Psoriasis: Cov duab, Cov tsos mob & Kev xaiv tshuaj kho mob

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Psoriasis Uncovered: Myths vs Truths

Lus dab neeg : Psoriasis tsuas yog 'qhuav' ntawm daim tawv nqaij.
Qhov tseeb : Psoriasis yog ib qho tiv thaiv kab mob ua rau daim tawv nqaij o (redness, irritation thiab o) nrog khaus thiab tuab, qhuav, nplai ntawm daim tawv nqaij. Nws ua rau muaj kev txaj muag thiab kev nyuaj siab rau cov neeg mob.



Lus dab neeg: Psoriasis yog kis tau.
Qhov tseeb : Koj tsis tuaj yeem 'ntau' psoriasis los ntawm lwm tus, txawm tias koj tau ntsib nrog lawv daim tawv nqaij. Nws tsis yog kab mob sib kis.



Lus dab neeg: Psoriasis tuaj yeem kho tau.
Qhov tseeb: Psoriasis yog ib qho mob ntev uas tsis muaj kev kho; txawm li cas los xij, muaj ntau kev kho mob zoo , thiab kev tshawb fawb tsis tu ncua rau tus mob no yog nquag siv.

Psoriasis yog dab tsi? Nws yog ntau tshaj li tawv nqaij sib sib zog nqus

Psoriasis yog ib tug mob ntev (ntev) autoimmune kab mob nyob rau hauv uas lub hlwb ntawm koj daim tawv nqaij yog hloov ntawm ib tug txawv txav ceev ceev.



  • Cov tawv nqaij hloov sai sai txhua ob peb hnub, tsis yog txhua 3 mus rau 4 lub lis piam.
  • Vim qhov kev hloov pauv sai sai no, cov tawv nqaij tawv ntxiv ua rau cov pob zeb loj uas tuaj yeem ua flaky, liab, thiab khaus.
  • Psoriasis feem ntau tshwm sim hauv cov neeg laus, thiab cov cov tsos mob tuaj thiab mus .

Tsis muaj kev kho rau psoriasis, tab sis cov tshuaj kho mob siab heev tso cai rau kwv yees li 80% mus rau 90% ntawm cov neeg mob kom muaj kev kho mob kom txo tau cov tsos mob thiab txhim kho cov tsos mob ntawm cov quav hniav.

Psoriasis zoo li cas?

Psoriasis tuaj yeem tshwm sim rau txhua qhov chaw ntawm lub cev , suav nrog ob txhais tes, ko taw, lub luj tshib, tawv taub hau lossis qhov chaw mos.

  • Nyob rau hauv cov quav hniav psoriasis, feem ntau hom psoriasis, daim tawv nqaij yuav qhuav, flaky, khaus, liab thiab them nrog dawb teev.
  • Psoriasis tuaj yeem cuam tshuam rau thaj chaw me me ntawm lub cev lossis nthuav dav heev.
  • Rau ntau tus neeg, psoriasis tuaj yeem ua rau muaj kev txaj muag, kev nco txog tus kheej, lossis kev ntxhov siab; Qee tus neeg yuav xav tau kev kho mob rau kev nyuaj siab lossis kev ntxhov siab.
  • Cov kws kho mob hauv tsev neeg, kws kho mob dermatologist, lossis kws kho mob rheumatologist tuaj yeem kho koj tus mob psoriasis nyob ntawm qhov chaw thiab qhov hnyav.
  • Saib ntxiv cov duab psoriasis .

Mob siab: Dab tsi ua rau Psoriasis?

Qhov tseeb ua rau psoriasis tsis paub meej. Ntau tus kws tshawb fawb ntseeg tias nws yog ib qho kev sib xyaw ua ke - suav nrog tsev neeg keeb kwm, kev tiv thaiv kab mob tsis zoo, thiab cuam tshuam los ntawm ib puag ncig.



  • Hauv cov neeg uas muaj psoriasis, qee cov qe ntshav dawb uas ib txwm tawm tsam cov kab mob es tsis txhob tawm tsam cov hlwb noj qab haus huv (qhov no hu ua kab mob autoimmune). Nws yog tus kab mob autoimmune uas muaj ntau tshaj plaws hauv Asmeskas.
  • Cov tawv nqaij tshiab tau tsim sai heev thiab ua rau cov txheej txheem tuag, scaly ntawm daim tawv nqaij thiab cov qe ntshav dawb uas nyob rau saum txheej ntawm daim tawv nqaij es tsis txhob sloughing tawm.
  • Cov kab mob ntawm daim tawv nqaij thiab qhov txhab no yog hu ua psoriatic lesions los yog plaque psoriasis .
  • Psoriasis tuaj yeem ua rau muaj kev txaj muag, kev nco txog tus kheej, thiab kev txhawj xeeb.

Leej twg tau Psoriasis?

Psoriasis yog cov kab mob autoimmune ntau tshaj plaws hauv Teb Chaws Asmeskas Txog 2 mus rau 3 feem pua ​​​​ntawm cov pej xeem, lossis kwv yees li 8 lab tus tib neeg, muaj psoriasis, raws li National Psoriasis Foundation.

  • Cov txiv neej thiab poj niam ob leeg tau txais psoriasis sib npaug, thiab feem ntau nws tshwm sim rau cov neeg laus hauv ob lub hnub nyoog - nruab nrab ntawm 20 txog 30 xyoo los yog los ntawm 50 mus rau 60 xyoo. Cov menyuam yaus kuj tuaj yeem kis tau nws, txawm hais tias nws feem ntau yog kab mob ntawm cov neeg laus.
  • Kwv yees li ntawm 30 feem pua ​​​​ntawm cov neeg uas muaj tus kab mob psoriasis kuj tuaj yeem txhim kho psoriatic mob caj dab , ib hom kab mob rheumatoid uas zoo li cuam tshuam rau cov pob qij txha ntawm tes thiab ko taw.
  • Qee tus, tab sis tsis yog txhua tus, cov neeg mob yuav muaj tsev neeg keeb kwm ntawm psoriasis.
  • Nco ntsoov, psoriasis tsis kis tau; koj tsis tuaj yeem ntes nws los ntawm lwm tus.

Puas muaj ntau tshaj ib hom Psoriasis? Yog lawm.

Muaj ntau ntau hom psoriasis, thiab qee qhov yuav tshwm sim tib lub sijhawm. Piv txwv ntawm ntau hom psoriasis muaj xws li:

  • Plaque Psoriasis : Feem ntau daim ntawv uas ua rau sawv, tawv nqaij liab tej zaum yuav khaus los yog flaky.
  • Cov tsos mob ntawm psoriasis : Tej zaum yuav yog keeb kwm yav dhau los ntawm tus kab mob streptococcal; tej zaum yuav tshwm sim rau cov menyuam yaus lossis cov neeg laus. Cov plaques me me ua rau ntawm qhov nruab nrab ntawm lub cev.
  • Pustular Psoriasis : Mob thiab mob hnyav ntawm psoriasis, nrog cov kua paug puv hauv cov kab mob psoriasis plaques tuaj yeem tawg. Ua npaws yuav tshwm sim.

Hom Psoriasis, Txuas ntxiv

Piv txwv ntawm lwm hom psoriasis muaj xws li:

  • Inverse Psoriasis: : Tus kab mob psoriasis no tuaj yeem cuam tshuam rau thaj chaw ntawm daim tawv nqaij xws li qhov chaw mos, hauv qab lub mis lossis caj npab, lossis ib ncig ntawm lub puab tais. Cov kab mob yog tiaj, liab, thiab feem ntau tsis muaj nplai.
  • Ntsia Psoriasis : Cov ntsia hlau tuaj yeem ua daj-xim av, pitted, flakes los yog tshem tawm ntawm tus ntsia thawv txaj.
  • Psoriatic mob caj dab : Tej zaum yuav tshwm sim txog li 30 feem pua ​​ntawm cov neeg mob psoriasis; cov tsos mob muaj xws li o ntawm lub hauv caug, pob taws, tes thiab ntiv taw pob qij txha; mob; thiab tej zaum yuav nrog tus ntsia thawv psoriasis.

Flare Ups: Feem ntau Psoriasis ua rau

Qee yam xwm txheej lossis yam khoom yuav ua rau koj tus mob psoriasis ua rau lossis ua rau nws tawm ntawm kev zam txim. Nws yog qhov zoo tshaj kom tsis txhob muaj qhov tshwm sim uas koj txheeb xyuas uas yuav ua rau muaj qhov tshwm sim ntawm koj tus mob psoriasis.

Common triggers muaj xws li:

  • Mob los yog kab mob
  • Daim tawv nqaij raug mob los yog kub hnyiab
  • Cov xwm txheej ntxhov siab lossis ntxhov siab
  • Huab cua txias, haus luam yeeb lossis haus luam yeeb
  • Kev haus cawv hnyav heev
  • Tej yam tshuaj xws li lithium , cov tshuaj noj ntshav siab ( beta-blockers ), tshuaj tiv thaiv mob malaria , thiab cov khoom siv iodide , xws li potassium iodide thiab sodium iodide.

Kev Kho Mob Psoriasis: Kuv Yuav Pib Qhov twg?

Muaj Muaj ntau ntau yam kev kho mob rau psoriasis , thiab yam koj siv yuav txawv raws li qhov hnyav, kev kho mob yav dhau los, hom psoriasis thiab qhov koj nyiam, suav nrog cov nqi .

Kev kho mob tuaj yeem txo qhov tsim ntawm cov tawv nqaij ntau dhau thiab pab rov qab koj cov tawv nqaij kom zoo dua qub.

Cov kev kho mob yuav muaj xws li:

  • tshuaj pleev ib ce los yog tshuaj pleev
  • phototherapy (kev kho lub teeb) nrog lossis tsis muaj qee yam tshuaj
  • Cov tshuaj noj uas yuav noj los ntawm qhov ncauj
  • Cov tshuaj txhaj tau siv tau los ntawm tus neeg mob hauv tsev lossis muab rau hauv tus kws kho mob lub chaw haujlwm.

Thawj Kab ntawm Kev Kho Mob - Topical Corticosteroids

Kev kho mob me me mus rau nruab nrab yog pib kho nrog qis rau nruab nrab-potency corticosteroid cream, tshuaj pleev, tshuaj tsuag lossis tshuaj pleev - xws li:

Tsawg potency khoom, xws li fluocinolone ( Kev sim , Derma-Smooth F/S ) tuaj yeem siv rau ntawm lub ntsej muag lossis lwm qhov chaw rhiab.

lexapro phiv rau poj niam

Lotions los yog foams yog qhov zoo tshaj plaws rau cov tawv taub hau, cream yog qhov zoo tshaj plaws rau cov kab mob oozing, thiab cov tshuaj pleev tuaj yeem kho cov tawv nqaij qhuav, tsa, lossis cov kab mob scaly.

Cov tshuaj muaj zog ntau dua yog tshwj tseg rau cov cheeb tsam tuab, tawv-rau-kho zoo li lub luj tshib lossis hauv caug. Tshuaj kho mob ua haujlwm zoo tshaj plaws rau thaj chaw me thiab me ntawm psoriasis.

Tshuaj pleev Corticosteriods - Kev nyab xeeb thiab kev phiv

Txawm hais tias cov tshuaj pleev corticosteroids xws li cream lossis tshuaj pleev yog siv rau ntawm daim tawv nqaij, lawv tseem tuaj yeem ua rau kev mob tshwm sim .

Kev siv sijhawm ntev lossis ntau dhau tuaj yeem ua rau tawv nqaij tawv, khaus khaus, dryness, lossis hloov xim ntawm daim tawv nqaij. Yog koj tus kws kho mob pom zoo rau koj occlude koj thaj chaw psoriasis -- qhwv lawv hauv cov yas tom qab siv tshuaj pleev corticosteroid los txhawb cov nyhuv - cov kev mob tshwm sim tuaj yeem tshwm sim ntau dua. Tsis txhob ua qhov no tshwj tsis yog koj tus kws kho mob qhia.

Cov kev mob tshwm sim hnyav dua tuaj yeem tshwm sim nrog cov tshuaj pleev corticosteroids yog tias siv cov koob tshuaj ntau rau lub sijhawm ntev. Koj tuaj yeem tiv taus cov txiaj ntsig zoo ntawm cov tshuaj pleev corticosteroids dhau sijhawm, ib yam nkaus.

Rau ib daim ntawv teev tag nrho ntawm cov kev mob tshwm sim, thov mus saib rau lub tus kheej tshuaj monographs .

Kev siv OTC Emollients thiab Creams

Cov tshuaj pleev emollients thiab cream yog cov tshuaj uas sooth thiab soften ntawm daim tawv nqaij. Emollients, xws li lanolin, yog nplua nuj nyob rau hauv cov rog thiab roj. Lawv ua haujlwm los ntawm moisturizing ntawm daim tawv nqaij thiab tiv thaiv nws los ntawm ziab.

Kev siv cov emollients tsis tu ncua Tej zaum yuav txo qhov xav tau los tiv thaiv kab mob xws li corticosteroids hauv psoriasis.

Cov kev npaj no muaj over-the-counter (OTC) yam tsis muaj ntawv sau tshuaj - Cov piv txwv uas muaj xws li:

Nug koj tus kws kho mob dermatologist, kws kho mob hauv tsev neeg, lossis kws muag tshuaj rau lawv cov lus pom zoo.

Vitamin D Analogues: Lawv Pab Li Cas

Vitamin D analogues yog siv los pab tswj overactive ntawm daim tawv nqaij cell ntau lawm los ntawm kev khi rau cov vitamin D receptors ntawm daim tawv nqaij hlwb.

Cov tshuaj vitamin D analogues xws li:

muaj txiaj ntsig zoo ntawm kev ua kom qeeb ntawm kev loj hlob ntawm daim tawv nqaij thiab tuaj yeem siv nrog emollients thiab tshuaj pleev corticosteroids siv rau ntawm daim tawv nqaij.

Calcipotriene nrog betamethasone yog vitamin D analogue uas twb tau ua ke nrog cov tshuaj tiv thaiv corticosteroid. Hom muaj xws li: Taclonex , Taclonex tawv taub hau , Wynzora thiab Stylish .

Cov kev mob tshwm sim feem ntau nrog cov neeg ua haujlwm no yog cov tawv nqaij me me. Qee cov tshuaj vitamin D analogues tuaj yeem siv li 6 mus rau 8 lub lis piam rau lawv cov txiaj ntsig tag nrho.

Qhov ncauj calcitriol (Rocaltrol capsules) kuj tuaj yeem siv rau psoriasis.

Cov tshuaj Retinoids: Vitamin A Derivatives

Tazarotene ( Tazorac ) yog ib tug vitamin A derivative uas cuam tshuam rau epidermal cell loj hlob (nyob rau hauv lub sab saum toj txheej ntawm daim tawv nqaij) nyob rau hauv psoriasis thiab muaj ib co anti-inflammatory kev txiav txim. Nws kuj muaj raws li qhov kev xaiv dav dav.

  • Tazarotene tuaj nyob rau hauv ib tug qab zib los yog gel (0.05% los yog 0.1% zog) thiab yog siv feem ntau rau mob me me rau mob psoriasis. Tazorac kuj tau pom zoo rau kev kho pob txuv.
  • Lwm lub npe ntawm tazarotene, tau pom zoo rau lwm yam kev siv, suav nrog Arazlo (pob txuv), Fabior (pob txuv) thiab Avage (siv los txo cov wrinkles, tsaus nti lossis freckles ntawm lub ntsej muag.)
  • Hauv xyoo 2019, kev sib xyaw ua ke ntawm halobetasol, tshuaj pleev corticosteroid, thiab tazarotene (hom npe: Duobrii Lotion ) los ntawm Bausch Health yog FDA pom zoo rau plaque psoriasis.

tshuaj acitretin ( Soriatane ) yog ib lub qhov ncauj retinoid, kuj yog ib daim ntawv ntawm vitamin A, uas los ua tshuaj ntsiav (10 mg, 25 mg lub zog).

  • Nws yog siv rau cov mob hnyav ntawm psoriasis uas tsis teb rau lwm yam kev kho mob. Acitretin tsis yog kev kho mob rau psoriasis, thiab koj tus kab mob psoriasis tuaj yeem rov qab los tom qab koj tsis noj cov tshuaj no.
  • Nws kuj muaj raws li qhov kev xaiv dav dav.

Cev xeeb tub thiab pub niam mis ceeb toom

Tseem ceeb : Saib cov ntaub ntawv qhia tus neeg mob rau Tazorac lossis Soriatane kom paub ntau ntxiv txog qhov Contraindications thiab ceeb toom rau kev siv thaum cev xeeb tub thiab pub niam mis thiab tham txog cov ntaub ntawv no nrog koj tus kws kho mob.

Cov vitamin A derivatives tazarotene (Tazorac) thiab acitretin (Soriatane) tsis yog siv. thaum koj cev xeeb tub los yog npaj cev xeeb tub vim muaj kev pheej hmoo rau kev yug me nyuam loj heev. Koj yuav tsum tsis txhob xeeb tub thaum koj pib kho lossis cev xeeb tub thaum kho. Tsis tas li ntawd, cov khoom no yuav tsum tsis txhob siv thaum pub niam mis. Ua ntej koj pib kho nrog cov tshuaj, nrog koj tus kws kho mob tham txog kev pheej hmoo ntawm cev xeeb tub thiab pub niam mis nrog cov tshuaj no.

Tsis tas li ntawd, koj yuav tsum TSIS cev xeeb tub thaum noj acitretin (Soriatane) thiab rau tsawg kawg yog 3 xyoos tom qab tso tseg acitretin , yog li ntawd cov tshuaj yuav raug tshem tawm kom qis dua cov ntshav siab uas yuav cuam tshuam nrog kev nce ntxiv ntawm kev yug me nyuam.

Phototherapy: Lighten koj cov tsos mob

Kev kho lub teeb (phototherapy) tuaj yeem siv yog cov tshuaj kho mob tsis zoo. Lub hnub ci ntuj lossis lub teeb ultraviolet (UVA lossis UVB) tuaj yeem siv los pab tshem tawm cov tawv nqaij ntawm psoriasis. Kev kho lub teeb tuaj yeem siv ib leeg lossis ua ke nrog cov tshuaj.

  • Ultraviolet lub teeb txo qhov kev loj hlob ntawm cov plaques, liab, o thiab khaus.
  • Methoxsalen ( Oxsoralen-Ultra ) tuaj yeem siv nrog UV teeb kuj (hu ua PUVA) thiab siv tau zoo hauv kev kho thaj chaw loj ntawm cov kab mob psoriasis.
  • Laser lub teeb (UVB) kuj tseem siv tau thiab tuaj yeem tsom ncaj qha rau psoriasis thiab zam cov tawv nqaij ib puag ncig.
  • Kev kho lub teeb tuaj yeem ua rau muaj kev pheej hmoo ntawm daim tawv nqaij kub hnyiab thiab mob qog noj ntshav thiab yuav tsum tsis txhob siv rau cov neeg uas muaj keeb kwm mob qog noj ntshav.

Topical Coal Tar: Ib qho qub Stand-By

Coal tar yog ib qho ntawm cov kev kho mob laus tshaj plaws rau psoriasis. Cov khoom no muaj txiaj ntsig zoo hauv kev kho mob me me mus rau nruab nrab psoriasis nrog qee qhov kev mob tshwm sim, tab sis tuaj yeem cuam tshuam nrog cov ntxhiab tsw ntxhiab, thiab tawm stains ntawm khaub ncaws thiab lwm yam ntaub.

Txoj kev tseeb uas thee tar kho psoriasis tsis paub. Txawm li cas los xij, nws ua rau cov tawv nqaij nqus ntawm UVB lub teeb kom muaj txiaj ntsig ntxiv.

Coal tar tuaj yeem pom hauv khw muag tshuaj zawv plaub hau, tshuaj pleev thiab tshuaj pleev ib ce thiab tuaj yeem siv ua ke nrog corticosteroids thiab emollients los ua kom tawv nqaij.

Nws kuj tseem siv nrog ultraviolet-B (UVB) lub teeb hauv kev kho mob hu ua Goeckerman kev kho mob .

  • Goeckerman kev kho mob yog ib chav kawm ntawm UV kho lub teeb ua ke nrog cov thee tar rau ntau qhov nruab nrab-rau- mob hnyav plaque psoriasis.
  • Nws yog qhov ntxhib thiab tsw ntxhiab, tab sis tuaj yeem ua haujlwm zoo; Txawm li cas los xij, tsis muaj ntau tus kws kho mob muab cov kev kho mob no Cov kev kho mob feem ntau yog muab txhua hnub nyob rau ob peb lub lis piam ib zaug.

Lub taub hau: Anthralin rau tawv taub hau Psoriasis

Anthralin ( Drithocreme , Zithranol Shampoo) yog cov tshuaj pleev ib ce los yog tshuaj zawv plaub hau rau cov tawv taub hau uas ua rau qeeb ntawm kev loj hlob ntawm daim tawv nqaij.

  • Anthralin, zoo li thee tar, tuaj yeem ntxhov, stain fabrics, thiab muaj ntxhiab tsw.
  • Anthralin tuaj yeem ua rau tawv nqaij lossis plaub hau nrog cov xim liab liab ib ntus.
  • Kev kho mob tuaj yeem siv rau lub sijhawm luv los pab txo qis staining thiab khaus khaus. Ua raws li koj tus kws kho mob cov lus qhia rau kev siv.

Zoo li cov thee tar, anthralin tuaj yeem siv ua ke nrog UV teeb los pab cov tsos mob ntawm daim tawv nqaij ntawm psoriasis, suav nrog dryness, redness, flaking, scaling, thiab khaus.

Salicylic Acid: Ib Keratolytic

Salicylic acid (Salitop, Keralyt) muaj nyob rau hauv ob qho tib si hauv khw muag khoom thiab tshuaj noj muaj zog. Nws yog lub npe hu ua 'keratolytic', uas txhais tau hais tias nws loosens cov tawv nqaij tuag los ntawm psoriasis plaque kom txo qhov scaling.

Salicylic acid muaj nyob rau hauv ntau yam OTC formulations, xws li tshuaj pleev ib ce, gels, cream, foams, tshuaj zawv plaub hau thiab lwm yam, los kho ob daim tawv nqaij thiab tawv taub hau psoriasis.

Salicylic acid tuaj yeem siv ua ke nrog lwm yam kev kho mob, xws li corticosteroid cream, anthralin, lossis thee tar kom ua tau zoo.

  • Nws yuav siv sijhawm li ob peb hnub ua ntej koj cov tsos mob yuav zoo dua.
  • Feem ntau cov kev mob tshwm sim ntawm salicylic acid yuav muaj xws li tawv nqaij khaus, tev, pob khaus, los yog blanching ntawm daim tawv nqaij.

Methotrexate (MTX): Kev Xaiv Lub Sij Hawm Ntev

Methotrexate (cov npe khoom lag luam: RediTrex , Trexall , Otrexup , Rasuvo ), yog folic acid antagonist, lub ntsiab lus nws thaiv qhov kev ua ntawm folic acid. Methotrexate feem ntau yog abbreviated 'MTX'.

  • Methotrexate los ua ib ntsiav tshuaj ntawm qhov ncauj ib zaug ib lub lim tiam lossis txhaj tshuaj uas ua rau lub cev tsis muaj zog thiab DNA synthesis kom qeeb ntawm daim tawv nqaij hloov pauv.
  • MTX tuaj yeem siv tau ntev rau nruab nrab mus rau mob hnyav psoriasis thiab rau mob caj dab psoriatic, tab sis cov txiaj ntsig nrog MTX yuav tsis pom ntau lub hlis. Tshuaj xyuas MTX dosing ntawm no .
  • Koj tus kws kho mob kuj tseem yuav sau cov tshuaj folic acid ntxiv rau MTX kom pab txo qis plab thiab lwm yam kev mob tshwm sim.
  • MTX tuaj yeem ua rau lub siab thiab lwm yam kabmob; kev soj ntsuam kuaj yuav xav tau.

MTX yuav tsum TSIS TAU siv rau cov poj niam cev xeeb tub lossis npaj cev xeeb tub; Cov txiv neej kuj tseem yuav tsum tsis txhob siv 3 lub hlis ua ntej xeeb tub. Siv cov tshuaj tiv thaiv zoo thaum thiab tom qab kho nrog methotrexate.

  • Kev tswj kev yug me nyuam yog pom zoo rau poj niam ntawm kev muaj peev xwm yug me nyuam thaum kho thiab tsawg kawg yog 6 lub hlis tom qab koob tshuaj zaum kawg.
  • Kev tiv thaiv zoo yog pom zoo rau txiv neej nrog poj niam koom tes ntawm kev muaj peev xwm yug me nyuam thaum kho thiab tsawg kawg yog 3 lub hlis Tom qab koob tshuaj kawg ntawm methotrexate.

Cyclosporine: Kev Xaiv Lub Sijhawm luv

Cyclosporine , zoo li methotrexate, ua rau lub cev tiv thaiv kab mob kom txo tau cov tawv nqaij ntawm tes thiab kev loj hlob.

Cyclosporine tuaj yeem ua rau muaj kev pheej hmoo kis mob, thiab tsis pom zoo siv rau ntau tshaj ib xyoos.

  • Qee cov kws kho mob yuav qhia tias cov neeg mob noj 'hnub so' los ntawm cyclosporine, siv lwm yam kev kho mob nyob rau ib ntus, thiab rov qab mus rau cyclosporine kho dua tom qab.
  • Qhov no yuav pab txo qis cov kev mob tshwm sim hnyav xws li lub raum puas lossis ntshav siab.
  • Cyclosporine tuaj yeem siv ua ke nrog emollients; kev txhim kho feem ntau pom hauv 2 lub lis piam; tab sis stabilization nrog cyclosporine yuav siv sij hawm 12 mus rau 16 lub lis piam.

Biologics thiab Biosimilars

Biologics los yog biosimilars yog hom tshuaj kho tus kheej thiab hom tshuaj uas tau siv los kho psoriasis.

  • Biologics feem ntau yog tshwj tseg rau kev siv tom qab lwm qhov kev sim tshuaj tsis ua tiav lossis tsis zam.
  • Cov no yog cov tshuaj muaj protein ntau uas tau muab los ntawm cov hlwb uas muaj sia nyob (cov kab mob, cov nroj tsuag, lossis cov tsiaj hlwb) thiab ua ke hauv chav kuaj.

Muaj ntau yam biologics thiab biosimilars pom zoo rau kev kho mob psoriasis, psoriatic mob caj dab, lossis ob qho tib si. Cov chav kawm ntawm biologics siv suav nrog: qog necrosis factor alpha (TNF-alpha) inhibitors , interleukin (IL) blockers (IL-17, IL-23, IL-12/23), thiab T-cell blockers .

Ua ntej pib ua ib qho biologic, cov neeg mob yuav tsum tau kuaj xyuas tuberculosis (TB). Qee cov tshuaj biologics tuaj yeem muab hauv tsev los ntawm tus cwj mem rau kev txhaj tshuaj subcutaneous, thaum qee qhov kev kho mob yuav tsum tau mus ntsib chaw ua haujlwm rau kev txhaj tshuaj IV. Kev kho mob yuav ua rau muaj kev phiv loj heev, yog li nco ntsoov tham nrog koj tus kws kho mob. Lawv tuaj yeem ua rau muaj kev pheej hmoo rau qee yam kab mob, suav nrog tuberculosis (TB).

Cov neeg sawv cev no tuaj yeem raug nqi ntau txhiab daus las hauv ib hlis yog tias koj them nyiaj ntsuab. Txawm li cas los xij, cov chaw tsim khoom kuj tuaj yeem pab them nqi los ntawm lawv daim npav Copay lossis Kev Pabcuam Neeg Mob. Tshawb xyuas nrog koj lub tuam txhab tuav pov hwm rau lawv cov khoom nyiam thiab txiav txim siab koj qhov kev them nyiaj yog tias koj muaj ntawv pov hwm.

Cov slides tom ntej no qhia txog biologics nrog kev nkag mus rau lawv cov ntaub ntawv khoom.

FDA pom zoo Biologics rau Psoriasis thiab Psoriatic Arthritis

Pom zoo los kho ob qho tib si plaque psoriasis thiab psoriatic mob caj dab :

Pom zoo los kho plaque psoriasis :

Pom zoo los kho psoriatic mob caj dab :

Otezla (zeeg)

Otezla (apremilast) yog phosphodiesterase 4 (PDE4) inhibitor pom zoo los ntawm FDA hauv 2014 rau plaque psoriasis thiab psoriatic mob caj dab.

Cov kev tshawb fawb pom tias Otezla thaiv cov enzyme PDE4 kom txo qis qhov mob hauv lub cev, thiab kev txhim kho psoriasis yuav pib hauv thawj ob peb lub lis piam ntawm kev kho mob, tab sis nws tsis paub meej txog cov txheej txheem. Otezla tsis raug cais raws li tus neeg sawv cev biologic.

Otezla dose (hauv kev nthuav dav ntxiv)

  • Otezla tau noj raws li cov ntsiav tshuaj los ntawm qhov ncauj, thiab koj yuav maj mam nce koj cov koob tshuaj Otezla thawj 5 hnub los pab txo qis qhov ua rau mob plab.
  • Tom qab thawj zaug nce koob tshuaj, Otezla noj ob zaug ib hnub, sawv ntxov thiab hmo ntuj.
  • Otezla tuaj yeem noj nrog lossis tsis muaj zaub mov. Tsis txhob zuaj, faib, lossis zom cov ntsiav tshuaj.
  • Cov neeg mob raum mob hnyav yuav noj Otezla nkaus xwb ib hnub ib zaug. Koj cov koob tshuaj kuj tseem yuav raug txo qis thaum lub sij hawm maj mam nce ntxiv.

Feem ntau Kev mob tshwm sim nrog Otezla Hauv kev tshawb fawb plaque psoriasis yog raws plab, xeev siab, ua pa sab sauv, mob taub hau, thiab mob taub hau.

IL-17 Blockers: Siliq, Taltz, thiab Cosentyx

Lub Ob Hlis 2017, FDA pom zoo Siliq ( brodalumab ) kev txhaj tshuaj, ib qho tshuaj tiv thaiv-interleukin-17-receptor monoclonal antibody (blocks IL-17) los ntawm Valeant Pharmaceuticals los kho cov neeg laus uas muaj mob hnyav-rau-mob plaque psoriasis.

Hauv peb qhov kev tshawb fawb randomized, tswj cov placebo nrog 4,373 tus neeg mob, ntau dua Siliq-kho cov neeg mob muaj cov tawv nqaij ntshiab lossis yuav luag ntshiab piv rau cov neeg mob placebo.

Txawm li cas los xij, muaj kev ceeb toom loj nrog cov khoom no. Kev xav tua tus kheej thiab kev coj tus cwj pwm, suav nrog kev tua tus kheej ua tiav, tau tshwm sim hauv cov neeg mob kho nrog Siliq thaum lub sijhawm sim, tab sis tsis tau txiav txim siab ncaj qha rau lub koom haum. Vim qhov kev pheej hmoo ua tau, a txwv kev nkag mus yog nyob rau hauv qhov chaw uas suav nrog:

  • ib Boxed Warning
  • Siliq REMS Program
  • Phau Ntawv Qhia Tshuaj

Taltz ( kev xav ) thiab Cosentyx (secukinumab) kuj yog interleukin-17 inhibitors pom zoo rau cov quav hniav psoriasis, psoriatic mob caj dab thiab ankylosing spondylitis. Txawm li cas los xij, tsis zoo li Siliq, Taltz thiab Cosentyx tsis muaj lus ceeb toom tua tus kheej lossis txwv tsis pub nkag mus rau REMS program.

Tag nrho peb cov khoom yog muab los ntawm subcutaneous (hauv qab daim tawv nqaij) nws tus kheej txhaj tshuaj.

cov teebmeem ntev ntawm Wellbutrin

Thawj-hauv-Class Agent: Tremfya

Thaum Lub Xya Hli 2017, Janssen's Tremfya (guselkumab) tau txais kev pom zoo los ntawm FDA rau kev kho mob nruab nrab-rau-mob plaque psoriasis hauv cov neeg laus uas yog cov neeg sib tw rau kev kho mob lossis kev kho mob phototherapy. Thaum Lub Xya Hli 2020, nws tau pom zoo rau kev kho mob caj dab psoriatic.

  • Tremfya yog thawj-hauv-chav kawm biologic uas thaiv IL-23, ib qho interleukin cytokine uas ua lub luag haujlwm tseem ceeb hauv kev mob thiab cov tsos mob ntawm psoriasis.
  • Tremfya yog muab raws li 100 mg subcutaneous (hauv qab daim tawv nqaij) nws tus kheej txhaj tshuaj. Cov pom zoo koob tshuaj yog 100 mg ntawm lub lis piam 0, Lub lis piam 4, thiab txhua txhua 8 lub lis piam tom qab ntawd.
  • Thaum siv rau kev mob caj dab psoriatic, Tremfya tuaj yeem muab ib leeg lossis ua ke nrog cov kab mob uas tsis yog biologic hloov kho cov tshuaj tiv thaiv kab mob (DMARD) xws li methotrexate.
  • Cov kev mob tshwm sim feem ntau muaj xws li kab mob ua pa sab saud, mob taub hau, qhov chaw txhaj tshuaj, mob pob qij txha, mob ntsws, mob plab, plab hnyuv, kab mob ntawm daim tawv nqaij, thiab kab mob herpes simplex.

Ib tug thib ob IL-23 blocker, Ilumya (tseem ceeb-tsim) tau pom zoo nyob rau lub Peb Hlis 2018 rau plaque psoriasis. Tam sim no nws tsis pom zoo rau kev mob caj dab psoriatic, zoo li Tremfya.

  • Ilumya muaj qhov zoo dua ntawm Tremfya nyob rau hauv uas nws tsuas yog muab txhua txhua 12 lub lis piam (hloov 8) tom qab thawj zaug thauj khoom ntawm lub lim tiam 0 thiab lub lim tiam 4. Tus neeg mob yuav muab los ntawm kev txhaj tshuaj subcutaneous tus kheej.
  • Feem ntau (≥1%) cov kev mob tshwm sim nrog kev kho Ilumya yog kab mob ua pa sab saud, qhov chaw txhaj tshuaj, thiab raws plab.

Tsis txhob cia Psoriasis Yeej: Sib Tw Rov Qab

Txawm hais tias psoriasis tuaj yeem ua rau lub neej ntev thiab mob ntev, cov tshuaj tuaj yeem ua rau muaj kev txhim kho ntawm daim tawv nqaij thiab ib qho kev nkag siab ntawm kev noj qab haus huv. Qhov ntawd txhais tau tias tsis muaj kev ntshai ntxiv los qhia me ntsis ntawm daim tawv nqaij; koj txoj kev txaj muag tau txo qis thiab koj txoj kev ntseeg siab tau txhawb nqa.

Txawm li cas los xij, cov tshuaj rau psoriasis yog qee qhov kev kho mob tshiab tshaj plaws ntawm kev ua lag luam thiab nws yog ib qho tseem ceeb uas koj nkag siab txog lawv cov kev siv thiab kev phiv. Nco ntsoov ua raws li cov lus qhia thiab kev taw qhia ntawm koj tus kws kho mob.

  • Txhawm rau nthuav koj txoj kev nkag siab, koom nrog lwm tus neeg mob uas koom nrog tib yam mob thiab muaj lus nug zoo sib xws.
  • Lub suab muaj kev txhawj xeeb nrog lwm tus neeg hauv pab pawg thiab nyob twj ywm nrog cov xov xwm tshiab psoriasis tshiab, tag nrho hauv Psoriasis Q&A Center thiab pab pawg txhawb nqa thiab cov Psoriatic Arthritis Pawg . Muaj ib txwm muaj hwj chim hauv cov lej!

Tiav: Psoriasis: Cov duab, Cov tsos mob & Kev xaiv tshuaj kho mob

Biosimilars yog dab tsi? Qhov tseeb tshaj plaws uas koj yuav tsis paub

Koj tau hnov ​​​​txog biosimilars, tab sis tej zaum koj tseem muaj lus nug: Puas yog biosimilars yog cov khoom lag luam, lossis qee yam txawv? Lawv puas muaj kev nyab xeeb thiab siv tau? Lawv puas yuav txuag kev noj qab haus huv ...

Memos ntawm Menopause - Yam Uas Txhua Tus Poj Niam Yuav Tsum Paub

Lub koom haum nyiam kho menopause raws li tus kab mob; ib yam dab tsi yuav tsum zam ntawm txhua tus nqi. Tab sis menopause tuaj yeem ua tau zoo. Tsis muaj kev hloov pauv txhua hli ntxiv, kev sib tsoo lub sijhawm, lossis kev txhawj xeeb xeeb menyuam. Kev ntseeg tus kheej thiab kev paub txog tus kheej ...

Qhov chaw

  • Nruab Nrab rau Mob Psoriasis thiab Psoriatic Mob caj dab: Biologic Drugs. National Psoriasis Foundation. Tau txais Lub Ib Hlis 14, 2021 ntawm https://www.psoriasis.org/about-psoriasis/treatments/biologics
  • FDA pom zoo Ixifi. Drugs.com. Tau txais Lub Ib Hlis 14, 2021 ntawm find-drugs-conditionsnewdrugs/fda-ap20oves-ixifi-infliximab-qbtx-biosimilar-remicade-4659.html
  • FDA pom zoo Renflexis. Drugs.com. Tau txais Lub Ib Hlis 14, 2021 ntawm find-drugs-conditionsnewdrugs/fda-approves-renflexis-infliximab-abda-biosimilar-remicade-4519.html
  • FDA pom zoo Cyltezo. Drugs.com. Tau txais Lub Ib Hlis 14, 2021 ntawm find-drugs-conditionsnewdrugs/fda-approves-cyltezo-adalimumab-adbm-biosimilar-humira-4583.html
  • FDA Pom Zoo Amjevita (adalimumab-atto), Biosimilar rau Humira. Drugs.com. Tau txais Lub Ib Hlis 14, 2021 ntawm find-drugs-conditionsnewdrugs/fda-approves-amjevita-adalimumab-atto-biosimilar-humira-4434.html
  • American Academy ntawm Dermatology. Clinical Guidelines. Psoriasis. Cov lus qhia ntawm kev saib xyuas kev tswj hwm ntawm psoriasis thiab psoriatic mob caj dab. Tau txais Lub Ib Hlis 14, 2021. http://www.aad.org/education/clinical-guidelines
  • National Psoriasis Foundation. Psoriasis. Daim ntawv qhia tshuaj steroids potency. Tau txais Lub Ib Hlis 14, 2021. http://www.psoriasis.org/about-psoriasis/treatments/topicals/steroids/potency-chart
  • National Psoriasis Foundation. Kev kho mob rau psoriasis, suav nrog steroids. Tau txais Lub Ib Hlis 14, 2021. http://www.psoriasis.org/
  • Mayo Clinic. Psoriasis. Tau txais Lub Ib Hlis 14, 2021. http://www.mayoclinic.com/health/psoriasis/DS00193
  • UpToDate. Cov Ntaub Ntawv Tus Neeg Mob: Psoriasis (Tshaj Tawm Qhov Tseem Ceeb). Tau txais Lub Ib Hlis 14, 2021. http://www.uptodate.com/contents/psoriasis-beyond-the-basics
  • Otezla (apremilast) Product Labeling. Celgene Corporation. Tau txais Lub Ib Hlis 14, 2021 ntawm http://www.celgene.com/content/uploads/otezla-pi.pdf
  • Skyrizi (risankizumab-rzaa) Khoom Labeling. AbbVie Inc. Nkag mus rau Lub Ib Hlis 14, 2021 ntawm http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7148c8eb-b39e-e20a-6494-a6df82392858
  • Duobrii (halobetasol thiab tazarotene) Lotion Product Labeling. Bausch Health Co. 4/2019. Tau txais Lub Ib Hlis 14, 2021 ntawm https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b3f0cdc0-69fd-43d1-baf2-d776a3a20715

Cov ntaub ntawv ntxiv

Nco ntsoov sab laj nrog koj tus kws kho mob kom paub tseeb tias cov ntaub ntawv qhia hauv nplooj ntawv no siv tau rau koj tus kheej qhov xwm txheej.