Larin Kev Ntseeg 1/20

Lub npe dav: Norethindrone acetate / ethinyl estradiol thiab ferrous fumarate
Dosage form: ntsiav tshuaj
Chav kawm tshuaj: Cov tshuaj tiv thaiv kab mob , Kev sib deev hormone ua ke

Ntawm nplooj ntawv no
Nthuav

Larin Kev Ntseeg 1/20



(Txhua ntsiav tshuaj daj daj muaj 1 mg norethindrone acetate thiab 20 mcg ethinyl estradiol. Txhua ntsiav tshuaj xim av muaj 75 mg ferrous fumarate.)

Cov neeg mob yuav tsum tau ntuas tias cov khoom no tsis tiv thaiv kab mob HIV (AIDS) thiab lwm yam kab mob sib kis.

ammonium lactate qab zib 12

Larin Kev Ntseeg 1/20 Description

Larin Fe 1/20 yog kev sib xyaw ua ke ntawm progestogen-estrogen.

Larin Fe 1/20: Txhua qhov muab cov tshuaj noj tas li uas muaj 21 ntsiav tshuaj tiv thaiv qhov ncauj thiab xya ferrous fumarate ntsiav tshuaj. Cov ntsiav tshuaj ferrous fumarate tam sim no los ua kom yooj yim ntawm kev tswj hwm tshuaj ntawm 28-hnub kev tswj hwm, tsis yog tshuaj hormones, thiab tsis ua haujlwm rau kev kho mob.

Txhua ntsiav tshuaj daj ntseg muaj norethindrone acetate (17 alpha-ethinyl-19-nortestosterone acetate), 1 mg; ethinyl estradiol (17 alpha-ethinyl-1,3,5(10)-estratriene-3, 17 beta-diol), 20 mcg. Kuj tseem muaj polyvinyl cawv, titanium dioxide, talc, macrogol/polyethylglycol 3350 NF, lecithin (soya), D&C Yellow No.10 Aluminium Lake, FD&C Blue No.2 Aluminium Lake, FD&CYellow No.6 Aluminium Lake, lactose, magnesium stearate thiab pob kws starch.

Cov qauv qauv yog raws li nram no:

Txhua cov tshuaj placebo xim av muaj ferrous fumarate, polyvinyl cawv, Talc, macrogol / polyethyleneglycol 3350 NF, lecithin (soya), hlau oxide dub, hlau oxide daj, microcrystalline cellulose, hydroxypropyl cellulose, magnesium stearate thiab crospovidone.

Larin Fe 1/20 - Chaw Kho Mob Pharmacology

Kev sib xyaw cov tshuaj tiv thaiv qhov ncauj ua los ntawm kev tawm tsam ntawm gonadotropins. Txawm hais tias lub luag haujlwm tseem ceeb ntawm qhov kev ua no yog inhibition ntawm ovulation, lwm yam kev hloov pauv muaj xws li kev hloov pauv hauv lub ncauj tsev menyuam (uas ua rau muaj kev nyuaj siab ntawm cov phev nkag mus rau hauv lub tsev menyuam) thiab endometrium (uas txo qis qhov tshwm sim ntawm implantation).

Pharmacokinetics

Cov tshuaj pharmacokinetics ntawm Larin Fe 1/20 tsis tau ua tus yam ntxwv; Txawm li cas los xij, cov ntaub ntawv tshuaj pharmacokinetic hauv qab no hais txog norethindrone acetate thiab ethinyl estradiol yog muab los ntawm cov ntaub ntawv.

Kev nqus

Norethindrone acetate zoo nkaus li ua tiav thiab sai deacetylated rau norethindrone tom qab kev tswj hwm qhov ncauj, vim tias qhov kev coj ua ntawm norethindrone acetate tsis txawv ntawm qhov ncauj ntawm qhov ncauj norethindrone ( ib ). Norethindrone acetate thiab ethinyl estradiol yog raug rau cov metabolism hauv thawj zaug tom qab noj qhov ncauj, uas ua rau muaj qhov bioavailability ntawm kwv yees li 64% rau norethindrone thiab 43% rau ethinyl estradiol ( 1-3 ).

Kev faib tawm

Qhov ntim ntawm kev faib tawm ntawm norethindrone thiab ethinyl estradiol ranges ntawm 2 txog 4 L / kg ( 1-3 ). Plasma protein khi ntawm ob qho tib si steroids yog qhov dav (ntau dua 95%); norethindrone khi rau ob qho tib si albumin thiab kev sib deev hormone binding globulin, whereas ethinyl estradiol khi tsuas yog rau albumin ( 4 ).

Metabolism

Norethindrone tau dhau los ua biotransformation, feem ntau ntawm kev txo qis, ua raws li sulfate thiab glucuronide conjugation. Feem ntau ntawm cov metabolites hauv kev ncig yog sulfates, nrog rau glucuronides accounting rau feem ntau ntawm cov zis metabolites ( 5 ). Ib qho me me ntawm norethindrone acetate yog metabolically hloov mus rau ethinyl estradiol. Ethinyl estradiol kuj tseem metabolized, ob qho tib si los ntawm oxidation thiab los ntawm kev sib txuas nrog sulfate thiab glucuronide. Sulfates yog cov loj circulating conjugates ntawm ethinyl estradiol thiab glucuronides predominate nyob rau hauv cov zis. Thawj oxidative metabolite yog 2-hydroxy ethinyl estradiol, tsim los ntawm CYP3A4 isoform ntawm cytochrome P450. Ib feem ntawm thawj-dhau metabolism ntawm ethinyl estradiol ntseeg tau tias tshwm sim hauv plab hnyuv mucosa. Ethinyl estradiol tuaj yeem nkag mus rau enterohepatic ncig ( 6 ).

Kev tso tawm

Norethindrone thiab ethinyl estradiol raug tso tawm hauv cov zis thiab quav, feem ntau yog cov metabolites (5,6). Plasma clearance qhov tseem ceeb rau norethindrone thiab ethinyl estradiol zoo sib xws (kwv yees li 0.4 L / hr / kg) ( 1-3 ).

Cov pejxeem tshwj xeeb

Haiv neeg:

Qhov cuam tshuam ntawm haiv neeg ntawm kev coj tus cwj pwm ntawm Larin Fe 1/20 tsis tau raug ntsuas.

Lub raum Insufficiency

Cov txiaj ntsig ntawm cov kab mob raum rau ntawm qhov chaw ntawm Larin Fe 1/20 tsis tau raug soj ntsuam. Hauv cov poj niam premenopausal uas muaj lub raum tsis ua haujlwm nyob rau hauv lub peritoneal dialysis uas tau txais ntau koob tshuaj ntawm qhov ncauj contraceptive uas muaj ethinyl estradiol thiab norethindrone, plasma ethinyl estradiol concentrations yog siab dua thiab norethindrone concentrations tsis tau hloov pauv piv rau cov concentrations hauv premenopausal cov poj niam uas muaj ntshav qab zib.

Hepatic Insufficiency

Cov txiaj ntsig ntawm kab mob siab rau kev ua haujlwm ntawm Larin Fe 1/20 tsis tau raug soj ntsuam. Txawm li cas los xij, ethinyl estradiol thiab norethindrone tuaj yeem ua tsis zoo rau cov neeg mob uas muaj lub siab ua haujlwm tsis zoo.

Tshuaj-Drug Interactions

Ntau yam tshuaj-tshuaj sib cuam tshuam tau raug tshaj tawm rau cov tshuaj tiv thaiv qhov ncauj. Cov ntsiab lus ntawm cov no muaj nyob rau hauv CEEB TOOM, Kev Sib Tham Tshuaj.

Cov lus qhia thiab kev siv rau Larin Fe 1/20

Larin Fe 1/20 yog qhia rau kev tiv thaiv kev xeeb tub hauv cov poj niam uas xaiv los siv cov tshuaj tiv thaiv qhov ncauj raws li ib txoj hauv kev tiv thaiv kab mob.

Cov tshuaj tiv thaiv qhov ncauj yog qhov ua tau zoo heev. Table I teev cov kev pheej hmoo ntawm cev xeeb tub rau cov neeg siv cov tshuaj tiv thaiv kab mob sib xyaw ua ke thiab lwm yam kev tiv thaiv kab mob. Qhov ua tau zoo ntawm cov kev tiv thaiv kab mob no, tshwj tsis yog kev ua kom tsis muaj menyuam, nyob ntawm qhov kev ntseeg tau uas lawv tau siv. Kev siv cov txheej txheem kom raug thiab zoo ib yam tuaj yeem ua rau qis qis dua.

Contraindications

  • Cov tshuaj tiv thaiv qhov ncauj yuav tsum tsis txhob siv rau cov poj niam uas tam sim no muaj cov xwm txheej hauv qab no:
  • Thrombophlebitis los yog thromboembolic mob
  • Cov keeb kwm yav dhau los ntawm cov hlab ntsha sib sib zog nqus thrombophlebitis lossis mob thromboembolic
  • Cerebral vascular lossis coronary artery kab mob
  • Paub los yog xav tias carcinoma ntawm lub mis
  • Carcinoma ntawm endometrium los yog lwm yam paub los yog xav tias estrogen-dependent neoplasia
  • Undiagnosed abnormal genital los ntshav
  • Cholestatic jaundice ntawm cev xeeb tub los yog jaundice nrog kev siv tshuaj ua ntej
  • Hepatic adenomas lossis carcinomas
  • Paub los yog xav tias xeeb tub
  • Puas tau txais kev sib xyaw tshuaj Hepatitis C uas muaj ombitasvir/paritaprevir/ritonavir, nrog lossis tsis muaj dasabuvir, vim muaj peev xwm ua rau ALT nce siab (saib Ceeb toom , Kev phom sij ntawm daim siab ENZYME ELEVATIONS nrog kev sib koom ua ke ntawm HEPATITIS C kho ).

Ceeb toom

Kev siv cov tshuaj tiv thaiv qhov ncauj yog txuam nrog kev pheej hmoo ntawm ntau yam mob hnyav xws li myocardial infarction, thromboembolism, mob stroke, hepatic neoplasia, thiab kab mob gallbladder, txawm hais tias qhov kev pheej hmoo ntawm kev mob hnyav lossis kev tuag tsawg heev hauv cov poj niam noj qab haus huv yam tsis muaj teeb meem tshwm sim. Qhov kev pheej hmoo ntawm kev mob ntshav qab zib thiab kev tuag yuav nce ntxiv thaum muaj lwm yam kev pheej hmoo xws li ntshav siab, hyperlipidemias, rog rog, thiab ntshav qab zib.

Cov kws kho mob sau tshuaj tiv thaiv qhov ncauj yuav tsum paub txog cov ntaub ntawv hauv qab no ntsig txog cov kev pheej hmoo no.

Cov ntaub ntawv uas muaj nyob rau hauv cov pob no yog qhov tseem ceeb raws li cov kev tshawb fawb tau ua nyob rau hauv cov neeg mob uas siv cov tshuaj tiv thaiv qhov ncauj nrog ntau dua formulations ntawm estrogens thiab progestogens tshaj cov uas siv niaj hnub no. Cov txiaj ntsig ntawm kev siv cov tshuaj tiv thaiv qhov ncauj mus ntev nrog cov qauv qis ntawm ob qho tib si estrogens thiab progestogens tseem yuav txiav txim siab.

Thoob plaws hauv qhov kev sau npe no, kev tshawb fawb txog kab mob kis tau tshaj tawm yog ob hom: kev tshawb fawb rov qab los yog kev tswj xyuas cov ntaub ntawv thiab cov kev tshawb fawb yav tom ntej lossis kev tshawb fawb. Cov kev tshawb fawb txog kev tswj xyuas cov ntaub ntawv muab ib qho kev ntsuas ntawm tus txheeb ze ntawm kev pheej hmoo ntawm tus kab mob, uas yog, apivntawm qhov tshwm sim ntawm tus kab mob ntawm cov neeg siv tshuaj tiv thaiv qhov ncauj rau qhov ntawd ntawm cov neeg tsis siv. Tus txheeb ze pheej hmoo tsis muab cov ntaub ntawv qhia txog qhov tshwm sim ntawm qhov tshwm sim ntawm tus kab mob. Cov kev tshawb fawb Cohort muab ib qho kev ntsuas ntawm qhov muaj feem cuam tshuam, uas yogtxawvnyob rau hauv qhov tshwm sim ntawm tus kab mob ntawm qhov ncauj contraceptive neeg siv thiab nonusers. Qhov kev pheej hmoo uas muaj feem cuam tshuam tau muab cov ntaub ntawv hais txog qhov tshwm sim tiag tiag ntawm cov kab mob hauv cov pej xeem (hloov los ntawm Cov Lus Qhia 8 thiab 9 nrog tus sau ntawv tso cai). Yog xav paub ntxiv, tus nyeem ntawv raug xa mus rau cov ntawv nyeem ntawm cov txheej txheem kis mob.

1. Thromboembolic Disorders thiab lwm yam teeb meem vascular

ib. Myocardial infarction

Kev pheej hmoo siab ntawm myocardial infarction tau raug ntaus nqi los ntawm kev siv tshuaj tiv thaiv qhov ncauj. Qhov kev pheej hmoo no feem ntau yog hauv cov neeg haus luam yeeb lossis cov poj niam uas muaj lwm yam kev pheej hmoo rau cov kab mob plawv xws li ntshav siab, hypercholesterolemia, morbid rog, thiab ntshav qab zib. Kev pheej hmoo ntawm kev mob plawv rau cov neeg siv tshuaj tiv thaiv qhov ncauj tam sim no tau kwv yees li ob mus rau rau ( 10-16 ). Qhov kev pheej hmoo tsawg heev rau hnub nyoog qis dua 30 xyoo.

Kev haus luam yeeb ua ke nrog kev siv tshuaj tiv thaiv qhov ncauj tau pom tias muaj txiaj ntsig zoo rau qhov tshwm sim ntawm myocardial infarctions hauv cov poj niam hauv lawv lub nrab-thirties lossis laus dua nrog kev haus luam yeeb rau feem ntau ntawm cov neeg mob ntau dhau ( 17 ). Cov neeg tuag feem ntau cuam tshuam nrog cov kab mob circulatory tau pom tias nce ntxiv hauv cov neeg haus luam yeeb hnub nyoog 35 xyoos thiab cov neeg tsis haus luam yeeb hnub nyoog 40 xyoo (Table II) ntawm cov poj niam uas siv cov tshuaj tiv thaiv qhov ncauj.

Cov tshuaj tiv thaiv kab mob hauv qhov ncauj tuaj yeem cuam tshuam cov txiaj ntsig ntawm qhov muaj txiaj ntsig zoo, xws li kub siab, ntshav qab zib, hyperlipidemias, hnub nyoog thiab rog ( 19 ). Hauv particular, qee cov progestogens paub tias yuav txo qis HDL cholesterol thiab ua rau cov piam thaj intolerance, thaum estrogens tuaj yeem tsim lub xeev ntawm hyperinsulinism ( 20-24 ). Cov tshuaj tiv thaiv qhov ncauj tau pom tias yuav ua rau cov ntshav siab ntxiv ntawm cov neeg siv (saib tshooj 9 hauv CEEB TOOM ). Cov kev cuam tshuam zoo sib xws ntawm cov xwm txheej muaj feem cuam tshuam nrog kev pheej hmoo siab ntawm kab mob plawv. Cov tshuaj tiv thaiv qhov ncauj yuav tsum tau siv nrog ceev faj rau cov poj niam uas muaj kab mob plawv.

b. Thromboembolism

Ib qho kev pheej hmoo ntawm thromboembolic thiab thrombotic kab mob cuam tshuam nrog kev siv cov tshuaj tiv thaiv qhov ncauj yog tsim tau zoo. Cov kev tshawb fawb tswj tau pom tias muaj kev pheej hmoo ntawm cov neeg siv piv rau cov neeg siv tsis yog 3 rau thawj zaug ntawm cov hlab ntsha ntawm cov hlab ntsha sab nraud, 4 txog 11 rau cov hlab ntsha sib sib zog nqus los yog pulmonary embolism, thiab 1.5 txog 6 rau cov poj niam uas muaj cov kab mob venous thromboembolic. kab mob ( 9, 10, 25-30 ). Cov kev tshawb fawb hauv pawg tau pom tias qhov kev pheej hmoo ntawm tus txheeb ze yuav qis dua, kwv yees li 3 rau cov neeg mob tshiab thiab txog 4.5 rau cov neeg mob tshiab uas yuav tsum tau mus pw hauv tsev kho mob ( 31 ). Qhov kev pheej hmoo ntawm tus kab mob thromboembolic vim yog cov tshuaj tiv thaiv kab mob hauv qhov ncauj tsis cuam tshuam txog qhov ntev ntawm kev siv thiab ploj tom qab siv tshuaj tua kab mob ( 8 ).

Ib qho kev nce ob mus rau plaub zaug hauv cov txheeb ze ntawm cov teeb meem tom qab mob thromboembolic tau tshaj tawm nrog kev siv cov tshuaj tiv thaiv qhov ncauj ( 15.32 Nws ). Qhov kev pheej hmoo ntawm venous thrombosis nyob rau hauv cov poj niam uas muaj cov kab mob predisposing yog ob zaug ntawm cov poj niam uas tsis muaj xws li mob ( 15.32 Nws ). Yog tias ua tau, cov tshuaj tiv thaiv qhov ncauj yuav tsum tau txiav tawm tsawg kawg plaub lub lis piam ua ntej thiab ob lub lis piam tom qab xaiv txoj kev phais ntawm ib hom uas cuam tshuam nrog kev pheej hmoo ntawm thromboembolism thiab thaum lub sij hawm thiab tom qab lub sij hawm ntev immobilization. Txij li thaum lub sijhawm tom qab yug me nyuam tam sim no tseem cuam tshuam nrog kev pheej hmoo ntawm thromboembolism, cov tshuaj tiv thaiv qhov ncauj yuav tsum tau pib tsis pub dhau plaub mus rau rau lub lis piam tom qab yug menyuam hauv cov poj niam uas xaiv tsis pub niam mis.

c. Kab mob cerebrovascular

Cov tshuaj tiv thaiv kab mob hauv qhov ncauj tau pom tias yuav ua rau muaj kev pheej hmoo ntawm cov kab mob cerebrovascular (thrombotic thiab hemorrhagic strokes), txawm hais tias, feem ntau, qhov kev pheej hmoo loj tshaj ntawm cov laus (ntau dua 35 xyoos), cov poj niam hypertensive uas tseem haus luam yeeb. Kev mob ntshav siab tau pom tias yog ib qho kev pheej hmoo rau cov neeg siv thiab cov neeg tsis siv, rau ob hom mob stroke, thaum haus luam yeeb cuam tshuam los ua kom muaj kev pheej hmoo rau hemorrhagic strokes ( 33-35 : kuv ).

Nyob rau hauv ib txoj kev tshawb fawb loj, qhov kev pheej hmoo ntawm thrombotic strokes tau pom tias muaj li ntawm 3 rau cov neeg siv tsis muaj zog mus rau 14 rau cov neeg siv ntshav siab ( 36 ). Qhov kev pheej hmoo ntawm hemorrhagic stroke tau tshaj tawm tias yog 1.2 rau cov neeg tsis haus luam yeeb uas siv cov tshuaj tiv thaiv qhov ncauj, 2.6 rau cov neeg haus luam yeeb uas tsis siv tshuaj tiv thaiv qhov ncauj, 7.6 rau cov neeg haus luam yeeb uas siv cov tshuaj tiv thaiv qhov ncauj, 1.8 rau cov neeg siv tsis muaj zog, thiab 25.7 rau cov neeg siv ntshav siab. ( 36 ). Qhov kev pheej hmoo tseem ceeb kuj muaj ntau dua rau cov poj niam laus ( 9 ).

d. Kev noj tshuaj muaj feem cuam tshuam txog kab mob vascular los ntawm cov tshuaj tiv thaiv qhov ncauj

Ib qho kev sib raug zoo tau raug pom ntawm tus nqi ntawm cov tshuaj estrogen thiab progestogen hauv cov tshuaj tiv thaiv qhov ncauj thiab kev pheej hmoo ntawm cov kab mob vascular ( 37-39 : kuv ). Kev poob qis hauv cov ntshav lipoproteins ntau ntom ntom (HDL) tau tshaj tawm nrog ntau tus neeg ua haujlwm progestational ( 20-22 ). Kev poob qis hauv cov ntshav ntshav siab high-ceev lipoproteins tau cuam tshuam nrog kev nce ntau dua ntawm cov kab mob plawv. Vim tias cov tshuaj estrogen nce HDL cholesterol, qhov txiaj ntsig ntawm kev tiv thaiv qhov ncauj yog nyob ntawm qhov sib npaug ua tiav ntawm cov tshuaj estrogen thiab progestin thiab qhov xwm ntawm progestin siv hauv cov tshuaj tiv thaiv. Tus nqi thiab kev ua haujlwm ntawm ob qho tshuaj hormones yuav tsum raug txiav txim siab hauv kev xaiv cov tshuaj tiv thaiv qhov ncauj.

Kev txo qis rau cov tshuaj estrogen thiab progestogen yog ua raws li cov hauv paus ntsiab lus zoo ntawm kev kho mob. Rau ib qho kev tiv thaiv kab mob hauv qhov ncauj, cov tshuaj noj tshuaj yuav tsum yog ib qho uas muaj tsawg kawg ntawm cov tshuaj estrogen thiab progestogen uas haum rau cov kev xav tau ntawm tus neeg mob. Cov neeg txais txiaj ntsig tshiab ntawm cov tshuaj tiv thaiv qhov ncauj yuav tsum tau pib ntawm kev npaj uas muaj cov tshuaj estrogen qis tshaj plaws uas ua rau muaj txiaj ntsig zoo rau tus neeg mob.

e. Kev pheej hmoo ntawm cov kab mob vascular

Muaj ob txoj kev tshawb fawb uas tau pom tias muaj kev pheej hmoo ntawm cov kab mob vascular rau cov neeg siv cov tshuaj tiv thaiv qhov ncauj. Hauv kev tshawb fawb hauv Tebchaws Meskas, qhov kev pheej hmoo ntawm kev tsim myocardial infarction tom qab txiav cov tshuaj tiv thaiv qhov ncauj tseem muaj tsawg kawg yog 9 xyoo rau cov poj niam 40-49 xyoo uas tau siv cov tshuaj tiv thaiv qhov ncauj rau 5 xyoos lossis ntau dua, tab sis qhov kev pheej hmoo ntau ntxiv no tsis tau pom nyob rau hauv lwm yam. pawg hnub nyoog ( 14 ). Hauv lwm txoj kev tshawb fawb hauv Great Britain, qhov kev pheej hmoo ntawm kev tsim cov kab mob cerebrovascular txuas ntxiv mus tsawg kawg 6 xyoo tom qab txiav cov tshuaj tiv thaiv qhov ncauj, txawm hais tias qhov kev pheej hmoo ntau dhau tsawg heev ( 40 ). Txawm li cas los xij, ob qho kev tshawb fawb tau ua nrog cov tshuaj tiv thaiv qhov ncauj uas muaj 50 mcg lossis siab dua ntawm cov tshuaj estrogen.

2. Kev kwv yees ntawm kev tuag los ntawm kev siv tshuaj tiv thaiv kab mob

Ib txoj kev tshawb fawb tau sau cov ntaub ntawv los ntawm ntau qhov chaw uas tau kwv yees cov neeg tuag uas cuam tshuam nrog ntau txoj kev tiv thaiv kab mob ntawm cov hnub nyoog sib txawv (Table III). Cov kev kwv yees no suav nrog kev pheej hmoo ntawm kev tuag uas cuam tshuam nrog txoj kev tiv thaiv kab mob ntxiv rau kev pheej hmoo ntawm cev xeeb tub thaum muaj kev tsis ua tiav. Txhua txoj kev tiv thaiv kab mob muaj nws cov txiaj ntsig tshwj xeeb thiab kev pheej hmoo. Txoj kev tshawb no xaus lus tias tshwj tsis yog cov neeg siv tshuaj tiv thaiv qhov ncauj 35 thiab laus dua uas haus luam yeeb thiab 40 thiab laus dua uas tsis haus luam yeeb, kev tuag cuam tshuam nrog txhua txoj hauv kev tiv thaiv kev yug me nyuam tsawg thiab qis dua uas cuam tshuam nrog kev yug menyuam. Kev soj ntsuam ntawm qhov muaj peev xwm ua rau muaj kev pheej hmoo tuag nrog hnub nyoog rau cov neeg siv tshuaj tiv thaiv qhov ncauj yog raws li cov ntaub ntawv sau tseg hauv xyoo 1970's tab sis tsis tau tshaj tawm txog xyoo 1983 ( 41 ). Txawm li cas los xij, kev coj noj coj ua tam sim no suav nrog kev siv cov tshuaj estrogen qis qis ua ke nrog kev ceev faj txog kev siv tshuaj tiv thaiv qhov ncauj rau cov poj niam uas tsis muaj ntau yam kev pheej hmoo uas tau teev tseg hauv daim ntawv lo no.

Vim tias cov kev hloov pauv hauv kev coj ua thiab, kuj, vim qee cov ntaub ntawv tshiab txwv uas qhia tias kev pheej hmoo ntawm cov kab mob plawv nrog kev siv cov tshuaj tiv thaiv qhov ncauj tam sim no yuav tsawg dua li yav dhau los tau pom (Porter JB, Hunter J, Jick H, thiab al. Obstet Gynecol 1985; 66: 1-4; thiab Porter JB, Hershel J, Walker AM. Kev tuag ntawm cov neeg siv tshuaj tiv thaiv qhov ncauj. Obstet Gynecol 1987; 70: 29-32), Fertility and Maternal Health Drugs Pawg Neeg Tawm Tswv Yim tau hais kom tshuaj xyuas cov ncauj lus hauv xyoo 1989. Pawg Neeg Saib Xyuas tau txiav txim siab tias txawm hais tias kev pheej hmoo ntawm cov kab mob plawv tuaj yeem nce ntxiv nrog kev siv tshuaj tiv thaiv qhov ncauj tom qab hnub nyoog 40 xyoo hauv cov poj niam noj qab haus huv tsis haus luam yeeb (txawm tias muaj cov tshuaj tsawg dua tshiab), muaj peev xwm ntau dua. Cov kev pheej hmoo ntawm kev noj qab haus huv cuam tshuam nrog kev xeeb tub hauv cov poj niam laus thiab nrog lwm txoj kev phais thiab kev kho mob uas yuav tsim nyog yog tias cov poj niam no tsis muaj peev xwm siv tau thiab siv tau txoj kev tiv thaiv kab mob.

Yog li, Pawg Neeg Saib Xyuas tau pom zoo tias cov txiaj ntsig ntawm kev siv tshuaj tiv thaiv qhov ncauj los ntawm cov poj niam noj qab haus huv uas tsis haus luam yeeb tshaj 40 xyoo tuaj yeem tshaj qhov kev pheej hmoo. Tau kawg, cov poj niam laus, zoo li txhua tus poj niam uas siv cov tshuaj tiv thaiv qhov ncauj, yuav tsum tau noj cov tshuaj qis tshaj plaws uas ua tau zoo.

3. Cov kab mob qog nqaij hlav ntawm lub cev xeeb tub

Ntau qhov kev tshawb fawb txog kab mob kis tau raug ua tiav ntawm qhov tshwm sim ntawm lub mis, endometrial, zes qe menyuam, thiab mob qog noj ntshav hauv cov poj niam uas siv cov tshuaj tiv thaiv qhov ncauj. Feem ntau ntawm cov kev tshawb fawb txog kev mob qog noj ntshav mis thiab kev siv tshuaj tiv thaiv qhov ncauj qhia tias kev siv tshuaj tiv thaiv qhov ncauj tsis cuam tshuam nrog kev nce hauv kev pheej hmoo ntawm kev mob qog noj ntshav mis ( 42, 44, 89 ib ). Qee qhov kev tshawb fawb tau tshaj tawm tias muaj kev pheej hmoo ntau ntxiv ntawm kev mob qog noj ntshav ntawm lub mis hauv qee pawg ntawm cov neeg siv tshuaj tiv thaiv qhov ncauj, tab sis qhov kev tshawb pom tau tshaj tawm hauv cov kev tshawb fawb no tsis sib xws ( 43.45-49.85-88 ib ).

Qee qhov kev tshawb fawb qhia tias kev siv tshuaj tiv thaiv qhov ncauj tau cuam tshuam nrog kev nce hauv kev pheej hmoo ntawm ncauj tsev menyuam intraepithelial neoplasia hauv qee cov poj niam ( 51-54 : kuv ). Txawm li cas los xij, tseem muaj kev tsis sib haum xeeb txog qhov uas qhov kev tshawb pom no yuav yog vim qhov sib txawv ntawm tus cwj pwm kev sib deev thiab lwm yam.

Txawm hais tias muaj ntau txoj kev tshawb fawb txog kev sib raug zoo ntawm kev siv tshuaj tiv thaiv kab mob hauv qhov ncauj thiab mob qog noj ntshav ntawm lub mis thiab lub ncauj tsev menyuam, tsis tau tsim muaj kev sib raug zoo thiab cov txiaj ntsig.

4. Hepatic Neoplasia

Benign hepatic adenomas yog txuam nrog kev siv tshuaj tiv thaiv qhov ncauj, txawm hais tias qhov tshwm sim ntawm cov qog nqaij hlav tsis tshua muaj nyob hauv Tebchaws Meskas. Kev suav tsis ncaj tau kwv yees qhov kev pheej hmoo yuav nyob hauv thaj tsam ntawm 3.3 tus neeg mob / 100,000 rau cov neeg siv, qhov kev pheej hmoo uas nce ntxiv tom qab plaub lossis ntau xyoo ntawm kev siv ( 55 ). Kev tawg ntawm tsawg, benign, hepatic adenomas tuaj yeem ua rau tuag los ntawm kev mob plab hauv plab ( 56.57 ib ).

Cov kev tshawb fawb los ntawm Tebchaws Askiv tau pom tias muaj kev pheej hmoo ntau ntxiv ntawm kev tsim kab mob hepatocellular carcinoma ( 58-60 : kuv ) nyob rau lub sij hawm ntev (ntau dua 8 xyoo) cov neeg siv tshuaj tiv thaiv qhov ncauj. Txawm li cas los xij, cov qog nqaij hlav no tsis tshua muaj neeg nyob hauv Asmeskas, thiab qhov kev pheej hmoo uas tshwm sim (qhov tshwm sim ntau dhau) ntawm cov qog nqaij hlav hauv siab hauv cov neeg siv tshuaj tiv thaiv qhov ncauj mus txog tsawg dua ib lab tus neeg siv.

5. Kev pheej hmoo ntawm daim siab Enzyme nce nrog kev kho kab mob siab C

Thaum lub sij hawm soj ntsuam nrog cov kab mob siab C ua ke cov tshuaj noj uas muaj ombitasvir / paritaprevir / ritonavir, nrog lossis tsis muaj dasabuvir, ALT nce siab dua 5 npaug ntawm qhov txwv siab tshaj ntawm ib txwm (ULN), suav nrog qee kis ntau dua 20 npaug ntawm ULN, tau nce ntau. Ntau zaus hauv cov poj niam siv cov tshuaj ethinyl estradiol-muaj xws li COCs. Txiav tawm cov norethindrone acetate thiab ethinyl estradiol ntsiav tshuaj ua ntej pib kho nrog kev sib xyaw ua ke ntawm cov tshuaj ombitasvir / paritaprevir / ritonavir, nrog lossis tsis muaj dasabuvir [saib Contraindications (4) ]. Norethindrone acetate thiab ethinyl estradiol ntsiav tshuaj tuaj yeem rov pib dua li ntawm 2 lub lis piam tom qab ua tiav kev kho mob nrog kev siv tshuaj sib xyaw ua ke.

6. Ocular Lesions

Muaj cov ntaub ntawv soj ntsuam ntawm cov retinal thrombosis cuam tshuam nrog kev siv cov tshuaj tiv thaiv qhov ncauj. Cov tshuaj tiv thaiv qhov ncauj yuav tsum tau txiav tawm yog tias tsis tau piav qhia ib feem lossis ua tiav qhov tsis pom kev; pib ntawm proptosis los yog diplopia; papillomas; los yog retinal vascular lesions. Kev kuaj mob thiab kev kho mob tsim nyog yuav tsum tau ua tam sim ntawd.

7. Kev siv tshuaj tiv thaiv qhov ncauj ua ntej thiab thaum ntxov cev xeeb tub

Kev tshawb fawb txog kab mob kis thoob qhov txhia chaw tau qhia tias tsis muaj kev pheej hmoo ntawm kev yug me nyuam hauv cov poj niam uas tau siv cov tshuaj tiv thaiv qhov ncauj ua ntej cev xeeb tub ( 61-63 : kuv ). Cov kev tshawb fawb tseem tsis tau qhia txog cov txiaj ntsig teratogenic, tshwj xeeb tshaj yog nyob rau hauv qhov tsis txaus ntseeg ntawm lub plawv thiab kev txo qis ntawm lub cev muaj kev txhawj xeeb ( 61, 62, 64, 65 ), thaum noj inadvertently thaum ntxov cev xeeb tub.

Kev tswj hwm cov tshuaj tiv thaiv qhov ncauj los ntxias kom tshem tawm los ntshav yuav tsum tsis txhob siv los ua kev kuaj cev xeeb tub. Cov tshuaj tiv thaiv qhov ncauj yuav tsum tsis txhob siv thaum cev xeeb tub los kho kev hem lossis rho menyuam tawm.

Nws raug pom zoo tias rau ib tus neeg mob uas tsis tau ob lub sijhawm sib law liag, cev xeeb tub yuav tsum raug txiav tawm ua ntej txuas ntxiv kev siv tshuaj tiv thaiv qhov ncauj. Yog tias tus neeg mob tsis tau ua raws li lub sijhawm teem tseg, qhov ua tau ntawm cev xeeb tub yuav tsum tau txiav txim siab thaum lub sijhawm thawj lub sijhawm tsis tuaj. Kev siv tshuaj tiv thaiv qhov ncauj yuav tsum tsis txhob txuas ntxiv yog tias cev xeeb tub.

8. Kab mob gallbladder

Cov kev tshawb fawb yav dhau los tau tshaj tawm txog kev pheej hmoo ntawm lub neej ntawm kev phais mob gallbladder hauv cov neeg siv tshuaj tiv thaiv qhov ncauj thiab tshuaj estrogen ( 66.67 ib ). Cov kev tshawb fawb tsis ntev los no, txawm li cas los xij, tau pom tias muaj kev pheej hmoo ntawm kev tsim kab mob gallbladder ntawm cov neeg siv tshuaj tiv thaiv qhov ncauj yuav tsawg ( 68-70 : kuv ). Cov kev tshawb pom tsis ntev los no ntawm kev pheej hmoo tsawg yuav cuam tshuam nrog kev siv cov tshuaj tiv thaiv hauv qhov ncauj uas muaj cov tshuaj hormonal qis ntawm cov tshuaj estrogen thiab progestogens.

9. Carbohydrate Thiab Lipid Metabolic cuam tshuam

Cov tshuaj tiv thaiv qhov ncauj tau pom tias ua rau cov piam thaj tsis haum rau feem pua ​​​​ntawm cov neeg siv khoom tseem ceeb ( 23 ). Cov tshuaj tiv thaiv qhov ncauj uas muaj ntau dua 75 mcg ntawm cov tshuaj estrogen ua rau hyperinsulinism, thaum txo qis ntawm cov tshuaj estrogen ua rau cov piam thaj tsis txaus ( 71 ). Progestogens nce insulin secretion thiab tsim cov tshuaj insulin, cov nyhuv no sib txawv nrog cov kab mob sib txawv ( 23.72 Nws ). Txawm li cas los xij, hauv cov poj niam uas tsis muaj ntshav qab zib, cov tshuaj tiv thaiv qhov ncauj zoo li tsis muaj txiaj ntsig rau kev yoo ntshav qabzib ( 73 ). Vim tias cov teebmeem no tshwm sim, cov poj niam prediabetic thiab ntshav qab zib yuav tsum tau ua tib zoo saib thaum noj cov tshuaj tiv thaiv qhov ncauj.

Ib feem me me ntawm cov poj niam yuav muaj hypertriglyceridemia tsis tu ncua thaum noj tshuaj. Raws li tau tham ua ntej (saib WARNINGS 1 ib a. thiab 1d ib. ), kev hloov pauv hauv cov ntshav triglycerides thiab lipoprotein qib tau tshaj tawm hauv cov neeg siv tshuaj tiv thaiv qhov ncauj.

10. Ntshav siab

Kev nce ntshav siab tau raug tshaj tawm hauv cov poj niam noj cov tshuaj tiv thaiv qhov ncauj ( 74 ) thiab qhov kev nce no muaj feem ntau dua hauv cov neeg siv tshuaj tiv thaiv qhov ncauj laus ( 75 ) thiab nrog kev siv txuas ntxiv ( 74 ). Cov ntaub ntawv los ntawm Royal College of General Practitioners ( 18 ) thiab cov kev sim randomized tom ntej tau pom tias qhov tshwm sim ntawm kev kub siab nce ntxiv nrog kev nce qib ntawm progestogens.

Cov poj niam uas muaj keeb kwm ntawm ntshav siab los yog cov kab mob ntshav siab los yog kab mob raum ( 76 ) yuav tsum tau txhawb kom siv lwm txoj kev tiv thaiv kab mob. Yog tias cov poj niam xaiv los siv cov tshuaj tiv thaiv hauv qhov ncauj, lawv yuav tsum tau saib xyuas kom zoo, thiab yog tias qhov nce siab ntawm cov ntshav siab tshwm sim, cov tshuaj tiv thaiv qhov ncauj yuav tsum txiav tawm. Rau cov poj niam feem ntau, cov ntshav siab yuav rov zoo li qub tom qab tso tseg cov tshuaj tiv thaiv qhov ncauj ( 75 ), thiab tsis muaj qhov sib txawv ntawm qhov tshwm sim ntawm kev kub siab ntawm ib puas thiab tsis siv neeg ( 74, 76, 77 ib ).

11. Mob taub hau

Qhov pib lossis exacerbation ntawm migraine lossis kev mob taub hau nrog tus qauv tshiab uas rov tshwm sim, tsis tu ncua, lossis hnyav yuav tsum tsis txhob siv tshuaj tiv thaiv qhov ncauj thiab tshuaj xyuas qhov ua rau.

12. Los ntshav tsis xwm yeem

Kev tawg los ntshav thiab pom pom qee zaum ntsib hauv cov neeg mob ntawm cov tshuaj tiv thaiv qhov ncauj, tshwj xeeb tshaj yog thaum thawj peb lub hlis ntawm kev siv. Qhov ua rau tsis yog hormonal yuav tsum raug txiav txim siab, thiab cov kev kuaj mob txaus los txiav txim siab tsis zoo lossis cev xeeb tub thaum muaj ntshav los ntshav, xws li nyob rau hauv cov ntaub ntawv ntawm qhov txawv txav ntawm qhov chaw mos los ntshav. Yog tias pathology tau raug cais tawm, lub sijhawm lossis kev hloov pauv mus rau lwm hom tshuaj yuav daws tau qhov teeb meem. Thaum muaj amenorrhea, cev xeeb tub yuav tsum tau txiav tawm.

Qee tus poj niam yuav ntsib cov tshuaj amenorrhea tom qab lossis oligomenorrhea, tshwj xeeb tshaj yog thaum muaj tus mob no.

Cov kev ceev faj

1. Cov neeg mob yuav tsum tau ntuas tias cov khoom no tsis tiv thaiv kab mob HIV (AIDS) thiab lwm yam kab mob sib kis.

2. Kev kuaj lub cev thiab ua raws

Nws yog ib txoj kev kho mob zoo rau txhua tus poj niam kom muaj keeb kwm txhua xyoo thiab kuaj lub cev, suav nrog cov poj niam siv cov tshuaj tiv thaiv qhov ncauj. Kev kuaj lub cev, txawm li cas los xij, yuav ncua mus txog thaum tom qab pib cov tshuaj tiv thaiv qhov ncauj yog tias tus poj niam thov thiab txiav txim siab los ntawm tus kws kho mob. Kev kuaj lub cev yuav tsum suav nrog kev siv tshwj xeeb rau cov ntshav siab, lub mis, lub plab thiab lub plab hauv plab, nrog rau lub ncauj tsev menyuam cytology, thiab cov kev kuaj mob ntsig txog. Nyob rau hauv cov ntaub ntawv ntawm undiagnosed, tsis tu ncua los yog rov tshwm sim ntawm qhov chaw mos los ntshav, tsim nyog ntsuas yuav tsum tau ua los txiav txim malignancy. Cov poj niam uas muaj keeb kwm ntawm tsev neeg muaj mob qog noj ntshav los yog muaj lub mis nodules yuav tsum tau saib xyuas tshwj xeeb.

3. Lipid Disorders

Cov poj niam uas raug kho rau hyperlipidemia yuav tsum tau ua tib zoo saib yog tias lawv xaiv siv cov tshuaj tiv thaiv qhov ncauj. Qee cov progestogens tuaj yeem nce qib LDL thiab tuaj yeem ua rau kev tswj hwm ntawm hyperlipidemias nyuaj dua.

4. Lub siab ua haujlwm

Yog hais tias daj ntseg tshwm sim nyob rau hauv ib tug poj niam uas tau txais cov tshuaj no, cov tshuaj yuav tsum tau txiav. Cov tshuaj steroids tuaj yeem ua rau metabolized tsis zoo hauv cov neeg mob uas muaj lub siab ua haujlwm tsis zoo.

5. Kev tuav dej

Cov tshuaj tiv thaiv qhov ncauj tuaj yeem ua rau qee qhov dej khaws cia. Lawv yuav tsum tau muab tshuaj nrog ceev faj, thiab tsuas yog nrog kev saib xyuas kom zoo, hauv cov neeg mob uas tej zaum yuav ua rau hnyav los ntawm kev tuav dej.

6. Kev xav tsis zoo

Cov poj niam uas muaj keeb kwm ntawm kev nyuaj siab yuav tsum tau ua tib zoo saib thiab cov tshuaj txiav tawm yog tias kev nyuaj siab rov tshwm sim rau qhov hnyav.

7. Cov Lenses

Cov neeg hnav lub ntsej muag uas tsim kev pom kev hloov pauv lossis hloov pauv ntawm lub lens kam rau ua yuav tsum tau soj ntsuam los ntawm tus kws kho qhov muag.

8. Kev Sib Tham Tshuaj

Cov txiaj ntsig ntawm Lwm Cov Tshuaj Hauv Qhov Ncauj Tiv Thaiv Kab Mob ( 78 )

Rifampin:Metabolism ntawm ob leeg norethindrone thiab ethinyl estradiol yog nce los ntawm rifampin. Kev txo qis hauv kev siv tshuaj tiv thaiv kab mob thiab nce qhov tshwm sim ntawm cov ntshav tawm thiab kev coj khaub ncaws tsis zoo tau cuam tshuam nrog kev siv rifampin sib xyaw.

Anticonvulsants:Anticonvulsants xws li phenobarbital, phenytoin, thiab carbamazepine, tau pom tias ua kom cov metabolism ntawm ethinyl estradiol thiab / lossis norethindrone, uas tuaj yeem ua rau txo qis kev tiv thaiv kab mob.

Troglitazone:Kev tswj hwm ntawm troglitazone nrog cov tshuaj tiv thaiv qhov ncauj uas muaj ethinyl estradiol thiab norethindrone txo cov ntshav plasma ntawm ob qho tib si li ntawm 30%, uas tuaj yeem ua rau txo qis hauv kev tiv thaiv kab mob.

Tshuaj tua kab mob:Kev xeeb tub thaum noj cov tshuaj tiv thaiv qhov ncauj tau raug tshaj tawm thaum cov tshuaj tiv thaiv qhov ncauj tau muab tshuaj tua kab mob xws li ampicillin, tetracycline, thiab griseofulvin. Txawm li cas los xij, kev tshawb fawb tshuaj pharmacokinetic tsis tau pom tias muaj kev cuam tshuam zoo ntawm cov tshuaj tua kab mob (tshwj tsis yog rifampin) ntawm plasma concentrations ntawm hluavtaws steroids.

Atorvastatin:Kev tswj hwm ntawm atorvastatin thiab cov tshuaj tiv thaiv qhov ncauj tau nce AUC qhov tseem ceeb rau norethindrone thiab ethinyl estradiol li ntawm 30% thiab 20%, feem.

Concomitant Siv nrog HCV Combination Therapy- Kev nce siab hauv siab Tsis txhob koom nrog [DRUG] nrog HCV cov tshuaj sib xyaw ua ke uas muaj ombitasvir/paritaprevir/ritonavir, nrog lossis tsis muaj dasabuvir, vim muaj peev xwm rau ALT nce siab (saib Ceeb toom , Kev pheej hmoo ntawm daim siab ENZYME ELEVATIONS nrog kev kho mob siab hepatitis C ).

Lwm yam:Ascorbic acid thiab acetaminophen tuaj yeem nce ntshav plasma ethinyl estradiol concentrations, tejzaum nws yog inhibition ntawm conjugation. Kev txo qis hauv kev siv tshuaj tiv thaiv kab mob thiab nce qhov tshwm sim ntawm cov ntshav los ntshav tau pom zoo nrog phenylbutazone.

Cov txiaj ntsig ntawm qhov ncauj tshuaj tiv thaiv kab mob rau lwm yam tshuaj

Cov tshuaj tiv thaiv qhov ncauj ua ke uas muaj ethinyl estradiol tuaj yeem cuam tshuam cov metabolism ntawm lwm cov tebchaw. Kev nce ntshav plasma ntau ntawm cyclosporine, prednisolone, thiab theophylline tau raug tshaj tawm nrog kev tswj hwm ntawm cov tshuaj tiv thaiv qhov ncauj. Tsis tas li ntawd, cov tshuaj tiv thaiv qhov ncauj tuaj yeem ua rau muaj kev sib txuas ntawm lwm cov tshuaj. Kev txo qis hauv plasma concentration ntawm acetaminophen thiab nce kev tshem tawm ntawm temazepam, salicylic acid, morphine, thiab clofibric acid tau raug sau tseg thaum cov tshuaj no tau muab tshuaj tiv thaiv qhov ncauj.

9. Kev sib cuam tshuam nrog kev sim kuaj

Qee qhov kev kuaj mob endocrine thiab daim siab ua haujlwm thiab cov ntshav hauv cov ntshav tuaj yeem cuam tshuam los ntawm cov tshuaj tiv thaiv qhov ncauj:

ib. Nce prothrombin thiab yam VII, VIII, IX, thiab X; txo antithrombin 3; nce norepinephrine-induced platelet aggregability.

b. Kev nce cov thyroid binding globulin (TBG) ua rau muaj kev nthuav dav tag nrho cov thyroid hormones, raws li ntsuas los ntawm protein-bound iodine (PBI), T4 los ntawm kab los yog los ntawm radioimmunoassay. Dawb T3 resin uptake yog txo, qhia txog TBG siab; dawb T4 concentration yog unchanged.

c. Lwm cov proteins uas khi tau tuaj yeem nce siab hauv cov ntshav.

d. Kev sib deev-binding globulins tau nce thiab ua rau nce qib ntawm tag nrho cov kev sib deev steroids thiab corticoids; Txawm li cas los xij, cov qib dawb lossis lom lom lom zem nyob tsis hloov.

e. Triglycerides tuaj yeem nce ntxiv.

f. Glucose kam rau ua yuav raug txo.

g. Cov qib folate hauv cov ntshav tuaj yeem ntxhov siab los ntawm kev kho qhov ncauj. Qhov no yuav yog qhov tseem ceeb hauv kev kho mob yog tias tus poj niam cev xeeb tub sai tom qab txiav cov tshuaj tiv thaiv qhov ncauj.

10. Carcinogenesis

Saib CEEB TOOM ntu.

11. Kev xeeb tub

Cev xeeb tub qeb X. Saib CONTRAINDICATIONS thiab CEEB TOOM ntu.

12. Niam laus

Cov tshuaj tiv thaiv qhov ncauj me me tau raug txheeb xyuas nyob rau hauv cov kua mis ntawm cov niam laus, thiab qee qhov kev cuam tshuam rau tus menyuam tau raug tshaj tawm, suav nrog jaundice thiab lub mis loj. Tsis tas li ntawd, cov tshuaj tiv thaiv qhov ncauj tau muab rau hauv lub sijhawm tom qab yug menyuam tuaj yeem cuam tshuam rau lactation los ntawm kev txo qis thiab qhov zoo ntawm cov kua mis. Yog tias ua tau, tus niam laus yuav tsum tau qhia kom tsis txhob siv cov tshuaj tiv thaiv qhov ncauj tab sis siv lwm hom kev tiv thaiv kab mob kom txog thaum nws tau txiav nws tus menyuam tag.

13. Kev siv menyuam yaus

Kev nyab xeeb thiab kev ua tau zoo ntawm norethindrone acetate thiab ethinyl estradiol tau tsim nyob rau hauv cov poj niam uas muaj hnub nyoog me nyuam yaus. Kev nyab xeeb thiab kev ua tau zoo yuav tsum zoo ib yam rau cov tub ntxhais hluas hnub nyoog qis dua 16 xyoo thiab rau cov neeg siv 16 xyoo thiab laus dua. Kev siv cov khoom no ua ntej menarche tsis qhia.

COV NTAUB NTAWV NTAWM TUS NEEG

Saib tus neeg mob daim ntawv lo luam tawm hauv qab no.

Kev Phem Tsis Zoo

Qhov kev pheej hmoo ntau ntxiv ntawm cov kev tsis zoo tshwm sim hauv qab no tau cuam tshuam nrog kev siv cov tshuaj tiv thaiv qhov ncauj (saib CEEB TOOM ntu):

  • thrombophlebitis
  • Arterial thromboembolism
  • Pulmonary embolism
  • Myocardial infarction
  • Cerebral hemorrhage
  • Cerebral thrombosis
  • Ntshav siab
  • Kab mob gallbladder
  • Hepatic adenomas lossis benign daim siab qog

Muaj pov thawj ntawm kev sib koom ua ke ntawm cov xwm txheej hauv qab no thiab kev siv cov tshuaj tiv thaiv qhov ncauj, txawm tias xav tau kev tshawb fawb ntxiv ntxiv:

  • Mesenteric thrombosis
  • Retinal thrombosis

Cov kev tsis zoo hauv qab no tau tshaj tawm hauv cov neeg mob uas tau txais cov tshuaj tiv thaiv kab mob hauv qhov ncauj thiab ntseeg tau tias muaj feem xyuam nrog tshuaj:

  • Ntshai
  • ntuav
  • Cov tsos mob ntawm plab hnyuv (xws li mob plab thiab tsam plab)
  • Los ntshav
  • Kev pom
  • Hloov hauv kev coj khaub ncaws
  • Amenorrhea
  • Kev muaj menyuam tsis taus ib ntus tom qab txiav kev kho mob
  • Edema
  • Melasma uas tuaj yeem tshwm sim
  • Kev hloov ntawm lub mis: rhiab, o, secretion
  • Hloov qhov hnyav (nce lossis txo)
  • Hloov ntawm ncauj tsev menyuam yaig thiab tso zis
  • Diminution hauv lactation thaum muab tam sim tom qab yug menyuam
  • Cholestatic jaundice
  • Migraine
  • Rash (kev ua xua)
  • Kev nyuaj siab
  • Txo kev kam rau siab rau carbohydrates
  • Qhov chaw mos candidiasis
  • Hloov pauv hauv pob txha curvature (steepening)
  • Intolerance rau cov lo ntsiab muag

Cov kev tsis zoo hauv qab no tau tshaj tawm hauv cov neeg siv tshuaj tiv thaiv qhov ncauj thiab lub koom haum tsis tau lees paub lossis tsis lees paub:

  • Pre-menstrual syndrome
  • Kab mob cataracts
  • Kev hloov hauv qab los noj mov
  • Cystitis-zoo li syndrome
  • Mob taub hau
  • Ntshai
  • kiv taub hau
  • Hirsutism
  • Cov plaub hau poob ntawm tawv taub hau
  • Erythema multiforme
  • Erythema nodosum
  • Hemorrhagic eruption
  • Vaginitis
  • Porphyria
  • Lub raum ua haujlwm tsis zoo
  • Hemolytic uremic syndrome
  • Budd-Chiari Syndrome
  • Pob txuv
  • Kev hloov hauv libido
  • Colitis

Kev noj ntau dhau

Cov tsos mob hnyav tsis tau tshaj tawm tom qab kev noj tshuaj ntau ntawm cov tshuaj tiv thaiv qhov ncauj los ntawm cov menyuam yaus. Kev noj ntau dhau tuaj yeem ua rau xeev siab, thiab tshem tawm los ntshav yuav tshwm sim hauv cov poj niam.

TSIS TXAUS SIAB HEALTH BENEFITS

Cov txiaj ntsig kev noj qab haus huv uas tsis yog tshuaj tiv thaiv kab mob hauv qab no cuam tshuam nrog kev siv cov tshuaj tiv thaiv qhov ncauj yog kev txhawb nqa los ntawm kev tshawb fawb txog kev kis kab mob uas siv cov tshuaj tiv thaiv kab mob hauv qhov ncauj uas muaj cov tshuaj estrogen ntau dua 0.035 mg ntawm ethinyl estradiol lossis 0.05 mg ntawm mestranol ( 79-84 : kuv ).

Cov teebmeem ntawm menses:

  • Nce kev coj khaub ncaws mus li qub
  • Txo ntshav poob thiab txo qhov tshwm sim ntawm hlau deficiency anemia
  • Txo qhov tshwm sim ntawm dysmenorrhea

Cov teebmeem cuam tshuam rau inhibition ntawm ovulation:

  • Txo qhov tshwm sim ntawm kev ua haujlwm ntawm zes qe menyuam cysts
  • Txo qhov tshwm sim ntawm ectopic cev xeeb tub

Qhov cuam tshuam los ntawm kev siv mus sij hawm ntev:

  • Txo qhov tshwm sim ntawm fibroadenomas thiab kab mob fibrocystic ntawm lub mis
  • Txo qhov tshwm sim ntawm tus mob pelvic inflammatory kab mob
  • Txo qhov tshwm sim ntawm mob qog noj ntshav endometrial
  • Txo qhov tshwm sim ntawm qog nqaij hlav zes qe menyuam

Larin Fe 1/20 Dosage and Administration

Cov ntsiav tshuaj dispenser tau tsim los ua kom cov tshuaj tiv thaiv qhov ncauj kom yooj yim thiab yooj yim li sai tau. Cov ntsiav tshuaj tau teem rau hauv peb lossis plaub kab ntawm xya ntsiav tshuaj txhua, nrog rau hnub ntawm lub lim tiam tshwm sim ntawm cov ntsiav tshuaj dispenser saum thawj kab ntawm cov ntsiav tshuaj.

Nco tseg:Txhua lub ntsiav tshuaj dispenser tau sau ua ntej nrog cov hnub ntawm lub lim tiam, pib hnub Sunday, txhawm rau pab txhawb rau hnub Sunday-Start regimen. Rau lub hnub sib txawv ntawm daim ntawv lo tau muab nrog Daim Ntawv Qhia Txog Tus Neeg Mob & Cov Ntsiab Lus Qhia Txog Tus Neeg Mob Ntxig txhawm rau txhawm rau txhawm rau ua kom haum rau Hnub-1 Pib Txoj Cai. Yog tias tus neeg mob tab tom siv Hnub-1 Pib Txoj Cai, nws yuav tsum tso nws tus kheej-nplaum hnub daim ntawv lo strip uas sib haum rau nws pib hnub dhau hnub uas tau luam tawm.

Tseem ceeb:Tus neeg mob yuav tsum tau qhia kom siv lwm txoj kev tiv thaiv kom txog thaum tom qab thawj lub lim tiam ntawm kev tswj hwm hauv thawj lub voj voog thaum siv hnub Sunday-Start regimen.

Qhov muaj peev xwm ntawm ovulation thiab conception ua ntej pib siv yuav tsum tau xav txog.

Dosage and Administration for 28-Hnub Dosage Regimen

Txhawm rau kom ua tiav qhov kev tiv thaiv zoo tshaj plaws, Larin Fe 1/20 yuav tsum tau noj raws nraim li tau hais tseg thiab nyob rau lub sijhawm tsis pub dhau 24 teev.

Larin Fe 1/20 muab cov kev tswj xyuas tas li uas muaj 21 cov ntsiav tshuaj daj daj ntawm norethindrone acetate thiab ethinyl estradiol thiab 7 xim av tsis-hormone uas muaj cov ntsiav tshuaj ntawm ferrous fumarate. Cov ntsiav tshuaj ferrous fumarate tam sim no los ua kom yooj yim ntawm kev tswj hwm tshuaj ntawm 28-hnub kev tswj hwm thiab tsis ua haujlwm rau kev kho mob. Tsis muaj qhov xav tau rau tus neeg mob suav hnub ntawm lub voj voog vim tias tsis muaj 'hnub tawm ntawm ntsiav tshuaj'.

A. Hnub Sunday-Start Regimen:Tus neeg mob pib noj cov ntsiav tshuaj xim xim thawj zaug los ntawm kab saum toj kawg nkaus ntawm lub tshuab xa khoom (sau npe hnub Sunday) thawj hnub Sunday tom qab kev coj khaub ncaws pib. Thaum kev coj khaub ncaws pib rau hnub Sunday, thawj lub ntsiav tshuaj xim xim tau noj rau tib hnub. Tus neeg mob siv ib ntsiav tshuaj xim xim ib hnub rau 21 hnub. Cov ntsiav tshuaj lub teeb xim kawg nyob rau hauv lub dispenser yuav raug coj mus rau hnub Saturday. Thaum ua tiav tag nrho 21 ntsiav tshuaj xim xim, thiab tsis muaj kev cuam tshuam, tus neeg mob siv ib ntsiav tshuaj xim av ib hnub rau 7 hnub. Tom qab kawm tiav thawj chav kawm ntawm cov ntsiav tshuaj no, tus neeg mob pib kawm thib ob ntawm 28-hnub ntsiav tshuaj, yam tsis muaj kev cuam tshuam, hnub tom qab (Sunday), pib nrog hnub Sunday lub teeb-xim ntsiav tshuaj nyob rau hauv kab saum toj kawg nkaus. Ua raws li cov txheej txheem no ntawm ib ntsiav tshuaj xim xim txhua hnub rau 21 hnub, ua raws li tsis muaj kev cuam tshuam los ntawm ib ntsiav tshuaj xim av txhua hnub rau xya hnub, tus neeg mob yuav pib tag nrho cov kev mus tom ntej rau hnub Sunday.

B. Hnub-1 Pib Regimen:Thawj hnub ntawm kev coj khaub ncaws yog Hnub 1. Tus neeg mob muab nws tus kheej-adhesive hnub daim ntawv lo strip uas sib haum mus rau nws pib hnub dhau los ntawm preprinted hnub ntawm lub ntsiav tshuaj dispenser. Nws pib noj ib ntsiav tshuaj lub teeb xim txhua hnub, pib nrog thawj lub teeb xim ntsiav tshuaj nyob rau hauv kab saum toj kawg nkaus. Tom qab noj cov ntsiav tshuaj xim av kawg (thaum kawg ntawm kab thib peb) tau noj, tus neeg mob mam li noj cov ntsiav tshuaj xim av rau ib lub lim tiam (7 hnub). Rau txhua lub voj voog tom ntej, tus neeg mob pib 28 ntsiav tshuaj tshiab nyob rau hnub thib yim tom qab noj nws cov ntsiav tshuaj xim xim kawg, rov pib nrog thawj ntsiav tshuaj nyob rau hauv kab saum toj kawg nkaus tom qab muab cov ntawv lo rau hnub tsim nyog tshaj hnub preprinted ntawm cov ntsiav tshuaj. lub tshuab luam ntawv. Ua raws li cov txheej txheem no ntawm 21 ntsiav tshuaj lub teeb xim thiab 7 ntsiav tshuaj xim av, tus neeg mob yuav pib tag nrho cov kev mus tom ntej nyob rau tib hnub ntawm lub lim tiam raws li thawj chav kawm.

Cov ntsiav tshuaj yuav tsum tau noj tsis tu ncua nrog noj mov lossis thaum mus pw. Nws yuav tsum tau hais tias kev ua tau zoo ntawm cov tshuaj yog nyob ntawm nruj ua raws li lub sijhawm teem sijhawm.

Cov Lus Qhia Tshwj Xeeb ntawm Kev Tswj Xyuas

Kev coj khaub ncaws feem ntau pib ob lossis peb hnub, tab sis yuav pib lig li hnub plaub lossis hnub thib tsib, tom qab cov ntsiav tshuaj xim av tau pib. Nyob rau hauv txhua rooj plaub, chav kawm tom ntej ntawm cov ntsiav tshuaj yuav tsum tau pib yam tsis muaj kev cuam tshuam. Yog tias pom pom tshwm sim thaum tus neeg mob noj cov ntsiav tshuaj xim xim, txuas ntxiv tshuaj yam tsis muaj kev cuam tshuam.

Yog tias tus neeg mob tsis nco qab noj ib lossis ntau dualub teeb ximntsiav tshuaj, cov hauv qab no tau pom zoo:

Ibntsiav tshuaj tsis tuaj

  • noj ntsiav tshuaj sai li sai tau
  • noj cov ntsiav tshuaj tom ntej ntawm lub sijhawm tsis tu ncua

ObCov ntsiav tshuaj sib law liag tsis tau (lub lim tiam 1 lossis lub lim tiam 2)

  • cojobntsiav tshuaj sai li sai tau
  • cojobntsiav tshuaj hnub tom qab
  • siv lwm txoj kev tswj kev yug me nyuam rau xya hnub tom qab cov ntsiav tshuaj uas tsis tau

Obcov ntsiav tshuaj sib law liag tsis tau (lub lim tiam 3)

Hnub Sunday-Start Regimen:

  • cojibntsiav tshuaj txhua hnub txog hnub Sunday
  • muab cov ntsiav tshuaj uas tseem tshuav
  • pib tshiab pob ntawm cov ntsiav tshuaj tam sim ntawd (Sunday)
  • siv lwm txoj kev tswj kev yug me nyuam rau xya hnub tom qab cov ntsiav tshuaj uas tsis tau

Hnub-1 Pib Regimen:

  • muab cov ntsiav tshuaj uas tseem tshuav
  • pib cov ntsiav tshuaj tshiab rau tib hnub ntawd
  • siv lwm txoj kev tswj kev yug me nyuam rau xya hnub tom qab cov ntsiav tshuaj uas tsis tau

Peb(lossis ntau dua) cov ntsiav tshuaj sib law liag

Hnub Sunday-Start Regimen:

  • cojibntsiav tshuaj txhua hnub txog hnub Sunday
  • muab cov ntsiav tshuaj uas tseem tshuav
  • pib tshiab pob ntawm cov ntsiav tshuaj tam sim ntawd (Sunday)
  • siv lwm txoj kev tswj kev yug me nyuam rau xya hnub tom qab cov ntsiav tshuaj uas tsis tau

Hnub-1 Pib Regimen:

  • muab cov ntsiav tshuaj uas tseem tshuav
  • pib cov ntsiav tshuaj tshiab rau tib hnub ntawd
  • siv lwm txoj kev tswj kev yug me nyuam rau xya hnub tom qab cov ntsiav tshuaj uas tsis tau

Qhov muaj peev xwm ntawm ovulation tshwm sim nce nrog txhua hnub ua tiav uas tau teem sijhawm cov ntsiav tshuaj xim xim tsis tuaj. Txawm hais tias tsis tshua muaj qhov tshwm sim ntawm ovulation tshwm sim yog tias tsuas yog ib lub ntsiav tshuaj xim xim tsis ploj, qhov tshwm sim ntawm qhov pom lossis los ntshav yog nce. Qhov no tshwj xeeb tshaj yog tshwm sim yog tias ob lossis ntau dua cov ntsiav tshuaj xim xim sib law liag tau ploj lawm.

Yog tias tus neeg mob tsis nco qab noj ib qho ntawm xya ntsiav tshuaj xim av hauv lub lis piam plaub, cov ntsiav tshuaj xim av uas tsis tau raug muab pov tseg thiab ib ntsiav tshuaj xim av tau noj txhua hnub kom txog thaum lub pob khoob. Tsis tas yuav muaj txoj kev tswj kev yug menyuam rov qab rau lub sijhawm no. Ib pob tshiab ntawm cov ntsiav tshuaj yuav tsum tau pib tsis pub dhau yim hnub tom qab noj cov ntsiav tshuaj xim xim kawg.

Hauv qhov tsis tshua muaj los ntshav uas zoo li kev coj khaub ncaws, tus neeg mob yuav tsum tau qhia kom tsis txhob siv tshuaj thiab tom qab ntawd pib noj cov ntsiav tshuaj los ntawm cov tshuaj ntsiav tshuaj tshiab rau hnub Sunday tom ntej lossis thawj hnub (Hnub-1), nyob ntawm nws txoj cai. Cov ntshav tsis tu ncua uas tsis tswj hwm los ntawm txoj kev no qhia tau hais tias yuav tsum tau rov kuaj xyuas tus neeg mob, thaum lub sijhawm tsis ua haujlwm yuav tsum tau txiav txim siab.

Kev siv cov tshuaj tiv thaiv qhov ncauj hauv qhov xwm txheej ntawm lub caij nyoog tsis zoo

1. Yog hais tias tus neeg mob tsis tau ua raws li cov kev cai noj ntau npaum li cas, yuav tsum tau txiav txim siab tias yuav xeeb tub tom qab thawj lub sij hawm tsis tuaj kawm ntawv thiab cov tshuaj tiv thaiv qhov ncauj yuav tsum tau txiav kom txog thaum cev xeeb tub.

2. Yog hais tias tus neeg mob tau ua raws li cov kev cai tswj hwm thiab tsis tau ob lub sij hawm sib law liag, cev xeeb tub yuav tsum raug txiav tawm ua ntej siv cov tshuaj tiv thaiv ntxiv.

Tom qab ob peb lub hlis ntawm kev kho mob, los ntshav yuav txo tau mus rau qhov tsis muaj virtual. Qhov kev txo qis no tuaj yeem tshwm sim los ntawm kev siv tshuaj, qhov twg nws tsis qhia txog kev xeeb tub.

Larin Fe 1/20 muab tau li cas

Larin Fe 1/20 muaj nyob rau hauv dispensers (NDC 16714-406-01) txhua tus muaj 21 ntsiav tshuaj daj daj thiab 7 ntsiav tshuaj xim av. Txhua daj daj, biconvex, round ntsiav tshuaj debossed nrog 'L2' ntawm ib sab muaj 1mg ntawm norethindrone acetate thiab 20 mcg ntawm ethinyl estradiol.

Txhua xim av, biconvex, round ntsiav tshuaj debossed nrog 'F' ntawm ib sab thiab 'N' ntawm sab nraud muaj 75 mg ferrous fumarate.

Larin Fe 1/20 ntsiav tshuaj muaj nyob rau hauv cov kev teeb tsa hauv qab no:

Carton ntawm 1 NDC 16714-406-02

Carton ntawm 3 NDC 16714-406-03

Carton ntawm 6 NDC 16714-406-04

Khaws ntawm 20 ˚ C ~ 25˚ C (68˚ F ~ 77 ˚ F) [Saib USP Controlled Room Temperature].

REFERENCES

1. Rov qab DJ, Breckenridge AM, Crawford FE, McIver M, Orme ML'E, Rowe PH thiab Smith E: Kinetics ntawm norethindrone hauv cov poj niam II. Ib koob tshuaj kinetics. Clin Pharmacol Ther 1978; 24:448-453.

2. Humpel M, Nieuweboer B, Wendt H thiab Speck U: Kev soj ntsuam ntawm cov tshuaj pharmacokinetics ntawm ethinyloestradiol rau kev txiav txim siab tshwj xeeb ntawm qhov tshwm sim thawj zaug hauv cov poj niam. Contraception 1979; 19:421-432.

3. Rov qab DJ, Breckenridge AM, Crawford FE, MacIver M, Orme ML'E, Rowe PH thiab Watts MJ. Kev tshawb fawb ntawm pharmacokinetics ntawm ethynylestradiol hauv cov poj niam siv radioimmunoassay. Contraception 1979; 20:263-273.

4. Hammond GL, Lahteenmaki PLA, Lahteenmaki P thiab Luukkainen T. Kev faib tawm thiab feem pua ​​​​ntawm cov tshuaj tiv thaiv kab mob tsis muaj protein ntau hauv tib neeg Serum. J Steriod Biochem 1982; 17:375-380.

5. Fotherby K. Pharmacokinetics thiab metabolism ntawm progestins nyob rau hauv tib neeg, nyob rau hauv Pharmacology ntawm lub contraceptive steroids, Goldzieher JW, Fotherby K (eds), Raven Press, Ltd., New York, 1994; 99-126 : kuv.

6. Goldzieher JW. Pharmacokinetics thiab metabolism ntawm ethynyl estrogens, nyob rau hauv Pharmacology ntawm lub contraceptive steroids, Goldzieher JW, Fotherby K (eds), Raven Press Ltd., New York, 1994; 127-151 : kuv.

7. Hatcher RA, et al. 1998. Contraceptive Technology, Seventeenth Edition. New York: Irvington Publishers.

8. Stadel, B.V.: Cov tshuaj tiv thaiv qhov ncauj thiab kab mob plawv. (Pt. 1). New England Journal of Medicine, 305:612-618, 1981.

9. Stadel, B.V.: Tshuaj tiv thaiv qhov ncauj thiab kab mob plawv. (Pt. 2). New England Journal of Medicine, 305:672-677, 1981.

10. Adas, S.A., thiab M. Thorogood: Kev tiv thaiv qhov ncauj thiab myocardial infarction revisited: Cov teebmeem ntawm kev npaj tshiab thiab cov qauv tshuaj. Brit. J. Obstet. thiab Gynec., 88:838-845, 1981.

11. Mann, J.I., and W.H. Inman: Cov tshuaj tiv thaiv qhov ncauj thiab tuag los ntawm myocardial infarction. Brit. Med. J., 2(5965): 245-248, 1975.

12. Mann, J.I., M.P. Vessey, M. Thorogood, thiab R. Doll: Myocardial infarction hauv cov poj niam hluas uas muaj kev qhia tshwj xeeb rau kev siv tshuaj tiv thaiv qhov ncauj. Brit. Med. J., 2(5956): 241-245, 1975.

13. Royal College of General Practitioners' Oral Contraception Study: Kev soj ntsuam ntxiv txog kev tuag ntawm cov neeg siv tshuaj tiv thaiv qhov ncauj. Lancet, 1:541-546, 1981.

14. Slone, D., S. Shapiro, D.W. Kaufman, L. Rosenberg, O.S. Miettinen, thiab P.D. Stolley: Kev pheej hmoo ntawm myocardial infarction cuam tshuam nrog tam sim no thiab tsis siv cov tshuaj tiv thaiv qhov ncauj. N.E.J.M., 305:420-424, 1981.

15. Vessey, M.P.: Poj niam cov tshuaj hormones thiab vascular kab mob: Ib qho kev nthuav dav dav dav. Brit. J. Fam. Npaj., 6:1–12, 1980.

16. Russell-Briefel, R.G., T.M. Ezzati, R. Fulwood, J.A. Perlman, thiab R.S. Murphy: Kev pheej hmoo mob plawv thiab kev siv tshuaj tiv thaiv qhov ncauj, Tebchaws Meskas, 1976-80. Tshuaj Tiv Thaiv, 15:352-362, 1986.

17. Goldbaum, G.M., J.S. Kendrick, G. C. Hogelin, thiab E.M. Gentry: Qhov cuam tshuam ntawm kev haus luam yeeb thiab kev siv tshuaj tiv thaiv qhov ncauj rau cov poj niam hauv Tebchaws Meskas. J.A.M.A., 258:1339-1342, 1987.

18. Layde, P.M., thiab V. Beral: Kev soj ntsuam ntxiv ntawm kev tuag ntawm cov neeg siv tshuaj tiv thaiv qhov ncauj: Royal College General Practitioners' Oral Contraception Study. (Table 5) Lancet, 1:541-546, 1981.

19. Knopp, R.H.: Arteriosclerosis txaus ntshai: Lub luag hauj lwm ntawm cov tshuaj tiv thaiv qhov ncauj thiab postmenopausal estrogens. J. ntawm Reprod. Med., 31(9) (Sab Ntxiv): 913-921, 1986.

20. Krauss, R.M., S. Roy, D.R. Mishell, J. Casagrande, thiab M.C. Pike: Cov teebmeem ntawm ob qhov tshuaj tiv thaiv qhov ncauj qis ntawm cov ntshav lipids thiab lipoproteins: Cov kev hloov pauv hauv cov lipoproteins siab ceev subclasses. Am. J. Obstet. Ib., 145:446-452, 1983.

21. Wahl, P., C. Walden, R. Knopp, J. Hoover, R. Wallace, G. Heiss, thiab B. Rifkind: Cov nyhuv ntawm estrogen/progestin potency ntawm lipid/lipoprotein cholesterol. N.E.J.M., 308:862-867, 1983.

22. Wynn, V., thiab R. Niththyananthan: Cov txiaj ntsig ntawm progestin hauv cov tshuaj tiv thaiv qhov ncauj ua ke ntawm cov lipids hauv cov ntshav nrog tshwj xeeb siv rau cov lipoproteins ntau ntom ntom. Am. J. Obstet. thiab Gyn., 142: 766-771, 1982.

23. Wynn, V., thiab I. Godsland: Cov tshuaj tiv thaiv qhov ncauj ntawm cov metabolism hauv carbohydrate. J. Reprod. Tshuaj, 31 (9) (Ntxiv): 892-897, 1986.

24. LaRosa, J.C.: Atherosclerotic risk factor nyob rau hauv cov kab mob plawv. J. Reprod. Med., 31(9) (Ntxiv): 906-912, 1986.

25. Inman, W.H., and M.P. Vessey: Kev tshawb nrhiav kev tuag los ntawm pulmonary, coronary, thiab cerebral thrombosis thiab embolism nyob rau hauv cov poj niam ntawm cov me nyuam muaj hnub nyoog. Brit. Med. J., 2(5599): 193-199, 1968.

26. Maguire, M.G., J. Tonascia, P.E. Sartwell, P.D. Stolley, thiab M.S. Tockman: Ua rau muaj kev pheej hmoo ntawm thrombosis vim kev siv tshuaj tiv thaiv qhov ncauj: Ib daim ntawv qhia ntxiv. Am. J. Epidemiology, 110(2): 188-195, 1979.

27. Pettiti, D.B., J. Wingerd, F. Pellegrin, thiab S. Ramacharan: Kev pheej hmoo ntawm cov kab mob vascular hauv cov poj niam: Kev haus luam yeeb, tshuaj tiv thaiv qhov ncauj, tshuaj tiv thaiv kab mob, thiab lwm yam. J.A.M.A., 242:1150-1154, 1979.

28. Vessey, M.P., thiab R. Doll: Kev tshawb fawb txog kev sib raug zoo ntawm kev siv tshuaj tiv thaiv qhov ncauj thiab kab mob thromboembolic. Brit. Med. J., 2(5599): 199-205, 1968.

29. Vessey, M.P., thiab R. Doll: Kev tshawb fawb txog kev sib raug zoo ntawm kev siv tshuaj tiv thaiv qhov ncauj thiab kab mob thromboembolic: Ib daim ntawv qhia ntxiv. Brit. Med. J., 2(5658): 651-657, 1969.

30. Porter, J.B., J.R. Hunter, D.A. Danielson, H. Jick, thiab A. Stergachis: Cov tshuaj tiv thaiv qhov ncauj thiab cov kab mob tsis ua rau tuag taus: Kev paub tsis ntev los no. Obstet. thiab Gyn., 59(3): 299-302, 1982.

31. Vessey, M., R. Doll, R. Peto, B. Johnson, thiab P. Wiggins: Kev tshawb nrhiav ntev ntev ntawm cov poj niam uas siv ntau txoj kev tiv thaiv kab mob: Daim ntawv qhia ib ntus. J. Biosocial. Sci., 8:375-427, 1976.

32. Royal College of General Practitioners: Cov tshuaj tiv thaiv qhov ncauj, venous thrombosis, thiab varicose veins. J. ntawm Royal College of General Practitioners, 28:393-399, 1978.

33. Pab pawg sib koom ua ke rau kev tshawb fawb txog kev mob stroke hauv cov poj niam hluas: kev tiv thaiv qhov ncauj thiab ua rau muaj kev pheej hmoo ntawm cerebral ischemia lossis thrombosis. N.E.J.M., 288:871-878, 1973.

34. Petitti, D.B., thiab J. Wingerd: Siv cov tshuaj tiv thaiv qhov ncauj, haus luam yeeb, thiab muaj feem yuav mob ntshav qab zib subarachnoid. Lancet, 2:234-236, 1978.

35. Inman, W.H.: Cov tshuaj tiv thaiv qhov ncauj thiab kev tuag subarachnoid hemorrhage. Brit. Med. J., 2(6203): 1468-70, 1979.

36. Pab pawg sib koom ua ke rau kev kawm txog kev mob stroke hauv cov poj niam hluas: Cov tshuaj tiv thaiv qhov ncauj thiab mob hlab ntsha tawg hauv cov poj niam hluas: Cov xwm txheej muaj feem cuam tshuam. J.A.M.A., 231:718-722, 1975.

37. Inman, W.H., M.P. Vessey, B. Westerholm, thiab A. Engelund: Tus kab mob Thromboembolic thiab cov ntsiab lus steroidal ntawm cov tshuaj tiv thaiv qhov ncauj. Ib tsab ntawv ceeb toom rau Pawg Neeg Saib Xyuas Kev Nyab Xeeb ntawm Tshuaj. Brit. Med. J., 2:203- 209, 1970.

38. Meade, T.W., G. Greenberg, thiab S.G. Thompson: Progestogens thiab cov kab mob plawv cuam tshuam nrog cov tshuaj tiv thaiv qhov ncauj thiab kev sib piv ntawm kev nyab xeeb ntawm 50-thiab 35-mcg estrogen npaj. Brit. Med. J., 280(6224): 1157-1161, 1980.

39. Kay, C.R.: Progestogens and arterial disease: Pov thawj los ntawm Royal College of General Practitioners txoj kev kawm. Amer. J. Obstet. Ib., 142: 762-765, 1982.

40. Royal College of General Practitioners: Muaj cov kab mob arterial ntawm cov neeg siv tshuaj tiv thaiv qhov ncauj. J. Col. Gen. Pract., 33:75–82, 1983.

41. Ory, H.W: Mortality txuam nrog fertility thiab fertility tswj: 1983. Family Planning Perspectives, 15:50-56, 1983.

42. Kev Tshawb Fawb Txog Kev Kho Mob Cancer thiab Steroid Hormone ntawm Lub Chaw Tswj Xyuas Kab Mob thiab Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv Hauv Tebchaws thiab Tib Neeg: Kev siv tshuaj tiv thaiv qhov ncauj thiab kev pheej hmoo ntawm mob qog noj ntshav mis. N.E.J.M., 315:405-411, 1986.

43. Pike, M.C., IB. Henderson, MD Krailo, A. Duke, thiab S. Roy: Mob qog noj ntshav mis rau cov poj niam hluas thiab siv cov tshuaj tiv thaiv qhov ncauj: Muaj peev xwm hloov kho cov nyhuv ntawm kev tsim thiab hnub nyoog thaum siv. Lancet, 2:926-929, 1983.

44. Paul, C., D. G. Skegg, G.F.S. Spears, thiab J.M. Kaldor: Cov tshuaj tiv thaiv qhov ncauj thiab mob qog noj ntshav: Kev tshawb fawb hauv tebchaws. Brit. Med. J., 293:723-725, 1986.

45. Miller, D.R., L. Rosenberg, D.W. Kaufman, D. Schottenfeld, P. D. Stolley, thiab S. Shapiro: Kev pheej hmoo mob qog noj ntshav hauv lub mis cuam tshuam nrog kev siv tshuaj tiv thaiv qhov ncauj thaum ntxov. Obstet. Gynec., 68:863-868, 1986.

46. ​​Olson, H., K. L. Olson, T. R. Moller, J. Ranstam, P. Holm: Kev siv tshuaj tiv thaiv qhov ncauj thiab mob qog noj ntshav hauv cov poj niam hluas hauv Sweden (tsab ntawv). Lancet, 2:748-749, 1985.

47. McPherson, K., M. Vessey, A. Neil, R. Doll, L. Jones, thiab M. Roberts: Kev siv tshuaj tiv thaiv ntxov ntxov thiab mob qog noj ntshav mis: Cov txiaj ntsig ntawm lwm qhov kev tshawb fawb txog kev tswj xyuas. Brit. J. Cancer, 56: 653-660, 1987.

48. Huggins, G.R., and P.F. Zucker: Cov tshuaj tiv thaiv qhov ncauj thiab neoplasia: 1987 hloov tshiab. Fertil. Steril., 47:733-761, 1987.

49. McPherson, K., and J.O. Drife: ntsiav tshuaj thiab mob qog noj ntshav mis: Vim li cas qhov tsis paub tseeb? Brit. Med. J., 293:709-710, 1986.

50. Shapiro, S.: Cov tshuaj tiv thaiv qhov ncauj: Lub sij hawm nqa khoom. N.E.J.M., 315:450-451, 1987.

51. Ory, H., Z. Naib, S.B. Conger, R.A. Hatcher, thiab C.W. Tyler: Kev xaiv tshuaj tiv thaiv kab mob thiab nthuav dav ntawm ncauj tsev menyuam dysplasia thiab carcinoma hauv qhov chaw. Am. J. Obstet. Gynec., 124:573-577, 1976.

52. Vessey, M.P., M. Lawless, K. McPherson, D. Yeates: Neoplasia ntawm lub tsev me nyuam lub tsev me nyuam thiab kev tiv thaiv kab mob: Qhov tshwm sim tsis zoo ntawm cov tshuaj. Luas, 2: 930, 1983.

53. Brinton, L.A., G.R. Huggins, H.F. Lehman, K. Malli, D.A. Savitz, E. Trapido, J. Rosenthal, thiab R. Hoover: Kev siv cov tshuaj tiv thaiv qhov ncauj mus ntev thiab muaj kev pheej hmoo ntawm kev mob qog noj ntshav hauv tsev menyuam. Int. J. Cancer, 38:339-344, 1986.

54. LEEJ TWG Kev Sib Koom Tes Kev Tshawb Fawb ntawm Neoplasia thiab Steroid Contraceptives: Invasive cervical cancer thiab ua ke cov tshuaj tiv thaiv qhov ncauj. Brit. Med. J., 290: 961-965, 1985.

55. Rooks, J.B., H.W. Ory, K. G. Ishak, L.T. Strauss, J.R. Greenspan, A.P. Hill, thiab C.W. Tyler: Epidemiology of hepatocellular adenoma: Lub luag haujlwm ntawm kev siv tshuaj tiv thaiv qhov ncauj. J.A.M.A., 242:644-648, 1979.

56. Bein, N.N., and H.S. Goldsmith: Rov tshwm sim loj heev los ntawm cov qog nqaij hlav hauv siab thib ob rau cov tshuaj tiv thaiv qhov ncauj. Brit. J. Surg., 64:433-435, 1977.

57. Klatskin, G.: Kab mob siab: Muaj kev sib raug zoo rau kev siv tshuaj tiv thaiv qhov ncauj. Gastroenterology, 73:386-394, 1977.

58. Henderson, B.E., S. Preston-Martin, H.A. Edmondson, R.L. Peters, thiab M.C. Pike: Hepatocellular carcinoma thiab tshuaj tiv thaiv qhov ncauj. Brit. J. Cancer, 48:437-440, 1983.

59. Neuberger, J., D. Forman, R. Doll, thiab R. Williams: Cov tshuaj tiv thaiv kab mob hauv qhov ncauj thiab kab mob hepatocellular carcinoma. Brit. Med. J., 292: 1355-1357, 1986.

60. Forman, D., T. J. Vincent, thiab R. Doll: Cancer ntawm daim siab thiab qhov ncauj contraceptives. Brit. Med. J., 292: 1357-1361, 1986.

61. Harlap, S., thiab J. Eldor: Kev yug me nyuam tom qab qhov ncauj tsis ua hauj lwm. Obstet. Gynec., 55:447-452, 1980.

62. Savolainen, E., E. Saksela, thiab L. Saxen: teratogenic txaus ntshai ntawm cov tshuaj tiv thaiv qhov ncauj tau tshuaj xyuas hauv lub teb chaws malformation register. Amer. J. Obstet. Gynec., 140: 521-524, 1981.

63. Janerich, D.T., J.M. Piper, and D.M. Glebatis: Cov tshuaj tiv thaiv qhov ncauj thiab kev yug me nyuam. Am. J. Epidemiology, 112:73–79, 1980.

64. Ferencz, C., G.M. Matanoski, P.D. Wilson, J.D. Rubin, C.A. Neill, thiab R. Gutberlet: Niam txoj kev kho tshuaj hormones thiab kab mob hauv lub plawv. Teratology, 21:225-239, 1980.

65. Rothman, K.J., D.C. Fyler, A. Goldbatt, and M.B. Kreidberg: Exogenous cov tshuaj hormones thiab lwm yam tshuaj raug rau cov menyuam yaus uas muaj kab mob hauv lub plawv. Am. J. Epidemiology, 109:433-439, 1979.

66. Boston Collaborative Drug Surveillance Program: Cov tshuaj tiv thaiv qhov ncauj thiab cov kab mob venous thromboembolic, phais mob gallbladder, thiab qog mis. Lancet, 1:1399-1404, 1973.

67. Royal College of General Practitioners: Oral Contraceptives and Health. New York, NY, Pittman, 1974, 100 p.

68. Lawd, P.M., M.P. Vessey, thiab D. Yeates: Kev pheej hmoo ntawm cov kab mob gallbladder: Ib qho kev tshawb fawb ntawm cov poj niam hluas uas tuaj koom cov tsev kho mob npaj tsev neeg. J. ntawm Epidemiol. thiab Comm. Kev Noj Qab Haus Huv, 36: 274-278, 1982.

69. Rome Group rau Kev Kab Mob Sib Kis thiab Kev Tiv Thaiv Kab Mob Cholelithiasis (GREPCO): Feem ntau ntawm cov kab mob gallstone nyob rau hauv cov neeg laus cov poj niam Italian. Am. J. Epidemiol., 119:796-805, 1984.

70. Strom, IB, R.T. Tamragouri, M. L. Mas, E.L. Lazar, S. L. West, P. D. Stolley, thiab J.K. Jones: Cov tshuaj tiv thaiv qhov ncauj thiab lwm yam kev pheej hmoo rau kab mob gallbladder. Clin. Pharmacol. Ther., 39:335-341, 1986.

71. Wynn, V., P. W. Adams, I.F. Godsland, J. Melrose, R. Niththyananthan, NW. Oakley, thiab A. Seedj: Kev sib piv ntawm cov teebmeem ntawm kev sib xyaw ua ke ntawm qhov ncauj-cov tshuaj tiv thaiv kab mob rau cov carbohydrate thiab lipid metabolism. Lancet, 1:1045-1049, 1979.

72. Wynn, V.: Cov nyhuv ntawm progesterone thiab progestins ntawm carbohydrate metabolism. Hauv Progesterone thiab Progestin. Edited by C.W. Bardin, E. Milgrom, P. Mauvis-Jarvis. New York, Raven Press, pp. 395-410, 1983.

73. Perlman, J.A., R. G. Roussell-Briefel, T. M. Ezzati, thiab G. Lieberknecht: Qhov ncauj qabzib kam rau siab thiab lub zog ntawm qhov ncauj tiv thaiv kab mob progestogens. J. Chronic Dis., 38:857-864, 1985.

74. Royal College of General Practitioners 'Oral Contraception Study Study: Cov txiaj ntsig ntawm kev kub siab thiab cov kab mob benign mis ntawm progestogen tivthaiv hauv cov tshuaj tiv thaiv qhov ncauj ua ke. Luas, 1:624, 1977.

75. Fisch, I.R., thiab J. Frank: Cov tshuaj tiv thaiv qhov ncauj thiab ntshav siab. J.A.M.A., 237:2499-2503, 1977.

76. Laragh, A.J.: Qhov ncauj contraceptive induced hypertension: Cuaj xyoo tom qab. Amer. J. Obstet. Gynecol., 126:141-147, 1976.

77. Ramcharan, S., E. Peritz, F.A. Pellegrin, thiab W.T. Williams: Kev kub ntxhov hauv Walnut Creek Contraceptive Drug Study cohort. Hauv Pharmacology ntawm Steroid Contraceptive Tshuaj. Edited los ntawm S. Garattini thiab H.W. Berendes. New York, Raven Press, pp. 277-288, 1977. (Monographs of the Mario Negri Institute for Pharmacological Research, Milan.)

78. Rov qab DJ, Orme ML'E. Cov tshuaj sib cuam tshuam, hauv Pharmacology ntawm cov tshuaj tiv thaiv kab mob steroids. Goldzieher JW, Fotherby K (eds), Raven Press, Ltd., New York, 1994, 407-425.

79. Kev Tshawb Fawb Txog Kev Kho Mob Cancer thiab Steroid Hormone ntawm Lub Chaw Tswj Xyuas Kab Mob thiab Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv Hauv Tebchaws thiab Tib Neeg: Kev siv tshuaj tiv thaiv qhov ncauj thiab kev pheej hmoo ntawm kev mob qog noj ntshav ntawm zes qe menyuam. J.A.M.A., 249:1596-1599, 1983.

80. Kev Tshawb Fawb Txog Kev Kho Mob Cancer thiab Steroid Hormone ntawm Lub Chaw Tswj Xyuas Kab Mob thiab Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv Hauv Tebchaws thiab Tib Neeg: Kev sib xyaw ua ke ntawm kev siv tshuaj tiv thaiv qhov ncauj thiab kev pheej hmoo ntawm kev mob qog noj ntshav endometrial. J.A.M.A., 257:796-800, 1987.

81. Ory, H.W.: Kev ua haujlwm ntawm zes qe menyuam hlwv thiab cov tshuaj tiv thaiv qhov ncauj: Cov koom haum tsis zoo tau lees paub kev phais. J.A.M.A., 228:68-69, 1974.

82. Ory, H.W., P. Cole, B. Macmahon, thiab R. Hoover: Cov tshuaj tiv thaiv qhov ncauj thiab txo kev pheej hmoo ntawm tus kab mob hauv lub mis. N.E.J.M., 294:41-422, 1976.

83. Ory, H.W.: Cov txiaj ntsig kev noj qab haus huv uas tsis yog tshuaj tiv thaiv kab mob los ntawm kev siv tshuaj tiv thaiv qhov ncauj. Fam. Npaj. Ntawv Moo Zoo, 14:182-184, 1982.

84. Ory, H.W., J.D. Forrest, thiab R. Lincoln: Kev Xaiv: Ntsuam xyuas cov kev pheej hmoo noj qab haus huv thiab cov txiaj ntsig ntawm txoj kev tswj kev yug menyuam. New York, Alan Guttmacher lub koom haum, p.1, 1983.

85. Miller, D.R., L. Rosenberg, D.W. Kaufman, P. Stolley, M.E. Warshauer, thiab S. Shapiro: mob qog noj ntshav mis ua ntej hnub nyoog 45 xyoos thiab kev siv tshuaj tiv thaiv qhov ncauj: kev tshawb pom tshiab. Am. J. Epidemiol., 129:269-280, 1989.

86. Kay, C.R., thiab P.C. Hannaford: Mob cancer mis thiab tshuaj ntsiav: ib daim ntawv qhia ntxiv los ntawm Royal College of General Practitioners Oral Contraception Study. Br. J. Cancer, 58:675-680, 1988.

87. Stadel, B.V., S. Lai, J.J. Schlesselman, thiab P. Murray: Cov tshuaj tiv thaiv qhov ncauj thiab mob cancer mis premenopausal hauv cov poj niam tsis muaj menyuam. Kev Txhaum Cai, 38:287-299, 1988.

88. UK National Case—Control Study Group: Kev siv tshuaj tiv thaiv qhov ncauj thiab kev pheej hmoo mob qog noj ntshav hauv cov poj niam hluas. Ib., 973-982, 1989.

89. Romieu, I., W.C. Willett, G. A. Colditz, M.J. Stampfer, B. Rosner, C.H. Hennekens, thiab F.E. Speizer: Txoj kev kawm yav tom ntej ntawm kev siv tshuaj tiv thaiv qhov ncauj thiab kev pheej hmoo ntawm mob qog noj ntshav hauv cov poj niam. J. Natl. Cancer Inst., 81:1313-1321, 1989.

Tus neeg mob daim ntawv lo rau cov khoom siv tshuaj tiv thaiv qhov ncauj tau teev tseg hauv qab no:

Cov khoom no (zoo li txhua yam tshuaj tiv thaiv qhov ncauj) yog npaj los tiv thaiv kev xeeb tub. Nws tsis tiv thaiv kab mob HIV (AIDS) thiab lwm yam kab mob sib kis.

QHOV CHAW UA HAUJ LWM PATIENT PACKAGE INSERT

Cov tshuaj tiv thaiv kab mob hauv qhov ncauj, tseem hu ua 'cov tshuaj tiv thaiv yug menyuam' lossis 'cov ntsiav tshuaj,' raug coj los tiv thaiv kev xeeb tub thiab, thaum noj kom raug, muaj qhov ua tsis tiav ntawm kwv yees li 1% hauv ib xyoos thaum siv yam tsis muaj cov tshuaj uas ploj lawm. Qhov feem ntau tsis ua haujlwm ntawm cov neeg siv tshuaj ntau yog tsawg dua 3% hauv ib xyoos thaum cov poj niam uas tsis tuaj yeem siv tshuaj. Rau cov poj niam feem ntau cov tshuaj tiv thaiv qhov ncauj kuj tsis muaj kev phiv loj lossis tsis zoo. Txawm li cas los xij, tsis nco qab noj tshuaj ntau heev yuav ua rau muaj kev xeeb tub.

Rau feem coob ntawm cov poj niam, cov tshuaj tiv thaiv qhov ncauj tuaj yeem ua rau muaj kev nyab xeeb. Tab sis muaj qee tus poj niam uas muaj kev pheej hmoo siab los tsim qee yam kab mob loj uas tuaj yeem ua rau muaj kev phom sij rau lub neej lossis ua rau muaj kev tsis taus ib ntus lossis mus tas li. Cov kev pheej hmoo cuam tshuam nrog kev noj cov tshuaj tiv thaiv qhov ncauj nce ntxiv yog tias koj:

  • Haus luam yeeb
  • Muaj ntshav siab, ntshav qab zib, cov roj cholesterol siab
  • Muaj los yog muaj kab mob plawv, plawv nres, mob stroke, angina pectoris, mob qog noj ntshav ntawm lub mis los yog cov kab mob sib deev, jaundice, los yog malignant lossis benign daim siab qog.

Koj yuav tsum tsis txhob noj tshuaj yog tias koj xav tias koj cev xeeb tub los yog muaj qhov tsis tau piav qhia qhov chaw mos los ntshav.

Feem ntau cov kev mob tshwm sim ntawm cov tshuaj tsis loj. Cov kev mob tshwm sim feem ntau yog xeev siab, ntuav, los ntshav thaum lub caij ua poj niam, qhov hnyav nce, lub mis rhiab, thiab nyuaj rau hnav cov tsom iav. Cov kev mob tshwm sim no, tshwj xeeb tshaj yog xeev siab, ntuav, thiab los ntshav tuaj yeem txo qis hauv thawj peb lub hlis ntawm kev siv.

Cov kev mob tshwm sim loj ntawm cov ntsiav tshuaj tshwm sim tsis tshua muaj, tshwj xeeb tshaj yog tias koj noj qab nyob zoo thiab tseem hluas. Txawm li cas los xij, koj yuav tsum paub tias cov mob hauv qab no tau cuam tshuam nrog lossis ua rau cov tshuaj phem dua:

1. Cov ntshav txhaws hauv ob txhais ceg (thrombophlebitis), ntsws (pulmonary embolism), nres lossis tawg ntawm cov hlab ntsha hauv lub hlwb (stroke), txhaws cov hlab ntsha hauv plawv (lub plawv nres lossis angina pectoris) lossis lwm yam kabmob ntawm cov hlab ntsha. lub cev. Raws li tau hais los saum toj no, kev haus luam yeeb ua rau muaj kev pheej hmoo ntawm kev mob plawv thiab mob stroke thiab yuav ua rau mob hnyav ntxiv.

2. Cov qog nqaij hlav hauv siab, uas tuaj yeem tawg thiab ua rau los ntshav hnyav. Kev sib koom ua tau tab sis tsis paub meej tau pom nrog cov tshuaj thiab mob qog noj ntshav. Txawm li cas los xij, mob qog noj ntshav siab yog qhov tsawg heev. Lub caij nyoog ntawm kev tsim mob qog noj ntshav los ntawm kev siv cov tshuaj yog li no txawm tsawg dua.

3. Cov ntshav siab, txawm hais tias ntshav siab feem ntau rov zoo li qub thaum cov tshuaj nres.

Cov tsos mob cuam tshuam nrog cov kev mob tshwm sim loj no tau tham hauv daim ntawv qhia ntxaws uas tau muab rau koj nrog koj cov tshuaj noj. Qhia rau koj tus kws kho mob lossis tus kws kho mob yog tias koj pom muaj kev cuam tshuam lub cev tsis zoo thaum noj tshuaj. Tsis tas li ntawd, cov tshuaj xws li rifampin, nrog rau qee cov tshuaj tiv thaiv kab mob thiab qee cov tshuaj tua kab mob, tuaj yeem txo qhov kev tiv thaiv qhov ncauj.

Feem ntau ntawm cov kev tshawb fawb txog hnub tim ntawm kev mob qog noj ntshav mis thiab kev siv tshuaj ntsiav tau pom tias tsis muaj kev pheej hmoo ntawm kev mob qog noj ntshav mis, txawm hais tias qee qhov kev tshawb fawb tau tshaj tawm tias muaj kev pheej hmoo ntawm kev mob qog noj ntshav mis hauv qee cov poj niam. Txawm li cas los xij, qee qhov kev tshawb fawb tau pom tias muaj kev pheej hmoo ntawm kev mob qog noj ntshav hauv tsev menyuam hauv cov poj niam noj tshuaj, tab sis qhov kev tshawb pom no yuav cuam tshuam txog qhov sib txawv ntawm kev sib deev tus cwj pwm lossis lwm yam tsis cuam tshuam txog kev siv tshuaj. Yog li ntawd, tsis muaj pov thawj txaus los txiav txim siab tias cov tshuaj yuav ua rau mob qog noj ntshav ntawm lub mis lossis lub ncauj tsev menyuam.

Noj cov ntsiav tshuaj muab qee cov txiaj ntsig tseem ceeb uas tsis yog tshuaj tiv thaiv kab mob. Cov no suav nrog kev ua poj niam mob tsawg dua, tsis muaj ntshav qab zib tsawg thiab ntshav ntshav, tsawg dua kab mob hauv plab, thiab qog nqaij hlav ntawm zes qe menyuam thiab hauv ob sab phlu ntawm lub tsev menyuam.

Nco ntsoov tham txog tej yam mob uas koj muaj nrog koj tus kws kho mob. Koj tus kws kho mob yuav sau ntawv kho mob thiab tsev neeg keeb kwm thiab tshuaj xyuas koj ua ntej muab tshuaj tiv thaiv qhov ncauj. Kev kuaj lub cev yuav raug ncua mus rau lwm lub sijhawm yog tias koj thov nws thiab koj tus kws kho mob ntseeg tias nws yog ib qho kev kho mob zoo kom ncua nws. Koj yuav tsum tau rov kuaj dua tsawg kawg ib xyoos ib zaug thaum noj cov tshuaj tiv thaiv qhov ncauj. Daim ntawv qhia ntxaws txog tus neeg mob muab cov ntaub ntawv ntxiv rau koj uas koj yuav tsum nyeem thiab sib tham nrog koj tus kws kho mob.

Cov khoom no (zoo li txhua yam tshuaj tiv thaiv qhov ncauj) yog npaj los tiv thaiv kev xeeb tub. Nws tsis tiv thaiv kev kis kab mob HIV (AIDS) thiab lwm yam kab mob sib kis xws li Chlamydia, qhov chaw mos herpes, qhov chaw mos, kab mob gonorrhea, kab mob siab B thiab syphilis.

QHIA RAU HAUV PATIENT

COMPACT TABLET DISPENSER

Larin Fe 1/20 compact ntsiav tshuaj dispenser tau tsim los ua kom cov tshuaj tiv thaiv qhov ncauj kom yooj yim thiab yooj yim li sai tau. Cov ntsiav tshuaj tau teem rau plaub kab ntawm xya ntsiav tshuaj txhua hnub ntawm lub lim tiam tshwm sim saum thawj kab ntawm cov ntsiav tshuaj.

Txhua ntsiav tshuaj daj ntseg muaj 1 mg norethindrone acetate thiab 20 mcg ethinyl estradiol.

Txhuaxim avntsiav tshuaj muaj 75 mg ferrous fumarate, thiab yog npaj los pab koj nco ntsoov noj cov ntsiav tshuaj kom raug. Cov ntsiav tshuaj xim av no tsis yog npaj kom muaj txiaj ntsig kev noj qab haus huv.

Kev taw qhia

Txhawm rau tshem tawm ib lub ntsiav tshuaj, nias rau ntawm nws nrog koj tus ntiv tes xoo lossis ntiv tes. Lub ntsiav tshuaj yuav poob los ntawm sab nraum qab ntawm lub ntsiav tshuaj dispenser. Tsis txhob nias nrog koj tus ntiv tes xoo, ntiv tes, lossis lwm yam khoom ntse.

YUAV UA LI CAS

TSEEM CEEB RAU KUV

Ua ntejKoj pib noj koj cov tshuaj:

1. Nco ntsoov nyeem cov lus qhia no: Ua ntej koj pib noj koj cov tshuaj.

Txhua lub sij hawm koj tsis paub yuav ua li cas.

2. TEJ CHAW UA HAUJ LWM HAUJ LWM HAUJ LWM HAUJ LWM HAUJ LWM HAUJ LWM HAUJ LWM HAUJ LWM HAUJ LWM HAUJ LWM NTAWM IB LUB TSEV KAWM NTAWV NTAWM LUB SIJ HAWM. Yog tias koj tsis noj tshuaj koj yuav xeeb tub. Qhov no suav nrog pib lub pob lig. Cov tshuaj ntau dua koj nco, qhov ntau dua koj yuav xeeb tub.

3. Muaj ntau tus poj niam tau pom los yog lub teeb los ntshav, los yog tej zaum yuav mob plab lawv lub plab, thaum lub sij hawm thawj 1-3 pcs ntawm cov ntsiav tshuaj. Yog tias koj muaj pob los yog los ntshav los yog mob plab, tsis txhob noj tshuaj. Qhov teeb meem feem ntau yuav ploj mus. Yog tias nws tsis ploj mus, nrog koj tus kws kho mob lossis chaw kuaj mob.

4. Cov tshuaj uas tsis tuaj yeem tuaj yeem ua rau pom los yog lub teeb los ntshav, txawm tias thaum koj ua cov tshuaj uas ploj lawm. Nyob rau hnub koj noj 2 ntsiav tshuaj los ua rau cov tshuaj uas ploj lawm, koj tuaj yeem hnov ​​​​mob me ntsis rau koj lub plab.

5. Yog tias koj muaj ntuav lossis zawv plab, yog vim li cas, lossis yog tias koj noj qee yam tshuaj, suav nrog qee cov tshuaj tua kab mob, koj cov tshuaj tiv thaiv kev yug menyuam yuav tsis ua haujlwm zoo. Siv txoj kev tiv thaiv kev yug menyuam rov qab (xws li hnab looj tes lossis ua npuas ncauj) kom txog thaum koj mus ntsib koj tus kws kho mob lossis chaw kho mob.

6. Yog tias koj muaj teeb meem nco ntsoov noj cov tshuaj, nrog koj tus kws kho mob lossis chaw kho mob tham txog yuav ua li cas kom noj cov ntsiav tshuaj yooj yim dua lossis txog kev siv lwm txoj kev tswj kev yug menyuam.

7. Yog tias koj muaj lus nug lossis tsis paub meej txog cov ntaub ntawv hauv daim ntawv no, hu rau koj tus kws kho mob lossis chaw kho mob.

Ua ntej koj pib noj koj cov tshuaj

1. Txiav txim siab hnub twg koj xav noj koj cov tshuaj. Nws yog ib qho tseem ceeb uas yuav tsum tau coj nws ntawm tib lub sijhawm txhua hnub.

2. Cov28-Hnub ntsiav tshuaj pobmuaj 21 'active' tshuaj daj daj (nrog rau cov tshuaj hormones) noj rau 3 lub lis piam, ua raws li 1 lub lis piam ntawm cov tshuaj ceeb toom xim av (tsis muaj tshuaj hormones).

3. TSIS MUAJ:

1) qhov twg ntawm pob pib noj tshuaj,

2) nyob rau hauv dab tsi thiaj li yuav noj cov tshuaj (ua raws li cov xub), thiab

3) lub lis piam tus lej raws li qhia hauv cov duab hauv qab no:

4. YUAV UA LI CAS YUAV TSUM TAU TXAIS NTAWM LUB SIJ HAWM:

LWM YAM TSEEM CEEB (xws li cov hnab looj tes lossis ua npuas ncauj) siv los rov qab yog tias koj tsis tshuaj.

Ib qho EXTRA, PAUB PILL PACK.

THAUM KOM KOM PAUB TIAS IB TUG PIV THAIV

Koj muaj kev xaiv hnub twg los pib noj koj thawj pob tshuaj. Txiav txim siab nrog koj tus kws kho mob lossis chaw kho mob uas yog hnub zoo tshaj rau koj. Xaiv ib lub sij hawm ntawm hnub uas yuav yooj yim rau nco ntsoov.

HNUB-1 PIB:

1. Xaiv daim ntawv lo hnub uas pib nrog thawj hnub ntawm koj lub sijhawm. (Nov yog hnub koj pib los ntshav lossis pom, txawm tias yuav luag ib tag hmo thaum pib los ntshav.)

2. Muab daim ntawv lo hnub no tso rau ntawm lub tshuab luam ntawv ntsiav tshuaj rau ntawm thaj chaw uas muaj hnub ntawm lub lim tiam (pib hnub Sunday) luam tawm ntawm cov yas.

3. Noj thawj 'active' tshuaj daj daj ntawm thawj pob thaum lub sij hawmthawj 24 teev ntawm koj lub sijhawm.

4. Koj yuav tsis tas yuav siv cov txheej txheem rov qab los ntawm kev tiv thaiv kev yug menyuam, txij li thaum koj pib cov tshuaj thaum pib ntawm koj lub sijhawm.

Hnub Sunday pib:

1. Noj thawj 'active' tshuaj daj daj ntawm thawj pob ntawm lubHnub Sunday tom qab koj lub sijhawm pib,txawm tias koj tseem los ntshav. Yog tias koj lub sijhawm pib hnub Sunday, pib lub pob ntawd tib hnub.

2. Siv lwm txoj kev tswj kev yug me nyuam ua ib txoj hauv kev rov qab yog tias koj muaj kev sib deev txhua lub sijhawm txij hnub Sunday koj pib koj thawj pob mus txog rau hnub Sunday tom ntej (7 hnub). Cov hnab looj qau los yog ua npuas ncauj yog cov txheej txheem rov qab zoo ntawm kev tiv thaiv kev yug menyuam.

YUAV UA LI CAS RAU LUB HLIS

1. Noj ib ntsiav tshuaj tib lub sij hawm txhua hnub kom txog thaum lub pob yog khoob.

Tsis txhob hla tshuaj txawm tias koj pom lossis los ntshav thaum lub hli los yog hnov ​​​​mob rau koj lub plab (xws li xeev siab).

Tsis txhob hla tshuaj txawm tias koj tsis sib deev ntau zaus.

2. Thaum koj ua tiav ib pob lossis hloov koj cov tshuaj ntsiav tshuaj:

28 ntsiav tshuaj:Pib lub pob tom ntej rau hnub tom qab koj cov tshuaj 'reminder' kawg. Tsis txhob tos ib hnub twg ntawm pob khoom.

YUAV UA LI CAS YOG KOJ TSIS POM

Yog kojMISS 1daj ntseg daj 'active' ntsiav tshuaj:

1. Nqa nws sai li sai tau thaum koj nco qab. Noj cov tshuaj tom ntej ntawm koj lub sijhawm. Qhov no txhais tau tias koj tuaj yeem noj 2 ntsiav tshuaj hauv 1 hnub.

2. Koj tsis tas yuav siv txoj kev tswj kev yug menyuam rov qab yog tias koj muaj kev sib deev.

Yog kojMISS 2daj ntseg daj 'active' tshuaj nyob rau hauv kabLUB 1 HLIS LUB 2ntawm koj pob:

1. Noj 2 ntsiav tshuaj rau hnub koj nco qab thiab 2 ntsiav tshuaj rau hnub tom qab.

tso zis tso quav thiab rhiab heev

2. Tom qab ntawd noj 1 ntsiav tshuaj ib hnub kom txog thaum koj ua tiav pob.

3. Koj tuaj yeem cev xeeb tub yog tias koj muaj kev sib deev hauv7 nojtom qab koj nco tshuaj. Koj YUAV TSUM siv lwm txoj kev tiv thaiv kev yug menyuam (xws li hnab looj qau lossis ua npuas ncauj) ua ib txoj hauv kev tiv thaiv kev yug menyuam kom txog thaum koj tau noj tshuaj daj daj ntseg 'active' txhua hnub rau 7 hnub.

Yog kojMISS 2daj ntseg daj 'active' tshuaj nyob rau hauv kabLUB 3 WEEK:

1. Yog tias koj yog Hnub-1 Pib:

Muab pov tseg tas ntawm cov ntsiav tshuaj thiab pib ib pob tshiab rau tib hnub ntawd.

Yog tias koj yog Hnub Sunday Pib:

Noj 1 ntsiav tshuaj txhua hnub kom txog rau thaum hnub Sunday. Hnub Sunday, muab pov tawm ntawm cov so ntawm pob thiab pib cov pob tshuaj tshiab ntawm tib hnub.

2. Tej zaum koj yuav tsis muaj koj lub sijhawm rau lub hlis no, tab sis qhov no xav tau. Txawm li cas los xij, yog tias koj tsis nco koj lub sijhawm 2 lub hlis sib law liag, hu rau koj tus kws kho mob lossis chaw kho mob vim tias koj yuav xeeb tub.

3. Koj tuaj yeem cev xeeb tub yog tias koj muaj kev sib deev hauv7 nojtom qab koj nco tshuaj. Koj YUAV TSUM siv lwm txoj kev tiv thaiv kev yug menyuam (xws li hnab looj qau lossis ua npuas ncauj) ua ib txoj hauv kev tiv thaiv kev yug menyuam kom txog thaum koj tau noj tshuaj daj daj ntseg 'active' txhua hnub rau 7 hnub.

Yog kojMISS 3 LUB NEEJCov tshuaj daj daj 'active' ua ke (thaum thawj 3 lub lis piam):

1. Yog tias koj yog Hnub-1 Pib:

Muab pov tseg tas ntawm cov ntsiav tshuaj thiab pib ib pob tshiab rau tib hnub ntawd.

Yog tias koj yog Hnub Sunday Pib:

Noj 1 ntsiav tshuaj txhua hnub kom txog rau thaum hnub Sunday. Hnub Sunday, muab pov tawm ntawm cov so ntawm pob thiab pib cov pob tshuaj tshiab ntawm tib hnub.

2. Tej zaum koj yuav tsis muaj koj lub sijhawm rau lub hlis no, tab sis qhov no xav tau. Txawm li cas los xij, yog tias koj tsis nco koj lub sijhawm 2 lub hlis sib law liag, hu rau koj tus kws kho mob lossis chaw kho mob vim tias koj yuav xeeb tub.

3. Koj tuaj yeem cev xeeb tub yog tias koj muaj kev sib deev hauv7 nojtom qab koj nco tshuaj. Koj YUAV TSUM siv lwm txoj kev tiv thaiv kev yug menyuam (xws li hnab looj qau lossis ua npuas ncauj) ua ib txoj hauv kev tiv thaiv kev yug menyuam kom txog thaum koj tau noj tshuaj daj daj ntseg 'active' txhua hnub rau 7 hnub.

NTAUB NTAWV RAU HAUV 28-HNUB PACKS:

Yog tias koj tsis nco qab ib qho ntawm 7 BROWN 'REMINDER' ntsiav tshuaj nyob rau lub lim tiam 4: Muab cov ntsiav tshuaj uas koj tsis nco qab.

Cia li noj 1 ntsiav tshuaj txhua hnub kom txog thaum lub pob khoob khoob.

KOJ TSIS TAU TXAIS IB TUG MENYUAM.

Thaum kawg, yog tias koj tseem tsis tau paub meej tias yuav ua li cas txog cov ntsiav tshuaj koj tau plam:

Siv txoj kev rov qab los txhua lub sij hawm koj muaj kev sib deev.

NRHIAV IB TUG DUA 'ACTIVE' PILL txhua hnub kom txog thaum koj tuaj yeem ncav cuag koj tus kws kho mob lossis chaw kho mob.

Raws li nws qhov kev ntsuam xyuas ntawm koj cov kev xav tau kev kho mob, koj tus kws kho mob lossis tus kws kho mob tau sau cov tshuaj no rau koj. Tsis txhob muab tshuaj no rau lwm tus.

Khaws qhov no thiab txhua yam tshuaj tawm ntawm qhov chaw me nyuam.

Rx xwb

Khaws ntawm 20 ˚ C ~ 25˚ C (68˚ F ~ 77 ˚ F) [Saib USP Controlled Room Temperature].

Cov khoom no (zoo li txhua yam tshuaj tiv thaiv qhov ncauj) yog npaj los tiv thaiv kev xeeb tub. Nws tsis tiv thaiv kab mob HIV (AIDS) thiab lwm yam kab mob sib kis.

KEV PAB CUAM TSHUAJ TIV THAIV PACKAGE INSERT

Yam Koj Yuav Tsum Paub Txog Cov Tshuaj Tiv Thaiv Qhov ncauj

Txhua tus poj niam uas txiav txim siab siv cov tshuaj tiv thaiv qhov ncauj ('cov tshuaj tiv thaiv yug menyuam' lossis 'cov ntsiav tshuaj') yuav tsum nkag siab txog cov txiaj ntsig thiab kev pheej hmoo ntawm kev siv daim ntawv tswj kev yug menyuam. Daim ntawv no yuav muab rau koj ntau cov ntaub ntawv koj yuav xav tau los txiav txim siab qhov no thiab tseem yuav pab koj txiav txim siab seb koj puas muaj kev pheej hmoo ntawm kev tsim cov kev mob tshwm sim loj ntawm cov tshuaj. Nws yuav qhia koj yuav ua li cas siv cov ntsiav tshuaj kom zoo kom nws thiaj li ua tau zoo. Txawm li cas los xij, daim ntawv no tsis yog hloov pauv rau kev sib tham ceev faj ntawm koj thiab koj tus kws kho mob. Koj yuav tsum sib tham txog cov lus qhia hauv daim ntawv no nrog nws, ob qho tib si thaum koj pib noj tshuaj thiab thaum koj rov mus xyuas dua. Koj yuav tsum tau ua raws li koj tus kws kho mob cov lus qhia txog kev kuaj xyuas tsis tu ncua thaum koj nyob hauv tshuaj.

KEV PAB CUAM NTAWM ORAL CONTRACEPTIVES

Cov tshuaj tiv thaiv kab mob hauv qhov ncauj lossis 'cov tshuaj tiv thaiv yug menyuam' lossis 'cov ntsiav tshuaj' yog siv los tiv thaiv kev xeeb tub thiab muaj txiaj ntsig zoo dua li lwm txoj hauv kev uas tsis yog phais ntawm kev yug menyuam. Thaum lawv tau noj kom raug, txoj hauv kev ntawm cev xeeb tub yog tsawg dua 1% (1 cev xeeb tub rau 100 tus poj niam hauv ib xyoos ntawm kev siv) thaum siv zoo kawg nkaus, tsis muaj cov tshuaj uas ploj lawm. Cov kev ua tsis tau zoo yog qhov ua tau 3% hauv ib xyoos. Lub caij nyoog ntawm cev xeeb tub nce ntxiv nrog rau txhua cov tshuaj uas tsis tau noj thaum lub sij hawm cev xeeb tub.

Hauv kev sib piv, tus nqi tsis ua haujlwm rau lwm txoj hauv kev tswj kev yug menyuam thaum thawj xyoo ntawm kev siv yog raws li hauv qab no:

Implant:<1%

Txhaj tshuaj:<1%

IUD:<1 to 2%

Diaphragm nrog spermicides: 20% Spermicides ib leeg: 26%

Vaginal Sponge: 20 mus rau 40%

Poj niam sterilization:<1%

Txiv neej sterilization:<1%

Cervical Cap: 20-40%

Condom ib leeg (txiv neej): 14%

Condom ib leeg (poj niam): 21%

Kev tsis lees paub lub sijhawm: 25%

Kev rho tawm: 19%

Tsis muaj txoj hauv kev: 85%

LEEJ TWG YUAV TSIS PAUB TXOJ CAI

Qee tus poj niam yuav tsum tsis txhob siv tshuaj. Piv txwv li, koj yuav tsum tsis txhob noj tshuaj yog tias koj cev xeeb tub lossis xav tias koj yuav xeeb tub. Koj yuav tsum tsis txhob siv cov ntsiav tshuaj yog tias koj muaj qee yam hauv qab no:

  • Keeb kwm ntawm lub plawv nres lossis mob stroke
  • Cov ntshav txhaws hauv ob txhais ceg (thrombophlebitis), ntsws (pulmonary embolism), lossis qhov muag
  • Keeb kwm ntawm cov ntshav txhaws nyob rau hauv cov hlab ntsha tob ntawm koj ob txhais ceg
  • Mob hauv siab (angina pectoris)
  • Paub los yog xav tias mob qog noj ntshav mis lossis mob qog noj ntshav ntawm lub tsev menyuam, lub tsev menyuam lossis qhov chaw mos
  • Qhov chaw mos los ntshav tsis tau piav qhia (txog thaum koj tus kws kho mob mus txog qhov kev kuaj mob)
  • Yellowing ntawm cov dawb ntawm lub qhov muag los yog ntawm daim tawv nqaij (jaundice) thaum cev xeeb tub los yog thaum yav tas los siv tshuaj
  • Cov qog nqaij hlav hauv siab (benign lossis mob qog noj ntshav)
  • Noj cov tshuaj ua ke nrog kab mob siab C uas muaj ombitasvir/paritaprevir/ritonavir, nrog lossis tsis muaj dasabuvir. Qhov no tuaj yeem nce qib ntawm daim siab enzyme 'alanine aminotransferase' (ALT) hauv cov ntshav.
  • Paub los yog xav tias xeeb tub

Qhia rau koj tus kws kho mob yog tias koj puas tau muaj tej yam mob no. Koj tus kws kho mob tuaj yeem pom zoo kom muaj kev nyab xeeb ntawm kev tswj kev yug menyuam.

Lwm yam kev txiav txim siab ua ntej noj qhov ncauj qhov ncauj

Qhia rau koj tus kws kho mob yog tias koj muaj:

  • Lub mis nodules, kab mob fibrocystic ntawm lub mis, qhov txawv txav ntawm lub mis x-ray lossis mammogram
  • Mob ntshav qab zib
  • Txo cov cholesterol los yog triglycerides
  • Ntshav siab
  • Migraine lossis lwm yam mob taub hau lossis qaug dab peg
  • Kev nyuaj siab
  • Gallbladder, plawv, lossis kab mob raum
  • Keeb kwm ntawm scanty los yog tsis xwm yeem coj khaub ncaws

Cov poj niam uas muaj cov mob no yuav tsum tau kuaj xyuas ntau zaus los ntawm lawv tus kws kho mob yog tias lawv xaiv siv cov tshuaj tiv thaiv qhov ncauj.

Tsis tas li, nco ntsoov qhia rau koj tus kws kho mob lossis tus kws kho mob yog tias koj haus luam yeeb lossis noj tshuaj.

NYIAJ NYIAJ NYIAJ NYIAJ NYIAJ NYIAJ KHWV NYIAJ

1. Kev pheej hmoo ntawm kev tsim cov ntshav txhaws

Cov ntshav txhaws thiab txhaws ntawm cov hlab ntsha yog qhov mob hnyav tshaj plaws ntawm kev noj cov tshuaj tiv thaiv qhov ncauj; tshwj xeeb, cov hlab ntsha hauv ob txhais ceg tuaj yeem ua rau thrombophlebitis, thiab cov hlab ntsha uas mus rau hauv lub ntsws tuaj yeem ua rau muaj kev cuam tshuam ntawm lub nkoj nqa ntshav mus rau lub ntsws. Tsis tshua muaj, txhaws tshwm sim hauv cov hlab ntsha ntawm qhov muag thiab yuav ua rau dig muag, pom ob lub qhov muag, lossis tsis pom kev.

Yog tias koj noj cov tshuaj tiv thaiv qhov ncauj thiab xav tau kev phais, yuav tsum tau pw hauv txaj rau kev mob ntev, lossis nyuam qhuav yug me nyuam, tej zaum koj yuav muaj kev pheej hmoo ntawm cov ntshav txhaws. Koj yuav tsum sab laj nrog koj tus kws kho mob txog kev txwv cov tshuaj tiv thaiv qhov ncauj peb mus rau plaub lub lis piam ua ntej kev phais thiab tsis txhob noj cov tshuaj tiv thaiv qhov ncauj rau ob lub lis piam tom qab kev phais lossis thaum pw tsaug zog. Koj yuav tsum tsis txhob noj cov tshuaj tiv thaiv qhov ncauj sai tom qab yug menyuam. Nws raug nquahu kom tos tsawg kawg plaub lub lis piam tom qab yug menyuam yog tias koj tsis pub niam mis. Yog tias koj pub niam mis, koj yuav tsum tos kom txog thaum koj tau txiav koj tus menyuam mos ua ntej siv tshuaj. (Saib cov nqe lus ntawm Kev pub niam mis rau hauv GENERAL PRECAUTIONS .)

2. Lub plawv nres thiab mob stroke

Cov tshuaj tiv thaiv hauv qhov ncauj tuaj yeem ua rau muaj kev cuam tshuam rau kev mob stroke (stoppage lossis rupture ntawm cov hlab ntsha hauv lub hlwb) thiab angina pectoris thiab lub plawv nres (kev thaiv cov hlab ntsha hauv plawv). Ib qho ntawm cov xwm txheej no tuaj yeem ua rau tuag lossis tsis taus.

Kev haus luam yeeb ua rau muaj peev xwm ua rau mob plawv thiab mob stroke. Tsis tas li ntawd, kev haus luam yeeb thiab siv cov tshuaj tiv thaiv qhov ncauj ua rau muaj feem cuam tshuam thiab tuag ntawm kab mob plawv.

3. Kab mob gallbladder

Cov neeg siv tshuaj tiv thaiv qhov ncauj tej zaum yuav muaj kev pheej hmoo ntau dua li cov neeg tsis siv cov kab mob gallbladder, txawm hais tias qhov kev pheej hmoo no yuav cuam tshuam nrog cov tshuaj uas muaj cov tshuaj estrogen ntau.

4. Kab mob siab

Muaj tsawg zaus, cov tshuaj tiv thaiv qhov ncauj tuaj yeem ua rau mob qog nqaij hlav hauv siab, tab sis txaus ntshai. Cov qog nqaij hlav hauv siab no tuaj yeem ua rau tawg thiab ua rau tuag taus los ntshav. Tsis tas li ntawd, ib qho kev sib koom ua tau tab sis tsis paub meej tau pom nrog cov ntsiav tshuaj thiab mob qog noj ntshav hauv ob txoj kev tshawb fawb, uas ob peb tus poj niam uas tsim cov qog nqaij hlav tsawg heev tau pom tias tau siv cov tshuaj tiv thaiv qhov ncauj rau lub sijhawm ntev. Txawm li cas los xij, mob qog noj ntshav siab yog qhov tsawg heev. Lub caij nyoog ntawm kev tsim mob qog noj ntshav los ntawm kev siv cov tshuaj yog li no txawm tsawg dua.

5. Mob qog noj ntshav ntawm cov qog nqaij hlav thiab lub mis

Muaj, tam sim no, tsis muaj pov thawj pom tseeb tias kev siv tshuaj tiv thaiv qhov ncauj ua rau muaj kev pheej hmoo ntawm kev tsim mob qog noj ntshav ntawm lub cev xeeb tub. Cov kev tshawb fawb txog niaj hnub ntawm cov poj niam noj cov tshuaj tau tshaj tawm cov kev pom tsis sib haum xeeb txog seb puas siv tshuaj ua rau muaj kev pheej hmoo ntawm kev mob qog noj ntshav ntawm lub mis lossis lub ncauj tsev menyuam. Feem ntau ntawm cov kev tshawb fawb txog kev mob qog noj ntshav thiab kev siv tshuaj ntsiav tau pom tias tsis muaj tag nrho qhov kev pheej hmoo ntawm kev mob qog noj ntshav mis, txawm hais tias qee qhov kev tshawb fawb tau tshaj tawm tias muaj kev pheej hmoo ntawm kev mob qog noj ntshav mis hauv qee cov poj niam. Cov poj niam uas siv cov tshuaj tiv thaiv qhov ncauj thiab muaj tsev neeg muaj keeb kwm ntawm mob qog noj ntshav mis lossis cov uas muaj lub mis nodules lossis txawv txav mammograms yuav tsum tau ua raws li lawv cov kws kho mob.

Qee qhov kev tshawb fawb tau pom tias muaj kev nce hauv kev mob qog noj ntshav ntawm lub ncauj tsev menyuam hauv cov poj niam uas siv cov tshuaj tiv thaiv qhov ncauj. Txawm li cas los xij, qhov kev tshawb pom no tuaj yeem cuam tshuam nrog lwm yam uas tsis yog siv cov tshuaj tiv thaiv qhov ncauj.

Kwv yees qhov pheej hmoo ntawm kev tuag los ntawm kev tswj kev yug menyuam los yog cev xeeb tub

Txhua txoj hauv kev tiv thaiv kev yug menyuam thiab cev xeeb tub yog txuam nrog kev pheej hmoo ntawm kev tsim cov kab mob uas yuav ua rau muaj kev tsis taus lossis tuag taus. Kev kwv yees ntawm tus naj npawb ntawm cov neeg tuag uas cuam tshuam nrog ntau txoj hauv kev tswj kev xeeb tub thiab cev xeeb tub tau raug xam thiab tau qhia hauv cov lus hauv qab no.

Nyob rau hauv cov lus saum toj no, qhov kev pheej hmoo ntawm kev tuag los ntawm ib txoj kev tswj kev yug me nyuam yog tsawg dua qhov kev pheej hmoo ntawm kev yug menyuam, tshwj tsis yog rau cov neeg siv tshuaj tiv thaiv qhov ncauj uas muaj hnub nyoog 35 xyoos uas haus luam yeeb thiab cov neeg siv tshuaj ntau dua 40 xyoo txawm tias lawv tsis haus luam yeeb. Nws tuaj yeem pom nyob rau hauv cov lus hais tias rau cov poj niam hnub nyoog 15 txog 39 xyoo, qhov kev pheej hmoo ntawm kev tuag yog siab tshaj thaum cev xeeb tub (7-26 tus neeg tuag rau 100,000 tus poj niam, nyob ntawm hnub nyoog). Ntawm cov neeg siv tshuaj uas tsis haus luam yeeb, qhov kev pheej hmoo ntawm kev tuag yeej ib txwm qis dua qhov cuam tshuam nrog kev xeeb tub rau txhua pab pawg hnub nyoog, txawm tias muaj hnub nyoog 40 xyoo, qhov kev pheej hmoo nce mus rau 32 tus neeg tuag rau 100,000 tus poj niam, piv rau 28 cuam tshuam nrog cev xeeb tub ntawm qhov ntawd. hnub nyoog. Txawm li cas los xij, rau cov neeg siv tshuaj uas haus luam yeeb thiab muaj hnub nyoog tshaj 35 xyoos, kwv yees tus naj npawb ntawm cov neeg tuag ntau dua li lwm txoj hauv kev tswj kev yug menyuam. Yog hais tias ib tug poj niam muaj hnub nyoog tshaj 40 xyoo thiab haus luam yeeb, nws kwv yees qhov kev pheej hmoo ntawm kev tuag yog plaub zaug siab dua (117/100,000 cov poj niam) dua li qhov kwv yees muaj feem cuam tshuam nrog cev xeeb tub (28/100,000 poj niam) hauv pawg hnub nyoog ntawd.

Cov lus qhia tias cov poj niam hnub nyoog tshaj 40 xyoo uas tsis haus luam yeeb yuav tsum tsis txhob noj cov tshuaj tiv thaiv qhov ncauj yog raws cov ntaub ntawv los ntawm cov laus cov tshuaj ntau dua thiab xaiv cov tshuaj tsawg dua li niaj hnub no. Pawg Neeg Tawm Tswv Yim ntawm FDA tau tham txog qhov teeb meem no hauv xyoo 1989 thiab pom zoo tias cov txiaj ntsig ntawm kev siv tshuaj tiv thaiv qhov ncauj los ntawm cov poj niam noj qab haus huv, tsis haus luam yeeb ntau dua 40 xyoo tuaj yeem ua rau muaj kev pheej hmoo ntau dua. Txawm li cas los xij, txhua tus poj niam, tshwj xeeb tshaj yog cov poj niam laus, tau ceeb toom kom siv cov tshuaj qis tshaj plaws uas muaj txiaj ntsig zoo.

CEEB TOOM

Yog tias ib qho ntawm cov teebmeem no tshwm sim thaum koj noj cov tshuaj tiv thaiv qhov ncauj, hu rau koj tus kws kho mob tam sim ntawd:

  • Mob hauv siab, hnoos ntshav, lossis ua tsis taus pa tam sim ntawd (qhia tau tias muaj cov ntshav txhaws hauv lub ntsws)
  • Mob nyob rau hauv lub calf (xws li ib tug ua tau pob txha nyob rau hauv ob txhais ceg)
  • Crushing mob hauv siab los yog hnyav hauv siab (xws li mob plawv nres)
  • Sudden mob taub hau lossis ntuav, kiv taub hau lossis qaug zog, cuam tshuam tsis pom kev lossis hais lus, tsis muaj zog, lossis loog ntawm caj npab lossis ceg (xws li mob stroke)
  • Sudden ib nrab lossis ua tiav qhov tsis pom kev (qhia tau tias muaj cov pob txha hauv qhov muag)
  • Cov qog nqaij hlav hauv lub mis (qhia tau tias muaj mob qog noj ntshav lossis mob fibrocystic ntawm lub mis; nug koj tus kws kho mob lossis tus kws kho mob kom qhia koj seb yuav kuaj koj lub mis li cas)
  • Mob hnyav los yog rhiab nyob rau hauv lub plab cheeb tsam (xws li ib tug tej zaum ruptured daim siab qog)
  • Nyuaj pw tsaug zog, tsis muaj zog, tsis muaj zog, qaug zog, lossis kev hloov hauv lub siab (tejzaum nws qhia tias muaj kev nyuaj siab loj)
  • Jaundice los yog yellowing ntawm daim tawv nqaij los yog pob qhov muag, nrog nquag kub taub hau, qaug zog, tsis qab los noj mov, cov zis muaj xim dub, los yog lub teeb xim plob tsis so tswj (xws li muaj teeb meem daim siab)

SIJ HAWM NTAWM ORAL CONTRACEPTIVES

1. Qhov chaw mos los ntshav

Qhov chaw mos los ntshav los yog pom tej zaum yuav tshwm sim thaum koj noj cov tshuaj. Los ntshav tsis tu ncua yuav txawv ntawm qhov me me ntawm lub caij nyoog poj niam cev xeeb tub mus rau kev los ntshav uas yog qhov ntws zoo li lub sijhawm tsis tu ncua. Los ntshav tsis tu ncua tshwm sim feem ntau thaum thawj ob peb lub hlis ntawm kev siv tshuaj tiv thaiv qhov ncauj, tab sis kuj tseem tuaj yeem tshwm sim tom qab koj tau noj tshuaj rau qee lub sijhawm. Cov ntshav zoo li no yuav yog ib ntus thiab feem ntau tsis qhia txog teeb meem loj. Nws yog ib qho tseem ceeb uas yuav tsum tau noj koj cov tshuaj ntxiv raws sijhawm. Yog tias cov ntshav tshwm sim ntau tshaj ib lub voj voog lossis kav ntev tshaj li ob peb hnub, nrog koj tus kws kho mob lossis tus kws kho mob tham.

2. Cov Lenses

Yog tias koj hnav cov lo ntsiab muag thiab pom qhov hloov pauv ntawm qhov muag lossis tsis muaj peev xwm hnav koj lub lo ntsiab muag, tiv tauj koj tus kws kho mob lossis tus kws kho mob.

3. Kev tuav kua dej

Cov tshuaj tiv thaiv qhov ncauj yuav ua rau edema (kwv dej) nrog cov ntiv tes los yog pob taws o thiab tuaj yeem ua rau koj cov ntshav siab. Yog tias koj muaj kev tuav dej, tiv tauj koj tus kws kho mob lossis tus kws kho mob.

4. Melasma

Ib qho chaw tsaus ntawm daim tawv nqaij yog ua tau, tshwj xeeb ntawm lub ntsej muag.

5. Lwm yam teebmeem

Lwm cov kev mob tshwm sim tuaj yeem suav nrog kev hloov hauv qab los noj mov, mob taub hau, ntxhov siab, kev nyuaj siab, kiv taub hau, poob ntawm tawv taub hau, pob khaus, thiab kab mob hauv qhov chaw mos.

Yog tias ib qho ntawm cov kev mob tshwm sim no cuam tshuam rau koj, hu rau koj tus kws kho mob lossis tus kws kho mob.

KEV KHO MOB

1. Ncua Sijhawm Nthuav Tawm thiab siv cov tshuaj tiv thaiv qhov ncauj ua ntej lossis thaum ntxov cev xeeb tub

Tej zaum yuav muaj qee lub sij hawm uas koj yuav tsis coj khaub ncaws tsis tu ncua tom qab koj tau ua tiav kev noj tshuaj. Yog tias koj tau noj koj cov tshuaj tsis tu ncua thiab tsis ua raws li kev coj khaub ncaws, txuas ntxiv noj koj cov tshuaj rau lub voj voog tom ntej tab sis nco ntsoov qhia rau koj tus kws kho mob ua ntej ua li ntawd. Yog tias koj tsis tau noj cov tshuaj txhua hnub raws li tau qhia thiab tsis ua raws li kev coj khaub ncaws, lossis yog tias koj tsis tau coj khaub ncaws ob zaug, koj yuav xeeb tub. Nrog koj tus kws kho mob tham tam sim ntawd seb koj puas xeeb tub. Tsis txhob siv cov tshuaj tiv thaiv qhov ncauj txuas ntxiv mus txog thaum koj paub tseeb tias koj tsis xeeb tub, tab sis txuas ntxiv siv lwm txoj kev tiv thaiv kab mob.

Tsis muaj pov thawj pom tseeb tias kev siv tshuaj tiv thaiv qhov ncauj yog cuam tshuam nrog kev nce hauv kev yug menyuam, thaum noj tsis tau thaum cev xeeb tub. Yav dhau los, ob peb txoj kev tshawb fawb tau tshaj tawm tias cov tshuaj tiv thaiv qhov ncauj yuav cuam tshuam nrog kev yug me nyuam, tab sis cov kev tshawb fawb no tsis tau lees paub. Txawm li cas los xij, cov tshuaj tiv thaiv qhov ncauj lossis lwm yam tshuaj yuav tsum tsis txhob siv thaum cev xeeb tub tshwj tsis yog tias tsim nyog thiab qhia los ntawm koj tus kws kho mob. Koj yuav tsum nrog koj tus kws kho mob tham txog kev pheej hmoo rau koj tus menyuam hauv plab ntawm cov tshuaj noj thaum cev xeeb tub.

2. Thaum pub niam mis

Yog tias koj pub niam mis, nrog koj tus kws kho mob tham ua ntej pib cov tshuaj tiv thaiv qhov ncauj. Qee cov tshuaj yuav kis mus rau tus menyuam hauv cov mis nyuj. Ob peb yam tsis zoo rau tus menyuam tau raug tshaj tawm, suav nrog kev daj ntawm daim tawv nqaij (daj daj) thiab lub mis loj. Tsis tas li ntawd, cov tshuaj tiv thaiv qhov ncauj tuaj yeem txo qhov nyiaj thiab zoo ntawm koj cov kua mis. Yog tias ua tau, tsis txhob siv cov tshuaj tiv thaiv qhov ncauj thaum pub niam mis. Koj yuav tsum siv lwm txoj kev tiv thaiv kab mob txij li kev pub niam mis tsuas yog ib feem kev tiv thaiv los ntawm kev xeeb tub thiab qhov kev tiv thaiv ib nrab txo qis thaum koj pub niam mis rau lub sijhawm ntev. Koj yuav tsum txiav txim siab pib cov tshuaj tiv thaiv qhov ncauj tsuas yog tom qab koj tau txiav koj tus menyuam tag.

3. Kev xeem kuaj

Yog tias koj tau teem sijhawm rau kev kuaj mob, qhia rau koj tus kws kho mob tias koj tab tom noj tshuaj tiv thaiv kab mob. Qee qhov kev kuaj ntshav yuav cuam tshuam los ntawm cov tshuaj tiv thaiv kev yug menyuam.

4. Kev Sib Tham Tshuaj

Qee cov tshuaj yuav cuam tshuam nrog cov tshuaj tiv thaiv kev yug menyuam kom tsis muaj txiaj ntsig zoo hauv kev tiv thaiv kev xeeb tub lossis ua rau muaj kev cuam tshuam los ntshav. Cov tshuaj xws li rifampin; cov tshuaj siv rau qaug dab peg xws li barbiturates (piv txwv li, phenobarbital), carbamazepine, thiab phenytoin (Dilantin® yog ib hom tshuaj no); troglitazone; phenylbutazone; thiab tej zaum yuav muaj qee yam tshuaj tua kab mob. Tej zaum koj yuav tau siv tshuaj tiv thaiv kab mob ntxiv thaum koj noj tshuaj uas tuaj yeem ua rau cov tshuaj tiv thaiv qhov ncauj tsis zoo.

Cov tshuaj tiv thaiv yug me nyuam cuam tshuam nrog qee yam tshuaj. Cov tshuaj no muaj xws li acetaminophen, clofibric acid, cyclosporine, morphine, prednisolone, salicylic acid, temazepam, thiab theophylline. Koj yuav tsum qhia rau koj tus kws kho mob yog tias koj noj cov tshuaj no.

5. Cov khoom no (zoo li txhua yam tshuaj tiv thaiv qhov ncauj) yog npaj los tiv thaiv kev xeeb tub. Nws tsis tiv thaiv kev kis kab mob HIV (AIDS) thiab lwm yam kab mob sib kis xws li Chlamydia, qhov chaw mos herpes, qhov chaw mos, kab mob gonorrhea, kab mob siab B, thiab syphilis.

QHIA RAU HAUV PATIENT

COMPACT TABLET DISPENSER

Larin Fe 1/20 compact ntsiav tshuaj dispenser tau tsim los ua kom cov tshuaj tiv thaiv qhov ncauj kom yooj yim thiab yooj yim li sai tau. Cov ntsiav tshuaj tau teem rau hauv peb lossis plaub kab ntawm xya ntsiav tshuaj txhua, nrog rau hnub ntawm lub lim tiam tshwm sim saum thawj kab ntawm cov ntsiav tshuaj.

Txhua ntsiav tshuaj daj ntseg muaj 1 mg norethindrone acetate thiab 20 mcg ethinyl estradiol.

Txhuaxim avntsiav tshuaj muaj 75 mg ferrous fumarate thiab yog npaj los pab koj nco ntsoov noj cov ntsiav tshuaj kom raug. Cov ntsiav tshuaj xim av no tsis yog npaj kom muaj txiaj ntsig kev noj qab haus huv.

Kev taw qhia

Txhawm rau tshem tawm ib lub ntsiav tshuaj, nias rau ntawm nws nrog koj tus ntiv tes xoo lossis ntiv tes. Lub ntsiav tshuaj yuav poob los ntawm sab nraum qab ntawm lub ntsiav tshuaj dispenser. Tsis txhob nias nrog koj tus ntiv tes xoo, ntiv tes, lossis lwm yam khoom ntse.

YUAV UA LI CAS

TSEEM CEEB RAU KUV

Ua ntejKoj pib noj koj cov tshuaj:

1. Nco ntsoov nyeem cov lus qhia no: Ua ntej koj pib noj koj cov tshuaj.

Txhua lub sij hawm koj tsis paub yuav ua li cas.

2. TEJ CHAW UA HAUJ LWM HAUJ LWM HAUJ LWM HAUJ LWM HAUJ LWM HAUJ LWM HAUJ LWM HAUJ LWM HAUJ LWM HAUJ LWM NTAWM IB LUB TSEV KAWM NTAWV NTAWM LUB SIJ HAWM. Yog tias koj tsis noj tshuaj koj yuav xeeb tub. Qhov no suav nrog pib lub pob lig. Cov tshuaj ntau dua koj nco, qhov ntau dua koj yuav xeeb tub.

3. Muaj ntau tus poj niam tau pom los yog lub teeb los ntshav, los yog tej zaum yuav mob plab lawv lub plab thaum lub sij hawm thawj 1-3 pob tshuaj. Yog tias koj muaj pob los yog los ntshav los yog mob plab, tsis txhob noj tshuaj. Qhov teeb meem feem ntau yuav ploj mus. Yog tias nws tsis ploj mus, nrog koj tus kws kho mob lossis chaw kuaj mob.

4. Cov tshuaj uas tsis tuaj yeem tuaj yeem ua rau pom los yog lub teeb los ntshav, txawm tias thaum koj ua cov tshuaj uas ploj lawm. Nyob rau hnub koj noj 2 ntsiav tshuaj los ua rau cov tshuaj uas ploj lawm, koj tuaj yeem hnov ​​​​mob me ntsis rau koj lub plab.

5. Yog tias koj muaj ntuav lossis zawv plab, yog vim li cas, lossis yog tias koj noj qee yam tshuaj, suav nrog qee cov tshuaj tua kab mob, koj cov tshuaj tiv thaiv kev yug menyuam yuav tsis ua haujlwm zoo. Siv txoj kev tiv thaiv kev yug menyuam rov qab (xws li hnab looj tes lossis ua npuas ncauj) kom txog thaum koj mus ntsib koj tus kws kho mob lossis chaw kho mob.

6. Yog tias koj muaj teeb meem nco ntsoov noj cov tshuaj, nrog koj tus kws kho mob lossis chaw kho mob tham txog yuav ua li cas kom noj cov ntsiav tshuaj yooj yim dua lossis txog kev siv lwm txoj kev tswj kev yug menyuam.

7. Yog tias koj muaj lus nug lossis tsis paub meej txog cov ntaub ntawv hauv daim ntawv no, hu rau koj tus kws kho mob lossis chaw kho mob.

Ua ntej koj pib noj koj cov tshuaj

1. Txiav txim siab hnub twg koj xav noj koj cov tshuaj. Nws yog ib qho tseem ceeb uas yuav tsum tau coj nws ntawm tib lub sijhawm txhua hnub.

2. Saib ntawm koj lub hnab ntim tshuaj kom pom tias nws muaj 21 lossis 28 ntsiav tshuaj:

Cov28-Hnub ntsiav tshuaj pobmuaj 21 'active' tshuaj daj daj (nrog rau cov tshuaj hormones) noj rau 3 lub lis piam, ua raws li 1 lub lis piam ntawm cov tshuaj ceeb toom xim av (tsis muaj tshuaj hormones).

3. TSIS MUAJ:

1) qhov twg ntawm pob pib noj tshuaj,

2) nyob rau hauv dab tsi thiaj li yuav noj cov tshuaj (ua raws li cov xub), thiab

3) lub lis piam tus lej raws li qhia hauv cov duab hauv qab no:

Larin Fe 1/20 yuav muaj:nees nkaum ibPALE DUA PILLSrauWEEKS 1, 2, thiab 3.WEEK 4yuav muajNYIAJ NYIAJ XWB

4. YUAV UA LI CAS YUAV TSUM TAU TXAIS NTAWM LUB SIJ HAWM:

LWM YAM TSEEM CEEB (xws li cov hnab looj tes lossis ua npuas ncauj) siv los rov qab yog tias koj tsis tshuaj.

Ib qho EXTRA, PAUB PILL PACK.

THAUM KOM KOM PAUB TIAS IB TUG PIV THAIV

Koj muaj kev xaiv hnub twg los pib noj koj thawj pob tshuaj. Txiav txim siab nrog koj tus kws kho mob lossis chaw kho mob uas yog hnub zoo tshaj rau koj. Xaiv ib lub sij hawm ntawm hnub uas yuav yooj yim rau nco ntsoov.

HNUB-1 PIB:

1. Xaiv daim ntawv lo hnub uas pib nrog thawj hnub ntawm koj lub sijhawm. (Nov yog hnub koj pib los ntshav lossis pom, txawm tias yuav luag ib tag hmo thaum pib los ntshav.)

2. Muab daim ntawv lo hnub no tso rau ntawm lub tshuab luam ntawv ntsiav tshuaj rau ntawm thaj chaw uas muaj hnub ntawm lub lim tiam (pib hnub Sunday) luam tawm ntawm cov yas.

3. Noj thawj 'active' tshuaj daj daj ntawm thawj pob thaum lub sij hawmthawj 24 teev ntawm koj lub sijhawm.

4. Koj yuav tsis tas yuav siv cov txheej txheem rov qab los ntawm kev tiv thaiv kev yug menyuam, txij li thaum koj pib cov tshuaj thaum pib ntawm koj lub sijhawm.

Hnub Sunday pib:

1. Noj thawj 'active' tshuaj daj daj ntawm thawj pob ntawm lubHnub Sunday tom qab koj lub sijhawm pib,txawm tias koj tseem los ntshav. Yog tias koj lub sijhawm pib hnub Sunday, pib lub pob ntawd tib hnub.

ob.Siv lwm txoj kev tswj kev yug menyuamraws li txoj kev rov qab yog tias koj muaj kev sib deev txhua lub sijhawm txij hnub Sunday koj pib koj thawj pob mus txog rau hnub Sunday tom ntej (7 hnub). Cov hnab looj qau los yog ua npuas ncauj yog cov txheej txheem rov qab zoo ntawm kev tiv thaiv kev yug menyuam.

YUAV UA LI CAS RAU LUB HLIS

1. Noj ib ntsiav tshuaj tib lub sij hawm txhua hnub kom txog thaum lub pob yog khoob.

Tsis txhob hla tshuaj txawm tias koj pom lossis los ntshav thaum lub hli los yog hnov ​​​​mob rau koj lub plab (xws li xeev siab).

Tsis txhob hla tshuaj txawm tias koj tsis sib deev ntau zaus.

phiv los ntawm chantix

2. Thaum koj ua tiav ib pob lossis hloov koj cov tshuaj ntsiav tshuaj:

28 ntsiav tshuaj:Pib lub pob tom ntej rau hnub tom qab koj cov tshuaj 'reminder' kawg. Tsis txhob tos ib hnub twg ntawm pob khoom.

YUAV UA LI CAS YOG KOJ TSIS POM

Yog kojMISS 1daj ntseg daj 'active' ntsiav tshuaj:

1. Nqa nws sai li sai tau thaum koj nco qab. Noj cov tshuaj tom ntej ntawm koj lub sijhawm. Qhov no txhais tau tias koj tuaj yeem noj 2 ntsiav tshuaj hauv 1 hnub.

2. Koj tsis tas yuav siv txoj kev tswj kev yug menyuam rov qab yog tias koj muaj kev sib deev.

Yog kojMISS 2daj ntseg daj 'active' tshuaj nyob rau hauv kabLUB 1 HLIS LUB 2ntawm koj pob:

1. Noj 2 ntsiav tshuaj rau hnub koj nco qab thiab 2 ntsiav tshuaj rau hnub tom qab.

2. Tom qab ntawd noj 1 ntsiav tshuaj ib hnub kom txog thaum koj ua tiav pob.

3. Koj tuaj yeem cev xeeb tub yog tias koj muaj kev sib deev hauv7 nojtom qab koj nco tshuaj. Koj YUAV TSUM siv lwm txoj kev tiv thaiv kev yug menyuam (xws li hnab looj qau lossis ua npuas ncauj) ua ib txoj hauv kev tiv thaiv kev yug menyuam kom txog thaum koj tau noj tshuaj daj daj ntseg 'active' txhua hnub rau 7 hnub.

Yog kojMISS 2dawb los yog ntsuab 'active' tshuaj nyob rau hauv kabLUB 3 WEEK:

1. Yog tias koj yog Hnub-1 Pib:

Muab pov tseg tas ntawm cov ntsiav tshuaj thiab pib ib pob tshiab rau tib hnub ntawd.

Yog tias koj yog Hnub Sunday Pib:

Noj 1 ntsiav tshuaj txhua hnub kom txog rau thaum hnub Sunday. Hnub Sunday, muab pov tawm ntawm cov so ntawm pob thiab pib cov pob tshuaj tshiab ntawm tib hnub.

2. Tej zaum koj yuav tsis muaj koj lub sijhawm rau lub hlis no, tab sis qhov no xav tau. Txawm li cas los xij, yog tias koj tsis nco koj lub sijhawm 2 lub hlis sib law liag, hu rau koj tus kws kho mob lossis chaw kho mob vim tias koj yuav xeeb tub.

3. Koj tuaj yeem cev xeeb tub yog tias koj muaj kev sib deev hauv7 nojtom qab koj nco tshuaj. Koj YUAV TSUM siv lwm txoj kev tiv thaiv kev yug menyuam (xws li hnab looj qau lossis ua npuas ncauj) ua ib txoj hauv kev tiv thaiv kev yug menyuam kom txog thaum koj tau noj tshuaj daj daj ntseg 'active' txhua hnub rau 7 hnub.

Yog kojMISS 3 LUB NEEJCov tshuaj daj daj 'active' ua ke (thaum thawj 3 lub lis piam):

1. Yog tias koj yog Hnub-1 Pib:

Muab pov tseg tas ntawm cov ntsiav tshuaj thiab pib ib pob tshiab rau tib hnub ntawd.

Yog tias koj yog Hnub Sunday Pib:

Noj 1 ntsiav tshuaj txhua hnub kom txog rau thaum hnub Sunday. Hnub Sunday, muab pov tawm ntawm cov so ntawm pob thiab pib cov pob tshuaj tshiab ntawm tib hnub.

2. Tej zaum koj yuav tsis muaj koj lub sijhawm rau lub hlis no, tab sis qhov no xav tau. Txawm li cas los xij, yog tias koj tsis nco koj lub sijhawm 2 lub hlis sib law liag, hu rau koj tus kws kho mob lossis chaw kho mob vim tias koj yuav xeeb tub.

3. Koj tuaj yeem cev xeeb tub yog tias koj muaj kev sib deev hauv7 nojtom qab koj nco tshuaj. Koj YUAV TSUM siv lwm txoj kev tiv thaiv kev yug menyuam (xws li hnab looj qau lossis ua npuas ncauj) ua ib txoj hauv kev tiv thaiv kev yug menyuam kom txog thaum koj tau noj tshuaj daj daj ntseg 'active' txhua hnub rau 7 hnub.

NTAUB NTAWV RAU HAUV 28-HNUB PACKS:

Yog tias koj tsis nco qab ib qho ntawm 7 BROWN 'REMINDER' ntsiav tshuaj nyob rau lub lim tiam 4: Muab cov ntsiav tshuaj uas koj tsis nco qab.

Cia li noj 1 ntsiav tshuaj txhua hnub kom txog thaum lub pob khoob khoob.

KOJ TSIS TAU TXAIS IB TUG MENYUAM.

Thaum kawg, yog tias koj tseem tsis tau paub meej tias yuav ua li cas txog cov ntsiav tshuaj koj tau plam:

Siv txoj kev rov qab los txhua lub sij hawm koj muaj kev sib deev.

NRHIAV IB TUG DUA 'ACTIVE' PILL txhua hnub kom txog thaum koj tuaj yeem ncav cuag koj tus kws kho mob lossis chaw kho mob.

PHIM NYUB VAIS PHEM TIAG TIAG TIAG

Qhov tshwm sim ntawm cov ntsiav tshuaj tsis ua haujlwm uas ua rau cev xeeb tub yog kwv yees li 1% (piv txwv li, ib cev xeeb tub rau 100 tus poj niam hauv ib xyoos) yog noj txhua hnub raws li tau qhia, tab sis feem ntau qhov ua tsis tau zoo yog kwv yees li 3%. Yog tias tsis ua tiav, qhov kev pheej hmoo rau tus menyuam hauv plab yog tsawg.

Kev xeeb tub tom qab tso tshuaj

Tej zaum yuav muaj qee qhov qeeb hauv kev xeeb tub tom qab koj tsis siv cov tshuaj tiv thaiv qhov ncauj, tshwj xeeb tshaj yog tias koj muaj kev coj khaub ncaws tsis zoo ua ntej koj siv cov tshuaj tiv thaiv qhov ncauj. Tej zaum nws yuav raug nquahu kom ncua kev xeeb tub mus txog thaum koj pib coj khaub ncaws tsis tu ncua thaum koj tau tso tseg cov tshuaj thiab muaj lub siab xav xeeb tub.

Tsis pom muaj qhov nce ntxiv ntawm kev yug me nyuam hauv cov me nyuam yug tshiab thaum cev xeeb tub tshwm sim sai tom qab tso tseg cov tshuaj.

Tshaj dhau

Cov tsos mob hnyav tsis tau tshaj tawm tom qab noj cov tshuaj tiv thaiv qhov ncauj ntau ntawm cov menyuam yaus. Kev noj ntau dhau tuaj yeem ua rau xeev siab thiab tshem tawm los ntshav hauv cov poj niam. Yog tias noj ntau dhau, tiv tauj koj tus kws kho mob lossis tus kws muag tshuaj.

Lwm yam ntaub ntawv

Koj tus kws kho mob yuav sau ntawv kho mob thiab tsev neeg keeb kwm thiab tshuaj xyuas koj ua ntej muab tshuaj tiv thaiv qhov ncauj. Kev kuaj lub cev yuav raug ncua mus rau lwm lub sijhawm yog tias koj thov nws thiab koj tus kws kho mob ntseeg tias nws yog ib qho kev kho mob zoo kom ncua nws. Koj yuav tsum tau rov kuaj dua tsawg kawg ib xyoos ib zaug. Nco ntsoov qhia rau koj tus kws kho mob yog tias muaj tsev neeg keeb kwm ntawm ib qho xwm txheej uas tau teev tseg yav dhau los hauv daim ntawv no. Nco ntsoov khaws txhua qhov kev teem sijhawm nrog koj tus kws kho mob, vim qhov no yog lub sijhawm los txiav txim siab seb puas muaj cov tsos mob tshwm sim ntxov ntawm kev siv tshuaj tiv thaiv qhov ncauj.

Tsis txhob siv cov tshuaj rau ib qho mob uas tsis yog qhov uas nws tau sau tseg. Cov tshuaj no tau raug sau tshwj xeeb rau koj; tsis txhob muab rau lwm tus uas xav tau tshuaj tiv thaiv kab mob.

KEV PAB CUAM KEV PAB CUAM NTAWM ORAL CONTRACEPTIVES

Ntxiv nrog rau kev tiv thaiv kev xeeb tub, kev siv tshuaj tiv thaiv qhov ncauj yuav muab qee yam txiaj ntsig. Lawv yog:

  • Kev coj khaub ncaws yuav ua tau ntau dua
  • Cov ntshav ntws thaum cev xeeb tub tuaj yeem sib dua thiab tsis muaj hlau yuav ploj. Yog li ntawd, anemia vim tsis muaj hlau tsis tshua muaj tshwm sim
  • Mob lossis lwm yam tsos mob thaum cev xeeb tub yuav raug ntsib tsawg dua
  • Ectopic (tubal) cev xeeb tub yuav tshwm sim tsawg zaus
  • Cov hlwv uas tsis yog mob qog noj ntshav lossis pob hauv lub mis yuav tshwm sim tsawg dua
  • Tus kab mob pelvic inflammatory yuav tshwm sim tsawg zaus
  • Kev siv tshuaj tiv thaiv qhov ncauj tuaj yeem muab qee yam kev tiv thaiv kev tsim tawm ob hom mob qog noj ntshav: mob qog noj ntshav ntawm zes qe menyuam thiab mob qog noj ntshav ntawm lub tsev menyuam.

Yog tias koj xav paub ntxiv txog cov tshuaj tiv thaiv kev yug menyuam, nug koj tus kws kho mob lossis tus kws muag tshuaj. Lawv muaj ib daim ntawv qhia ntau dua hu ua 'Physician Insert', uas koj xav tau nyeem.

Nco ntsoov noj cov ntsiav tshuaj raws li lub sijhawm yog qhov nyuaj vim nws qhov tseem ceeb hauv kev muab kev tiv thaiv qib siab tshaj plaws rau koj.

TSIS TXAUS SIAB QHOV CHAW UA HAUJ LWM rau ob qho tib si DOSAGE REGIMENS

Qee lub sij hawm yuav tsis muaj kev coj khaub ncaws tom qab lub voj voog ntawm cov tshuaj. Yog li ntawd, yog tias koj tsis nco ib lub caij nyoog poj niam tab sis tau noj cov tshuajraws nraim li koj yuav tsum tau, txuas ntxiv li qub mus rau lub voj voog tom ntej. Yog tias koj tsis tau noj cov tshuaj kom raug thiab tsis ua raws li kev coj khaub ncaws,tej zaum koj yuav xeeb tubthiab yuav tsum tsis txhob noj cov tshuaj tiv thaiv qhov ncauj kom txog thaum koj tus kws kho mob lossis tus kws kho mob txiav txim siab seb koj puas xeeb tub.

Txog thaum koj tuaj yeem mus ntsib koj tus kws kho mob lossis tus kws kho mob, siv lwm hom kev tiv thaiv kab mob. Yog tias ob lub caij tsis cev khaub ncaws tsis tu ncua, koj yuav tsum tsis txhob noj tshuaj kom txog thaum nws txiav txim siab seb koj puas xeeb tub. Txawm hais tias tsis muaj qhov tshwm sim tsis zoo hauv kev yug menyuam hauv cov menyuam yug tshiab yog tias koj cev xeeb tub thaum siv cov tshuaj tiv thaiv qhov ncauj, koj yuav tsum tham nrog koj tus kws kho mob lossis tus kws kho mob.

Kev kuaj mob ib ntus

Koj tus kws kho mob lossis tus kws kho mob yuav ua tiav cov ntaub ntawv kho mob thiab tsev neeg keeb kwm ua ntej muab tshuaj tiv thaiv qhov ncauj. Lub sijhawm ntawd thiab ib xyoos ib zaug tom qab ntawd, nws feem ntau yuav tshuaj xyuas koj cov ntshav siab, lub mis, plab, thiab lub plab hauv plab (xws li Papanicolaou smear, piv txwv li, kuaj mob qog noj ntshav).

Khaws qhov no thiab txhua yam tshuaj tawm ntawm qhov chaw me nyuam.

Rx xwb

Khaws ntawm 20 ˚ C ~ 25˚ C (68˚ F ~ 77 ˚ F) [Saib USP Controlled Room Temperature].

Chaw tsim tshuaj paus: Northstar Rx LLC

38141 Memphis TN

Hu rau dawb ntawm 1-800-206-7821

Tsim los ntawm: Novast Laboratories Ltd.

Nantong, Suav teb 226009

i0097 ib. 04/2019 Rev. A

Txhawm rau tshaj tawm SUSPECTED ADVERSE REACTIONS, hu rau Northstar Rx LLC.Tau-Dawb ntawm 1-800-206-7821 lossis FDA ntawm 1-800-FDA-1088 lossiswww.fda.gov/medwatch.

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

Larin Kev Ntseeg 1/20
Norethindrone acetate / ethinyl estradiol thiab ferrous fumarate cov khoom siv
Cov ntaub ntawv khoom
Yam khoom HUMAN PRESCRIPTION DRUG LABEL Yam khoom Code (Source) NDC: 16714-406
Ntim
# Yam khoom Code Pob piav qhia
ib NDC: 16714-406-01 1 BLISTER PACK hauv 1 PACKET
ib 1 KIT hauv 1 BLISTER PACK
ob NDC: 16714-406-02 1 BLISTER PACK hauv 1 CARTON
ob 1 KIT hauv 1 BLISTER PACK
3 NDC: 16714-406-03 3 BLISTER PACK hauv 1 CARTON
3 1 KIT hauv 1 BLISTER PACK
4 NDC: 16714-406-04 6 BLISTER PACK hauv 1 CARTON
4 1 KIT hauv 1 BLISTER PACK
Ntau Yam
Ntu # Ntim Ntim Tag nrho cov khoom kom muaj nuj nqis
Ntu 1 nees nkaum ib
Ntu 2 7
Ntu 1 ntawm 2
NORETHINDRONE ACETATE / ETINYL ESTRADIOL thiab FERROUS FUMARATE
Norethindrone acetate thiab ethinyl estradiol ntsiav tshuaj
Cov ntaub ntawv khoom
Txoj kev tswj hwm ORAL DEA Teem caij
Cov khoom xyaw nquag / Active Moiety
Cov khoom xyaw npe Lub hauv paus muaj zog Lub zog
NORETHINDRONE ACETATE (NORETHINDRONE) NORETHINDRONE ACETATE 1mg ib
ETHINYL ESTRADIOL (ETHINYL ESTRADIOL) ETHINYL ESTRADIOL 20 ugj
Cov khoom xyaw uas tsis muaj zog
Cov khoom xyaw npe Lub zog
POLYVINYL ALCOHOL
TITANIUM DIOXIDE
TALC
POLYETHYLENE GLYCOL 3350
LECITHIN, SOYBEAN
D&C YELLOW NO. 10
FD&C BLUE NO. 2
FD&C YELLOW NO. 6
LACTOSE
MAGNESIUM STEARATE
STARCH, PREGELATINIZED CORN
Cov yam ntxwv ntawm cov khoom
Xim YELLOW (paj) Cov qhab nias tsis muaj qhab nias
Cov duab ROV Loj 5mm ib
Nplaim Imprint Code L2
Muaj
Cov ntaub ntawv lag luam
Kev lag luam qeb Daim ntawv thov Number los yog Monograph Citation Hnub pib ua lag luam Hnub Kawg Ua Lag Luam
KOJ TIAB SA 091454 08/26/2013
Ntu 2 ntawm 2
INERT
ntsiav tshuaj placebo
Cov ntaub ntawv khoom
Txoj kev tswj hwm ORAL DEA Teem caij
Cov khoom xyaw uas tsis muaj zog
Cov khoom xyaw npe Lub zog
FERROUS FUMARATE 75mg ib
POLYVINYL ALCOHOL
TALC
POLYETHYLENE GLYCOL 3350
LECITHIN, SOYBEAN
FERROSOFERRIC OXIDE
FERRIC OXIDE Daj
CELLULOSE, MICROCRYSTALLINE
HYDROXYPROPYL CELLULOSE
MAGNESIUM STEARATE
CROSPOVIDONE
Cov yam ntxwv ntawm cov khoom
Xim Xim av Cov qhab nias tsis muaj qhab nias
Cov duab ROV Loj 5mm ib
Nplaim Imprint Code F; N
Muaj
Cov ntaub ntawv lag luam
Kev lag luam qeb Daim ntawv thov Number los yog Monograph Citation Hnub pib ua lag luam Hnub Kawg Ua Lag Luam
KOJ TIAB SA 091454 08/26/2013
Cov ntaub ntawv lag luam
Kev lag luam qeb Daim ntawv thov Number los yog Monograph Citation Hnub pib ua lag luam Hnub Kawg Ua Lag Luam
KOJ TIAB SA 091454 08/26/2013
Labeler -Northstar Rx LLC (830546433)
Sau npe -Novast Laboratory Co., Ltd. (527695995)
Kev tsim kho
Lub npe Chaw nyob ID/FEI Kev ua haujlwm
Novast Laboratories Co., Ltd. 52769595 ib tsom xam (16714-406), daim ntawv lo (16714-406), tsim khoom (16714-406), pob (16714-406)
Northstar Rx LLC