Mucomyst

Lub npe dav: acetylcysteine ​​​
Dosage form: daws
Chav kawm tshuaj: Mucolytics



Ntawm nplooj ntawv no
Nthuav

Lub npe Mucomyst tau raug txiav tawm hauv Teb Chaws Asmeskas Yog tias cov khoom siv dav dav ntawm cov khoom no tau pom zoo los ntawm FDA, tej zaum yuav muaj. generic equivalents muaj .



Mucomyst Description

Mucomyst hom acetylcysteine ​​​​yog rau kev nqus pa (tus neeg sawv cev mucolytic) lossis kev tswj hwm qhov ncauj (acetaminophen antidote), thiab muaj cov tshuaj tsis muaj menyuam, tsis muaj tshuaj tiv thaiv (tsis yog txhaj tshuaj). Cov kev daws teeb meem muaj 20% (Mucomyst-20) lossis 10% (Mucomyst-10) acetylcysteine, nrog edetate disodium hauv dej huv. Sodium hydroxide yog ntxiv los kho pH rau 7. Acetylcysteine ​​​​yog N-acetyl derivative ntawm cov amino acid uas tshwm sim, cysteine ​​​​. Lub compound yog dawb crystalline hmoov nrog cov mis molecular C5H9TSIS TAU3S, ib qho hnyav molecular ntawm 163.2, thiab tshuaj npe ntawm N-acetyl-L-cysteine. Acetylcysteine ​​muaj cov qauv hauv qab no.

Cov khoom no muaj cov khoom xyaw hauv qab no: edetate disodium, sodium hydroxide, thiab dej huv.



Mucomyst®Cov tshuaj acetylcysteine ​​​​(USP)
Raws li Mucolytic Agent

mis nyuj ntawm magnesia phiv

Mucomyst - Clinical Pharmacology

Lub viscosity ntawm pulmonary mucous secretions nyob ntawm qhov ntau ntawm mucoprotein thiab, rau qhov tsawg dua, deoxyribonucleic acid (DNA). Qhov tom kawg nce nrog nce purulence vim muaj cov khib nyiab ntawm tes. Qhov kev txiav txim mucolytic ntawm acetylcysteine ​​​​yog cuam tshuam nrog sulfhydryl pawg hauv cov molecule. Cov pab pawg no tej zaum 'qhib' disulfide kev sib txuas hauv cov hnoos qeev uas ua rau txo cov viscosity. Kev ua haujlwm mucolytic ntawm acetylcysteine ​​​​tsis hloov pauv los ntawm qhov muaj DNA, thiab nce nrog nce pH. Qhov tseem ceeb mucolysis tshwm sim ntawm pH 7 thiab 9.

Acetylcysteine ​​​​ua kom sai deacetylation hauv vivo kom tawm los cysteine ​​lossis oxidation kom tawm los diacetylcystine.



Qee lub sij hawm, cov neeg mob tau txais kev nqus ntawm acetylcysteine ​​aerosol teb nrog kev txhim kho ntawm cov hlab ntsws ntxiv ntawm qhov sib txawv thiab qhov tsis tuaj yeem tshwm sim. Cov neeg mob uas yog reactors tsis tuaj yeem txheeb xyuasua ntejlos ntawm cov neeg mob random. Txawm tias cov neeg mob paub tias tau hnov ​​​​mob yav dhau los rau kev nqus ntawm acetylcysteine ​​aerosol, lawv yuav tsis hnov ​​​​qab thaum kho tom ntej. Cov lus sib tham kuj muaj tseeb; Cov neeg mob uas tau txais kev kho qhov nqus pa ntawm acetylcysteine ​​​​tsis muaj qhov xwm txheej tseem tuaj yeem hnov ​​​​mob tom qab nqus pa nrog kev ua pa ntau ntxiv. Feem ntau cov neeg mob uas muaj bronchospasm tau sai sai sai los ntawm kev siv lub bronchodilator muab los ntawm nebulization. Yog hais tias bronchospasm zuj zus, cov tshuaj yuav tsum tau txiav tam sim ntawd.

Kev taw qhia thiab kev siv rau Mucomyst

Mucomyst yog qhia raws li kev kho mob rau cov neeg mob uas txawv txav, viscid, los yog inspissated mucous secretions nyob rau hauv xws li mob xws li:

Mob bronchopulmonary kab mob (mob emphysema, emphysema nrog bronchitis, mob ntsws asthmatic bronchitis, tuberculosis, bronchiectasis thiab thawj amyloidosis ntawm lub ntsws)
Mob bronchopulmonary kab mob (pneumonia, bronchitis, tracheobronchitis)
Pulmonary teeb meem ntawm cystic fibrosis
Kev kho mob tracheostomy
Pulmonary teeb meem cuam tshuam nrog kev phais
Siv thaum siv tshuaj loog
Post-traumatic mob hauv siab
Atelectasis vim mucous obstruction
Diagnostic bronchial kev tshawb fawb (bronchograms, bronchospirometry, thiab bronchial wedge catheterization)

Contraindications

Mucomyst yog contraindicated nyob rau hauv cov neeg mob uas rhiab heev rau nws.

Ceeb toom

Tom qab kev tswj hwm zoo ntawm Mucomyst (acetylcysteine), qhov ntim ntawm cov kua dej bronchial yuav tshwm sim. Thaum hnoos tsis txaus, txoj hlab pa yuav tsum qhib los ntawm cov tshuab nqus dej yog tias tsim nyog. Qhov twg muaj cov tshuab thaiv vim lub cev txawv teb chaws los yog hauv zos tsub zuj zuj, txoj hauv kev yuav tsum tau tshem tawm los ntawm kev ua rau endotracheal aspiration, nrog lossis tsis muaj bronchoscopy. Asthmatics nyob rau hauv kev kho mob nrog Mucomyst yuav tsum tau ua tib zoo saib. Feem ntau cov neeg mob uas muaj bronchospasm tau sai sai sai los ntawm kev siv lub bronchodilator muab los ntawm nebulization. Yog hais tias bronchospasm zuj zus, cov tshuaj yuav tsum tau txiav tam sim ntawd.

Cov kev ceev faj

General

Nrog rau kev tswj hwm ntawm Mucomyst, tus neeg mob tuaj yeem pom thawj zaug tsis pom zoo tsis hnov ​​​​tsw uas sai sai tsis pom. Nrog lub ntsej muag lub ntsej muag tej zaum yuav muaj qhov nplaum ntawm lub ntsej muag tom qab nebulization. Qhov no yooj yim tshem tawm los ntawm kev ntxuav nrog dej.

Hauv qee qhov xwm txheej, kev hloov xim tuaj yeem tshwm sim hauv Mucomyst hauv lub raj mis qhib. Lub teeb liab xim yog qhov tshwm sim ntawm cov tshuaj tiv thaiv uas tsis cuam tshuam rau kev nyab xeeb lossis kev ua haujlwm ntawm mucolytic ntawm Mucomyst.

Kev txuas ntxiv ntawm cov tshuaj Mucomyst nrog cov roj qhuav yuav ua rau muaj kev nce ntxiv ntawm cov tshuaj hauv cov tshuaj vim yog evaporation ntawm cov kuab tshuaj. Cov concentration siab heev tuaj yeem cuam tshuam rau nebulization thiab xa cov tshuaj zoo. Dilution ntawm nebulizing tov nrog cov nqi tsim nyog ntawm Sterile Dej rau Txhaj, USP, raws li concentration tshwm sim, yuav obviate qhov teeb meem no.

Kev Sib Tham Tshuaj

Tshuaj stability thiab kev nyab xeeb ntawm Mucomyst (acetylcysteine) thaum tov nrog lwm yam tshuaj nyob rau hauv ib tug nebulizer tsis tau tsim.

CARCINOGENESIS, MUTAGENESIS, Impairment of Fertility

Carcinogenesis

Kev tshawb fawb txog carcinogenicity hauv cov tsiaj kuaj tsis tau ua nrog acetylcysteine ​​ib leeg, thiab nrog acetylcysteine ​​​​rau hauv kev sib xyaw nrog isoproterenol.

Kev tshawb fawb qhov ncauj ntev ntawm acetylcysteine ​​​​rau ib leeg hauv nas (12 lub hlis ntawm kev kho mob ua raws li 6 lub hlis ntawm kev soj ntsuam) ntawm koob tshuaj txog 1,000 mg / kg / hnub (5.2 npaug ntawm tib neeg mucolytic koob) tsis muaj pov thawj ntawm kev ua oncogenic.

Mutagenesis

Cov ntaub ntawv luam tawmibqhia tias acetylcysteine ​​tsis yog mutagenic hauv Ames kuaj, ob qho tib si nrog thiab tsis muaj kev ua kom metabolic.

Kev puas tsuaj ntawm Fertility

Kev ntsuam xyuas kev ua menyuam muaj kuab lom los ntsuas qhov muaj feem cuam tshuam ntawm fertility tau ua nrog acetylcysteine ​​(10%) ua ke nrog isoproterenol (0.05%) thiab muab raws li aerosol rau hauv chav tsev ntawm 12.43 cubic meters. Kev sib xyaw ua ke tau muab rau 25, 30, lossis 35 feeb ob zaug hauv ib hnub rau 68 hnub ua ntej sib yuav, rau 200 tus txiv neej thiab 150 tus nas poj niam; tsis muaj kev phiv tshwm sim nyob rau hauv dams los yog menyuam dev. Cov poj niam tom qab mating tau txuas ntxiv kho rau 42 hnub tom ntej.

Kev tshawb fawb txog kev yug menyuam ntawm acetylcysteine ​​​​hauv cov nas tau muab cov koob tshuaj ntawm qhov ncauj ntawm acetylcysteine ​​mus txog 1,000 mg / kg (5.2 npaug ntawm tib neeg cov tshuaj mucolytic) kuj tau tshaj tawm hauv cov ntaub ntawv.ibQhov tshwm sim tsuas yog qhov tshwm sim tsis zoo yog qhov txo qis me ntsis ntawm kev xeeb tub ntawm koob tshuaj 500 lossis 1,000 mg / kg / hnub (2.6 lossis 5.2 npaug ntawm tib neeg cov tshuaj mucolytic) hauv ntu Kuv kawm.

Cev xeeb tub: Cov teebmeem Teratogenic: Cev xeeb tub qeb B

Hauv kev tshawb fawb teratology ntawm acetylcysteine ​​​​hauv luav, koob tshuaj ntawm qhov ncauj ntawm 500 mg / kg / hnub (2.6 npaug ntawm tib neeg mucolytic koob) tau muab rau cev xeeb tub los ntawm kev tso ntshav rau hnub 6 txog 16 ntawm cev xeeb tub. Acetylcysteine ​​​​tau pom tias yog nonteratogenic nyob rau hauv cov xwm txheej ntawm txoj kev tshawb no.

Hauv cov luav, ob pawg (ib ntawm 14 thiab ib tus ntawm 16 tus poj niam cev xeeb tub) tau raug tshuaj aerosol ntawm 10% acetylcysteine ​​​​thiab 0.05% isoproterenol hydrochloride rau 30 lossis 35 feeb ob zaug hauv ib hnub txij li 6 txog 18 hnub ntawm cev xeeb tub. Tsis muaj cov teebmeem teratogenic tau pom ntawm cov xeeb ntxwv.

Teratology thiab kev tshawb fawb perinatal thiab postnatal toxicity hauv nas tau ua nrog kev sib xyaw ntawm acetylcysteine ​​thiab isoproterenol tswj los ntawm txoj kev nqus pa. Hauv cov nas, ob pawg ntawm 25 tus poj niam cev xeeb tub txhua tus tau raug tshuaj aerosol rau 30 thiab 35 feeb, raws li, ob zaug hauv ib hnub txij li 6 txog 15 hnub ntawm cev xeeb tub. Tsis muaj cov teebmeem teratogenic tau pom ntawm cov xeeb ntxwv.

Hauv cov nas cev xeeb tub (30 nas rau ib pawg), ob zaug-hnub raug rau aerosol ntawm acetylcysteine ​​thiab isoproterenol rau 30 lossis 35 feeb txij hnub 15 ntawm cev xeeb tub mus txog hnub 21 tom qab yug me nyuam tsis muaj kev cuam tshuam rau cov dams lossis cov menyuam mos.

Kev tshawb fawb txog kev tsim tawm ntawm Mucomyst nrog isoproterenol tau ua nyob rau hauv nas thiab ntawm acetylcysteine ​​​​ib leeg hauv luav ntawm koob tshuaj txog 2.6 npaug ntawm tib neeg koob. Cov no tau nthuav tawm tsis muaj pov thawj ntawm kev ua tsis taus pa lossis ua mob rau tus menyuam hauv plab vim yog acetylcysteine ​​​​. Txawm li cas los xij, tsis muaj kev tshawb fawb txaus thiab tswj tau zoo hauv cov poj niam cev xeeb tub. Vim hais tias kev tshawb fawb txog kev yug tsiaj tej zaum yuav tsis yog ib txwm kwv yees ntawm tib neeg cov lus teb, cov tshuaj no yuav tsum tau siv thaum cev xeeb tub tsuas yog xav tau kom meej.

Niam laus

Nws tsis paub tias cov tshuaj no puas tawm hauv tib neeg cov kua mis. Vim tias ntau cov tshuaj tau tawm hauv tib neeg cov kua mis, yuav tsum tau ceev faj thaum siv Mucomyst rau tus poj niam laus.

Kev Phem Tsis Zoo

Cov teebmeem tsis zoo muaj xws li stomatitis, xeev siab, ntuav, ua npaws, rhinorrhea, tsaug zog, clamminess, hauv siab nruj, thiab bronchoconstriction. Clinically overt acetylcysteine ​​​​induced bronchospasm tshwm sim infrequently thiab unpredictably txawm nyob rau hauv cov neeg mob uas muaj mob hawb pob bronchitis los yog bronchitis complicating bronchial hawb pob.

Tsis tshua muaj tshwm sim rau acetylcysteine ​​​​rhiab heev. Cov ntawv ceeb toom ntawm kev nkag siab ntawm cov neeg mob tsis tau lees paub los ntawm kev kuaj thaj. Kev hnov ​​​​mob tau raug lees paub hauv ntau tus kws kho qhov nqus pa uas tau tshaj tawm txog keeb kwm ntawm dermal erruptions tom qab nquag thiab txuas ntxiv mus rau acetylcysteine ​​​​.

Cov ntaub ntawv qhia txog kev khaus khaus rau cov hlab ntsha thiab cov hlab ntsws tau txais thiab txawm tias hemoptysis tau tshwm sim hauv cov neeg mob tau txais acetylcysteine ​​​​cov kev tshawb pom no tsis tshua muaj tshwm sim hauv cov neeg mob uas muaj kab mob bronchopulmonary thiab kev sib raug zoo tsis tau tsim.

Mucomyst Dosage thiab Administration

General

Mucomyst muaj nyob rau hauv roj hmab stoppered iav vials uas muaj 4, 10, los yog 30 mL. Cov tshuaj 20% yuav raug diluted kom tsawg dua nrog Sodium Chloride rau Kev Txhaj Tshuaj, Sodium Chloride rau Inhalation, Sterile Dej rau Txhaj, los yog Sterile Water for Inhalation. Cov 10% tshuaj yuav siv tau undiluted.

Mucomyst tsis muaj cov tshuaj tua kab mob, thiab yuav tsum tau saib xyuas kom txo tau cov kab mob tsis muaj menyuam. Yog hais tias tsuas yog ib feem ntawm cov tshuaj nyob rau hauv ib lub vial yog siv, khaws cov seem nyob rau hauv lub tub yees thiab siv rau inhalation tsuas yog nyob rau hauv 96 teev.

NEBULIZATION-FACE MASK, NOJ QAB, TRACHESTOMY

Thaum nebulized rau hauv lub ntsej muag lub ntsej muag, lub qhov ncauj daim, los yog tracheostomy, 1 mus rau 10 mL ntawm 20% tov los yog 2 mus rau 20 mL ntawm 10% tshuaj yuav muab txhua txhua 2 mus rau 6 teev; Cov koob tshuaj pom zoo rau cov neeg mob feem ntau yog 3 mus rau 5 mL ntawm 20% kev daws lossis 6 mus rau 10 mL ntawm 10% tshuaj 3 mus rau 4 zaug hauv ib hnub.

NEBULIZATION TENT, CROUPETTE

Nyob rau hauv cov xwm txheej tshwj xeeb nws yuav tsim nyog rau nebulize rau hauv lub tsev pheeb suab ntaub lossis Croupette, thiab txoj kev siv no yuav tsum yog tus kheej los txiav txim siab txog cov khoom siv thiab cov neeg mob cov kev xav tau tshwj xeeb. Daim ntawv no ntawm kev tswj hwm yuav tsum muaj ntau qhov kev daws teeb meem, qee zaus ntau npaum li 300 mL thaum lub sijhawm kho.

Yog tias lub tsev pheeb suab lossis Croupette yuav tsum tau siv, cov koob tshuaj pom zoo yog qhov ntim ntawm Mucomyst (siv 10% lossis 20%) uas yuav ua kom muaj huab cua hnyav heev hauv lub tsev pheeb suab lossis Croupette rau lub sijhawm xav tau. Kev tswj hwm rau ib ntus lossis ncua sij hawm ntev, suav nrog thaum tsaus ntuj, tej zaum yuav xav tau.

DIRECT INSTILLATION

Thaum siv los ntawm instillation ncaj qha, 1 mus rau 2 mL ntawm 10% mus rau 20% kev daws yuav raug muab ntau npaum li txhua teev.

Thaum siv rau kev kho mob niaj hnub ntawm cov neeg mob tracheostomy, 1 mus rau 2 mL ntawm 10% mus rau 20% kev daws yuav raug muab txhua 1 mus rau 4 teev los ntawm instillation rau hauv tracheostomy.

Mucomyst tuaj yeem qhia ncaj qha rau hauv ib ntu ntawm tsob ntoo bronchopulmonary los ntawm kev ntxig (hauv qab tshuaj loog hauv zos thiab pom kev ncaj qha) ib qho me me yas catheter rau hauv trachea. Ob mus rau 5 mL ntawm 20% kev daws yuav tom qab ntawd muab los ntawm kev siv lub koob txhaj tshuaj txuas nrog lub catheter.

Mucomyst kuj tseem tuaj yeem muab los ntawm ib qho percutaneous intracheal catheter. Ib mus rau 2 mL ntawm 20% los yog 2 mus rau 4 mL ntawm 10% tshuaj txhua 1 mus rau 4 teev yuav muab los ntawm ib tug syringe uas txuas rau lub catheter.

DIAGNOSTIC BRONCHOGRAMS

Rau kev kuaj mob bronchial kev tshawb fawb, ob mus rau peb txoj kev tswj hwm ntawm 1 mus rau 2 mL ntawm 20% tshuaj lossis 2 mus rau 4 mL ntawm 10% tshuaj yuav tsum tau muab los ntawm nebulization lossis los ntawm instillation intracheally, ua ntej cov txheej txheem.

Kev tswj hwm ntawm Aerosol

Khoom siv

Mucomyst tej zaum yuav raug siv los siv cov tshuaj pleev ib ce ua los ntawm cov yas lossis iav. Qee cov ntaub ntawv siv hauv cov khoom siv tshuaj tua kab mob ua rau acetylcysteine ​​​​. Qhov feem ntau reactive ntawm cov no yog cov hlau (tshwj xeeb yog hlau thiab tooj liab) thiab roj hmab. Qhov twg cov ntaub ntawv tuaj yeem nkag mus rau hauv cov tshuaj Mucomyst, cov khoom siv los ntawm cov khoom siv hauv qab no yuav tsum tau siv: iav, yas, aluminium, anodized aluminium, chromed hlau, tantalum, sterling nyiaj, lossis stainless hlau. Nyiaj yuav dhau los ua tarnished tom qab raug, tab sis qhov no tsis muaj teeb meem rau cov tshuaj yeeb tshuaj lossis rau tus neeg mob.

GAS NEBULIZING

Compressed tank gas (cua) los yog cua compressor yuav tsum tau siv los muab siab rau nebulizing cov tshuaj. Oxygen kuj tseem siv tau tab sis yuav tsum tau siv nrog kev ceev faj ib txwm muaj rau cov neeg mob uas muaj kab mob ua pa hnyav thiab COobkhaws cia.

APPARATUS

Mucomyst feem ntau yog tswj hwm zoo li nebulae thiab cov nebulizer siv yuav tsum muaj peev xwm muab qhov zoo tshaj plaws ntawm qhov tsim nyog ntawm qhov ntau thiab tsawg.

Cov khoom lag luam muaj nyob rau hauv cov khoom lag luam yuav tsim cov nebulae ntawm Mucomyst txaus siab rau kev khaws cia hauv cov hlab ntsws. Feem ntau ntawm cov tshuaj ntsuam xyuas nebulizers yuav muab cov kev faib ua feem ntau ntawm cov tshuaj tov raws li cov khoom ntawm tsawg dua 10 microns inch. Mitchellobtau qhia tias cov khoom tsawg dua 10 microns yuav tsum tau khaws cia rau hauv txoj kev ua pa kom txaus siab.

Ntau yam sib cuam tshuam zoo ua pa cov cuab yeej nebulized Mucomyst nrog kev ua haujlwm zoo xws li: No. 40 De Vilbiss (Lub De Vilbiss Co., Somerset, Pennsylvania) thiab Bennett Twin-Jet Nebulizer (Puritan Bennett Corp., Oak ntawm 13th, Kansas City, Missouri).

Cov tshuaj nebulized yuav nqus tau ncaj qha los ntawm nebulizer. Nebulizers kuj tseem tuaj yeem txuas rau lub ntsej muag lub ntsej muag lossis lub qhov ncauj yas. Qhov tsim nyog nebulizers kuj yuav haum rau siv nrog ntau yam sib cuam tshuam zoo siab ua pa (IPPB) tshuab. Cov khoom siv nebulizing yuav tsum tau muab ntxuav tam sim ntawd tom qab siv vim tias cov khoom seem tuaj yeem txhaws cov orifices me me lossis corrode hlau qhov chaw.

Cov qij tes tsis pom zoo rau niaj hnub siv rau nebulizing Mucomyst vim tias lawv cov zis feem ntau me dhau. Tsis tas li ntawd, qee cov tes ua haujlwm nebulizers xa cov khoom uas loj dua qhov zoo tshaj plaws rau kev nqus pa.

Mucomyst yuav tsum tsis txhob muab tso ncaj qha rau hauv lub chamber ntawm ib tug rhuab (kub lauj kaub) nebulizer.Ib tug rhuab nebulizer tej zaum yuav yog ib feem ntawm lub nebulization los ua ke los muab ib tug sov so saturated huab cua yog hais tias lub Mucomyst aerosol yog qhia los ntawm ib tug cais unheated nebulizer. Kev ceev faj ib txwm rau kev tswj hwm ntawm sov saturated nebulae yuav tsum tau ua raws.

Cov tshuaj nebulized yuav ua pa ncaj qha los ntawm nebulizer. Nebulizers kuj tseem tuaj yeem txuas nrog lub ntsej muag lub ntsej muag, lub ntsej muag lub ntsej muag, lub qhov ncauj ntawm lub qhov ncauj, cov tsev pheeb suab yas pa, lossis lub taub hau tsev pheeb suab. Qhov tsim nyog nebulizers kuj yuav haum rau siv nrog ntau yam sib cuam tshuam zoo siab ua pa (IPPB) tshuab.

Cov khoom siv nebulizing yuav tsum tau ntxuav tam sim ntawd tom qab siv, txwv tsis pub cov khoom seem yuav ua rau cov orifices zoo lossis corrode hlau qhov chaw.

NRHIAV NEBULIZATION

Thaum peb feem plaub ntawm thawj qhov ntim ntawm Mucomyst cov tshuaj tau raug muab tshuaj, ib qhov ntau ntawm Cov Dej Sterile rau Txhaj (kwv yees li qhov sib npaug ntawm qhov ntim ntawm cov tshuaj tshuav) yuav tsum tau ntxiv rau hauv nebulizer. Qhov no obviates ib qho concentration ntawm tus neeg sawv cev nyob rau hauv cov residual hnyav ntxiv tom qab ntev nebulization.

Kev sib haum xeeb

Kev sib raug zoo ntawm lub cev thiab tshuaj lom neeg ntawm Mucomyst cov kev daws teeb meem nrog qee lwm cov tshuaj uas tuaj yeem ua ke los ntawm kev siv tshuaj tua kab mob, kev sib txuas ncaj qha, lossis kev siv tshuaj pleev ib ce tau kawm.

Mucomyst yuav tsum tsis txhob tov nrog qee yam tshuaj tua kab mob. Piv txwv li, cov tshuaj tua kab mob tetracycline hydrochloride, oxytetracycline hydrochloride, thiab erythromycin lactobionate tau pom tias tsis sib haum thaum sib xyaw hauv tib cov tshuaj. Cov neeg sawv cev no yuav raug tswj hwm los ntawm cov kev daws teeb meem sib cais yog tias kev tswj hwm ntawm cov neeg ua haujlwm no xav tau.

Kev muab cov ntaub ntawv no yuav tsum tsis txhob muab txhais raws li kev pom zoo rau kev sib txuas Mucomyst nrog rau lwm yam tshuaj. Cov lus tsis tau nthuav tawm raws li kev lees paub zoo tias tsis muaj qhov tsis sib haum xeeb yuav tshwm sim, vim tias cov ntaub ntawv no tsuas yog ua raws li kev tshawb fawb txog kev sib raug zoo nyob rau lub sijhawm luv luv hauv Mead Johnson Research Center. Cov neeg tsim khoom tuaj yeem hloov lawv cov qauv, thiab qhov no tuaj yeem hloov pauv kev sib raug zoo. Cov ntaub ntawv no tsuas yog tsim los ua ib qho kev qhia rau kev kwv yees cov teeb meem sib xyaw.

Yog tias nws pom zoo kom npaj cov tshuaj sib tov, nws yuav tsum tau muab tshuaj sai li sai tau tom qab kev npaj. Tsis txhob khaws cov khoom sib tov uas tsis siv.

Hauv VITROKev sib haum xeebibKuaj ACETYLCYSTEINE
TSHUAJ TIV THAIV6
KHOOM THIAB/lossis tus neeg sawv cev Kev sib haum xeeb
RATING
ACETYL-
CYSTEINE
KHOOM
LUB SIJ HAWM
1. Qhov ntsuas,Tsis sib haum, yog raws li tsim los ntawm precipitate, hloov nyob rau hauv clarity, immiscibility, los yog ib tug sai sai poob ntawm potency ntawm acetylcysteine ​​​​los yog lub active ingredient ntawm cov khoom THIAB/los yog AGENT nyob rau hauv lub admixture.
Qhov ntsuas,Tau tshaj, txhais tau hais tias tsis muaj kev hloov pauv ntawm lub cev tseem ceeb hauv cov khoom sib xyaw thaum piv nrog kev tswj xyuas cov khoom thiab / lossis tus neeg sawv cev, thiab tsis muaj kev kwv yees tsis sib haum xeeb. Tag nrho cov admixtures tau raug sim rau lub sij hawm luv luv chemical compatibility los ntawm kev soj ntsuam rau cov concentration ntawm acetylcysteine ​​​​tom qab sib tov.
2. Cov khoom xyaw nquag hauv PRODUCT AND/OR AGENT kuj tau soj ntsuam tom qab sib tov. Qee qhov admixtures tsim cov kev hloov me me ntawm lub cev uas tau txiav txim siab tsis txaus los ntsuas qhov sib xyaw ua ke tsis sib xws. Cov no muaj nyob rau hauv cov lus hauv qab 3, 4, thiab 5.
3. Cov ntxhiab tsw muaj zog tsim tom qab cia rau 24 teev ntawm chav tsev kub.
4. Cov khoom sib xyaw ua ke yog qhov ntxoov ntxoo me ntsis ntawm cov xim daj dua li kev tswj xyuas cov khoom siv THIAB/lossis tus neeg sawv cev.
5. Ib lub teeb tan xim tsim tom qab cia rau 24 teev ntawm chav tsev kub.
6. Kev nkag yog qhov kawg siab kawg nkaus. Cov txiaj ntsig hauv kab lus hais txog qhov ntim ntawm Mucomyst cov kev daws teeb meem rau ntim cov kev daws teeb meem.
ANESTHETIC, GAS
Halothane Tau tshaj nees nkaum% Tsis kawg
Nitrous Oxide Tau tshaj nees nkaum% Tsis kawg
ANESTHETIC, LOCAL
Cocaine HCl Tau tshaj 10% 5%
Lidocaine HCl Tau tshaj 10% ob%
Tetracaine HCl Tau tshaj 10% ib%
ANTIBACTERIALS(Ib daim ntawv parenteral ntawm txhua cov tshuaj tua kab mob tau siv)
Bacitracin23(sib tov thiab siv ib zaug) Tau tshaj 10% 5,000 U / ml
Chloramphenicol Sodium Succinate Tau tshaj nees nkaum% 20 mg/ml
Carbenicillin Disodium hmoovob
(sib tov thiab siv ib zaug)
Tau tshaj 10% 125 mg/ml
Gentamicin Sulfateob Tau tshaj 10% 20 mg/ml
Kanamycin Sulfateob
(sib tov thiab siv ib zaug)
Tau tshaj 10% 167 mg/ml
Tau tshaj 17% 85 mg/ml
Lincomycin HClob Tau tshaj 10% 150 mg/ml
Neomycin Sulfateob Tau tshaj 10% 100 mg/ml
Novobiocin Sodiumob Tau tshaj 10% 25 mg/ml
Penicillin G Potassiumob Tau tshaj 10% 25,000 U / ml
(sib tov thiab siv ib zaug) Tau tshaj 10% 100,000 U / ml
Polymyxin B Sulfateob Tau tshaj 10% 50,000 U / ml
Cephalothin Sodium Tau tshaj 10% 110 mg/ml
Colistimethate Sodiumob
(sib tov thiab siv ib zaug) Tau tshaj 10% 37.5 mg/ml
Vancomycin HClob Tau tshaj 10% 25 mg/ml
Amphotericin B Tsis sib haum 4% -15% 1.0-4.0 mg/ml
Chlortetracycline HClob Tsis sib haum 10% 12.5 mg/ml
Erythromycin Lactobionate Tsis sib haum 10% 15 mg/ml
Oxytetracycline HCl Tsis sib haum 10% 12.5 mg/ml
Ampicillin Sodium hmoov Tsis sib haum 10% 50 mg/ml
Tetracycline HCl Tsis sib haum 10% 12.5 mg/ml
BRONCHODILATORS
Isoproterenol HClob Tau tshaj 3.0% 0.5%
Isoproterenol HClob Tau tshaj 10% 0.05%
Isoproterenol HClob Tau tshaj nees nkaum% 0.05%
Isoproterenol HCl Tau tshaj 13.3% (2 ntu) .33% (1 feem)
Isoetharine HCl Tau tshaj 13.3% .33% (1 feem)
Epinephrine HCl Tau tshaj 13.3% (2 ntu) .33% (1 feem)
CONTRAST Media
Iodized Roj Tsis sib haum 20% / 20 mL yog ' 40% / 10 mL yog '
DECONGESTANTS
Phenylephrine HClob Tau tshaj 3.0% .25%
Phenylephrine HCl Tau tshaj 13.3% (2 ntu) .17% (1 ntu)
ENZYMES
Chymotrypsin Tsis sib haum 5% 400 γ / mL
Trypsin Tsis sib haum 5% 400 γ / mL
SOLVENTS
Cawv Tau tshaj 12% 10% - 20%
Propylene Glycol Tau tshaj 3% 10%
STERIDS
Dexamethasone Sodium Phosphate Tau tshaj 16% 0.8 mg/ml
Prednisolone Sodium Phosphate5 Tau tshaj 16.7% 3.3 mg/ml
Lwm tus neeg sawv cev
Hydrogen Peroxide Tsis sib haum (Txhua qhov sib piv)
Sodium Bicarbonate Tau tshaj 20% (1 ntu) 4.2% (1 feem)

Mucomyst®(Acetylcysteine ​​solution, USP) Raws li Tshuaj Tiv Thaiv rau Acetaminophen Overdose

Mucomyst - Clinical Pharmacology

(Antidotal) Acetaminophen yog absorbed sai sai los ntawm lub plab hnyuv siab raum nrog cov ntshav plasma siab tshaj plaws tshwm sim ntawm 30 thiab 60 feeb tom qab noj tshuaj thiab feem ntau nyob rau hauv 4 teev tom qab noj ntau dhau. Cov niam txiv compound, uas tsis yog tshuaj lom, yog feem ntau metabolized nyob rau hauv lub siab los tsim cov sulphate thiab glucuronide conjugates uas tseem tsis muaj tshuaj lom thiab tau tawm sai sai hauv cov zis. Ib feem me me ntawm kev noj tshuaj yog metabolized nyob rau hauv daim siab los ntawm cytochrome P-450 sib xyaw ua haujlwm oxidase enzyme system los tsim ib qho reactive, muaj peev xwm toxic, nruab nrab metabolite uas nyiam conjugates nrog hepatic glutathione los tsim cov nontoxic cysteine ​​thiab mercapturic acid derivatives uas yog. ces excreted los ntawm lub raum. Kev kho cov koob tshuaj ntawm acetaminophen tsis saturate glucuronide thiab sulfate conjugation txoj hauv kev thiab tsis ua rau kev tsim cov metabolite txaus txaus kom txo cov khw muag khoom glutathione. Txawm li cas los xij, tom qab noj cov tshuaj ntau dhau (150 mg / kg lossis ntau dua) txoj hauv kev glucuronide thiab sulfate conjugation yog saturated uas ua rau feem ntau ntawm cov tshuaj tau metabolized los ntawm txoj kev P-450. Kev tsim cov metabolite ntau ntxiv tuaj yeem ua rau cov khw muag khoom hepatic ntawm glutathione nrog kev sib txuas ntawm cov metabolite rau cov protein molecules hauv cov hepatocyte uas ua rau cov cellular necrosis.

Acetylcysteine ​​​​tau pom tias txo qis ntawm daim siab raug mob tom qab acetaminophen overdose. Nws cov txiaj ntsig yog nyob ntawm kev tswj hwm qhov ncauj thaum ntxov, nrog cov txiaj ntsig pom nyob rau hauv cov neeg mob kho tsis pub dhau 16 teev ntawm kev siv tshuaj ntau dhau. Acetylcysteine ​​​​tej zaum tiv thaiv daim siab los ntawm kev tswj lossis kho cov qib glutathione, lossis los ntawm kev ua lwm yam substrate rau conjugation nrog, thiab yog li detoxification ntawm, reactive metabolite.

QHOV TSEEB

acetylcysteine ​​​​ntaus lus, tau qhia tias yog tshuaj tua kab mob los tiv thaiv lossis txo qis kev raug mob ntawm lub siab uas yuav tshwm sim tom qab noj cov tshuaj hepatotoxic ntau ntawm acetaminophen.

Nws yog ib qho tseem ceeb uas yuav tau pib kho sai li sai tau tom qab noj tshuaj ntau dhau thiab, txawm li cas los xij, hauv 24 teev tom qab noj.

Contraindications

Tsis muaj contraindications rau kev tswj qhov ncauj ntawm acetylcysteine ​​​​hauv kev kho mob ntawm acetaminophen overdose.

Ceeb toom

Generalized urticaria tau pom tsis tshua muaj nyob rau hauv cov neeg mob tau txais qhov ncauj acetylcysteine ​​​​rau acetaminophen overdose. Yog tias qhov no tshwm sim lossis lwm cov tsos mob ua xua tshwm sim, kev kho mob nrog acetylcysteine ​​​​tshuaj yuav tsum tsis txhob txuas ntxiv tshwj tsis yog tias nws yog qhov tseem ceeb thiab cov tsos mob ua xua tuaj yeem tswj tau lwm yam.

Yog hais tias encephalopathy vim lub siab tsis ua haujlwm tau tshwm sim, kev kho acetylcysteine ​​yuav tsum tsis txhob txuas ntxiv kom tsis txhob siv cov tshuaj nitrogenous ntxiv. Tsis muaj cov ntaub ntawv qhia tias acetylcysteine ​​​​ cuam tshuam rau lub siab tsis ua haujlwm, tab sis qhov no tseem muaj peev xwm ua tau.

Cov kev ceev faj

Qee zaum mob hnyav thiab ntuav ntuav tshwm sim raws li cov tsos mob ntawm tus mob acetaminophen overdose. Kev kho mob ntawm qhov ncauj acetylcysteine ​​​​ tuaj yeem ua rau ntuav. Cov neeg mob uas muaj kev pheej hmoo ntawm plab hemorrhage (piv txwv li, esophageal varices, peptic ulcers, thiab lwm yam) yuav tsum tau soj ntsuam txog kev pheej hmoo ntawm kev mob plab hnyuv siab rau qhov kev pheej hmoo ntawm kev tsim cov kab mob siab, thiab kev kho mob nrog acetylcysteine ​​​​tau muab raws li.

Dilution ntawm acetylcysteine ​​​​(saib Kev npaj Mucomyst (Acetylcysteine) rau kev tswj qhov ncauj ) txo qhov propensity ntawm qhov ncauj acetylcysteine ​​​​kom ua rau ntuav.

Kev Phem Tsis Zoo

Kev tswj hwm qhov ncauj ntawm acetylcysteine ​​​​, tshwj xeeb tshaj yog nyob rau hauv cov koob tshuaj loj uas xav tau los kho acetaminophen overdose, tuaj yeem ua rau xeev siab, ntuav thiab lwm yam tsos mob ntawm plab hnyuv. Cov pob khaus nrog lossis tsis ua npaws me me tau pom tsis tshua muaj.

Mucomyst Dosage thiab Administration

General

Txawm hais tias muaj ntau npaum li cas ntawm acetaminophen tau tshaj tawm tias tau noj, noj Mucomyst (acetylcysteine) tam sim ntawd yog tias 24 teev lossis tsawg dua tau dhau los ntawm lub sijhawm tshaj tawm ntawm kev noj tshuaj ntau dhau ntawm acetaminophen. Tsis txhob tos cov txiaj ntsig ntawm kev ntsuam xyuas rau qib acetaminophen ua ntej pib kho nrog Mucomyst. Cov txheej txheem hauv qab no raug pom zoo:

  1. Lub plab yuav tsum tau nteg tam sim ntawd los ntawm lavage los yog inducing emesis nrog phoov ntawm ipecac. Syrup ntawm ipecac yuav tsum tau muab nyob rau hauv ib koob ntawm 15 mL rau cov me nyuam mus txog rau hnub nyoog 12 thiab 30 mL rau cov hluas thiab cov neeg laus ua raws li tam sim ntawd los ntawm kev haus dej ntau ntau. Cov koob tshuaj yuav tsum rov ua dua yog tias emesis tsis tshwm sim hauv 20 feeb.

  2. Nyob rau hauv cov ntaub ntawv ntawm ib tug sib tov tshuaj overdose, activated charcoal yuav qhia tau hais tias. Txawm li cas los xij, yog tias activated charcoal tau muab tshuaj, lavage ua ntej muab kev kho mob acetylcysteine ​​​​. Activated charcoal adsorbs acetylcysteine ​​​​hauv vitrothiab tej zaum yuav ua tau li ntawd rau cov neeg mob thiab yog li ntawd yuav txo tau nws cov hauj lwm zoo.

  3. Kos ntshav rau kev kuaj ntshav acetaminophen plasma thiab cov hauv paus ntsiab lus SGOT, SGPT, bilirubin, lub sijhawm prothrombin, creatinine, BUN, ntshav qab zib thiab electrolytes.

  4. Siv cov tshuaj acetylcysteine ​​​​ntaus, 140 mg ib kg ntawm lub cev hnyav. (Npaj Mucomyst rau kev tswj hwm qhov ncauj raws li tau piav qhia hauv Cov Lus Qhia Txog Kev Noj Qab Haus Huv tshwj xeeb thiab Kev Npaj.)

  5. Txiav txim siab qhov kev txiav txim tom ntej raws li cov ntaub ntawv predetoxification plasma acetaminophen. XaivIbntawm plaub yam kev kho mob hauv qab no.

    1. Predetoxification plasma acetaminophen theem yog kom meej meej nyob rau hauv ntau yam tshuaj lom (Saib Acetaminophen Assays - Kev Txhais Lus thiab Txheej Txheem hauv qab no):

      Thawj koob tshuaj thawj zaug (70 mg / kg acetylcysteine) 4 teev tom qab noj tshuaj. Kev saib xyuas koob tshuaj yog rov ua dua ntawm 4-teev ib ntus rau tag nrho ntawm 17 koob tshuaj.

      Saib xyuas lub siab thiab lub raum ua haujlwm thiab electrolytes thoob plaws hauv cov txheej txheem detoxification.

    2. Predetoxification acetaminophen qib tsis tuaj yeem tau txais:

      Ua raws li hauv A.

    3. Predetoxification acetaminophen theem yog kom meej meej nyob rau hauv lub nontoxic ntau yam (hauv qab kab dashed ntawm lub nomogram) thiab koj paub tias acetaminophen overdose tshwm sim tsawg kawg yog 4 teev ua ntej lub predetoxification acetaminophen plasma tshuaj ntsuam xyuas:

      Tshem tawm kev tswj hwm ntawm acetylcysteine ​​​​.

    4. Predetoxification acetaminophen qib yog nyob rau hauv ntau yam tsis muaj tshuaj lom, tab sis lub sij hawm noj tsis paub los yog tsawg dua 4 teev.

      Vim tias qib ntawm acetaminophen thaum lub sij hawm ntawm qhov kev ntsuam xyuas ua ntej yuav tsis yog tus nqi siab tshaj plaws (nruab nrab yuav tsis ua tiav ua ntej 4 teev tom qab noj), tau txais qib thib ob hauv cov ntshav txhawm rau txiav txim siab seb puas yog tag nrho 17-dose detoxification. kev kho mob yog tsim nyog.

  6. Yog tias tus neeg mob ntuav ib qho koob tshuaj ntawm qhov ncauj hauv 1 teev tom qab kev tswj hwm, rov ua qhov koob tshuaj ntawd.

  7. Hauv qee lub sijhawm uas tus neeg mob pheej tsis tuaj yeem khaws cov tshuaj acetylcysteine ​​​​ntawm qhov ncauj, cov tshuaj tua kab mob tuaj yeem siv los ntawm duodenal intubation.

  8. Rov ua dua SGOT, SGPT, bilirubin, lub sijhawm prothrombin, creatinine, BUN, ntshav qab zib thiab electrolytes txhua hnub yog tias qib acetaminophen plasma nyob rau hauv qhov muaj peev xwm muaj tshuaj lom raws li tau tham hauv qab no.

Kev npaj Mucomyst (Acetylcysteine) rau kev tswj qhov ncauj

Kev tswj hwm qhov ncauj yuav tsum tau dilution ntawm 20% kev daws nrog kev noj haus cola lossis lwm yam dej qab zib, mus rau qhov kawg ntawm 5% (saib Dosage Guide thiab Kev Npaj rooj). Yog tias siv los ntawm txoj hlab plab lossis lub raj Miller-Abbott, cov dej yuav raug siv los ua cov diluent. Cov dilutions yuav tsum tau npaj tshiab thiab siv nyob rau hauv ib teev. Cov kev daws teeb meem uas tsis muaj nyob hauv cov vials qhib tuaj yeem khaws cia hauv lub tub yees txog li 96 teev.Mucomyst tsis pom zoo rau kev txhaj tshuaj rau niam txiv.

Acetaminophen Assays - Kev Txhais Lus thiab Txheej Txheem

Kev noj tshuaj acetaminophen hauv qhov ntau ntawm 150 mg / kg lossis ntau dua tuaj yeem ua rau mob siab rau lub siab. Txawm li cas los xij, cov ntaub ntawv keeb kwm qhia txog qhov ntau ntawm cov tshuaj noj raws li kev noj tshuaj ntau dhau yog feem ntau tsis raug thiab tsis yog cov lus qhia txhim khu kev qha rau kev kho cov tshuaj overdose.Yog li ntawd, cov ntshav plasma los yog cov tshuaj acetaminophen concentRATIONS, txiav txim siab thaum ntxov raws li muaj peev xwm, tab sis tsis sai li sai tau tshaj 4 teev tom qab ib tug mob overdoSE, yog ib qho tseem ceeb ntawm kev ntsuam xyuas lub peev xwm ntawm POTENTIAL RI. Yog tias qhov kev ntsuam xyuas rau ACETAMINOPEN tsis tuaj yeem tau txais, nws yog qhov tsim nyog los xav tias qhov ntau dhau yog qhov muaj peev xwm ua rau muaj kuab lom.

Kev txhais lus ntawm ACETAMINOPEN ASSAYS
  1. Thaum cov txiaj ntsig ntawm plasma acetaminophen assay muaj, xa mus rau cov nomogram hauv qab no los txiav txim siab seb cov ntshav plasma concentration yog nyob rau hauv qhov muaj feem cuam tshuam. Cov txiaj ntsig saum toj no cov kab sib txuas 200 µg / mL ntawm 4 teev nrog 50 µg / mL ntawm 12 teev yog cuam tshuam nrog kev muaj peev xwm ua rau mob siab yog tias tsis siv tshuaj tua kab mob. (Tsis txhob tos rau qhov kev ntsuam xyuas kom pib kho acetylcysteine ​​.)
  2. Yog tias qib predetoxification plasma siab dua cov kab tawg txuas ntxiv nrog kev saib xyuas koob tshuaj acetylcysteine ​​​​. Nws yog qhov zoo dua rau kev ua yuam kev ntawm kev nyab xeeb thiab yog li cov kab tawg tau muab tso rau 25% hauv qab cov kab khoom uas txhais tau tias muaj peev xwm toxicity.
  3. Yog tias qib predetoxification plasma qis dua cov kab tawg uas tau piav qhia saum toj no, muaj kev pheej hmoo tsawg kawg ntawm kev mob siab rau lub siab thiab kev kho acetylcysteine ​​​​tuaj yeem raug txiav.
ACETAMINOPHEN ASSAY METHODOLOGY

Cov txheej txheem soj ntsuam zoo tshaj plaws rau kev txiav txim siab acetaminophen concentrations siv lub siab siab ua kua chromatography (HPLC) lossis roj chromatography (GLC). Qhov kev ntsuam xyuas yuav tsum ntsuas tsuas yog niam txiv acetaminophen thiab tsis sib txuas. Cov txheej txheem ntsuam xyuas tau teev tseg hauv qab no ua raws li qhov yuav tsum tau ua:

TSEEM CEEB TECHNIQUES (NONINCLUSIVE)

HPLC:

ib.
Blair D, Rumack BH. Clin Chem. Xyoo 1977; 23(4): 743-745.
ob.
Howie D, Andriaenssens Pl, Prescott LF. J Pharm Pharmacol 1977; 29 (4): 235-237.

GLC

3.
Prescott LF. J Pharm Pharmacol 1971; 23(10): 807-808.

Xim xim

Plaub.
Glynn JP, Kendal SE. Lancet 1975; 1 (Tsib Hlis 17): 1147-1148.

Txhawb Kev Kho Mob ntawm Acetaminophen Overdose

  1. Khaws cov kua thiab electrolyte tshuav raws li kev soj ntsuam kev soj ntsuam ntawm lub xeev ntawm hydration thiab cov ntshav electrolytes.
  2. Kho raws li qhov tsim nyog rau hypoglycemia.
  3. Siv cov vitamin KibYog hais tias lub sij hawm prothrombin ntau tshaj 1.5 los yog tshiab khov plasma yog tias lub sij hawm prothrombin piv tshaj 3.0.
  4. Diuretics thiab yuam diuresis yuav tsum zam.

KEV PAB CUAM THIAB KEV PAB CUAM

Cov koob tshuaj cuam tshuam rau lub cev hnyav yog:

Loading Dose of Mucomyst® (acetylcysteine ​​​)
Lub cev hnyav grams
Acetylcysteine ​​​​
ml ntawm 20%
Mucomyst
mL ua
Diluent
Total mL os
5% Kev daws teeb meem
(kg) (lb)
100-109 : kuv 220-240 : kuv kaum tsib 75 225 300
90-99 : kuv 198-218 : kuv 14 70 210 280
80-89 : kuv 176-196 : kuv 13 65 195 260
70-79 ib 154-174 : kuv kaum ib 55 165 220
60-69 ib 132-152 : kuv 10 tsib caug 150 200
50-59 : kuv 110-130 : kuv 8 40 120 160
40-49 : kuv 88-108 : kuv 7 35 105 140
30-39 : kuv 66-86 : kuv 6 30 90 120
20-29 44-64 : kuv 4 nees nkaum 60 80
Kho koob tshuaj**
** Yog tias tus neeg mob hnyav dua 20 kg (feem ntau yog cov neeg mob qis dua 6 xyoo), suav cov koob tshuaj Mucomyst. Txhua mL ntawm 20% Mucomyst muaj 200 mg ntawm acetylcysteine ​​​​. Kev thauj khoom noj yog 140 mg rau ib kg ntawm lub cev hnyav. Kev saib xyuas koob tshuaj yog 70 mg / kg. Peb (3) mL ntawm diluent ntxiv rau txhua mL ntawm 20% Mucomyst. Tsis txhob txo qhov kev faib ua feem ntawm diluent.
Lub cev hnyav grams
Acetylcysteine ​​​​
ml ntawm 20%
Mucomyst
mL ua
Diluent
Total mL os
5% Kev daws teeb meem
(kg) (lb)
100-109 : kuv 220-240 : kuv 7.5 37 113 150
90-99 : kuv 198-218 : kuv 7 35 105 140
80-89 : kuv 176-196 : kuv 6.5 33 97 ib 130
70-79 ib 154-174 : kuv 5.5 28 82 110
60-69 ib 132-152 : kuv 5 25 75 100
50-59 : kuv 110-130 : kuv 4 nees nkaum 60 80
40-49 : kuv 88-108 : kuv 3.5 18 52 70
30-39 : kuv 66-86 : kuv 3 kaum tsib Plaub. Tsib 60
20-29 44-64 : kuv ob 10 30 40
Kev kwv yees muaj peev xwm rau Hepatoxicity

Cov nomogram hauv qab no tau tsim los kwv yees qhov tshwm sim uas cov ntshav plasma cuam tshuam nrog lub sijhawm tom qab noj mov yuav ua rau hepatoxocity.

Hloov los ntawm Rumack thiab Matthews, Pediatrics 1975; 55: 871-876.

Yuav ua li cas yog Mucomyst Supplied

Mucomyst muaj nyob rau hauv roj hmab stoppered iav vials uas muaj 4, 10, los yog 30 mL. Cov tshuaj 20% yuav raug diluted kom tsawg dua nrog Sodium Chloride rau Txhaj Tshuaj, Sodium Chloride rau Inhalation, Sterile Dej rau Txhaj, lossis Sterile Water for Inhalation. Cov 10% tshuaj yuav siv tau undiluted.

Mucomyst (acetylcysteine) yog tsis muaj menyuam, tsis yog txhaj tshuaj thiab siv tau rau kev nqus pa (mucolytic agent) lossis kev tswj qhov ncauj (acetaminophen antidote). Nws muaj xws li:

Mucomyst®- nees nkaum: 20% tshuaj acetylcysteine ​​​​(200 mg acetylcysteine ​​ib mL).

NDC 0087-0570-03 Cartons ntawm peb 10 mL vials, 1 yas dropper
NDC 0087-0570-09 Cartons ntawm peb 30 mL vials
NDC 0087-0570-07 Cartons ntawm kaum ob 4 mL vials

Mucomyst®-10: 10% tshuaj acetylcysteine ​​​​(100 mg acetylcysteine ​​ib mL).

NDC 0087-0572-01 Cartons ntawm peb 10 mL vials, 1 yas dropper
NDC 0087-0572-02 Cartons ntawm peb 30 mL vials
NDC 0087-0572-03 Cartons ntawm kaum ob 4 mL vials

Cia

Khaws cov vials uas tsis tau qhib ntawm qhov chaw tswj qhov kub thiab txias, 59 ° txog 86 ° F (15 ° txog 30 ° C).

Mucomyst tsis muaj cov tshuaj tua kab mob, thiab yuav tsum tau saib xyuas kom txo tau cov kab mob tsis muaj menyuam. Dilutions ntawm Mucomyst yuav tsum tau siv tshiab npaj thiab siv nyob rau hauv ib teev. Yog hais tias tsuas yog ib feem ntawm cov tshuaj nyob rau hauv ib lub vial yog siv, khaws cov seem uas tsis tau muab tso rau hauv lub tub yees thiab siv li ntawm 96 teev.

REFERENCES

  1. Bonanomi L, Gazzaniga A. Toxicological, pharmacokinetic thiab metabolic kev tshawb fawb ntawm acetylcysteine ​​​​.Eur J Respir DisXyoo 1981; 61 (suppl III): 45-51.
  2. Am Rev Respir DisXyoo 1960; 82: 627-639.

APOTHECON®
Tsim los ntawm Bristol-Myers Squibb Company
Princeton, NJ 08543 USA
Tshaj tawm los ntawm Geneva Pharmaceuticals, Inc.
Dayton, NJ 08810, USA

1081063A 1
057 TSI-02
Lub Ib Hlis 2001

Mucomyst
Cov tshuaj acetylcysteine ​​​​
Cov ntaub ntawv khoom
Yam khoom HUMAN PRESCRIPTION DRUG LABEL Yam khoom Code (Source) NDC: 0087-0570
Txoj kev tswj hwm KEV PAB CUAM (INHALATION), ORAL DEA Teem caij
Cov khoom xyaw nquag / Active Moiety
Cov khoom xyaw npe Lub hauv paus muaj zog Lub zog
acetylcysteine ​​​ (acetylcysteine) acetylcysteine ​​​ 200 mg hauv 1 mL
Cov khoom xyaw uas tsis muaj zog
Cov khoom xyaw npe Lub zog
tshem tawm disodium
sodium hydroxide
dej
Ntim
# Yam khoom Code Pob piav qhia
ib NDC: 0087-0570-03 3 VIAL, GLASS (3 VIAL) hauv 1 CARTON
ib 10 mL (10 MILLITER) hauv 1 VIAL, GLASS
ob NDC: 0087-0570-09 3 VIAL, GLASS (3 VIAL) hauv 1 CARTON
ob 30 mL (30 MILLITER) hauv 1 VIAL, GLASS
3 NDC: 0087-0570-07 12 VIAL, GLASS (12 VIAL) hauv 1 CARTON
3 4 mL (4 MILLITER) hauv 1 VIAL, GLASS
Mucomyst
Cov tshuaj acetylcysteine ​​​​
Cov ntaub ntawv khoom
Yam khoom HUMAN PRESCRIPTION DRUG LABEL Yam khoom Code (Source) NDC: 0087-0572
Txoj kev tswj hwm KEV PAB CUAM (INHALATION), ORAL DEA Teem caij
Cov khoom xyaw nquag / Active Moiety
Cov khoom xyaw npe Lub hauv paus muaj zog Lub zog
acetylcysteine ​​​ (acetylcysteine) acetylcysteine ​​​ 100 mg hauv 1 mL
Cov khoom xyaw uas tsis muaj zog
Cov khoom xyaw npe Lub zog
tshem tawm disodium
sodium hydroxide
dej
Ntim
# Yam khoom Code Pob piav qhia
ib NDC: 0087-0572-01 3 VIAL, GLASS (3 VIAL) hauv 1 CARTON
ib 10 mL (10 MILLITER) hauv 1 VIAL, GLASS
ob NDC: 0087-0572-02 3 VIAL, GLASS (3 VIAL) hauv 1 CARTON
ob 30 mL (30 MILLITER) hauv 1 VIAL, GLASS
3 NDC: 0087-0572-03 12 VIAL, GLASS (12 VIAL) hauv 1 CARTON
3 4 mL (4 MILLITER) hauv 1 VIAL, GLASS
Labeler -Bristol-Myers Squibb
Bristol-Myers Squibb