Rovera Chewable Tablets

• Rovera Chewable Tablets Indications
• Lus ceeb toom thiab ceeb toom rau Rovera Chewable Tablets
• Cov lus qhia thiab ntau npaum li cas rau Rovera Chewable Tablets

Rovera Chewable Tablets

• Cov dev

(carprofen)

Chewable Tablets

Non-steroidal anti-inflammatory tshuaj

Rau qhov ncauj siv rau dev xwb

Rovera Chewable Tablets Ceev faj

Tsoom Fwv Teb Chaws txoj cai txwv cov tshuaj no siv los ntawm lossis raws li kev txiav txim ntawm tus kws kho tsiaj muaj ntawv tso cai.

Kev piav qhia

Rovera (carprofen) yog cov tshuaj uas tsis yog-steroidal anti-inflammatory tshuaj (NSAID) ntawm cov chav kawm propionic acid uas suav nrog ibuprofen, naproxen, thiab ketoprofen. Carprofen yog lub npe tsis tsim nyog rau kev hloov pauv carbazole, 6-chloro-α-methyl-9H-carbazole-2-acetic acid. Tus qauv empirical yog C_{kaum tsib}H₁₂ClNO_obthiab qhov hnyav molecular 273.72. Cov qauv tshuaj ntawm carprofen yog:

Carprofen yog dawb, crystalline compound. Nws yog dawb do soluble nyob rau hauv ethanol, tab sis xyaum insoluble nyob rau hauv dej ntawm 25 ° C.

Clinical Pharmacology

Cov txheej txheem ntawm kev ua ntawm carprofen, zoo li lwm cov NSAIDs, ntseeg tau tias muaj feem xyuam nrog inhibition ntawm cyclooxygenase kev ua haujlwm. Ob qhov tshwj xeeb cyclooxygenases tau piav qhia hauv cov tsiaj nyeg.^obLub constitutive cyclooxygenase, COX-1, synthesizes prostaglandins tsim nyog rau lub plab zom mov thiab lub raum ua haujlwm. Lub inducible cyclooxygenase, COX-2, generates prostaglandins koom rau hauv o. Inhibition ntawm COX-1 yog xav tias yuav cuam tshuam nrog plab hnyuv thiab lub raum toxicity thaum inhibition ntawm COX-2 muab kev tiv thaiv kab mob. Qhov tshwj xeeb ntawm NSAID tshwj xeeb rau COX-2 piv rau COX-1 yuav txawv ntawm hom mus rau hom.³Hauv ib hauv vitro kawm siv cov kab lis kev cai ntawm tes, carprofen qhia kev xaiv inhibition ntawm COX-2 piv rau COX-1.⁴Kev soj ntsuam qhov tseeb ntawm cov ntaub ntawv no tsis tau qhia. Carprofen kuj tau pom tias inhibit qhov kev tso tawm ntawm ntau prostaglandins nyob rau hauv ob inflammatory cell systems: nas polymorphonuclear leukocytes (PMN) thiab tib neeg rheumatoid synovial hlwb, qhia inhibition ntawm mob (PMN system) thiab ntev (synovial cell system) inflammatory tshua.^ib

Ntau qhov kev tshawb fawb tau pom tias carprofen muaj kev cuam tshuam rau ob qho tib si humoral thiab cellular tiv thaiv kab mob.^5-9Cov ntaub ntawv tseem qhia tau tias carprofen inhibits qhov tsim ntawm osteoclast-activating factor (OAF), PGE._ib, thiab PGE_oblos ntawm nws cov nyhuv inhibitory hauv prostaglandin biosynthesis.^ib

Raws li kev sib piv nrog cov ntaub ntawv tau txais los ntawm kev tswj hwm txoj hlab ntshav, carprofen tau nrawm thiab yuav luag tag nrho absorbed (ntau tshaj 90% bioavailable) thaum noj qhov ncauj.¹⁰Qhov siab tshaj plaws ntshav plasma concentration yog ua tiav hauv 1-3 teev tom qab noj qhov ncauj ntawm 1, 5, thiab 25 mg / kg rau dev. Qhov nruab nrab nruab nrab ntawm lub neej ntawm carprofen yog kwv yees li 8 teev (ntau 4.5-9.8 teev) tom qab ib koob tshuaj ntawm qhov ncauj txawv ntawm 1-35 mg / kg ntawm lub cev hnyav. Tom qab 100 mg ib koob tshuaj bolus, qhov kev tshem tawm ib nrab ntawm lub neej yog kwv yees li 11.7 teev hauv tus dev. Rovera yog ntau dua 99% khi rau cov ntshav plasma protein thiab nthuav tawm qhov ntim me me ntawm kev faib tawm.

Carprofen raug tshem tawm hauv tus dev feem ntau los ntawm biotransformation hauv daim siab ua raws li kev tshem tawm sai ntawm cov metabolites (ester glucuronide ntawm carprofen thiab ether glucuronides ntawm 2 phenolic metabolites, 7-hydroxy carprofen thiab 8-hydroxy carprofen) hauv cov quav (70). -80%) thiab zis (10-20%). Qee qhov enterohepatic ncig ntawm cov tshuaj tau pom.

Rovera Chewable Tablets Indications

Rovera yog qhia rau kev kho mob thiab mob txuam nrog osteoarthritis thiab rau kev tswj cov mob postoperative cuam tshuam nrog cov nqaij mos thiab orthopedic phais nyob rau hauv dev.

Contraindications

Rovera yuav tsum tsis txhob siv rau hauv cov dev uas muaj qhov ua rau muaj kev ntxhov siab dhau los rau carprofen.

Ceeb toom

Txhua tus dev yuav tsum tau ua tib zoo tshawb xyuas keeb kwm thiab kev kuaj lub cev ua ntej pib kho NSAID. Kev kuaj xyuas tsim nyog los tsim cov ntaub ntawv hematological thiab serum biochemical hauv paus ua ntej, thiab ib ntus, kev tswj hwm ntawm NSAID yuav tsum raug txiav txim siab. Cov tswv yuav tsum raug qhia kom ua raws li cov cim qhia txog kev muaj peev xwm tshuaj toxicity (saib Cov Ntaub Ntawv rau Cov Tswv Cuab, Kev Pom Zoo, Kev Nyab Xeeb Tsiaj thiab Kev Pom Zoo Tom Qab).

Cov kev ceev faj

Carprofen yog ib qho NSAID, thiab ib yam li lwm tus hauv chav kawm, cov kev tsis zoo yuav tshwm sim nrog nws siv. Feem ntau tshaj tawm cov teebmeem yog cov tsos mob ntawm plab hnyuv. Cov xwm txheej uas xav tias lub raum, hematologic, neurologic, dermatological, thiab hepatic teebmeem kuj tau raug tshaj tawm. Cov neeg mob uas muaj kev pheej hmoo loj tshaj plaws rau lub raum toxicity yog cov uas lub cev qhuav dej, ntawm kev kho diuretic concomitant, lossis cov neeg muaj lub raum, lub plawv, thiab / lossis lub siab ua haujlwm tsis zoo. Kev tswj hwm ib txhij ntawm cov tshuaj muaj peev xwm nephrotoxic yuav tsum tau ua kom ceev faj, nrog kev saib xyuas tsim nyog. Kev siv Rovera nrog lwm cov tshuaj tiv thaiv kab mob, xws li lwm yam NSAIDs lossis corticosteroids, yuav tsum zam vim tias muaj peev xwm ua rau muaj kev cuam tshuam tsis zoo, suav nrog kev mob plab hnyuv thiab / lossis perforations. rhiab heev rau cov tshuaj uas cuam tshuam nrog kev phiv tshuaj txawv nrog tus neeg mob. Cov dev uas tau ntsib kev tsis zoo los ntawm ib qho NSAID tuaj yeem ntsib kev tsis zoo los ntawm lwm NSAID. Kev kho Rovera tsis cuam tshuam nrog rau lub raum toxicity lossis gastrointestinal ulceration nyob rau hauv kev tswj kev nyab xeeb kev tshawb fawb txog li kaum npaug ntawm koob tshuaj rau cov dev noj qab nyob zoo.

Rovera tsis pom zoo siv rau hauv cov dev uas muaj cov kab mob los ntshav (xws li, Von Willebrand tus kab mob), vim tias kev nyab xeeb tsis tau tsim hauv cov dev nrog cov kab mob no. Kev nyab xeeb siv Rovera hauv cov tsiaj tsawg dua 6 lub lis piam, cov dev cev xeeb tub, dev siv rau kev yug me nyuam, lossis hauv lactating bitches tsis tau tsim. Cov kev tshawb fawb los txiav txim siab txog kev ua haujlwm ntawm Rovera thaum siv nrog rau lwm cov protein-bound lossis cov tshuaj metabolized zoo sib xws tsis tau ua. Tshuaj compatibility yuav tsum tau saib xyuas nyob rau hauv cov neeg mob xav tau kev kho mob ntxiv. Xws li cov tshuaj feem ntau siv xws li mob plawv, tshuaj tiv thaiv kab mob thiab kev coj cwj pwm. Nws tau raug qhia tias kev kho mob nrog carprofen tuaj yeem txo qis cov tshuaj loog uas xav tau.^{kaum tsib}

Yog tias cov tshuaj kho mob ntxiv tau raug lees paub tom qab kev tswj hwm ntawm tag nrho cov tshuaj niaj hnub ntawm Rovera, lwm txoj kev kho mob yuav tsum raug txiav txim siab. Tsis pom zoo siv lwm NSAID. Xav txog lub sijhawm ntxuav kom tsim nyog thaum hloov ntawm ib qho NSAID mus rau lwm qhov lossis thaum hloov los ntawm corticosteroids siv rau NSAID siv.

Vim lub palatable xwm ntawm Rovera chewable ntsiav tshuaj, cia tawm ntawm ncav cuag ntawm dev nyob rau hauv ib tug ruaj ntseg qhov chaw. Kev tsis zoo tshwm sim tuaj yeem tshwm sim yog tias noj cov ntsiav tshuaj ntau heev. Yog tias koj xav tias koj tus dev tau noj Rovera chewable ntsiav tshuaj saum toj sau npe, thov hu rau koj tus kws kho tsiaj kom tau txais kev pab tam sim ntawd thiab hu rau 1-800-916-8305.

INFORMATION RAU DOG OWNERS:

Rovera, zoo li lwm yam tshuaj ntawm nws cov chav kawm, tsis pub dawb los ntawm kev phiv tshuaj. Cov tswv yuav tsum tau qhia txog qhov muaj peev xwm ua rau muaj kev cuam tshuam tsis zoo thiab raug ceeb toom ntawm cov tsos mob tshwm sim cuam tshuam nrog kev tsis haum tshuaj. Cov tshuaj tiv thaiv tsis zoo yuav muaj xws li kev poob qab los noj mov, ntuav, raws plab, tsaus nti lossis tarry quav, noj dej ntau ntxiv, tso zis ntau ntxiv, cov pos hniav daj vim yog ntshav qab zib, yellowing ntawm cov pos hniav, tawv nqaij lossis dawb ntawm lub qhov muag vim jaundice, lethargy, incoordination, qaug dab peg, los yog kev hloov tus cwj pwm. Cov kev phiv loj heev cuam tshuam nrog chav kawm tshuaj no tuaj yeem tshwm sim yam tsis muaj kev ceeb toom thiab qee zaus ua rau tuag taus (saib Cov Kev Pom Tsis Zoo). Cov tswv yuav tsum raug qhia kom txiav Rovera txoj kev kho mob thiab tiv tauj lawv tus kws kho tsiaj tam sim ntawd yog tias pom tias muaj kev tsis haum tshuaj. Feem coob ntawm cov neeg mob uas muaj cov tshuaj tiv thaiv tsis zoo tau rov zoo dua thaum pom cov tsos mob, cov tshuaj raug tshem tawm, thiab kev kho tsiaj, yog tias tsim nyog, pib. Cov tswv yuav tsum tau qhia txog qhov tseem ceeb ntawm kev saib xyuas txhua lub sijhawm rau txhua tus dev thaum tswj hwm NSAID.

Kev Phem Tsis Zoo

Tsis muaj qhov tshwm sim tsis zoo tshwm sim thaum kev tshawb fawb soj ntsuam nrog kev tswj hwm ib hnub ntawm 2 mg / lb. Cov pawg hauv qab no ntawm kev soj ntsuam kev noj qab haus huv txawv txav tau tshaj tawm. Cov khoom siv tsheb ua haujlwm tswj.

Clinical pathology parameters teev sawv cev cov lus ceeb toom ntawm qhov nce ntawm qhov kev kho mob ua ntej; kev txiav txim kho mob yog qhov tsim nyog los txiav txim qhov cuam tshuam ntawm kev kho mob.

Hauv kev tshawb nrhiav kev tshawb fawb txog kev phais mob rau lub caplet formulation, tsis muaj cov tshuaj tiv thaiv tseem ceeb hauv tsev kho mob tau tshaj tawm. Cov khoom siv tsheb ua haujlwm tswj.

* Ib tus dev ib leeg yuav tau ntsib ntau dua ib qho tshwm sim ntawm qhov xwm txheej.

Hauv kev tshawb nrhiav kev tshawb nrhiav rau cov ntsiav tshuaj uas tuaj yeem noj tau, cov cim qhia hauv plab tau pom hauv qee tus dev. Cov paib no suav nrog ntuav thiab cov quav mos.

Tom qab kev pom zoo:

Txawm hais tias tsis yog txhua qhov kev tshwm sim tsis zoo raug tshaj tawm, cov kev cuam tshuam tsis zoo hauv qab no yog ua raws li kev tso cai tom qab kev pom zoo tsis zoo rau kev tshaj tawm txog tshuaj. Cov pawg ntawm cov kev tsis zoo tshwm sim tau teev nyob rau hauv kev txo qis ntawm qhov zaus ntawm lub cev.

plab hnyuv: ntuav, raws plab, cem quav, inappetence, melena, hematemesis, gastrointestinal ulceration, gastrointestinal los ntshav, pancreatitis .

Mob siab: Inappetence, ntuav, jaundice, mob hepatic toxicity, hepatic enzyme elevation, txawv txav daim siab ua hauj lwm (s), hyperbilirubinemia, bilirubinuria, hypoalbuminemia. Kwv yees li ib feem plaub ntawm cov kab mob siab tau nyob hauv Labrador Retrievers .

Neurological: Ataxia, paresis, tuag tes tuag taw, qaug dab peg, vestibular cim, disorientation.

tso zis: Hematuria, polyuria, polydipsia, urinary incontinence, urinary kab mob, azotemia, mob raum tsis ua hauj lwm, tubular abnormalities xws li mob tubular necrosis, raum tubular acidosis, glucosuria. .

Kev coj cwj pwm: Sedation, lethargy, hyperactivity, nyob tsis tswm, aggressiveness.

Hematology: Immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, ntshav poob anemia, epistaxis .

Dermatology: Pruritus, nce shedding, alopecia, pyotraumatic moist dermatitis (kub me ntsis), necrotizing panniculitis / vasculitis, ventral ecchymosis .

Immunologic lossis hypersensitivity: Lub ntsej muag o, khaus, erythema.

Nyob rau hauv cov xwm txheej tsis tshua muaj, kev tuag tau cuam tshuam nrog qee qhov kev tsis zoo uas tau teev tseg saum toj no.

Yog xav paub ntxiv txog cov tshuaj tiv thaiv tsis zoo hu rau 1-800-916-8305.

Dosage thiab Administration

PALATABILITY: Kev tswj xyuas palatability txoj kev tshawb fawb tau ua uas qhia tau hais tias Rovera chewable ntsiav tshuaj tau nkag tau txais thiab noj rau thawj zaug los ntawm feem ntau ntawm cov dev.

Kev ua tau zoo

Sib cais cov placebo-tswj, npog ntsej muag, ntau qhov kev tshawb fawb hauv cheeb tsam tau lees paub qhov kev tiv thaiv kab mob thiab kev ua kom lub cev muaj zog ntawm Rovera caplets thaum noj ntawm 2 mg / lb ib hnub ib zaug lossis thaum muab faib thiab muab tshuaj ntawm 1 mg / lb ob zaug ib hnub. Hauv cov kev tshawb fawb 2 no, cov dev tau kuaj mob osteoarthritis tau pom qhov kev txhim kho tseem ceeb tag nrho raws li kev ntsuam xyuas lameness los ntawm kws kho tsiaj thiab tus tswv kev soj ntsuam thaum muab Rovera ntawm cov tshuaj sau npe.

Sib cais cov placebo-tswj, npog ntsej muag, ntau qhov kev tshawb fawb hauv cheeb tsam tau lees paub qhov ua tau zoo ntawm Rovera caplets rau kev tswj cov mob tom qab phais thaum txhaj tshuaj ntawm 2 mg / lb ib hnub ib zaug hauv ntau hom dev. Hauv cov kev tshawb fawb no, cov dev tau nthuav tawm rau ovariohysterectomy, kho cruciate thiab aural surgeries raug muab Rovera ua ntej thiab rau qhov siab tshaj plaws ntawm 3 hnub (cov ntaub so ntswg) lossis 4 hnub (orthopedic) postoperatively. Feem ntau, cov dev noj Rovera pom qhov txo qis hauv cov qhab nia mob piv rau kev tswj hwm.

TSEV KAWM NTAWV: Kev tshawb fawb hauv chav kuaj hauv cov dev uas tsis muaj tshuaj loog thiab kev sim tshuaj ntsuam xyuas tau pom tias Rovera tau txais txiaj ntsig zoo hauv cov dev tom qab kev tswj hwm qhov ncauj.

Hauv cov phiaj xwm kev tshawb fawb txog kev nyab xeeb tsiaj, Rovera tau hais lus rau cov dev noj qab haus huv Beagle ntawm 1, 3, thiab 5 mg / lb ob zaug ib hnub (1, 3 thiab 5 npaug ntawm qhov pom zoo tag nrho cov koob tshuaj txhua hnub) rau 42 hnub sib law liag uas tsis muaj qhov cuam tshuam loj heev. Serum albumin rau ib tus dev ib leeg tau txais 5 mg / lb ob zaug ib hnub poob qis rau 2.1 g / dL tom qab 2 lub lis piam ntawm kev kho mob, rov qab mus rau tus nqi kho mob ua ntej (2.6 g / dL) tom qab 4 lub lis piam kho, thiab yog 2.3 g / dL ntawm qhov kev ntsuam xyuas zaum kawg 6 lub lis piam. Tshaj li 6 lub lis piam kho mob, cov quav dub lossis ntshav tau pom hauv 1 tus dev (1 qhov xwm txheej) kho nrog 1 mg / lb ob zaug ib hnub thiab hauv 1 tus dev (2 qhov xwm txheej) kho nrog 3 mg / lb ob zaug ib hnub. Redness ntawm lub plab mucosa tau pom hauv 1 txiv neej uas tau txais 3 mg / lb ob zaug ib hnub.

Ob ntawm 8 tus dev tau txais 10 mg / lb ntawm qhov ncauj ob zaug hauv ib hnub (10 npaug ntawm qhov pom zoo tag nrho cov koob tshuaj txhua hnub) rau 14 hnub pom pom hypoalbuminemia. Qhov nruab nrab qib albumin hauv cov dev uas tau txais koob tshuaj no yog qis dua (2.38 g / dL) dua li txhua ntawm 2 pawg tswj hwm cov placebo (2.88 thiab 2.93 g / dL, feem). Peb qhov xwm txheej ntawm cov quav dub lossis ntshav tau pom hauv 1 tus dev. Tsib ntawm 8 tus dev tau nthuav tawm thaj chaw reddened ntawm duodenal mucosa ntawm tag nrho cov kab mob pathologic. Kev kuaj mob histologic ntawm cov cheeb tsam no tau qhia tsis muaj pov thawj ntawm qhov mob, tab sis tau pom tias muaj qhov paug tsawg ntawm lamina propria hauv 2 ntawm 5 tus dev.

Hauv kev tshawb fawb txog kev nyab xeeb sib cais ntev li 13 thiab 52 lub lis piam, raws li txoj cai, cov dev tau noj qhov ncauj mus txog 11.4 mg / lb / hnub (5.7 npaug ntawm qhov pom zoo txhua hnub koob tshuaj ntawm 2 mg / lb) ntawm carprofen. Hauv ob qho tib si kev tshawb fawb, cov tshuaj tau txais txiaj ntsig zoo los ntawm kev kho mob los ntawm txhua tus tsiaj. Tsis muaj tag nrho lossis kev hloov pauv histological tau pom hauv ib qho ntawm cov tsiaj kho. Hauv ob qho kev tshawb fawb, cov dev tau txais koob tshuaj ntau tshaj plaws tau nce qhov nruab nrab hauv cov ntshav L-alanine aminotransferase (ALT) ntawm kwv yees li 20 IU.

Hauv kev tshawb fawb 52-lub lim tiam, kev hloov pauv me me tshwm sim hauv cov dev hauv txhua pab pawg kho mob tab sis tsis nyob hauv cov dev tswj. Cov kev hloov pauv tau piav qhia me ntsis liab lossis pob liab liab thiab tau kuaj pom tias tsis yog dermatitis. Qhov muaj peev xwm tshwm sim tau tias cov kab mob me me no tau muaj kev kho mob, tab sis tsis muaj kev sib raug zoo ntawm koob tshuaj.

Cov kev tshawb fawb soj ntsuam tau ua nrog 549 tus dev ntawm ntau hom tsiaj ntawm qhov pom zoo koob tshuaj rau 14 hnub (297 dev tau suav nrog hauv kev tshawb fawb ntsuas 1 mg / lb ob zaug ib hnub thiab 252 dev tau suav nrog hauv kev tshawb fawb cais ntsuas 2 mg / lb ib hnub ib zaug. ). Hauv ob qho tib si kev tshawb fawb, cov tshuaj tau txais txiaj ntsig zoo thiab qhov tshwm sim ntawm cov tshuaj tiv thaiv tsis zoo rau cov tsiaj kho Rovera tsis siab dua li cov placebo-kho tsiaj (placebo muaj cov khoom xyaw tsis muaj zog hauv Rovera). Rau cov tsiaj uas tau txais 1 mg / lb ob zaug ib hnub twg, qhov nruab nrab tom qab kho cov ntshav qab zib ALT qhov tseem ceeb yog 11 IU ntau dua thiab 9 IU tsawg dua qhov kev kho mob ua ntej rau cov dev tau txais Rovera thiab placebo, raws li. Qhov sib txawv tsis yog qhov tseem ceeb. Rau cov tsiaj uas tau txais 2 mg / lb ib hnub ib zaug, qhov nruab nrab tom qab kev kho cov ntshav ntshav ALT qhov tseem ceeb yog 4.5 IU ntau dua thiab 0.9 IU tsawg dua qhov kev kho mob ua ntej rau cov dev tau txais Rovera thiab placebo, raws li. Hauv kev tshawb fawb tom kawg, 3 Rovera-kho dev tau tsim 3-fold lossis ntau dua qhov nce hauv (ALT) thiab / lossis (AST) thaum lub sijhawm kho. Ib tus dev uas tau txais placebo muaj ntau dua 2-fold nce hauv ALT. Tsis muaj ib qho ntawm cov tsiaj no pom cov tsos mob tshwm sim cuam tshuam nrog kev hloov pauv tus nqi hauv chav kuaj. Kev hloov pauv hauv qhov chaw kuaj mob qhov tseem ceeb (hematology thiab chaw kho mob chemistry) tsis suav tias yog qhov tseem ceeb hauv chaw kho mob. 1 mg / lb ob zaug ib hnub ntawm kev kho mob tau rov ua dua raws li qhov xav tau ntawm 2 lub lis piam nyob rau hauv 244 tus dev, qee qhov ntev li 5 xyoos.

Cov kev tshawb fawb soj ntsuam tau ua nyob rau hauv 297 tus dev ntawm ntau hom kev phais mob orthopedic lossis mos mos. Cov dev tau muab 2 mg / lb ntawm Rovera ob teev ua ntej kev phais tom qab ntawd ib hnub ib zaug, raws li xav tau rau 2 hnub (mob phais) lossis 3 hnub (kev phais orthopedic). Rovera tau txais txiaj ntsig zoo thaum siv nrog ntau yam tshuaj loog uas cuam tshuam nrog. Hom thiab qhov hnyav ntawm kev saib xyuas kev noj qab haus huv tsis zoo hauv Rovera- thiab cov tsiaj kho cov tshuaj placebo yog kwv yees li sib npaug thiab ob peb tus lej (saib Cov Kev Tsis Txaus Siab). Kev soj ntsuam kev noj qab haus huv ntau zaus yog ntuav thiab tau pom nyob ntawm kwv yees li tib zaus hauv Rovera- thiab cov tsiaj kho cov placebo. Cov kev hloov pauv hauv cov ntsuas ntsuas ntawm hematopoietic, lub raum, lub siab, thiab cov hlab ntshav tsis ua haujlwm tseem ceeb. Qhov nruab nrab tom qab kev kho mob ntshav qab zib ALT qhov tseem ceeb yog 7.3 IU thiab 2.5 IU tsawg dua qhov kev kho mob ua ntej rau cov dev uas tau txais Rovera thiab placebo, feem. Qhov nruab nrab tom qab kho AST qhov tseem ceeb yog 3.1 IU tsawg dua rau cov dev tau txais Rovera thiab 0.2 IU ntau dua rau cov dev tau txais cov placebo.

Cia

Yuav Ua Li Cas

Cov ntaub ntawv

1. Baruth H, thiab al: Hauv Tshuaj Tiv Thaiv Kab Mob thiab Tshuaj Tiv Thaiv Rheumatic, Vol. II, Newer Anti-Inflammatory Drugs, Rainsford KD, ed. CRC Xovxwm, Boca Raton, p. Peb 33, 1986.

2. Vane JR, Botting RM: Mechanism of action of anti-inflammatory drug. Scand J Rheumatol 25:102, pp. 9–21.

3. Grossman CJ, Wiseman J, Lucas FS, thiab al: Inhibition ntawm constitutive thiab inducible cyclooxygenase kev ua si nyob rau hauv tib neeg platelets thiab mononuclear hlwb los ntawm NSAIDs thiab COX-2 inhibitors. Kev Tshawb Fawb Txog Kab Mob 44: 253-257, 1995.

4. Ricketts AP, Lundy KM, Seibel SB: Kev ntsuam xyuas ntawm kev xaiv inhibition ntawm canine cyclooxygenase 1 thiab 2 los ntawm carprofen thiab lwm yam nonsteroidal anti-inflammatory tshuaj. Am J Vet Res 59:11 ,wb. 1441-1446, Kaum Ib Hlis 1998.

5. Ceuppens JL, thiab al: Non-steroidal anti-inflammatory agents inhibit lub synthesis ntawm IgM rheumatoid yam hauv vitro . Lancet Peb 1: 528, 1982.

6. Ceuppens JL, thiab al: Endogenous prostaglandin E_obtxhim kho polyclonal immunoglobulin ntau lawm los ntawm ionically inhibiting T suppressor cell kev ua. Cell Immunol Peb 70:41, 1982.

7. Schleimer NP, thiab al: Cov teebmeem ntawm prostaglandin synthesis inhibition ntawm lub cev tiv thaiv kab mob. Immunopharmacology Peb 3:205, 1981.

8. Lee KH, thiab al: Modulation ntawm txoj kev loj hlob ntawm cell mediated kev tiv thaiv: Ua tau lub luag hauj lwm ntawm cov khoom ntawm cyclooxygenase thiab lipoxygenase txoj kev ntawm arachidonic acid metabolism. Int J Immunopharmacology 4:195, 1982, ib.

9. Veit BC: Immunoregulatory kev ua ntawm kab lis kev cai-induced suppressor macrophages. Cell Immunol Peb 72:14, 1982.

10. Schmitt M. thiab al: Kev soj ntsuam biopharmaceutical ntawm carprofen tom qab txhaj tshuaj ib leeg, qhov ncauj, thiab qhov quav hauv dev. Biopharm Dispos 11(7):585, 1990.

11. Kore AM: Toxicology ntawm nonsteroidal anti-inflammatory tshuaj. Veterinary Clinics ntawm North America, Me Tsiaj xyaum Peb Hlis 20, 1990.

12. Binns SH: Pathogenesis thiab pathophysiology ntawm ischemic raug mob thaum mob raum tsis ua haujlwm. Compend rau Cont Ed Peb 16:1, 1994.

13. Boothe DM: Prostaglandins: Physiology thiab kev soj ntsuam cuam tshuam. Compend rau Cont Ed Peb 6:11, 1984.

14. Rubin SI: Nonsteroidal anti-inflammatory tshuaj, prostaglandins, thiab lub raum. JAVMA 188:9, Peb 1986.

15. Ko CH, Lange DN, Mandsager RE, thiab al: Cov teebmeem ntawm butorphanol thiab carprofen ntawm qhov tsawg kawg nkaus alveolar concentration ntawm isoflurane hauv dev. JAVMA 217:1025-1028, 2000 Nws.

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