Taxol Side Effects

Lub npe dav: paclitaxel

Nco tseg: Cov ntaub ntawv no muaj cov ntaub ntawv cuam tshuam txog paclitaxel. Qee cov ntaub ntawv noj tshuaj uas tau teev tseg rau ntawm nplooj ntawv no yuav tsis siv rau lub npe Taxol.



Rau Cov Neeg Siv Khoom

Siv rau paclitaxel : tso tshuaj

Ceeb toom

Intravenous route (Kev daws)

Anaphylaxis thiab mob hnyav hypersensitivity tshwm sim los ntawm ua tsis taus pa thiab hypotension xav tau kev kho mob, angioedema , thiab generalized urticaria tau tshwm sim hauv kev sim tshuaj. Cov tshuaj tiv thaiv tuag tau tshwm sim hauv cov neeg mob txawm tias muaj kev kho mob ua ntej, thiab txhua tus neeg mob yuav tsum tau kho nrog corticosteroids, diphenhydramine , thiab H2 antagonists . Cov neeg mob uas muaj kev ntxhov siab heev rau paclitaxel yuav tsum tsis txhob rov hais dua nrog cov tshuaj. Paclitaxel txoj kev kho yuav tsum tsis txhob muab rau cov neeg mob uas muaj cov qog nqaij hlav uas muaj cov hauv paus neutrophil suav tsawg dua 1500 hlwb / hli (3) thiab yuav tsum tsis txhob muab rau cov neeg mob uas muaj AIDS. Kaposi lub sarcoma Yog hais tias qhov nruab nrab neutrophil suav tsawg dua 1000 hlwb/mm(3). Saib xyuas cov qe ntshav peripheral suav ntau zaus.

Kev mob tshwm sim yuav tsum tau mus kho mob tam sim

Nrog rau nws cov teebmeem xav tau, paclitaxel (cov khoom muaj nyob hauv Taxol ) tej zaum yuav ua rau tej yam tsis xav tau. Txawm hais tias tsis yog tag nrho cov kev mob tshwm sim no tuaj yeem tshwm sim, yog tias lawv tshwm sim lawv yuav xav tau kev kho mob.

Nrog koj tus kws kho mob lossis tus kws saib xyuas neeg mob tham tam sim ntawd Yog tias ib qho ntawm cov kev mob tshwm sim hauv qab no tshwm sim thaum noj paclitaxel:

Feem ntau

  • Cov quav dub los yog tarry quav
  • qhov muag tsis pom kev
  • hlawv, ua tsis taus pa , tingling, los yog mob heev
  • tsis meej pem
  • hnoos los yog hoarseness nrog kub taub hau los yog txias
  • kiv taub hau , faintness, los yog lightheadedness thaum sawv tam sim ntawd los ntawm ib tug dag los yog zaum
  • kev xav sov
  • ua npaws los yog txias
  • sab nraub qaum lossis sab mob
  • mob los yog tso zis nyuaj
  • tawv nqaij tawv
  • liab ntawm lub ntsej muag, caj dab, caj npab, thiab qee zaus, sab hauv siab
  • ua tsis taus pa
  • daim tawv nqaij ua pob los yog khaus
  • mob caj pas
  • tawm hws
  • ua pa nyuaj nrog kev tawm dag zog
  • rwj, mob, los yog pob dawb nyob rau hauv lub qhov ncauj
  • kev tsis khov los yog ua tsis taus pa
  • txawv txav los ntshav los yog bruising
  • qaug zog los yog qaug zog txawv txawv
  • qaug zog ntawm caj npab, tes, ceg, lossis ko taw

Tsawg dua

  • Ntshav hauv cov zis los yog quav
  • ua tsis taus pa nyuaj
  • pinpoint liab me ntsis ntawm daim tawv nqaij
  • ua tsis taus pa (mob hnyav)
  • lub plawv dhia qeeb
  • nruj hauv siab
  • hawb pob

Qhov xwm txheej tsis paub

  • Kev ntxhov siab
  • daim di ncauj xiav, ntiv tes, lossis daim tawv nqaij
  • ua tsis taus pa nyuaj lossis teeb meem
  • ua tsis taus pa
  • lub plawv dhia ceev
  • irregular, ceev los yog qeeb, los yog ntiav ua pa
  • sudden ua tsis taus pa

Kev mob tshwm sim tsis tas yuav tsum tau kho mob tam sim

Qee qhov kev mob tshwm sim ntawm paclitaxel tuaj yeem tshwm sim uas feem ntau tsis xav tau kev kho mob . Cov kev mob tshwm sim no yuav ploj mus thaum kho raws li koj lub cev hloov kho rau cov tshuaj. Tsis tas li ntawd, koj tus kws kho mob tuaj yeem qhia koj txog txoj hauv kev los tiv thaiv lossis txo qee qhov kev mob tshwm sim.

Tshawb xyuas nrog koj tus kws kho mob yog tias muaj cov kev mob tshwm sim hauv qab no txuas ntxiv los yog thab plaub los yog koj muaj lus nug txog lawv:

Feem ntau

  • Los ntshav, blistering, kub hnyiab, txias, discoloration ntawm daim tawv nqaij, zoo siab, khaus khaus , kis kab mob, o, khaus, pob, loog, mob, pob khaus, liab, caws pliav, mob, stinging, o, rhiab, tingling, ulceration, los yog sov so ntawm qhov chaw txhaj tshuaj.
  • tawg daim di ncauj
  • raws plab
  • nyuaj nrog nqos
  • plaub hau poob
  • xeev siab los yog ntuav
  • loog loog, kub hnyiab, los yog tingling ntawm tes los yog ko taw
  • mob hauv pob qij txha los yog cov leeg, tshwj xeeb tshaj yog nyob rau hauv caj npab los yog ob txhais ceg
  • thinning ntawm cov plaub hau

Rau Cov Kws Kho Mob

Siv rau paclitaxel: cov tshuaj txhaj tshuaj

Mob plawv

Feem ntau (10% lossis ntau dua): Hypotension

Feem ntau (1% mus rau 10%): Bradycardia

Tsis tshua muaj (0.1% rau 1%): Cardiomyopathy, asymptomatic ventricular tachycardia , tachycardia nrog bigeminy, atrioventricular thaiv thiab syncope , myocardial infarction, kub siab, thrombosis, thrombophlebitis

Tsis tshua muaj (0.01% rau 0.1%): Mob plawv tsis ua hauj lwm

Tsawg heev (tsawg dua 0.01%): Atrial fibrillation , supraventricular tachycardia , poob siab

nemex 2 daim ntawv qhia ntau npaum rau menyuam dev

Zaus tsis qhia : Phlebitis[ Ref ]

Dermatology

Feem ntau (10% lossis ntau dua): Alopecia (90%), liab

Feem ntau (1% mus rau 10%): Kev hloov pauv ntawm cov ntsia hlau me me thiab cov tawv nqaij hloov pauv, hloov xim ntawm tus ntsia thawv txaj

Tsis tshua muaj (0.01% rau 0.1%): Pruritus , liab, erythema

Tsawg heev (tsawg dua 0.01%): Stevens-Johnson Syndrome , tshuaj lom epidermal necrolysis (TEN), erythema multiforme, exfoliative dermatitis, urticaria, onycholysis (cov neeg mob ntawm kev kho yuav tsum hnav lub hnub tiv thaiv ntawm tes thiab ko taw), kab mob scleroderma -zoo li cov tshuaj tiv thaiv[ Ref ]

plab hnyuv

Feem ntau (10% lossis ntau dua): xeev siab (52%), mucositis (31%), ntuav, raws plab mucosal o

Tsis tshua muaj (tsawg dua 0.1%): Peritonitis, plab hnyuv mob plab hnyuv perforation, ischemic mob plab , pancreatitis

Tsawg heev (tsawg dua 0.01%): Pseudomembranous colitis , mesenteric thrombosis, neutropenic colitis, esophagitis , cem quav , ascites [ Ref ]

Hematology

Feem ntau (10% lossis ntau dua): Myelosuppression, neutropenia (90%), anemia, thrombocytopenia , leukopenia, los ntshav

Tsis tshua muaj (tsawg dua 0.1%): Febrile neutropenia [ Ref ]

Mob siab

Feem ntau (10% lossis ntau dua): alkaline phosphatase (22%), siab AST (SGOT) (19%)

Feem ntau (1% mus rau 10%): nce bilirubin

Tsawg heev (tsawg dua 0.01%): Hepatic necrosis, hepatic encephalopathy (ob qho tib si nrog cov xwm txheej ntawm qhov tshwm sim tuag)[ Ref ]

Mob siab heev

Feem ntau (10% lossis ntau dua): Cov tshuaj tiv thaiv me me (tsuas yog dej ntws tawm thiab ua pob liab liab)

Tsis tshua muaj (0.1% mus rau 1%): Cov tshuaj tiv thaiv hypersensitivity tseem ceeb uas yuav tsum tau kho (piv txwv li, hypotension, angioneurotic edema ua pa nyuaj, generalized urticaria, ua daus no, mob nraub qaum mob hauv siab, tachycardia, mob plab , mob hauv qhov kawg, diaphoresis, kub siab)

Tsis tshua muaj (tsawg dua 0.1%): Cov tshuaj tiv thaiv anaphylactic

Tsawg heev (tsawg dua 0.01%): Anaphylactic poob siab [ Ref ]

Immunologic

Feem ntau (10% lossis ntau dua): Cov kab mob (feem ntau yog cov kab mob tso zis thiab kab mob ua pa sab saud), nrog rau cov ntaub ntawv qhia txog kev tuag

Tsis tshua muaj (0.1% mus rau 1%): Septic shock

Tsis tshua muaj (tsawg dua 0.1%): Sepsis , pseudomembranous colitis[ Ref ]

Hauv zos

Feem ntau (1% mus rau 10%): Qhov chaw txhaj tshuaj (nrog rau hauv zos edema , mob, erythema, induration, nyob rau lub sij hawm extravasation tuaj yeem ua rau cellulitis daim tawv nqaij fibrosis thiab daim tawv nqaij necrosis)

Tsis tshua muaj (tsawg dua 0.1%): Phlebitis[ Ref ]

Musculoskeletal

Feem ntau (10% lossis ntau dua): Arthralgia / myalgia (44%)

Zaus tsis qhia : Systemic lupus erythematosus , mob scleroderma[ Ref ]

claritin d thaum pub mis niam

Metabolic

Feem ntau (1% mus rau 10%): Kev nce siab hauv aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase (SGOT)), hnyav nce hauv alkaline phosphatase

Tsis tshua muaj (0.1% mus rau 1%): Kev nce siab hauv bilirubin

Tsis tshua muaj (0.01% rau 0.1%): Lub cev qhuav dej , nce ntshav creatinine

Tsawg heev (tsawg dua 0.01%): Anorexia

Zaus tsis qhia : Tumor lysis syndrome [ Ref ]

Lub paj hlwb

Feem ntau (10% lossis ntau dua): Neurotoxicity (feem ntau peripheral neuropathy )

Tsis tshua muaj (0.01% mus rau 0.1%): Lub cev muaj zog neuropathy (nrog rau qhov tshwm sim me me tsis muaj zog)

Tsawg heev (tsawg dua 0.01%): Autonomic neuropathy (ua rau tuag tes tuag taw ileus thiab orthostatic hypotension ), optic paj hlwb cuam tshuam, grand mal qaug dab peg , convulsions, encephalopathy , kiv taub hau, mob taub hau , ataxia[ Ref ]

Ocular

Tsawg heev (tsawg dua 0.01%): Optic paj hlwb thiab/los yog qhov muag tsis pom kev (scintilating scotomata), tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas tau txais koob tshuaj ntau tshaj qhov pom zoo

Zaus tsis qhia : Macular edema, photopsia, vitreous floaters[ Ref ]

Oncology

Tsawg heev (tsawg dua 0.01%): Mob myeloid leukemia , myelodysplastic syndrome[ Ref ]

Lwm yam

Tsis tshua muaj (0.01% mus rau 0.1%): Asthenia, pyrexia, edema, malaise

Tsawg heev (tsawg dua 0.01%): Ototoxicity, tsis hnov ​​lus , tinnitus , vertigo [ Ref ]

Kev puas siab puas ntsws

Tsawg heev (tsawg dua 0.01%): Lub xeev tsis meej pem[ Ref ]

Ua pa

Tsis tshua muaj (0.01% rau 0.1%): Mob ntsws o , ua tsis taus pa, pleural effusion , interstitial pneumonia, ntsws fibrosis, pulmonary embolism , ua pa tsis ua haujlwm

Zaus tsis qhia : Bronchospasm

Tsawg heev (tsawg dua 0.01%): hnoos[ Ref ]

Cov ntaub ntawv

1. Cerner Multum, Inc. 'Australian Product Information.' O 0

2. 'Cov ntaub ntawv khoom. Paclitaxel (PACLitaxel). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.

3. Cerner Multum, Inc. 'UK Summary of Product Characteristics.' O 0

Cov ntaub ntawv ntxiv

Nco ntsoov sab laj nrog koj tus kws kho mob kom paub tseeb tias cov ntaub ntawv uas tshwm sim hauv nplooj ntawv no siv tau rau koj tus kheej.

Qee qhov kev mob tshwm sim yuav tsis qhia. Koj tuaj yeem qhia lawv mus rau lub vev xaib FDA .