CattleMaster Kub FP 5

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CattleMaster Kub FP 5

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Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza ₃ -Cov tshuaj tiv thaiv kab mob Respiratory Syncytial Virus

Hloov Kho Nyob thiab tua Kab Mob

KHOOM PLIG: CattleMaster GOLD FP 5 yog txhaj tshuaj tiv thaiv cov nyuj noj qab haus huv, suav nrog nyuj cev xeeb tub, ua ib qho kev pab tiv thaiv kev rho menyuam los ntawm kev kis kab mob bovine rhinotracheitis (IBR, bovine herpesvirus Type 1), tsis tu ncua kis tus nyuj los ntawm tus kab mob bovine diarrhea (BVD1) thiab hom kab mob. 2, thiab kab mob ua pa los ntawm IBR, BVD (Hom 1 thiab 2), parainfluenza₃(PI₃), thiab bovine respiratory syncytial virus (BRSV). CattleMaster GOLD FP 5 yog kev npaj khov-qhuav ntawm cov tshuaj hloov pauv ntawm IBR thiab PI₃Cov kab mob thiab hloov kho BRSV nyob, ntxiv rau cov kua, ntxiv kev npaj ntawm inactivated BVD tus kab mob (Hom 1 thiab 2). Cov khoom ua kua yog siv los ua kom cov dej khov-qhuav kom qhuav. Viral antigens yog propagated ntawm ib tug tsim cell kab. Cov khoom no muaj ib qho kev sib xyaw ua ke ntawm adjuvants, suav nrog Amphigen^®, txhawm rau txhim kho lub cev tiv thaiv kab mob rau nws cov feem. Lub BVD diluent ntawm CattleMaster GOLD FP 5 yog ua tiav los ntawm ib lub tswv yim tsim los pab kom muaj kev sib luag ntawm cov qauv.

DISEASE DESCRIPTION: IBR thiab BVD feem ntau cuam tshuam nrog kev ua me nyuam thiab ua pa thaum BRSV thiab PI₃feem ntau yog txuam nrog cov kab mob ua pa. Tus kab mob IBR yog tus cwj pwm los ntawm qhov kub thiab txias, tawm qhov ntswg ntau, conjunctivitis thiab ocular paug, qhov ntswg (qhov ntswg liab), nce qhov ua pa, hnoos, tsis qab los noj mov, thiab kev nyuaj siab. Cov nyuj muaj kab mob thaum cev xeeb tub tuaj yeem rho menyuam. Ib tug yam ntxwv ntawm tus kab mob IBR yog tias nws tsim ib tug kab mob latent nyob rau hauv sensory neurons, feem ntau trigeminal ganglia los yog iliosacral dorsal cag ganglia.^ibLos ntawm cov chaw no ntawm latency, nws tuaj yeem rov ua haujlwm thaum tus tsiaj muaj mob hnyav lossis raug mob. Tom qab ntawd, tus kab mob no tawm thiab kis tau los ntawm kev sib cuag mus rau lwm tus nyuj.

Tus kab mob BVD tuaj yeem kis tau hauv qhov ntswg qhov ntswg, qaub ncaug, ntshav, quav, thiab / lossis zis, thiab los ntawm kev sib cuag ncaj qha nrog cov khoom tsis huv; nws invades los ntawm lub qhov ntswg thiab qhov ncauj thiab replicates systemically. Kev kis kab mob thaum cev xeeb tub tuaj yeem ua rau rho menyuam tawm, fetal resorption, lossis congenital malformation ntawm fetus. Tsis tas li ntawd, yog tias cov nyuj raug mob tau kis tus kab mob noncytopathic BVD thaum thawj peb lub hlis twg ntawm cev xeeb tub, lawv cov nyuj yuav yug los tsis tu ncua nrog tus kab mob. Kev nthuav tawm ntawm cov nyuj no rau qee yam kab mob BVD kab mob tuaj yeem ua rau muaj kab mob BVD-mucosal. Ob qho BVD Hom 1 thiab 2 tuaj yeem pom ntau yam kev kuaj mob. Cov paib yuav me me thiab tsis pom meej meej. Cov tsos mob tshwm sim tuaj yeem suav nrog kev tiv thaiv kab mob hnyav, raws plab, anorexia, kev nyuaj siab, kub taub hau thiab kab mob ua pa. Yog tias kis tau qee hom 2 hom BVD, thrombocytopenia hnyav tuaj yeem tshwm sim thiab pom cov hemorrhaging.

PI₃Tus kab mob no feem ntau localizes nyob rau hauv lub Upper ua pa ib ntsuj av tau, ua rau kom kub thiab nruab nrab qhov ntswg thiab ocular paug. Txawm hais tias cov tsos mob tshwm sim feem ntau yog mob me, PI₃kab mob ua rau cov ntaub so ntswg ua pa tsis muaj zog. Invasion thiab replication ntawm lwm yam kab mob, tshwj xeeb tshaj yog Pasteurella spp., yog li no yooj yim thiab yuav ua rau mob ntsws.

BRSV yog tus neeg sawv cev ntawm tus kab mob ua pa tshwj xeeb ntawm cov nyuj ntawm txhua lub hnub nyoog, suav nrog cov menyuam mos. Tus kab mob no tshwm sim los ntawm kev ua pa sai, hnoos, tsis qab los noj mov, tawm ntawm qhov ntswg thiab qhov muag, ua npaws, thiab o nyob ib ncig ntawm caj pas thiab caj dab. Hauv kev kis mob hnyav, kev tuag tuaj yeem ua raws li hauv 48 teev tom qab pib tshwm sim. Clinically, tus kab mob BRSV tuaj yeem paub qhov txawv ntawm lwm cov kab mob sib kis nrog rau cov kab mob ua pa nyuaj. Tus kab mob BRSV, zoo li PI₃, pab txhawb kev ntxeem tau thiab rov ua dua ntawm lwm cov kab mob ua pa. Exacerbation ntawm cov tsos mob tshwm sim tau raug sau tseg thaum muaj kev sib kis BRSV thiab BVD lossis IBR.

SAFETY THIAB EFFICACY: Hauv kev tshawb fawb txog kev nyab xeeb uas tau ua nrog CattleMaster GOLD FP 5, tsis muaj qhov cuam tshuam loj heev rau kev txhaj tshuaj tiv thaiv thiab txhaj tshuaj tiv thaiv cov nyuj cev xeeb tub tau yug menyuam zoo li qub. Kev nyab xeeb tau pom nyob rau hauv prebreeding thiab cev xeeb tub nyuj nyob rau hauv tag nrho 3 trimesters. Cov o nyob hauv ib puag ncig, tshwm sim los ntawm kev tsim cov tshuaj ntxiv, tau qee zaus pom ntawm qhov chaw txhaj tshuaj.

Lub latency thiab tom qab tso tawm ntawm tus kab mob IBR feem ntawm CattleMaster GOLD FP 5 tau txiav txim siab hauv txoj kev tshawb fawb txog kev nyab xeeb uas nyuj tau txhaj tshuaj intramuscularly nrog qhov txo qis, kub-rhiab IBR tus kab mob tiv thaiv thiab tom qab muab corticosteroid los rov ua dua latent herpesvirus. Kev txhaj tshuaj tiv thaiv tau ua rau cov yam ntxwv serological teb uas tseem tsis tau hloov pauv txawm tias tom qab kho corticosteroid, qhia tias tsis muaj kab mob rov ua haujlwm. Tsis tas li ntawd, tsis muaj BHV1 tau zoo los ntawm cov mucosal swabs khaws cov tshuaj tiv thaiv tom qab lossis kev kho mob postcorticosteroid, thiab tsis tau kis mus rau cov menyuam mos uas tsis tau txhaj tshuaj tiv thaiv kab mob sib txuas nrog cov tshuaj tiv thaiv rau lub sijhawm kawm. Tsis tas li ntawd, tsis muaj BHV1 DNA lossis latency ntsig txog RNA tau kuaj pom hauv trigeminal lossis iliosacral spinal dorsal root ganglia sau tom qab kev tswj hwm ntawm corticosteroid. Ob leeg nucleic acids tau kuaj pom nyob rau hauv ib qho piv txwv ntawm ncauj tsev menyuam ganglion, qhia txog kev txhaj tshuaj ncaj qha lossis sib npaug. BHV1 muab los ntawm kev txhaj tshuaj intramuscular (IM) tsis tuaj yeem rov ua haujlwm los ntawm trigeminal ganglia, qhov chaw tseem ceeb ntawm BHV1 latency, qhia tias tsis muaj cov kab mob sib kis tau zoo hauv cov neurons hnov ​​​​qab. Tsis suav nrog kev txhaj tshuaj rau hauv cov hlab ntsha (los ntawm qhov ua kom rov ua haujlwm tsis tau pom), IBR feem ntawm CattleMaster GOLD FP 5 muab los ntawm IM txoj kev qhia tsis muaj kev xav tsim kom muaj kab mob herpesvirus latent.

Kev ua tau zoo ntawm txhua feem ntawm CattleMaster GOLD FP 5 tau tshwm sim hauv kev tshawb fawb txog kev tiv thaiv kab mob. Cov nyuj txhaj tshuaj tiv thaiv nrog ib feem ntawm CattleMaster GOLD FP 5, ua raws li kev sib tw intranasal nrog cov kab mob ua rau cov kab mob ntawm cov feem, muaj cov tsos mob tsawg dua li cov nyuj uas tsis tau txhaj tshuaj tiv thaiv.

Kev ua tau zoo ntawm IBR thiab BVD Hom 1 thiab 2 feem ntawm CattleMaster GOLD FP 5 kuj tau pom nyob rau hauv kev sib tw-ntawm-kev tiv thaiv, kev tshawb fawb tiv thaiv fetal. Qhov kev ua tau zoo ntawm CattleMaster GOLD FP 5 hauv kev tiv thaiv kev rho menyuam tawm ntawm IBR tau tshwm sim los ntawm kev txhaj tshuaj tiv thaiv heifers li 5 thiab 2 lub lis piam ua ntej yug me nyuam. Cov tshuaj tiv thaiv heifers, nrog rau ib pab pawg tswj tsis tau txhaj tshuaj, tau tawm tsam nrog tus kab mob IBR virus (Cooper strain) ntawm kwv yees li 180 hnub tom qab yug me nyuam. Tom qab qhov kev sib tw, > 90% ntawm cov nyuj txhaj tshuaj tiv thaiv yug menyuam nyuj noj qab nyob zoo whereas > 90% ntawm cov tswj tsis tau txhaj tshuaj rho tawm.

Ib txoj kev tshawb fawb zoo sib xws tau siv los ua kom pom qhov ua tau zoo ntawm CattleMaster GOLD FP 5 hauv kev tiv thaiv tus menyuam mos uas pheej kis mob nrog rau BVD Hom 1 thiab 2. Hauv cov kev tshawb fawb no, nyuj tau sib tw ntawm kwv yees li 82 hnub tom qab yug me nyuam siv cov kab mob phem BVD. Hauv kev tswj tsis tau txhaj tshuaj, kev sib tw nrog BVD Hom 1 ua rau 100% fetal kis kab mob, thiab kev sib tw nrog BVD Hom 2 ua rau muaj ntau dua 85% ntawm tus menyuam hauv plab. Hloov pauv, 100% ntawm cov nyuj yug los rau nyuj txhaj tshuaj tiv thaiv nrog CattleMaster GOLD FP 5 tau tiv thaiv los ntawm kev kis kab mob tsis tu ncua tom qab kev sib tw los ntawm BVD Hom 1 thiab 2.

Cov lus qhia rau kev siv

ib. Cov lus qhia dav dav: Kev txhaj tshuaj tiv thaiv nyuj noj qab nyob zoo, suav nrog nyuj cev xeeb tub, raug pom zoo. Aseptically rehydrate cov tshuaj tiv thaiv kom qhuav qhuav nrog cov tshuaj tiv thaiv ua kua, co zoo, thiab muab 2 mL subcutaneously.

ob. Kev txhaj tshuaj thawj zaug: Cov nyuj noj qab nyob zoo yuav tsum tau txais thawj zaug 2 koob tshuaj 3 lub lis piam sib nrug. Raws li kev pabcuam los tiv thaiv kev rho menyuam tawm ntawm IBR thiab BVD tsis tu ncua cov menyuam mos, muab 2-mL koob tshuaj ntawm kwv yees li 5 thiab 2 lub lis piam ua ntej yug me nyuam. Calves txhaj tshuaj tiv thaiv ua ntej lub hnub nyoog ntawm 6 lub hlis yuav tsum tau rov txhaj tshuaj tom qab muaj hnub nyoog 6 hli.

3. Revaccination: Revaccination ib xyoos ib zaug nrog ib koob tshuaj yog pom zoo.

4. Kev ua liaj ua teb zoo thiab kev tswj xyuas tsiaj txhu yuav tsum tau ua haujlwm.

Cov kev ceev faj

1. Khaws ntawm 2 ° -7 ° C. Kev raug rau qhov kub thiab/los yog lub hnub ci ncaj qha tuaj yeem cuam tshuam qhov muaj zog. Tsis txhob khov.

2. Siv tag nrho cov ntsiab lus thaum xub qhib.

3. Yuav tsum tau siv cov koob txhaj tshuaj thiab koob txhaj tshuaj kom tsis muaj menyuam los txhaj tshuaj tiv thaiv. Tsis txhob muab tshuaj tua kab mob vim tias cov tshuaj tua kab mob tuaj yeem ua rau cov tshuaj tiv thaiv tsis tau.

4. Cov tshuaj tiv thaiv ib puag ncig ib puag ncig tuaj yeem pom ntawm qhov chaw txhaj tshuaj.

5. Hlawv cov thawv thiab tag nrho cov khoom tsis siv.

6. Tsis txhob txhaj tshuaj tiv thaiv tsis pub dhau 21 hnub ua ntej tua.

7. Muaj gentamicin ua cov tshuaj tua kab mob.

8. Kev tuav cov nyuj pub mis ib txwm muaj, suav nrog kev tswj hwm cov tshuaj tiv thaiv xws li CattleMaster GOLD FP 5, tau cuam tshuam nrog kev txo qis ntawm cov kua mis ib ntus.

9. Raws li nrog ntau cov tshuaj tiv thaiv, anaphylaxis yuav tshwm sim tom qab siv. Thawj cov tshuaj tua kab mob ntawm epinephrine tau pom zoo thiab yuav tsum tau ua raws li kev kho mob uas tsim nyog.

10. Cov khoom no tau pom tias muaj txiaj ntsig zoo hauv cov tsiaj noj qab haus huv. Kev tiv thaiv tiv thaiv kab mob yuav tsis raug tshem tawm yog tias cov tsiaj tsis tu ncua nrog tus kab mob BVD lossis incubating tus kab mob sib kis, tsis noj zaub mov los yog kab mob, muaj kev ntxhov siab vim kev xa khoom lossis ib puag ncig, tsis muaj kev tiv thaiv kab mob, lossis cov tshuaj tiv thaiv tsis raug tswj hwm raws li daim ntawv lo. cov lus qhia.

Cov ntaub ntawv

1. Jones C: Alphaherpesvirus latency: Nws lub luag haujlwm hauv cov kab mob thiab kev ciaj sia ntawm tus kab mob hauv qhov xwm txheej. Adv in Vir Res 51:81-133, 1999.

Kev nug yuav tsum raug xa mus rau Zoetis Inc. Veterinary Services, (888) 963-8471 (USA), (800) 461-0917 (Canada).

Rau kev siv kws kho tsiaj nkaus xwb

U.S. Veterinary License No. 190

Zoetis Inc., Kalamazoo, MI 49007, USA

clavamox yam tsis muaj daim ntawv yuav tshuaj

30063800 ib

Kev nthuav qhia: 5 koob tshuaj, 10 koob tshuaj thiab 25 koob tshuaj vials.

CPN: 3690218.4 ib

Txhua qhov kev siv zog tau ua los xyuas kom meej qhov tseeb ntawm CattleMaster GOLD FP 5 cov ntaub ntawv luam tawm saum toj no. Txawm li cas los xij, nws tseem yog lub luag haujlwm ntawm cov neeg nyeem kom paub txog lawv tus kheej nrog cov ntaub ntawv cov khoom lag luam uas muaj nyob rau hauv Teb Chaws Asmeskas cov khoom lag luam lossis cov pob ntxig.

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