Nattokinase

Hom Lub Npe: Flite Tabs, Natto-K, Natto, NattoMax, Ntuj Super Kinase - Spray Dried (NSK-SD), Vein Caps, Cardiokinase, fermented soybeans, Nattokinase, Subtilisin NAT, Subtilisin natto

Clinical Overview

Siv

Nattokinase yog txhawb rau kev siv los ua tus neeg sawv cev fibrinolytic; Txawm li cas los xij, kev sim tshuaj tam sim no tsis muaj los txhawb qhov kev siv no. Tsis muaj cov pov thawj tseem ceeb uas nattokinase txo cov ntshav siab hauv cov ntshav siab. Nattokinase tau siv nrog pycnogenol rau kev tiv thaiv ntawm cov hlab ntsha sib sib zog nqus thrombosis (DVT) hauv kev ya dav hlau ntev.



Dosing

Kev tshawb fawb soj ntsuam los qhia kev nyab xeeb thiab siv tau zoo yog tsis muaj. Nattokinase 100 mg (sib npaug rau 2,000 fibrin units [FU]) noj txog 3 zaug hauv ib hnub, tau siv hauv qee qhov kev tshawb fawb.

Contraindications

Tsis txhob noj nattokinase hauv cov neeg mob uas muaj ischemic stroke, peptic ulcer, thiab coagulation disorders, nrog rau ua ntej thiab tom qab phais.

Cev xeeb tub/Lactation

Cov ntaub ntawv hais txog kev nyab xeeb thiab kev ua tau zoo hauv cev xeeb tub thiab lactation tsis muaj.

Kev sib tham

Nattokinase muaj cov tshuaj pharmacological uas tuaj yeem ua rau muaj kev pheej hmoo los ntshav nrog cov tshuaj anticoagulants thiab cov tshuaj tiv thaiv kab mob. High concentration ntawm vitamin Kobhauv natto tuaj yeem txo qhov kev sib piv thoob ntiaj teb normalized (INR) nrog warfarin; Qhov no kuj yuav tshwm sim nrog cov tshuaj nattokinase yog vitamin Kobtsis raug tshem tawm thaum lub sij hawm tsim khoom.

Kev Phem Tsis Zoo

Cov kev sim me me luv luv ntsuas cov txiaj ntsig ntawm nattokinase qhia tsis muaj kev phiv tshuaj. Muaj qhov kev pheej hmoo ntawm kev los ntshav, raws li cov ntaub ntawv qhia txog kev mob plab cerebellar hemorrhage hauv tus neeg mob uas muaj keeb kwm ntawm ischemic stroke. Thrombosis tau tshaj tawm tom qab hloov pauv ntawm nattokinase rau warfarin hauv tus neeg mob nrog lub tshuab aortic valve. Tsis tshua muaj tshwm sim ntawm lig-pib anaphylaxis nrog natto tau raug ntaus nqi rau poly (gamma-glutamic acid), ib yam khoom ntawm cov txheej txheem fermentation uas tej zaum yuav muaj nyob rau hauv cov tshuaj nattokinase.

Kuv puas tuaj yeem siv tylenol nrog diclofenac?

Toxicology

Nattokinase yog nonmutagenic hauv Ames kuaj thiab kev tshawb fawb ntawm tes-based chromosomal aberration hauv cov chaw tsim khoom. Qhov nruab nrab tus neeg tuag koob tshuaj (LDtsib caug) hauv kev tshawb fawb nas yog ntau tshaj 1,000 mg / kg.

Qhov chaw

Nattokinase yog ib qho fibrinolytic enzyme pom nyob rau hauv natto, ib txwm Japanese zaub mov. Nws yog tsim los ntawm Bacillus subtilis (tseem hu ua Bacillus natto los yog Bacillus subtilis natto) thaum lub sij hawm fermentation txheej txheem uas tig boiled soybeans rau natto. Cov enzymes fibrinolytic zoo sib xws muaj nyob hauv lwm cov khoom noj fermented, suav nrog chungkook-jang hauv Kaus Lim Kauslim, douchi hauv Suav teb, thua nao hauv Thaib teb, thiab tempeh hauv Indonesia. ib , ob Fermentation technology yog siv los tsim cov tshuaj nattokinase uas tau tsim ua hmoov, tshuaj, thiab tshuaj ntsiav, ib leeg lossis nrog lwm cov khoom xyaw. ob , 3

Keeb kwm

Lub fermentation ntawm soybeans yog ib txwm siv rau cov neeg Esxias thiab African ua noj ua haus. Natto yog cov zaub mov Japanese uas tau noj tsawg kawg 1,000 xyoo. Nws feem ntau yog noj tshais nrog mov, ntawm toast, lossis ua sushi; nws kuj muaj raws li ice cream tsw. Kev lig kev cai, nws tau raug siv rau lub plawv mob, txo kev qaug zog, thiab ua ib tus neeg sawv cev antiberiberi. Nyob rau xyoo 1980, cov kws tshawb fawb tshawb nrhiav cov khoom noj rau cov khoom thrombolytic cais cov enzyme nattokinase los ntawm natto. ib , 3 , 4 Thawj cov khoom lag luam nattokinase tau muag hauv Nyiv xyoo 1998. 5 Txawm hais tias nws tau raug muag raws li kev noj zaub mov ntxiv hauv ntau qhov chaw hauv ntiaj teb txij li lub sijhawm ntawd, xyoo 2012, Health Canada tau txiav txim siab tias kev txhawj xeeb txog kev nyab xeeb, suav nrog qhov muaj peev xwm los ntshav ntau ntxiv, tsis tau hais kom tsim nyog rau kev lag luam ntawm nattokinase. 6 Ib daim ntawv thov raug foob hauv European Union rau kev pom zoo ntawm nattokinase ua zaub mov tshiab. 7 Nattokinase tam sim no tsis muaj feem ntau lees paub tias muaj kev nyab xeeb (GRAS) nrog US Food and Drug Administration.

Chemistry

Natto muaj tus yam ntxwv tsis hnov ​​tsw (tejzaum yog vim nws cov ntsiab lus pyrazine), muaj cov tsw, thiab tau piav qhia qhov tsw, thiab tau piav qhia tias yog 'zaub mov cheese' vim nws muaj xwm txheej. Txawm hais tias lub npe txhais tau hais tias nws yog kinase, nattokinase yog ib qho alkaline serine protease nrog cov amino acid ib ntus zoo ib yam li subtilisin, uas yog siv rau hauv cov ntxhua khaub ncaws ntxhua khaub ncaws. Nws muaj 275 amino acids thiab muaj qhov hnyav molecular ntawm 27.7 kDa. ob Lub enzyme catalyzes lub cleavage ntawm cov proteins rau polypeptides thiab muaj siab substrate tshwj xeeb rau fibrin, nrog ntau yam fibrinolytic kev ua ntawm ib tug pH ntau ntawm 6 mus rau 12. ob Kev ua haujlwm proteolytic ntawm nattokinase yog ntsuas hauv fibrin units (FU). 8 Ib 50 g ntawm natto muab 1,500 FU ntawm nattokinase. Cov enzyme tuaj yeem tiv taus qhov kub txog li 50 ° C thiab rov ua kom khov thiab thawing, tab sis nws tsis ua haujlwm hauv acidic. Microencapsulated thiab enteric-coated formulations tau tsim los txo qis degradation ntawm nattokinase los ntawm gastric acid. ob

B. subtilis kuj tsim thiab secretes vitamin Kob(menaquinone-7), bacillopeptidase F (lwm lub fibrinolytic enzyme marketed raws li kev noj haus ntxiv), thiab lwm yam proteolytic enzymes thaum lub sij hawm natto fermentation txheej txheem. 9 , 10 Vitamin Kobtej zaum yuav raug tshem tawm ntawm cov tshuaj nattokinase hauv kev tsim khoom. Cov txheej txheem tau piav qhia txhawm rau txhim kho kev tsim cov enzyme, tshem tawm cov vitamin Kob, thiab tshem tawm cov yam ntxwv natto tsw los ntawm cov khoom nattokinase. 3 , 4 , kaum ib , 12 , 13 , 14 , kaum tsib

lub sijhawm nrog nuvaring tseem nyob hauv

Pharmacokinetics

Ib txoj kev tshawb fawb ib zaug tshuaj ntsuam xyuas cov tshuaj pharmacokinetics ntawm qhov ncauj nattokinase hauv 11 tus neeg tuaj yeem noj qab haus huv. 16 Peak ntshav concentrations tau mus txog ntawm 13.3 ± 2.5 teev tom qab koob tshuaj 2,000 FU. Vim hais tias nattokinase tau kuaj pom nyob rau hauv cov ntshav nrog ib qho enzyme-txuas immunosorbent assay siv cov tshuaj tiv thaiv polyclonal uas cuam tshuam nrog ob qho tib si nattokinase thiab metabolites, nws tsis paub meej tias nattokinase kuaj pom hauv qhov kev tshawb fawb no puas muaj roj ntsha.

Siv thiab Pharmacology

Fibrinolysis thiab thrombolysis

Hauv vitro / tsiaj tshawb fawb

Qhov kev ua ntawm fibrinolytic ntawm nattokinase tau kawm ntau hauv kev tshawb fawb hauv vitro. Tsis zoo li streptokinase, nattokinase tsis ua ncaj qha rau plasminogen. Cov enzyme zoo nkaus li tshem tawm plasminogen activator inhibitor hom 1, yog li ua kom cov haujlwm ntawm cov ntaub so ntswg plasminogen activator thiab txhawb kev hloov pauv ntawm plasminogen mus rau plasmin, nrog rau kev nce hauv cov ntshav txhaws. Nattokinase tseem ua ncaj qha rau ntawm thrombi los ntawm lysing crosslinked fibrin. Qhov kev txiav txim fibrinolytic ntawm nattokinase tau tshaj tawm 4 npaug ntawm plasmin. Siv tib neeg cov ntshav tawm mus rau nattokinase, koob tshuaj-dependant txo qis hauv cov ntshav liab sib sau ua ke thiab qis-shear viscosity kuj tau pom. 3 , 4 , 17 , 18 , 19

Nattokinase tau absorbed thoob cov hnyuv. Cov kev ua haujlwm fibrinolytic thiab thrombolytic ntawm nattokinase tau raug soj ntsuam hauv cov tsiaj sim uas ua rau thrombi thiab endothelial raug mob hauv cov hlab ntsha femoral thiab cov hlab ntsha carotid hauv cov nas. Kev noj zaub mov ntxiv nrog nattokinase suppressed intimal thickening, modulated lysis ntawm mural thrombi, thiab txhim kho arterial ntshav txaus zoo dua plasmin thiab elastase. Hauv cov dev, kev tswj hwm qhov ncauj ntawm nattokinase tau ua tiav tag nrho cov ntshav txhaws los ntawm cov leeg ceg loj hauv 5 teev ntawm kev tswj hwm, thaum cov hlab ntsha hauv cov dev tau txais cov placebo tsis pom muaj thrombolysis txog 18 teev. 17 , nees nkaum , nees nkaum ib , 22 , 23 Ob txoj kev tshawb fawb soj ntsuam nattokinase nyob rau hauv tus qauv nas ntawm qhov mob thrombosis siv cov tshuaj carrageenan. Hauv thawj txoj kev tshawb fawb, kev txhaj tshuaj ntawm nattokinase rau hauv nas tails ua ntej thrombosis txo qhov ntev ntawm tus Tsov tus tw thrombosis los ntawm kwv yees li 15%. 24 Hauv kev tshawb fawb thib ob, thaj tsam ntawm thrombosis raug txo los ntawm kev tswj hwm ntawm nattokinase tom qab thrombosis. 25 Cov kev tshawb fawb no qhia tias nattokinase cuam tshuam rau kev tsim cov hlab ntsha thiab kev daws teeb meem.

Cov ntaub ntawv kho mob

Kev sim tshuaj tsawg tsawg tsis tau ua tiav cov txiaj ntsig tau hais txog kev ua tau zoo ntawm nattokinase raws li fibrinolytic. 4 , 26 Ib qhov kev sim tshuaj ntsuam xyuas cov txiaj ntsig ntawm kev noj txhua hnub ntawm nattokinase ntawm cov ntsuas hematological ntawm 12 tus neeg ua haujlwm noj qab haus huv Nyij Pooj thiab pom tias muaj kev ua kom muaj zog fibrinolytic. Ib qho kev nce ntxiv hauv euglobulin fibrinolytic kev ua si, nce hauv cov khoom lag luam fibrin degradation, thiab nce hauv cov ntaub so ntswg plasminogen activator tau sau tseg. Cov ntaub ntawv rau txhua yam kev kawm tsis tau luam tawm. 4 , 17 Kev sim qhib-daim ntawv tshuaj ntsuam xyuas cov txiaj ntsig ntawm kev tswj hwm nattokinase tshaj li 2 lub hlis ntawm cov neeg ua haujlwm noj qab haus huv, nrog rau cov neeg mob uas muaj kev pheej hmoo ntawm cov hlab plawv thiab cov neeg mob ntawm kev lim ntshav. Kev txo qis hauv plasma fibrinogen thiab coagulation yam VII thiab VIII tau pom nyob rau lub sijhawm hauv txhua pab pawg; txawm li cas los xij, tsis muaj kev cuam tshuam pab pawg. Tus qauv loj (N = 45) yog qhov me me dhau los ua qhov kev txiav txim siab ruaj khov los ntawm kev kawm. 27 Lwm qhov kev sim tshuaj ntsuam xyuas qhov kev tiv thaiv ntawm nattokinase hauv cov ntsiab lus uas muaj kev pheej hmoo ntawm DVT thaum lub dav hlau ntev. Nattokinase, nyob rau hauv ib koob tshuaj uas tsis tau teev ua ke nrog pycnogenol, noj 2 teev ua ntej thiab 6 teev rau hauv lub davhlau tau tshaj tawm los txo cov xwm txheej thrombotic, raws li kev txiav txim los ntawm ultrasounds ntawm lub venous system. Cov qhab nia edema kuj raug txo, tej zaum vim yog cov nyhuv diuretic ntawm pycnogenol. Txawm li cas los xij, kev txiav txim siab txog kev ua haujlwm fibrinolytic ntawm nattokinase tsis tuaj yeem rub los ntawm txoj kev tshawb no vim tias nws tau soj ntsuam cov khoom uas muaj ob qho tib si nattokinase thiab pycnogenol. 4 , 28

Ntshav siab

Hauv vitro / tsiaj tshawb fawb

Angiotensin-hloov enzyme (ACE) tau inhibited los ntawm nattokinase hauv kev tshawb fawb hauv vitro. 29 ACE inhibition tshwm sim los ntawm kev sib kho los ntawm nattokinase peptide fragments thiab tsis muaj feem xyuam rau cov kev ua haujlwm proteolytic ntawm nattokinase tsis zoo.

Ib txoj kev tshawb fawb nyob rau hauv spontaneously hypertensive nas ntsuam xyuas lub antihypertensive mechanism ntawm kev txiav txim ntawm tsis zoo nattokinase thiab nattokinase peptide fragments. 30 Txawm hais tias ob qho tib si cov enzymes tsis zoo thiab cov khoom tawg tau txo cov ntshav siab, tsuas yog cov tsis zoo nattokinase txo cov ntshav plasma fibrinogen. Qhov tsis zoo nattokinase tsis muaj kev cuam tshuam rau renin-angiotensin system. Cov nattokinase peptide fragments txo plasma angiotensin II tab sis tsis muaj kev cuam tshuam rau renin lossis ACE kev ua haujlwm. Cov kws sau ntawv hais tias cov kev ua haujlwm fibrinolytic ntawm qhov tsis zoo nattokinase txo cov ntshav siab los ntawm kev txo cov ntshav viscosity; Txawm li cas los xij, cov txheej txheem ntawm nattokinase peptide fragments tsis meej. Hauv kev tshawb fawb thib ob, natto hmoov uas muaj gamma-aminobutyric acid thiab nattokinase txo cov ntshav siab hauv cov nas uas muaj ntshav siab, tab sis tsis nyob hauv cov nas uas muaj ntshav siab. 31 Captopril txo cov ntshav siab ntau dua li natto hmoov.

Cov ntaub ntawv kho mob

Ob qhov muag tsis pom kev, randomized soj ntsuam kev sim tsim los soj ntsuam cov nyhuv hypotensive ntawm nattokinase (N = 86) pom qhov txo qis hauv systolic thiab diastolic ntshav siab ntawm 8 lub lis piam, tab sis tsis yog ntawm 4 lub lis piam, ntawm kev tswj hwm nattokinase txhua hnub. Txoj kev tshawb no tau tso npe rau cov neeg mob prehypertension lossis kub siab me me nrog qhov ntsuas ntshav siab ntawm kwv yees li 145/95 mm Hg ntawm lub hauv paus. Cov txiaj ntsig tsis sib haum xeeb tau txais rau cov txiaj ntsig ntawm plasma renin. 32 Ib txoj kev tshawb nrhiav ob qhov muag tsis pom kev sib piv cov txiaj ntsig ntawm nattokinase thiab bacillopeptidase F ntawm cov ntshav siab hauv 20 cov neeg mob uas hu ua 'lifestyle' kab mob, suav nrog ntshav siab, hyperlipidemia, thiab hom 2 mob ntshav qab zib. 10 Txoj kev tshawb no qhia tias ntshav siab poob qis tom qab kev kho mob nrog bacillopeptidase F tab sis tsis yog tom qab kev kho nattokinase. Qhov tseem ceeb ntawm kev kho mob ntawm cov txiaj ntsig no tsis meej vim tias cov neeg mob tsis muaj ntshav siab ntawm qhov pib. Tsis muaj cov nyhuv hypotensive tau pom nyob rau hauv kev tshawb fawb soj ntsuam cov nyhuv fibrinolytic ntawm nattokinase 27 los yog hauv lwm txoj kev tshawb fawb ntsuas qhov cuam tshuam ntawm lipid profile. 33

Lwm yam kev siv

Amyloid plaque

Hauv kev tshawb fawb hauv vitro, nattokinase degraded amyloid fibrils, qhia txog lub luag haujlwm tseem ceeb hauv kev kho cov kab mob amyloid xws li Alzheimer kab mob. 3. 4 Hauv kev tshawb nrhiav nas, nattokinase nce kev qhia ntawm cov noob rau ADAM10, cov protein uas txo cov teebmeem ntawm amyloid precursor protein. 35 Hauv txoj kev xav, nce ADAM10 kev ua haujlwm yuav muaj lub luag haujlwm yav tom ntej hauv kev tswj hwm tus kab mob Alzheimer.

Antiplatelet kev ua haujlwm

Ex vivo cov kev tshawb fawb qhia tias nattokinase tuaj yeem muaj kev ua haujlwm antiplatelet. Nattokinase inhibited collagen- thiab thrombin-induced platelet aggregation hauv kev tshawb fawb siv luav platelets. 36 Nattokinase tshwm sim inhibit thromboxane Aobtsim los ntawm activated platelets. Hauv lwm txoj kev tshawb fawb, nattokinase nce cyclic adenosine monophosphate hauv nas platelets, uas inhibits platelet aggregation. 37 Hauv tib neeg platelets, nattokinase tau tshwm sim los cuam tshuam kev txav ntawm cov khw muag khoom calcium hauv platelets hauv cov lus teb rau platelet activation los ntawm thrombin.

Dyslipidemia

Ob qhov muag tsis pom kev, randomized soj ntsuam sim tsim los soj ntsuam cov nyhuv ntawm nattokinase hauv hyperlipidemia pom kev hloov pauv hauv triglycerides thiab high-density lipoprotein los ntawm lub hauv paus, tab sis tsis muaj qhov sib txawv piv nrog cov placebo tuaj yeem pom tau. 33 Hauv kev tshawb fawb soj ntsuam cov nyhuv fibrinolytic ntawm nattokinase, tsis pom muaj qhov cuam tshuam rau lipid profile. 27 Hauv kev sib piv kev sib piv nrog bacillopeptidase F, 4 lub lis piam ntawm kev kho mob nrog nattokinase tsis muaj kev cuam tshuam rau lipid profile. 10

tshuaj rau mob raum

Vitreolysis

Hauv kev sim ua hauv luav, intravitreal nattokinase induced posterior vitreous detachment ntawm hydrolysis ntawm collagen fibers; Txawm li cas los xij, kev tshawb fawb hauv kev kho mob hauv tib neeg los ua lwm txoj hauv kev phais tsis muaj. 38

Dosing

Kev tshawb fawb soj ntsuam los qhia kev nyab xeeb thiab siv tau zoo yog tsis muaj. Nattokinase 100 mg (sib npaug rau 2,000 FU) noj 3 zaug hauv ib hnub, tau siv hauv qee qhov kev tshawb fawb. 17 , 27 , 32

Cev xeeb tub / lactation

Cov ntaub ntawv hais txog kev nyab xeeb thiab kev ua tau zoo hauv cev xeeb tub thiab lactation tsis muaj.

Kev sib tham

Cov tshuaj antithrombotic, fibrinolytic, thiab antiplatelet kev ua haujlwm tau pom nrog nattokinase hauv vitro thiab tsiaj kev tshawb fawb ua rau muaj kev txhawj xeeb tias nws yuav ua rau muaj kev pheej hmoo los ntshav thaum noj tshuaj anticoagulants thiab cov tshuaj antiplatelet. nees nkaum , 25 , 37 Hauv ib txoj kev tshawb fawb tsis tau tshaj tawm, 12 tus neeg mob tau pw hauv tsev kho mob rau ischemic stroke uas tau txais heparin thiab cov tshuaj aspirin qis lossis clopidogrel kuj tau txais nattokinase 6,000 FU / hnub rau 7 hnub. 7 , 8 Coadministration ntawm nattokinase tau tshaj tawm tias lub sij hawm los ntshav thiab lub sij hawm txhaws thiab txo lub sij hawm prothrombin, lub sij hawm thromboplastin, thiab D-dimer qib. Peb qhov kev tshwm sim tsis zoo ib ntus tau tshaj tawm. Hauv lwm txoj kev tshawb fawb tsis tau tshaj tawm, nattokinase 1,700 FU txhua hnub tau muab rau 30 tus neeg mob kho nrog warfarin rau 26 lub lis piam. 7 , 8 Coadministration ntawm nattokinase tau tshaj tawm tias ruaj khov INRs, tab sis cov ntsiab lus tsis txaus rau kev ntsuam xyuas.

Cov neeg mob kho nrog warfarin yuav tsum tsis txhob noj natto vim tias nws tuaj yeem txo INR. 9 , 39 Muaj ntau thiab txhawb nqa nce hauv cov ntshav vitamin Kobyog ntaus nqi rau siab concentrations ntawm vitamin nyob rau hauv natto thiab ntev ib nrab-lub neej ntawm vitamin K.ob. Tsis tas li ntawd, noj B. subtilis tuaj yeem tsim cov vitamin Kobnyob rau hauv plab mus txog rau ib lub lim tiam tom qab noj natto. Ntxuav thiab boil natto ua ntej noj mov yuav tiv thaiv kom tsis txhob muaj cov vitamin Kobntshav concentrations, nrog rau txo B. subtilis rov qab los ntawm quav. 40 Vitamin Kobraug tshem tawm ntawm qee cov tshuaj nattokinase kom tshem tawm qhov kev txhawj xeeb no.

Kev Phem Tsis Zoo

Kev sim tshuaj ntsuam xyuas cov txiaj ntsig ntawm nattokinase uas qhia tias tsis muaj kev cuam tshuam tsis zoo rau cov neeg mob tsawg txog li 7 lub hlis. 6 , 10 , 17 , 27 , 28 , 32 , 39 Hauv kev sim 4-lub lim tiam, nattokinase tsis muaj txiaj ntsig zoo rau kev kuaj ntshav rau hematologic, lub raum, thiab lub siab ua haujlwm. Kev nce me me hauv hematocrit, platelet suav, thiab serum cholinesterase tseem nyob hauv qhov qub. 10

Lub peev xwm los ntshav txaus txaus ntshai nrog nattokinase tsis tau pom meej meej. Ib daim ntawv tshaj tawm tau piav qhia txog kev mob ntshav qab zib hauv cov poj niam hnub nyoog 52 xyoo uas muaj keeb kwm ntawm ischemic stroke. Txawm hais tias tus neeg mob tau noj cov tshuaj aspirin txhua hnub thiab pib nattokinase ntawm 400 mg txhua hnub, kev ua rau tsis tuaj yeem tsim tau vim nws keeb kwm. 41 Txawm li cas los xij, vim muaj kev pheej hmoo los ntshav, nattokinase yuav tsum tsis txhob noj los ntawm cov neeg mob uas muaj ischemic stroke, peptic ulcer, lossis coagulation disorders; los ntawm cov uas tau txais kev kho mob anticoagulant concomitant; los yog ua ntej lossis tom qab kev phais. Vim hais tias cov vitamin Kobnyob rau hauv natto tuaj yeem cuam tshuam qhov kev pheej hmoo los ntshav, Health Canada tsa kev txhawj xeeb uas tshem tawm cov vitamin Koblos ntawm cov tshuaj nattokinase tuaj yeem ua rau muaj kev pheej hmoo los ntshav. 6 Cov ntaub ntawv kev nyab xeeb tam sim no rau cov tshuaj nattokinase tsis hais txog qhov kev txhawj xeeb no.

Ib tsab ntawv ceeb toom qhia txog qhov muaj feem cuam tshuam ntawm kev hloov cov tshuaj tiv thaiv coagulant nrog nattokinase. Tus neeg mob uas muaj lub tshuab aortic valve tsim thrombosis xav tau hloov lub valve kwv yees li ib xyoos tom qab nws hloov nattokinase 100 mg / hnub rau warfarin. 42

Natto tuaj yeem tsis tshua muaj tshwm sim anaphylaxis lig, nrog cov tsos mob tshwm sim tom qab 4 mus rau 15 teev tom qab noj. 43 , 44 Kev kuaj tawv nqaij tau cuam tshuam poly (gamma-glutamic acid), ib yam khoom ntawm cov txheej txheem fermentation, ua qhov ua rau. Txawm hais tias cov ntsiab lus ntawm poly (gamma-glutamic acid) tuaj yeem txo qis hauv cov txheej txheem tsim khoom, cov neeg mob uas muaj keeb kwm ntawm kev tsis haum tshuaj rau natto yuav tsum zam cov tshuaj nattokinase. kaum tsib

mob nyob hauv qab taw

Toxicology

Ib qho kev tsim ntawm nattokinase tau tshaj tawm los ntawm cov chaw tsim khoom kom tsis txhob mutagenic hauv Ames kuaj siv 5 hom kab mob, nrog rau hauv kev tshawb fawb ntawm tes-based chromosomal aberration ua nyob rau hauv CHL / IU hlwb. 8 Nws tsis muaj tshuaj lom nyob rau hauv cov kev tshawb fawb nas uas tau txhaj tshuaj txog li 1,000 mg / kg / hnub rau txog 90 hnub. Lub LDtsib caugHauv kev tshawb fawb nas yog ntau dua 20,000 FU / kg (ntau dua 1,000 mg / kg).

Cov ntaub ntawv

1. Inatsu Y, Nakamura N, Yuriko Y, Fushimi T, Watanasiritum L, Kawamoto S. Cov yam ntxwv ntawm Bacillus subtilis Cov kab mob hauv Thua nao, ib txwm fermented soybean zaub mov nyob rau sab qaum teb Thaib teb. Lett Appl Microbiol . 2006;43(3):237-242.16910925 2. Dabbagh F, Negahdaripour M, Berenjian A, et al. Nattokinase: ntau lawm thiab daim ntawv thov. Appl Microbiol Biotechnol . 2014;98(22):9199-9206.25348469 3. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. Ib tug tshiab fibrinolytic enzyme (nattokinase) nyob rau hauv cov zaub cheese natto; ib yam khoom noj taum pauv thiab nrov hauv cov zaub mov Japanese. Kev paub . 1987;43(10):1110-1111.3478223 4. Tai MW, Sweet BV. Nattokinase rau kev tiv thaiv ntawm thrombosis. Am J Health Syst Pharm . 2006;63(12):1121-1123.16754735 5. Nyiv Bio Science Laboratories Company, Ltd. NSK-SD nattokinase. 2013. http://www.ethorn.com/ssw/files/Japan%20Bio%20Science%20Laboratory.pdf . Nkag mus rau Lub Ob Hlis 17, 2015. 6. Health Canada. Daim ntawv ceeb toom rau cov neeg muaj feem cuam tshuam ntawm nattokinase. Kaum Ib Hlis 6, 2012. http://www.hc-sc.gc.ca/dhp-mps/prodnatur/legislation/docs/nattokinase-eng.php . Nkag mus rau Lub Ob Hlis 17, 2015. 7. Pawg Neeg Tawm Tswv Yim ntawm Cov Khoom Noj thiab Cov Txheej Txheem Tshiab, European Commission. Pawg Neeg Saib Xyuas Kev Sib Tham: Nattokinase ACNFP/108/6. 2012. http://acnfp.food.gov.uk/sites/default/files/mnt/drupal_data/sources/files/multimedia/pdfs/acnfp10806natv2.pdf . Nkag mus rau Lub Ob Hlis 15, 2015. 8. Nyiv Bio Science Laboratories Company, Ltd. NSK-SD nattokinase: txhim kho kev ncig & txhawb kev mob plawv. Xyoo 2011. http://www.dyna-nutrition.com/wp-content/uploads/2014/08/NSK-white-paper-4Oct2011.pdf . Nkag mus rau lub Kaum Ob Hlis 23, 2014. 9. Kaneki M, Hodges SJ, Hosoi T, et al. Japanese fermented soybean zaub mov raws li qhov tseem ceeb ntawm kev txiav txim siab ntawm thaj chaw loj sib txawv hauv cov qib ntawm cov vitamin Kob: Muaj feem cuam tshuam rau kev pheej hmoo ntawm pob txha pob txha. Khoom noj khoom haus . 2001; 17 (4): 315-321.11369171 10. Hitosugi M, Hamada K, Misaka K, Ichihashi K. Effects of. Bacillus noj cov khoom lag luam ntawm cov ntshav siab hauv cov neeg mob uas muaj kab mob ua neej [tshaj tawm online Lub Ib Hlis 29, 2014]. J Hypertens (Los Angeles) . 3:135.10.4172/2167-1095.1000135 11. Ku TW, Tsai RL, Pan TM. Ib txoj hauv kev yooj yim thiab txuag nqi kom ua kom zoo tshaj plaws ntawm subtilisin NAT los ntawm kev cog qoob loo ntawm submerged. Bacillus subtilis noj. J Agric Food Chem . 2009;57(1):292-296.19063639 12. Wang C, Du M, Zheng D, Kong F, Zu G, Feng Y. Purification thiab characterization of nattokinase los ntawm Bacillus subtilis natto B-12. J Agric Food Chem . 2009;57(20):9722-9729.19788184 13. Fujita M, Nomura K, Hong K, Ito Y, Asada A, Nishimuro S. Purification thiab characterization ntawm ib tug muaj zog fibrinolytic enzyme (nattokinase) nyob rau hauv cov zaub cheese natto, ib tug nrov soybean fermented zaub mov hauv Nyiv. Biochem Biophys Res Commun . 1993; 197(3): 1340-1347.8280151 14. Weng M, Zheng Z, Bao W, Cai Y, Yin Y, Zou G. Enhancement of oxidative stability of the subtilisin nattokinase by site-directed mutagenesis expressed in Escherichia coli . Biochim Biophys Acta . 2009; 1794(11): 1566-1572.19631297 15. Wei X, Luo M, Xie Y, et al. Kev tshuaj ntsuam lim, fermentation, sib cais, thiab encapsulation rau kev tsim cov khoom noj khoom haus nattokinase. Appl Biochem Biotechnol . 2012;168(7):1753-1764.22987066 16. Ero MP, Ng CM, Mihailovski T, Harvey NR, Lewis BH. Ib txoj kev tshawb fawb ntawm cov tshuaj serum pharmacokinetics ntawm nattokinase hauv tib neeg tom qab ib zaug, qhov ncauj, noj txhua hnub. Altern Ther Health Med . 2013; 19(3): 16-19.23709455 17. Peng Y, Yang X, Zhang Y. Microbial fibrinolytic enzymes: ib tug txheej txheem cej luam ntawm qhov chaw, ntau lawm, zog, thiab thrombolytic kev ua si nyob rau hauv vivo. Appl Microbiol Biotechnol . 2005;69(2):126-132.16211381 18. Pais E, Alexy T, Holsworth RE Jr, Meiselman HJ. Cov teebmeem ntawm nattokinase, ib qho pro-fibrinolytic enzyme, ntawm cov qe ntshav liab aggregation thiab tag nrho cov ntshav viscosity. Clin Hemorheol Microcirc . 2006;35(1-2):139-142.16899918 19. Urano T, Ihara H, Umemura K, et al. Lub profibrinolytic enzyme subtilisin NAT purified los ntawm Bacillus subtilis cleaves thiab inactivates plasminogen activator inhibitor hom 1. J Biol Chem . 2001;276(27):24690-24696.11325965 20. Suzuki Y, Kondo K, Matsumoto Y, et al. Kev noj haus ntxiv ntawm fermented soybean, natto, suppresses intimal thickening thiab modulates lysis ntawm mural thrombi tom qab endothelial raug mob nyob rau hauv nas femoral hlab ntsha. Lub Neej Sci . 2003; 73(10): 1289-1298.12850244 21. Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T, Umemura K. Kev noj haus ntxiv nrog fermented soybeans suppresses intimal thickening. Khoom noj khoom haus . 2003;19(3):261-264.12620531 22. Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in nas. Biol Pharm Bull . 1995;18(10):1387-1391.8593442 23. Chang CH, Chen KT, Lee TH, et al. Cov teebmeem ntawm natto extract ntawm kev raug mob endothelial hauv tus qauv nas. feeb Med Okayama . 2010; 64(6): 399-406.21173810 24. Kamiya S, Hagimori M, Ogasawara M, Arakawa M. Nyob rau hauv vivo kev soj ntsuam txoj kev ntawm cov nyhuv ntawm nattokinase ntawm carrageenan-induced tail thrombosis nyob rau hauv ib tug nas qauv. Haematol Act . 2010;124(4):218-224.21071931 25. Xu J, Du M, Yang X, Chen Q, Chen H, Lin DH. Thrombolytic teebmeem nyob rau hauv vivo ntawm nattokinase nyob rau hauv ib tug carrageenan-induced nas qauv ntawm thrombosis. Haematol Act . 2014;132(2):247-253.24862625 26. Lee T. Nug tus kws kho mob. Kuv xav nrhiav kev nyab xeeb, yooj yim dua lwm txoj rau warfarin, uas kuv tau noj ob peb xyoos. Kuv tau hnov ​​​​txog nattokinase - Kuv puas tuaj yeem coj nws los ntawm warfarin? Harv Heart Lett . 2006;17(2):7.21698808 27. Hsia CH, Shen MC, Lin JS, et al. Nattokinase txo qis qib plasma ntawm fibrinogen, yam VII, thiab yam VIII hauv tib neeg. Nutr Res . 2009;29(3):190-196.19358933 28. Cesarone MR, Belcaro G, Nicolaides AN, et al. Kev tiv thaiv ntawm venous thrombosis nyob rau hauv lub davhlau ntev nrog Flite Tabs: LONFLIT-FLITE randomized, tswj kev sim. Angiology . 2003;54(5):531-539.14565628 29. Murakami K, Yamanaka N, Ohnishi K, Fukayama M, Yoshino M. Inhibition of angiotensin I converting enzyme by subtilisin NAT (nattokinase) in natto, a Japanese fermented food. Food Funct . 2012;3(6):674-678.22453301 30. Fujita M, Ohnishi K, Takaoka S, Ogasawara K, Fukuyama R, Nakamuta H. Antihypertensive cov teebmeem ntawm kev noj qab haus huv ntawm qhov ncauj ntawm nattokinase thiab nws cov fragments nyob rau hauv spontaneously hypertensive nas. Biol Pharm Bull . 2011;34(11):1696-1701.22040882 31. Suwanmanon K, Hsieh PC. Cov nyhuv ntawm γ-aminobutyric acid thiab nattokinase-enriched fermented taum ntawm cov ntshav siab ntawm spontaneously hypertensive thiab normotensive Wistar-Kyoto nas. J Food Drug Anal . 2014; 22(4): 485-491. 32. Kim JY, Gum SN, Paik JK, et al. Cov teebmeem ntawm nattokinase ntawm cov ntshav siab: ib qho randomized, tswj kev sim. Hypertens Res . 2008;31(8):1583-1588.18971533 33. Yang NC, Chou CW, Chen CY, Hwang KL, Yang YC. Ua ke nattokinase nrog cov poov xab liab tab sis tsis yog nattokinase ib leeg muaj peev xwm cuam tshuam rau cov ntshav lipids hauv tib neeg cov neeg mob hyperlipidemia. Asia Pac J Clin Nutr . 2009;18(3):310-317.19786378 34. Hsu RL, Lee KT, Wang JH, Lee LY, Chen RP. Amyloid-degrading peev xwm ntawm nattokinase los ntawm Bacillus subtilis natto . J Agric Food Chem . 2009;57(2):503-508.19117402 35. Fadl NN, Ahmed HH, Booles HF, Sayed AH. Serrapeptase thiab nattokinase kev cuam tshuam rau kev txo qis Alzheimer's kab mob pathophysiology hauv nas qauv. Hum Exp Toxicol . 2013;32(7):721-735.23821590 36. Jang JY, Kim TS, Cai J, et al. Nattokinase txhim kho cov ntshav khiav los ntawm inhibiting platelet aggregation thiab thrombus tsim. Lab Anim Res . 2013;29(4):221-225.24396387 37. Ji H, Yu L, Liu K, et al. Mechanisms ntawm nattokinase tiv thaiv cerebral ischemia. Eur J Pharmacol . 2014;745:144-151.25446567 38. Takano A, Hirata A, Ogasawara K, et al. Posterior vitreous detachment induced los ntawm nattokinase (subtilisin NAT): ib tug tshiab enzyme rau pharmacologic vitreolysis. Kev nqis peev Ophthalmol Vis Sci . 2006;47(5):2075-2079.16639018 39. Homma K, Wakana N, Suzuki Y, et al. Kev kho mob ntawm natto, fermented soybean npaj, los tiv thaiv cov ntshav vitamin K ntau ntau hauv cov neeg mob noj warfarin. J Nutr Sci Vitaminol (Tokyo) . 2006; 52 (5): 297-301.17190098 40. Hitosugi M, Hamada K, Misaka K. Cov nyhuv ntawm. Bacillus subtilis var. natto cov khoom ntawm cov tsos mob tshwm sim los ntawm cov ntshav txaus cuam tshuam rau cov poj niam cov neeg mob uas muaj kab mob hauv lub neej. Int J Gen Med . 2015; 8:41-46.25653551 41. Chang YY, Liu JS, Lai SL, Wu HS, Lan MY. Cerebellar hemorrhage provoked los ntawm kev siv cov nattokinase thiab tshuaj aspirin nyob rau hauv ib tug neeg mob uas muaj cerebral microbleeds. Sab hauv Med . 2008;47(5):467-469.18310985 42. Elahi MM, Choi CH, Konda S, Shake JG. Qhov tshwm sim ntawm tus neeg mob hloov pauv ntawm nattokinase rau warfarin tom qab hloov lub aortic valve nrog cov neeg kho tshuab prosthesis. Proc (Bayl Univ Med Cent) . 2015; 28(1): 81-82.25552810 43. Inomata N, Chin K, Nagashima M, Ikezawa Z. Late-onset anaphylaxis vim poly (γ-glutamic acid) nyob rau hauv cov kua zaub ntawm cov lag luam txias suav noodles hauv tus neeg mob tsis haum rau fermented soybeans (natto). Allergol Int . 2011;60(3):393-396.21430437 44. Ikezawa Z, Isoda Y, Inomata N, Matsukura S, Aihara M. Kev tshuaj xyuas ntawm 18 tus neeg mob uas muaj late-onset anaphylaxis tom qab noj ntawm Bacillus subtilis - fermented soybeans (natto). [Cov Lus Qhia] 30th Symposium ntawm Collegium Internationale Allergologicum. Petersberg, Lub teb chaws Yelemees. Cuaj hlis 15, 2014. http://www.ciaweb.org/UserFiles/sym14-finalv11_lores.pdf . Nkag mus rau Lub Ob Hlis 2, 2015. 45. Sugimoto S, Fujii T, Morimiya T, Johdo O, Nakamura T. Cov kev ua haujlwm fibrinolytic ntawm ib qho tshiab protease muab los ntawm tempeh tsim cov fungus, Fusarium sp. BLB. Biosci Biotechnol Biochem Cov . Xyoo 2007; 71(9): 2184-2189.17827689

Tsis lees paub

Cov ntaub ntawv no muaj feem xyuam rau tshuaj ntsuab, vitamin, ntxhia los yog lwm yam kev noj haus ntxiv. Cov khoom no tsis tau raug tshuaj xyuas los ntawm FDA los txiav txim seb nws puas muaj kev nyab xeeb lossis siv tau thiab tsis raug raws li cov qauv zoo thiab cov qauv sau cov ntaub ntawv kev nyab xeeb uas siv tau rau feem ntau cov tshuaj. Cov ntaub ntawv no yuav tsum tsis txhob siv los txiav txim siab seb puas yuav coj cov khoom no. Cov ntaub ntawv no tsis pom zoo rau cov khoom no tias muaj kev nyab xeeb, muaj txiaj ntsig, lossis pom zoo rau kev kho tus neeg mob lossis kev noj qab haus huv. Qhov no tsuas yog cov ntsiab lus luv luv ntawm cov ntaub ntawv dav dav txog cov khoom no. Nws tsis suav nrog tag nrho cov ntaub ntawv hais txog kev siv tau, cov lus qhia, ceeb toom, kev ceev faj, kev cuam tshuam, kev tsis zoo, lossis kev pheej hmoo uas yuav siv tau rau cov khoom no. Cov ntaub ntawv no tsis yog cov lus qhia tshwj xeeb rau kev kho mob thiab tsis hloov cov ntaub ntawv koj tau txais los ntawm koj tus kws kho mob. Koj yuav tsum tham nrog koj tus kws kho mob kom paub meej txog cov kev pheej hmoo thiab cov txiaj ntsig ntawm kev siv cov khoom no.

Cov khoom no tuaj yeem cuam tshuam tsis zoo rau qee yam kev noj qab haus huv thiab kev kho mob, lwm yam tshuaj thiab tshuaj tom khw muag khoom, khoom noj, lossis lwm yam tshuaj noj. Cov khoom no yuav tsis muaj kev nyab xeeb thaum siv ua ntej kev phais lossis lwm yam kev kho mob. Nws yog ib qho tseem ceeb kom qhia tag nrho koj tus kws kho mob txog tshuaj ntsuab, vitamins, minerals lossis lwm yam tshuaj uas koj noj ua ntej txhua yam kev phais lossis kev kho mob. Nrog rau kev zam ntawm qee yam khoom uas feem ntau lees paub tias muaj kev nyab xeeb nyob rau hauv ib txwm muaj, suav nrog kev siv cov tshuaj folic acid thiab cov vitamins thaum cev xeeb tub, cov khoom no tsis tau kawm txaus los txiav txim siab seb nws puas muaj kev nyab xeeb siv thaum cev xeeb tub lossis laus lossis cov neeg hluas. muaj hnub nyoog tshaj 2 xyoos.

Cov ntaub ntawv ntxiv

Nco ntsoov sab laj nrog koj tus kws kho mob kom paub tseeb tias cov ntaub ntawv uas tshwm sim hauv nplooj ntawv no siv tau rau koj tus kheej.