Polyethylene Glycol 3350

Hais lus

(pol i ETH i leen GLY kol 3350)

Index Terms

  • Macrogol
  • PEG

Daim ntawv noj tshuaj

Excipient cov ntaub ntawv nthuav tawm thaum muaj (tsawg, tshwj xeeb tshaj yog rau cov khoom siv); sab laj tshwj xeeb cov khoom labeling. [DSC] = Cov khoom lag luam txiav tawm



Kit, Qhov ncauj:

Gialax: [muaj aspartame, polyethylene glycol (kev sib cuam tshuam starch), tartrazine (fd&c daj #5)]

Pob ntawv, Qhov ncauj:

HealthyLax: 17 g / dose (1 ea, 14 ea, 100 ea) [muaj polyethylene glycol (interact starch)]

MiraLax: 17 g / dose (1 ea [DSC], 10 ea, 12 ea [DSC], 24 ea) [muaj polyethylene glycol (kev sib cuam tshuam cov hmoov txhuv nplej siab)]

Generic: 17 g / koob (1 ea, 14 ea, 30 ea, 100 ea)

Hmoov, Qhov ncauj:

GaviLAX: 17 g / dose (238 g, 510 g) [muaj polyethylene glycol (interact starch)]

GlycoLax: 17 g / dose (119 g, 255 g, 527 g) [muaj polyethylene glycol (interact starch)]

mob hauv qab txoj kab tav tav thiab nraub qaum

MiraLax: 17 g / dose (1 ea, 119 g, 238 g, 510 g, 765 g) [muaj polyethylene glycol (interact starch)]

PEGyLAX: 17 g / dose (527 g [DSC]) [muaj polyethylene glycol (interact starch)]

Ntim: 17 g / dose (119 g, 238 g, 255 g, 510 g, 527 g, 850 g)

Hom Lub Npe: U.S.

  • GaviLAX [OTC]
  • Gialax
  • GlycoLax [OTC]
  • HealthyLax [OTC]
  • MiraLax [OTC]
  • PEGyLAX [DSC]

Pharmacologic qeb

  • Laxative, Osmotic

Pharmacology

Tus neeg sawv cev osmotic, polyethylene glycol 3350 ua rau cov dej tuav hauv cov quav; nce quav zaus.

Kev nqus

Tsawg kawg (<0.28%; Pelham, 2008)

Kev tso tawm

Cov quav (93%); tso zis (0.2%) (Pelham, 2008)

Pib ntawm Kev Ua

Lub sij hawm xa tuaj: 24-96 teev

Siv: Cov ntawv cim npe

Constipation, qee zaus: Kev kho mob raws plab

Off Label Siv

Kev npaj plab hnyuv ua ntej colonoscopy

Raws li Daim Ntawv Pom Zoo Pom Zoo ntawm Kev Npaj Plawv Ua Ntej Colonoscopy los ntawm American Society of Colon thiab Rectal Surgeons (ASCRS), American Society for Gastrointestinal and Endoscopy (ASGE), thiab Lub Koom Haum American Gastrointestinal and Endoscopic Surgeons (SAGES), polyethylene glycol 3350 ua ke nrog bisacodyl ncua-tso ntsiav tshuaj lossis magnesium citrate yog qhov zoo thiab pom zoo rau kev npaj plab hnyuv ua ntej colonoscopy.[Wexner 2006].

Contraindications

Hypersensitivity rau polyethylene glycol los yog ib yam khoom ntawm cov formulation; paub los yog xav tias plab hnyuv obstruction

OTC daim ntawv lo: Thaum siv tshuaj rau tus kheej, tsis txhob siv yog tias koj muaj kab mob raum tshwj tsis yog muaj kev qhia los ntawm tus kws kho mob

Canadian labeling: Ntxiv contraindications (tsis yog nyob rau hauv US daim ntawv lo): Relaxa: Siv rau cov me nyuam<18 years of age unless advised by a physician

Dosing: Neeg laus

Kev npaj plab hnyuv ua ntej colonoscopy (tsis siv daim ntawv lo): Qhov ncauj: 17 g (~ 1 heaping tablespoon) hauv 240 mL (8 ooj) ntawm cov kua ntshiab txhua 10 feeb kom txog thaum 2,000 mL ntawm cov ntim tau noj (pib li 6 teev tom qab noj cov tshuaj bisacodyl ncua-tso ntsiav tshuaj lossis magnesium citrate) (ASCRS / ASGE /SAGES [Wexner 2006])

Constipation, qee zaus: Qhov ncauj: 17 g (~ 1 heaping tablespoon) yaj hauv 120 mus rau 240 mL (4 mus rau 8 ooj) dej haus, ib hnub ib zaug; tsis txhob siv li 1 mus rau 2 lub lis piam (cov khoom tshwj xeeb) tshwj tsis yog cov kws kho mob qhia. Hauv kev sim tshuaj, 34 g ib hnub ib zaug tau pom tias muaj txiaj ntsig zoo, tab sis muaj kev cuam tshuam ntau ntxiv (DiPalma 1999).

Dosing: Geriatric

Xa mus rau cov neeg laus noj.

Dosing: Pediatric

Kev npaj plab hnyuv: Cov ntaub ntawv txwv muaj: Cov Me Nyuam> 2 xyoos thiab Cov Hluas: Qhov ncauj: 1.5 g / kg / hnub rau 4 hnub; Qhov siab tshaj plaws noj txhua hnub: 100 g / hnub (Pashankar 2004)

cem quav: Cov ntaub ntawv txwv muaj: Cov Me Nyuam, Me Nyuam, thiab Cov Hluas: Qhov ncauj: 0.2 txog 0.8 g/kg/hnub (NASPGHAN [Tabbers] 2014); ntau dua thawj koob tshuaj ntawm 1 g / kg tau pom zoo (Loening-Buck 2004; Pashankar 2001); Qhov siab tshaj plaws noj txhua hnub: 17 g / hnub. Nco tseg: Kev noj tshuaj yuav tsum yog tus kheej kom ua tiav cov txiaj ntsig xav tau, cov menyuam mos thiab cov menyuam yaus yuav xav tau koob tshuaj ntau dua li cov menyuam yaus hnub nyoog kawm ntawv (Loening-Buck 2004; Pashankar 2001)

Fecal impaction, qeeb disimpaction: Cov ntaub ntawv txwv muaj: Cov Me Nyuam thiab Cov Hluas: Qhov ncauj: 1 txog 1.5 g / kg ib hnub rau 3 mus rau 6 hnub sib law liag (NASPGHAN [Tabbers] 2014; Youssef 2002); Qhov siab tshaj plaws noj txhua hnub: 100 g / hnub (Youssef 2002); Tom qab kev saib xyuas tsis zoo ntawm 0.4 g / kg ib hnub yuav tsum tau txuas ntxiv rau ≥ 2 lub hlis (NASPGHAN [Tabbers] 2014)

Kev kho dua tshiab

Dissolve hmoov tag nrho hauv 120 mus rau 240 mL (4 mus rau 8 ooj) dej, kua txiv, dej qab zib, kas fes, los yog tshuaj yej.

Kev tswj hwm

Qhov ncauj:

cem quav, qee zaus: Muab cov hmoov sib tov rau hauv 120 mus rau 240 mL (4 mus rau 8 ooj) dej, kua txiv hmab txiv ntoo, dej qab zib, kas fes, los yog tshuaj yej kom txog thaum yaj thiab muab tam sim ntawd.

Kev npaj plab hnyuv rau colonoscopy (tshwj tsis yog siv daim ntawv lo): Tswj cov ntsiav tshuaj bisacodyl ncua sij hawm tso tawm lossis magnesium citrate ua ntej kev tswj hwm polyethylene glycol. Tom qab lub plab zom mov (los yog mus txog 6 teev tom qab yog tias tsis muaj lub plab zom mov), do hmoov hauv 240 mL (8 ooj) ntawm cov kua ntshiab kom txog thaum yaj thiab muab tshuaj tam sim ntawd. Kev txhaj tshuaj yog rov ua dua txhua 10 feeb kom txog thaum 2,000 mL ntawm ntim tau noj.

Cia

Khaws ntawm 20 ° C txog 25 ° C (68 ° F txog 77 ° F); Kev mus ncig ua si raug tso cai ntawm 15 ° C txog 30 ° C (59 ° F txog 86 ° F).

Cov tshuaj sib cuam tshuam

Dichlorphenamide: Laxatives tuaj yeem txhim kho cov nyhuv hypokalemic ntawm Dichlorphenamide. Saib xyuas kev kho mob

Digoxin: Polyethylene Glycol 3350 tuaj yeem txo cov ntshav concentration ntawm Digoxin. Saib xyuas kev kho mob

Kev Phem Tsis Zoo

Cov tshuaj tiv thaiv tsis zoo hauv qab no thiab qhov tshwm sim yog muab los ntawm cov khoom lag luam tshwj tsis yog tau teev tseg.

> 10%: Gastrointestinal: Gastrointestinal signs and tsos (32%; Di Palma 2007), raws plab (11%; DiPalma 2006)

1% mus rau 10%: Gastrointestinal: Flatulence (7%; DiPalma 2006), xeev siab (6%; DiPalma 2006), mob plab (5%; DiPalma 2006), quav quav (4%; DiPalma 2006), 3 mob plab (3%) %; DiPalma 2006)

v 3601 daj

Zaus tsis tau txhais.

Gastrointestinal: Dyspepsia (Di Palma 2007), eructation (Di Palma 2007), plab tsis xis nyob (Di Palma 2007)

Hematologic & oncologic: Rectal hemorrhage (Di Palma 2007)

Lus Ceeb Toom/Precautions

Kev txhawj xeeb txog cov teebmeem tsis zoo:

• Electrolyte imbalance: Ntev, nquag, los yog siv ntau dhau yuav ua rau electrolyte tsis txaus.

• Hypersensitivity: Tsis txhob siv yog tias koj hypersensitive rau polyethylene glycol. Yog tias muaj kev ua xua tshwm sim (piv txwv li, ua pob liab vog, o, ua pa nyuaj), tsis txhob siv tam sim ntawd thiab nrhiav kev kho mob.

Kev txhawj xeeb txog kab mob:

• Mob plab hnyuv: Ntsuam xyuas cov neeg mob uas muaj cov tsos mob ntawm plab hnyuv, mob plab, lossis mob plab (xws li, ntuav, mob plab lossis mob plab) ua ntej siv; Kev siv yog contraindicated nyob rau hauv cov neeg mob uas paub los yog xav tias plob tsis so tswj.

• Lub raum tsis zoo: Siv ceev faj rau cov neeg mob lub raum tsis zoo. Tsis txhob siv raum tsis zoo tshwj tsis yog nyob rau hauv kev saib xyuas ntawm tus kws kho mob.

Lwm yam lus ceeb toom / ceev faj:

• Kev tswj hwm: Yog tias mob raws plab hnyav, tsis txhob siv. Thaum siv rau kev npaj plab hnyuv rau colonoscopy (tshwj tsis yog siv daim ntawv lo), cov tshuaj noj hauv qhov ncauj yuav tsum tsis pub dhau 1 teev tom qab pib kho.

• Duration ntawm kev kho: Tsis txhob siv ntev tshaj li 1 mus rau 2 lub lis piam (cov khoom tshwj xeeb); 2 mus rau 4 hnub yuav tsum tau ua kom lub plab zom mov.

• OTC daim ntawv lo: Thaum siv tshuaj rau tus kheej, cov neeg mob yuav tsum sab laj nrog tus kws kho mob ua ntej siv yog tias lawv muaj xeev siab, ntuav, lossis mob plab, mob plab plob tsis so tswj, lossis kev hloov pauv sai sai ntawm kev tso quav rau > 2 lub lis piam. Cov neeg mob yuav tsum tau qhia kom tsis txhob siv thiab sab laj nrog kws kho mob yog tias lawv muaj mob raws plab, los ntshav hauv plab, yog mob plab, tsam plab, mob plab, lossis xeev siab, lossis yog tias xav tau siv rau > 1 lub lis piam.

Kev xav txog kev xeeb tub

Polyethylene glycol (PEG) muaj qhov nqus dej tsawg heev thiab yuav tsis zoo li ua rau lub cev tsis zoo. Kev kho mob cem quav hauv cov poj niam cev xeeb tub zoo ib yam li cov neeg mob uas tsis muaj cev xeeb tub thiab cov tshuaj yuav siv tau thaum kev noj zaub mov thiab kev hloov pauv kev ua neej tsis zoo. Polyethylene glycol yuav siv tau thaum xav tau osmotic laxative (Gomes 2018; Shin 2015).

Kev Kawm Tus Neeg Mob

Cov tshuaj no siv rau dab tsi?

• Nws yog siv los kho cem quav.

Txhua yam tshuaj yuav ua rau muaj kev phiv. Txawm li cas los xij, ntau tus neeg tsis muaj kev phiv los yog tsuas yog muaj kev phiv me me xwb. Hu rau koj tus kws kho mob lossis tau txais kev pab kho mob yog tias ib qho ntawm cov kev mob tshwm sim no lossis lwm yam kev mob tshwm sim cuam tshuam rau koj lossis tsis ploj mus:

• Mob plab

• mob plab

ntau npaum li cas levemir yog heev npaum li cas

• mob plab

• xeev siab

• Dhau roj

CEEB TOOM/CEEB TOOM: Txawm hais tias nws yuav tsis tshua muaj, qee tus neeg yuav muaj qhov phem heev thiab qee zaum ua rau muaj kev phom sij thaum noj tshuaj. Qhia rau koj tus kws kho mob lossis tau txais kev pab kho mob tam sim yog tias koj muaj ib qho ntawm cov tsos mob hauv qab no lossis cov tsos mob uas yuav cuam tshuam rau qhov tshwm sim tsis zoo:

• kiv taub hau hnyav

• Hla tawm

• Mob plab

• Ntshav los ntshav

• Mob qhov quav

• Cov tsos mob ntawm kev ua xua, xws li pob liab liab; khaus khaus; khaus; liab, o, hlwv, lossis tawv nqaij nrog lossis tsis ua npaws; hawb pob; nruj ntawm lub hauv siab los yog caj pas; ua tsis taus pa, nqos, lossis hais lus; hoarseness txawv txawv; los yog o ntawm qhov ncauj, ntsej muag, daim di ncauj, tus nplaig, los yog caj pas.

Nco tseg: Qhov no tsis yog ib daim ntawv teev tag nrho cov kev mob tshwm sim. Tham nrog koj tus kws kho mob yog tias koj muaj lus nug.

Cov Ntaub Ntawv Cov Neeg Siv Khoom Siv thiab Tsis lees paub: Cov ntaub ntawv no yuav tsum tsis txhob siv los txiav txim seb puas yuav noj cov tshuaj no lossis lwm yam tshuaj. Tsuas yog tus kws kho mob muaj kev paub thiab kev cob qhia los txiav txim seb cov tshuaj twg tsim nyog rau tus neeg mob tshwj xeeb. Cov ntaub ntawv no tsis pom zoo rau cov tshuaj uas muaj kev nyab xeeb, muaj txiaj ntsig, lossis pom zoo rau kev kho tus neeg mob lossis kev noj qab haus huv. Qhov no tsuas yog cov ntsiab lus luv luv ntawm cov ntaub ntawv dav dav txog cov tshuaj siv los ntawm daim ntawv qhia kev kawm ntawm tus neeg mob thiab tsis yog tsim los ua kom dav. Cov ntsiab lus luv luv no TSIS suav nrog txhua cov ntaub ntawv muaj txog kev siv tau, cov lus qhia, lus ceeb toom, kev ceev faj, kev cuam tshuam, kev cuam tshuam, lossis kev pheej hmoo uas yuav siv tau rau cov tshuaj no. Cov ntaub ntawv no tsis yog tsim los muab cov lus qhia kho mob, kuaj mob lossis kev kho mob thiab tsis hloov cov ntaub ntawv koj tau txais los ntawm tus kws kho mob. Yog xav paub ntxiv txog cov lus qhia ntxaws ntxaws txog qhov txaus ntshai thiab cov txiaj ntsig ntawm kev siv cov tshuaj no, thov tham nrog koj tus kws kho mob thiab tshuaj xyuas tag nrho cov ntawv qhia txog tus neeg mob.

Cov ntaub ntawv ntxiv

Nco ntsoov sab laj nrog koj tus kws kho mob kom paub meej tias cov ntaub ntawv uas tshwm sim hauv nplooj ntawv no siv tau rau koj tus kheej.