Topamax Dosage

Lub npe tseem ceeb: topiramate 25mg
Daim ntawv tshuaj: ntsiav tshuaj, coated; capsule, coated pellets

Dosing hauv Monotherapy Epilepsy

Cov neeg laus thiab menyuam yaus muaj hnub nyoog 10 xyoo thiab laus dua



Cov koob tshuaj pom zoo rau TOPAMAX®monotherapy nyob rau hauv cov neeg laus thiab cov menyuam yaus hnub nyoog 10 xyoo thiab laus dua yog 400 mg / hnub hauv ob koob tshuaj. Cov koob tshuaj yuav tsum tau ua tiav los ntawm titration raws li lub sijhawm teem tseg (Table 1):

Table 1: Monotherapy Titration Schedule rau Cov Neeg Laus thiab Pediatric Cov Neeg Mob 10 xyoo thiab laus dua
Noj hmo Noj hmo
Lub lis piam 1 25 mg ib 25 mg ib
Lub lis piam 2 50 mg ib 50 mg ib
Lub lis piam 3 75mg ib 75mg ib
Lub lis piam 4 100 mg 100 mg
Lub lis piam 5 150 mg 150 mg
Lub lis piam 6 200 mg 200 mg

Cov neeg mob menyuam yaus hnub nyoog 2 txog 9 xyoos

Kev noj tshuaj rau cov neeg mob hnub nyoog 2 txog 9 xyoos yog nyob ntawm qhov hnyav. Thaum lub sij hawm titration, thawj koob tshuaj TOPAMAX®yog 25 mg / hnub ib hmo rau thawj lub lim tiam. Raws li kev kam rau siab, cov koob tshuaj tuaj yeem nce mus rau 50 mg / hnub (25 mg ob zaug ib hnub) hauv lub lim tiam thib ob. Kev noj tshuaj tuaj yeem nce ntxiv los ntawm 25-50 mg / hnub txhua lub lim tiam tom ntej raws li kev zam. Titration rau qhov tsawg kawg nkaus koob tshuaj yuav tsum tau sim tshaj 5-7 lub lis piam ntawm tag nrho cov titration lub sij hawm. Raws li kev kam rau siab thiab kev soj ntsuam cov lus teb, ntxiv titration rau ntau dua (mus txog qhov siab tshaj plaws kho koob tshuaj) tuaj yeem sim ntawm 25-50 mg / hnub ntxiv txhua lub lim tiam. Tag nrho cov koob tshuaj txhua hnub yuav tsum tsis pub tshaj qhov koob tshuaj ntau tshaj plaws rau txhua qhov hnyav ntawm lub cev (Table 2).

Table 2: Monotherapy Target Tag Nrho Cov Kev Kho Mob Txhua Hnub Rau Cov Neeg Mob 2 txog 9 Xyoos
Qhov hnyav (kg) Tag Nrho Cov Tshuaj Txhua Hnub (mg / hnub) * Yam tsawg kawg ntawm Kev Kho Mob Tag Nrho Cov Tshuaj Txhua Hnub (mg / hnub) * Kev Kho Kom Zoo Tshaj Plaws
*
Kev tswj hwm hauv ob koob tshuaj sib npaug
Mus txog 11 150 250
12–22 : kuv 200 300
23–31 : kuv 200 350
32-38 : kuv 250 350
Ntau tshaj 38 250 400

Dosing hauv Adjunctive Therapy Epilepsy

Cov neeg laus (17 xyoo thiab laus dua)

Qhov pom zoo tag nrho cov koob tshuaj txhua hnub ntawm TOPAMAX®Raws li kev kho mob ntxiv rau cov neeg laus uas muaj qhov pib qaug dab peg los yog Lennox-Gastaut Syndrome yog 200 txog 400 mg / hnub hauv ob koob tshuaj, thiab 400 mg / hnub hauv ob koob tshuaj raws li kev kho mob ntxiv rau cov neeg laus uas muaj thawj qhov tshwm sim ntawm tonic-clonic qaug dab peg. TOPAMAX®yuav tsum tau pib ntawm 25 mus rau 50 mg / hnub, tom qab ntawd los ntawm titration mus rau ib koob tshuaj zoo hauv kev nce ntxiv ntawm 25 mus rau 50 mg / hnub txhua lub lis piam. Titrating increments ntawm 25 mg / hnub txhua lub lis piam yuav ncua sij hawm mus txog rau ib tug zoo koob tshuaj. Cov koob tshuaj ntau dua 400 mg / hnub tsis tau pom tias yuav txhim kho cov lus teb rau cov neeg laus uas muaj kev qaug dab peg ib nrab.

Cov neeg mob menyuam yaus hnub nyoog 2 txog 16 xyoo

Qhov pom zoo tag nrho cov koob tshuaj txhua hnub ntawm TOPAMAX®raws li kev kho mob ntxiv rau cov menyuam yaus hnub nyoog 2 txog 16 xyoo nrog qee qhov pib qaug dab peg, thawj qhov tshwm sim ntawm tonic-clonic qaug dab peg, lossis qaug dab peg cuam tshuam nrog Lennox-Gastaut syndrome yog kwv yees li 5 txog 9 mg / kg / hnub hauv ob koob tshuaj. Titration yuav tsum pib ntawm 25 mg / hnub (lossis tsawg dua, raws li qhov ntau ntawm 1 txog 3 mg / kg / hnub) ib hmos rau thawj lub lim tiam. Cov koob tshuaj yuav tsum tau nce ntxiv ntawm 1- lossis 2-lub lim tiam ib ntus los ntawm kev nce ntxiv ntawm 1 mus rau 3 mg / kg / hnub (ib zaug hauv ob koob tshuaj), kom ua tiav cov lus teb kho mob zoo. Kev txhaj tshuaj titration yuav tsum tau coj los ntawm kev soj ntsuam cov txiaj ntsig. Tag nrho cov koob tshuaj txhua hnub yuav tsum tsis pub tshaj 400 mg / hnub.

Dosing rau Kev Tiv Thaiv Kev Kho Mob Migraine

Qhov pom zoo tag nrho cov koob tshuaj txhua hnub ntawm TOPAMAX®Raws li kev kho mob rau cov neeg mob hnub nyoog 12 xyoos thiab laus dua rau kev tiv thaiv kev kho mob migraine yog 100 mg / hnub muab faib ua ob koob tshuaj (Table 3). Qhov pom zoo titration tus nqi rau TOPAMAX®rau kev tiv thaiv ntawm migraine yog raws li nram no:

ntev npaum li cas ua minocycline phiv kawg
Table 3: Kev Tiv Thaiv Kev Kho Mob Migraine Titration Schedule rau cov neeg mob hnub nyoog 12 xyoos thiab laus dua
Noj hmo Noj hmo
Lub lis piam 1 Tsis muaj 25 mg ib
Lub lis piam 2 25 mg ib 25 mg ib
Lub lis piam 3 25 mg ib 50 mg ib
Lub lis piam 4 50 mg ib 50 mg ib

koob tshuaj thiab titration tus nqi yuav tsum tau coj los ntawm kev soj ntsuam cov txiaj ntsig. Yog tias xav tau, siv sijhawm ntev dua ntawm kev hloov kho koob tshuaj.

Cov ntaub ntawv tswj hwm

TOPAMAX®tuaj yeem noj yam tsis xav noj mov.

TOPAMAX®Cov ntsiav tshuaj

Vim lub iab saj, cov ntsiav tshuaj yuav tsum tsis txhob tawg.

TOPAMAX®Sprinkle Capsules

TOPAMAX®Sprinkle Capsules tuaj yeem nqos tag nrho lossis yuav raug muab los ntawm kev ua tib zoo qhib lub tshuaj ntsiav thiab nphoo tag nrho cov ntsiab lus ntawm ib qho me me (teaspoon) ntawm cov zaub mov muag. Cov tshuaj no / zaub mov sib tov yuav tsum tau nqos tam sim ntawd thiab tsis zom. Nws yuav tsum tsis txhob muab khaws cia rau yav tom ntej.

Dosing nyob rau hauv cov neeg mob uas muaj lub raum tsis ua hauj lwm

Hauv cov neeg mob lub raum tsis zoo (creatinine tshem tawm tsawg dua 70 mL / min / 1.73 m)ob), ib nrab ntawm cov neeg laus li ib txwm koob tshuaj TOPAMAX®pom zoo[saib Siv hauv Cov Pej Xeem Tshwj Xeeb (8.5 , 8.6) , Tshuaj Kho Mob (12.3) ].

Dosing nyob rau hauv cov neeg mob uas tab tom kho hemodialysis

Txhawm rau kom tsis txhob poob sai hauv topiramate plasma concentration thaum lub sij hawm hemodialysis, ib koob tshuaj ntxiv ntawm TOPAMAX®tej zaum yuav xav tau. Qhov kev hloov kho tiag tiag yuav tsum coj mus rau hauv tus account 1) lub sijhawm ntawm lub sijhawm lim ntshav, 2) tus nqi tshem tawm ntawm lub tshuab lim ntshav siv, thiab 3) lub raum tshem tawm ntawm topiramate hauv tus neeg mob tau dialyzed.[saib Siv hauv Cov Pej Xeem Tshwj Xeeb (8.7) , Tshuaj Kho Mob (12.3) ].

Cov ntaub ntawv ntxiv

Nco ntsoov sab laj nrog koj tus kws kho mob kom paub meej tias cov ntaub ntawv uas tshwm sim hauv nplooj ntawv no siv tau rau koj tus kheej.