1c hloov pauv los ntawm lub hauv paus mus rau lub lim tiam 32, ob pawg BIF tau ua tiav qhov tsis muaj qhov tsis zoo, nrog kev txo qis ntawm 0.6, 0.6, thiab 0.7 feem pua, raws li, rau BIF-A1, BIF-A2, thiab insulin. degludec. Piv nrog rau BIF caj npab, insulin degludec tau ua tiav ntau dua cov piam thaj hauv cov ntshav qis dua los ntawm qhov pib. Thaum ntsuas cov xwm txheej hypoglycemic ≦70 mg / dL, ob pawg BIF koob tshuaj tau pom muaj cov xwm txheej tsawg dua piv nrog insulin degludec. Cov xwm txheej hypoglycemic<54 mg/dL did not differ significantly between the three groups. In BIF-A2, there were two severe hypoglycemic events. Compared with insulin degludec, both BIF groups had a significantly smaller increase in body weight from baseline to week 32.
'Raws li peb cov ntaub ntawv cog lus, kev tshawb fawb ntxiv nrog BIF tau pib rau cov neeg mob mob ntshav qab zib hom 1 thiab lwm yam mob ntshav qab zib hom 2 Cov neeg mob cov neeg mob, 'Frias tau hais hauv nqe lus.
Ntau tus kws sau ntawv tau nthuav tawm kev sib raug zoo nyiaj txiag rau Eli Lilly thiab Tuam Txhab, uas tab tom txhim kho kev txhaj tshuaj ib zaug ib lim piam thiab pab nyiaj rau kev sim.
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