Metronidazole Cev xeeb tub thiab pub niam mis ceeb toom

Metronidazole tseem hu ua: Flagyl , Flagyl 375 , ib. Flagyl ER , Flagyl IV , Metro, Metro IV, Metryl, Protostat

qhov siab tshaj plaws ntawm ativan hauv 24 teev

Metronidazole Cev xeeb tub

Tsiaj cov kev tshawb fawb tau ua tsis tau tejyam qhia pov thawj ntawm teratogenicity, fetotoxicity, los yog lwm yam fetal raug mob; Cov kev tshawb fawb txog kev yug me nyuam hauv nas, luav, thiab nas ntawm koob tshuaj zoo ib yam li qhov siab tshaj plaws tau pom zoo txhua hnub (raws li kev sib piv ntawm lub cev saum npoo av) tsis pom muaj pov thawj ntawm kev mob fetal. Cov tshuaj no hla lub placenta thiab sai sai nkag mus rau hauv fetal ncig. Cov ntaub ntawv tshaj tawm suav nrog ntau dua 5000 tus poj niam cev xeeb tub uas tau siv cov tshuaj no thaum cev xeeb tub (ntau lub sijhawm thawj peb lub hlis twg); 1 txoj kev tshawb fawb pom tau tias muaj kev pheej hmoo ntawm daim di ncauj cleft (nrog lossis tsis muaj cleft palate) hauv cov menyuam mos uas raug rau hauv lub tsev menyuam, tab sis cov kev tshawb pom no tsis tau lees paub. Ntau tshaj 10 txoj kev tshawb fawb tau tso npe ntau dua 5000 tus poj niam cev xeeb tub los ntsuas kev siv tshuaj tua kab mob (nrog rau cov tshuaj no) rau cov kab mob vaginosis ntawm qhov tshwm sim ntawm kev yug menyuam ntxov ntxov; Feem ntau cov kev tshawb fawb tsis tau pom tias muaj kev pheej hmoo ntau ntxiv rau kev tsis sib haum xeeb los yog lwm yam kev tshwm sim tsis zoo tom qab raug rau cov tshuaj no thaum cev xeeb tub. Tsis muaj kev pheej hmoo ntxiv tau pom nyob rau hauv 3 txoj kev tshawb fawb ntsuas qhov kev pheej hmoo ntawm tus menyuam mos mob qog noj ntshav tom qab raug rau cov tshuaj no thaum cev xeeb tub; Txawm li cas los xij, cov kev tshawb fawb no tau txwv tsis pub muaj peev xwm txheeb xyuas qhov teeb meem no. Tsis muaj cov ntaub ntawv tswj tau hauv tib neeg cev xeeb tub.

AU TGA cev xeeb tub qeb B2: Cov tshuaj uas tau noj los ntawm cov poj niam cev xeeb tub nkaus xwb thiab cov poj niam uas muaj hnub nyoog yug me nyuam, tsis muaj qhov nce ntawm qhov zaus ntawm malformation lossis lwm yam cuam tshuam ncaj qha lossis tsis ncaj rau tib neeg fetus tau pom. Cov kev tshawb fawb hauv cov tsiaj tsis txaus lossis tej zaum yuav tsis muaj, tab sis cov ntaub ntawv muaj qhia tsis muaj pov thawj ntawm qhov tshwm sim ntawm kev puas tsuaj rau fetal.

US FDA qeb cev xeeb tub Tsis Tau Txais: US FDA tau hloov kho txoj cai cev xeeb tub rau cov khoom siv tshuaj kom xav tau cov ntawv sau uas suav nrog cov ntsiab lus ntawm kev pheej hmoo, kev sib tham ntawm cov ntaub ntawv txhawb nqa cov ntsiab lus, thiab cov ntaub ntawv tseem ceeb los pab cov kws kho mob txiav txim siab. thiab qhia cov poj niam txog kev siv tshuaj thaum cev xeeb tub. Cov poj niam cev xeeb tub A, B, C, D, thiab X tau raug txiav tawm.



Trichomoniasis :
-Raws li qee tus tub ceev xwm: Kev siv yog contraindicated thaum thawj peb lub hlis twg ntawm cev xeeb tub.
-Raws li qee tus tub ceev xwm: tsis pom zoo siv thaum thawj peb lub hlis twg ntawm cev xeeb tub; siv nyob rau hauv lub thib ob thiab peb trimesters yuav tsum tau tshwj tseg rau cov neeg uas nyob rau hauv lub zos palliative kev kho mob tsis txaus los tswj cov tsos mob.
-Raws li qee tus tub ceev xwm: Kev siv tsis pom zoo tshwj tsis yog tus kws kho mob pom zoo; Nyob rau hauv xws li mob, luv luv-dose regimens tsis pom zoo.

Tag nrho lwm yam Indications :
-Raws li qee tus tub ceev xwm: tsis pom zoo siv thaum thawj peb lub hlis twg ntawm cev xeeb tub.
-Raws li qee cov tub ceev xwm :
--- Kev kho IV: Kev siv tsis pom zoo tshwj tsis yog xav tau kom meej.
--- Kev kho qhov ncauj: Kev siv tsis pom zoo tshwj tsis yog tus kws kho mob pom zoo; Nyob rau hauv xws li mob, luv luv-dose regimens tsis pom zoo.
-Raws li qee tus tub ceev xwm: Cov tshuaj no yuav tsum tau siv thaum cev xeeb tub nkaus xwb yog tias cov txiaj ntsig zoo dua qhov kev pheej hmoo.

AU TGA cev xeeb tub qeb: B2
US FDA qeb cev xeeb tub: Tsis tau muab.

Cov ntsiab lus ntawm kev pheej hmoo: Tsis muaj cov ntaub ntawv tswj tau muaj nyob rau ntawm kev siv cov tshuaj no hauv cov poj niam cev xeeb tub kom qhia txog kev pheej hmoo ntawm kev siv tshuaj.

Cov lus pom :
-Raws li US CDC, cov poj niam cov tsos mob, ntawm txhua theem ntawm cev xeeb tub, yuav tsum tau kuaj thiab txiav txim siab rau kev kho mob trichomoniasis.

Saib cov ntaub ntawv

Metronidazole Cov lus ceeb toom pub mis niam

Nrog rau niam txiv IV thiab kev kho qhov ncauj, cov menyuam mos noj mis tau txais cov tshuaj no hauv koob tshuaj tsawg dua li cov uas siv los kho cov kab mob hauv cov menyuam mos, txawm hais tias cov metabolite nquag ntxiv rau tag nrho cov menyuam mos raug; Cov tshuaj thiab cov qib metabolite plasma ntsuas tau, tab sis tsawg dua li cov ntshav plasma niam. Cov kab mob candidal thiab raws plab tau raug tshaj tawm; Kev sib piv kev sim qhia pom qhov ncauj thiab qhov quav colonization nrog Candida tej zaum yuav muaj ntau dua nyob rau hauv cov me nyuam mos raug rau cov tshuaj no.

Genotoxicity thiab mutagenicity nyob rau hauv cov kab mob, carcinogenicity nyob rau hauv cov tsiaj, thiab muaj peev xwm mutagenicity nyob rau hauv tib neeg tau ua rau muaj kev txhawj xeeb txog kev kis tus me nyuam noj qab nyob zoo rau cov tshuaj no los ntawm cov kua mis. Qhov tseeb ntawm cov kev tshawb pom no tau raug nug; tsis muaj kev tshawb fawb meej tau ua rau tib neeg.

Ib koob tshuaj 200 mg ib zaug tau muab rau 10 tus poj niam ntawm 5 hnub tom qab yug menyuam. Cov mis nyuj nruab nrab yog 3.4, 2.8, thiab 1.3 mg / L ntawm 4, 8, thiab 12 teev tom qab noj, raws li; theem 12-teev tau nruab nrab ntawm 5 tus poj niam. Tom qab koob tshuaj leej niam, cov menyuam mos hnub nyoog 5 hnub (n=10) tau pub niam mis txhua 4 teev. Thaum 8 teev tom qab txhaj tshuaj, 2 tus menyuam mos muaj cov tshuaj ntshav hauv cov ntshav ntawm 0.28 thiab 0.4 mg / L thiab qib tsis ntsuas tau (tsawg dua 0.05 mg / L) hauv 3 tus menyuam mos; tom qab 12 teev tom qab txhaj tshuaj, lwm 2 tus menyuam mos muaj cov tshuaj hauv cov ntshav ntawm 0.2 mg / L thiab qib tsis ntsuas hauv lwm 3 tus menyuam mos. Tsis muaj cov tsos mob ntawm qhov ncauj lossis plab hnyuv tau pom hauv 10 tus menyuam mos thaum lub sijhawm kawm 12-teev.

Hauv kev tshawb fawb randomized, 17 leej niam tau txais 200 mg ntawm qhov ncauj 3 zaug hauv ib hnub rau 7 hnub tom qab yug menyuam; cov tshuaj mis nyuj (sau rau hnub 6; lub sij hawm tsis muab) nruab nrab 4.7 mg/L (ntau: 1.1 txog 15.2 mg/L).

Ib koob tshuaj 2 g ntawm qhov ncauj tau muab rau 3 tus poj niam rau trichomoniasis. Cov mis nyuj nruab nrab yog 45.8, 27.9, 19.1, 12.6, thiab 3.5 mg / L ntawm 2, 8, 12, 18, thiab 36 teev tom qab noj, raws li; theem 18-teev thiab 36-teev tau nruab nrab ntawm 2 tus poj niam. Raws li kev kwv yees tus sau, cov menyuam mos yuav tau txais 25.3 mg (tag nrho) nyob rau 48 teev tom qab noj tshuaj.

Thaum 0 mus rau 22 hnub tom qab yug me nyuam, 11 tus poj niam tau txais 200 mg ntawm qhov ncauj 3 zaug hauv ib hnub thiab 4 tus poj niam tau txais 400 mg ntawm qhov ncauj 3 zaug hauv ib hnub rau kev mob endometritis tom qab yug me nyuam. Ib qho piv txwv ntawm cov mis nyuj tau sau tom qab 1 mus rau 9 hnub ntawm kev kho thiab los ntawm 30 feeb mus rau 4 teev tom qab noj 200 mg muaj 1.6 txog 12.2 mg / L ntawm cov tshuaj tsis hloov pauv thiab 1.1 txog 3.8 mg / L ntawm hydroxymetronidazole; Cov mis kuaj tau sau 2 mus rau 3 teev tom qab noj tshuaj 400 mg muaj 11.6 txog 18 mg / L ntawm cov tshuaj tsis hloov pauv thiab 2.4 txog 6.3 mg / L ntawm hydroxymetronidazole. Cov ntshav tau sau los ntawm lawv cov me nyuam mos uas pub mis niam 1 mus rau 2 teev tom qab noj niam mis. Hauv 11 tus menyuam mos uas nws niam tau noj 600 mg / hnub, cov tshuaj plasma thiab hydroxymetronidazole qib nruab nrab yog 0.8 mg / L (ntau: 0.3 txog 1.4 mg / L) thiab 0.4 mg / L (ntau: 0.1 txog 0.8 mg / L), feem. ; Hauv 4 tus menyuam mos uas leej niam tau noj 1200 mg / hnub, qib tshuaj plasma thiab hydroxymetronidazole qib nruab nrab yog 2.4 mg / L (ntau: 0.6 txog 4.9 mg / L) thiab 1.1 mg / L (ntau: 0.4 txog 2.3 mg / L), feem. . Cov ntshav tau sau los ntawm lawv cov me nyuam mos uas pub mis niam 1 mus rau 2 teev tom qab noj niam mis. Hauv 11 tus menyuam mos uas nws niam tau noj 600 mg / hnub, cov tshuaj plasma thiab hydroxymetronidazole qib nruab nrab yog 0.8 mg / L (ntau: 0.3 txog 1.4 mg / L) thiab 0.4 mg / L (ntau: 0.1 txog 0.8 mg / L), feem. ; Hauv 4 tus menyuam mos uas leej niam tau noj 1200 mg / hnub, qib tshuaj plasma thiab hydroxymetronidazole qib nruab nrab yog 2.4 mg / L (ntau: 0.6 txog 4.9 mg / L) thiab 1.1 mg / L (ntau: 0.4 txog 2.3 mg / L), feem. . Cov me nyuam mos muaj cov tshuaj plasma thiab cov ntshav plasma hydroxymetronidazole li ntawm 4% mus rau 32% thiab 8% mus rau 96% ntawm cov niam txiv plasma, feem. Tsis muaj kev phiv tshwm sim tshwm sim hauv 16 tus menyuam mos noj mis niam (hnub nyoog 0 txog 22 hnub) thaum 9 hnub ntawm txoj kev tshawb no.

Hnub 3 thiab 4 tom qab yug me nyuam, cov qauv mis tau sau los ntawm 12 tus poj niam noj 400 mg ntawm qhov ncauj 3 zaug hauv ib hnub ntawm qhov nruab nrab ntawm 4.3 hnub tom qab yug menyuam; 7 ntawm lawv cov menyuam mos noj mis muaj ntshav ntsuas 4 mus rau 8 teev tom qab noj niam thiab 30 mus rau 90 feeb tom qab pub niam mis. Cov mis nyuj ntawm cov tshuaj tsis hloov pauv yog qhov nruab nrab ntawm 15.5, 12.9, 10.6, thiab 9.1 mg / L ntawm 2, 4, 6, thiab 8 teev tom qab noj, feem; cov mis nyuj theem ntawm hydroxymetronidazole nruab nrab yog 5.5, 5.7, 5.6, thiab 5.5 mg / L ntawm 2, 4, 6, thiab 8 teev tom qab noj, feem. Raws li kev kwv yees tus kws sau ntawv, ib tus menyuam mos uas pub niam mis noj 500 mL mis nyuj / hnub nrog rau cov niam txiv no yuav tau txais tsawg dua 10% ntawm cov menyuam yug tshiab ntawm cov tshuaj no. Cov me nyuam plasma qib nruab nrab yog 1.6 mg / L rau cov tshuaj tsis hloov pauv thiab 1.4 mg / L rau hydroxymetronidazole; Cov qib no sib raug rau 12.5% ​​thiab 25.6% ntawm niam txiv plasma qib rau cov tshuaj tsis hloov pauv thiab hydroxymetronidazole, raws li.

Thaum 1 lub hlis tom qab yug me nyuam, ib koob tshuaj 500 mg IV tau muab rau 15 tus poj niam; cov kua mis hauv nruab nrab yog 7.55 mg / L ntawm 2 teev tom qab noj.

Tom qab phais tas, 3 tus poj niam tom qab yug me nyuam tau txais 500 mg IV 3 zaug hauv ib hnub rau 2 hnub. Ib qho piv txwv ntawm niam mis tau sau los ntawm cov poj niam 1 mus rau 2 teev tom qab noj tshuaj rau hnub thib ob ntawm kev kho mob; mis nyuj cov tshuaj yog 7.3, 9.6, thiab 10.1 mg / L.

Ib rooj plaub ntawm kev mob raws plab thiab kev tsis haum lactose theem ob yog qhov tshwm sim yog vim tus menyuam mos tau txais cov tshuaj no los ntawm cov kua mis hauv lub sijhawm menyuam yaus thaum ntxov.

Hauv kev sib piv kev tshawb fawb, 35 tus menyuam mos yug tshiab tau saib xyuas rau 10 hnub thaum niam txiv kho nrog cov tshuaj no thiab lwm yam tshuaj tua kab mob (33 ampicillin, 1 erythromycin, thiab 1 cephalexin) rau kev kis kab mob tom qab yug menyuam / prophylaxis; koob tshuaj thiab kev tswj xyuas tsis tau muab, tab sis qee leej niam tau txais cov tshuaj IV thawj zaug thiab tom qab ntawd hloov mus rau qhov ncauj kho. Piv nrog rau cov menyuam mos ntawm cov niam uas siv ampicillin ib leeg lossis tsis muaj tshuaj tua kab mob, ntau tus menyuam mos uas tau txais cov tshuaj no thiab ampicillin muaj cov quav xoob ntau dua li lwm pab pawg, tshwj xeeb tshaj yog thaum siv IV. Kev loj hlob ntau dua thiab hnyav dua ntawm hom Candida tau pom nyob rau hauv qhov ncauj thiab perianal swabs ntawm cov me nyuam mos raug rau cov tshuaj no, tab sis qhov tseem ceeb ntawm cov ntaub ntawv tsis tau mus txog. Qhov ncauj thrush tsim nyob rau hauv 1 tus menyuam mos raug rau cov tshuaj no thiab ampicillin. Tsis muaj qhov sib txawv ntawm cov pab pawg hauv cov pob khaus, cov teeb meem pub mis, lossis qhov hnyav nce mus rau lub sijhawm tawm.

iophen c nr kua siab

Kev txiav txim siab yuav tsum txiav txim siab kom tsis txhob pub mis niam lossis txiav cov tshuaj, suav nrog qhov tseem ceeb ntawm cov tshuaj rau leej niam.
-Raws li qee tus tub ceev xwm: Kev pub niam mis tsis pom zoo thaum siv cov tshuaj no.
-Raws li qee tus tub ceev xwm: Kev siv tsis pom zoo tshwj tsis yog tias tus kws kho mob pom zoo.

Tshaj tawm rau hauv tib neeg cov kua mis: Yog

Cov lus pom :
-Cov tshuaj no yog secreted nyob rau hauv cov kua mis nyob rau hauv cov concentrations zoo ib yam li cov muaj nyob rau hauv lub plasma.
-Vim qhov muaj peev xwm ntawm cov qog nqaij hlav hauv cov tsiaj tshawb fawb, tus niam laus tuaj yeem xaiv tso nws cov kua mis pov tseg thaum kho thiab rau 24 teev tom qab kev kho mob tas thiab pub nws tus menyuam mos uas khaws cov mis nyuj los yog mis nyuj.
-Qee qhov chaw pom zoo kom tsis txhob pub niam mis ntxiv rau 12 mus rau 24 teev tom qab noj ib koob tshuaj niam txiv; cov kev xav sib txawv ntawm cov kws tshaj lij txawm hais tias kev siv yog pom zoo rau kev kho mob ntev dua thaum pub niam mis.

Saib cov ntaub ntawv

Cov ntaub ntawv qhia txog kev xeeb tub

  1. 'Cov ntaub ntawv khoom. Flagyl (metronidazole). Searle, Skokie, IL.
  2. Cerner Multum, Inc. 'UK Summary of Product Characteristics.' O 0
  3. Melbourne: Therapeutic Guidelines Limited 'eTG tiav [Online] Muaj los ntawm: URL: http://online.tg.org.au/complete/desktop/tgc.htm.' ([2014, Nov -]):
  4. Cerner Multum, Inc. 'Australian Product Information.' O 0
  5. CDC. Cov Chaw Tswj Xyuas Kabmob thiab Tiv Thaiv Kab Mob 'Cov Lus Qhia Txog Kev Tiv Thaiv Kab Mob Sib Kis, 2015. Muaj los ntawm: URL: http://www.cdc.gov/std/tg2015/default.htm.' (Lub Rau Hli 5, 2015):

Cov ntaub ntawv qhia txog kev pub niam mis

  1. Cerner Multum, Inc. 'Australian Product Information.' O 0
  2. 'Cov ntaub ntawv khoom. Flagyl (metronidazole). Searle, Skokie, IL.
  3. Melbourne: Therapeutic Guidelines Limited 'eTG tiav [Online] Muaj los ntawm: URL: http://online.tg.org.au/complete/desktop/tgc.htm.' ([2014, Nov -]):
  4. Cerner Multum, Inc. 'UK Summary of Product Characteristics.' O 0
  5. United States National Library of Medicine 'Toxnet. Toxicology Data Network. Muaj los ntawm: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT.' ([cai 2013 -]):

Cov ntaub ntawv ntxiv

Nco ntsoov sab laj nrog koj tus kws kho mob kom paub tseeb tias cov ntaub ntawv uas tshwm sim hauv nplooj ntawv no siv tau rau koj tus kheej.