Cov teebmeem ntawm Tramadol

Hauv Summary

Feem ntau tshaj tawm cov kev mob tshwm sim ntawm tramadol muaj xws li: pruritus, agitation, ntxhov siab vim, cem quav, raws plab, hallucination, xeev siab, tshee, ntuav, thiab diaphoresis. Lwm cov kev mob tshwm sim muaj xws li: insomnia. Saib hauv qab no kom paub cov npe ntawm cov teebmeem tsis zoo.

Rau Cov Neeg Siv Khoom

Siv rau tramadol : Lub qhov ncauj capsule ncua kev tso tawm, qhov ncauj capsule ncua tso tawm 24 teev, qhov ncauj tshuaj, qhov ncauj ncua kev kawm ntawv, qhov ncauj ntsiav tshuaj, qhov ncauj ntsiav tshuaj ncua kev tso tawm



Ceeb toom

Txoj kev ntawm qhov ncauj (Tablet; Tablet, Extended Release; Capsule, Extended Release; Solution)

Kev quav yeeb quav tshuaj, kev tsim txom, thiab kev siv tsis raug

TraMADol hydrochloride nthuav tawm cov neeg mob thiab lwm tus neeg siv rau kev pheej hmoo ntawm kev quav tshuaj opioid, kev tsim txom, thiab kev siv tsis raug, uas tuaj yeem ua rau ntau dhau thiab tuag. Txheeb xyuas txhua tus neeg mob qhov kev pheej hmoo ua ntej yuav tshuaj traMADol hydrochloride, thiab saib xyuas txhua tus neeg mob tsis tu ncua rau kev txhim kho tus cwj pwm lossis cov xwm txheej no.

Opioid Analgesic Risk Evaluation and Mitigation Strategy (REMS)

Kom paub meej tias cov txiaj ntsig ntawm opioid analgesics Tshaj qhov txaus ntshai ntawm kev quav tshuaj, kev tsim txom thiab kev siv tsis raug, Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) tau xav tau REMS rau cov khoom no. Raws li qhov yuav tsum tau ua ntawm REMS, cov tuam txhab tshuaj uas pom zoo siv tshuaj kho mob opioid yuav tsum ua kom REMS-raws li kev kawm ntawv muaj rau cov kws kho mob. Cov kws kho mob tau txhawb kom: ua kom tiav REMS-raws li kev kawm txuj ci, ntuas cov neeg mob thiab / lossis lawv cov neeg saib xyuas, nrog rau txhua daim ntawv tshuaj, ntawm kev siv nyab xeeb, kev pheej hmoo loj, kev cia khoom, thiab pov tseg ntawm cov khoom no, hais qhia rau cov neeg mob thiab lawv cov neeg saib xyuas txog qhov tseem ceeb. ntawm kev nyeem Phau Ntawv Qhia Tshuaj Txhua zaus nws muab los ntawm lawv cov kws muag tshuaj, thiab xav txog lwm yam cuab yeej los txhim kho tus neeg mob, tsev neeg, thiab zej zog kev nyab xeeb.

Txoj Kev Ua Phem Txhaum Kev Nyuaj Siab

Mob hnyav, ua rau tuag taus, lossis tuag taus ua pa nyuaj siab Tej zaum yuav tshwm sim nrog kev siv traMADol hydrochloride. Saib xyuas kev ua pa kev nyuaj siab , tshwj xeeb tshaj yog thaum pib ntawm traMADol hydrochloride lossis tom qab noj tshuaj nce ntxiv. Qhia cov neeg mob kom nqos traMADol hydrochloride ncua kev tso tawm cov tshuaj tsis tu ncua, thiab tsis txhob txiav, tawg, zom, zom, lossis yaj cov ntsiav tshuaj kom tsis txhob raug rau cov tshuaj traMADol uas yuav ua rau tuag taus.

Kev mob tshwm sim

Kev sib tsoo ntawm ib koob ntawm traMADol hydrochloride, tshwj xeeb tshaj yog los ntawm cov menyuam yaus, tuaj yeem ua rau tuag taus ntau dhau ntawm traMADol.

Ultra-Rapid Metabolism ntawm TraMADol thiab Lwm Yam Tseem Ceeb rau Kev Ua Phem Rau Kev Nyuaj Siab Hauv Cov Me Nyuam

Kev ua pa nyuaj rau lub neej thiab kev tuag tau tshwm sim hauv cov menyuam yaus uas tau txais traMADol. Feem ntau ntawm cov xwm txheej tau tshwm sim tom qab tonsillectomy thiab / lossis adenoidectomy, thiab ntau tus menyuam yaus muaj pov thawj tias yog ib qho metabolizer sai sai ntawm traMADol vim yog CYP2D6 polymorphism. TraMADol hydrochloride ntsiav tshuaj yog contraindicated rau cov menyuam yaus hnub nyoog qis dua 12 xyoos thiab cov menyuam yaus hnub nyoog qis dua 18 xyoo tom qab tonsillectomy thiab / lossis adenoidectomy. Tsis txhob siv cov ntsiav tshuaj traMADol hydrochloride rau cov tub ntxhais hluas hnub nyoog 12 txog 18 xyoo uas muaj lwm yam kev pheej hmoo uas yuav ua rau lawv rhiab heev rau kev ua pa nyuaj ntawm traMADol.

Neonatal Opioid Withdrawal Syndrome

Kev siv sijhawm ntev ntawm traMADol hydrochloride thaum cev xeeb tub tuaj yeem ua rau muaj menyuam hauv plab kev tshem tawm opioid Syndrome, uas tej zaum yuav ua rau muaj kev phom sij rau lub neej yog tias tsis lees paub thiab kho, thiab yuav tsum muaj kev tswj hwm raws li cov txheej txheem tsim los ntawm cov kws paub txog neonatology. Yog tias yuav tsum tau siv tshuaj opioid rau lub sijhawm ntev hauv tus poj niam cev xeeb tub, qhia tus neeg mob txog kev pheej hmoo ntawm tus mob opioid tshem tawm tus mob neonatal thiab xyuas kom muaj kev kho mob tsim nyog.

Kev cuam tshuam nrog tshuaj cuam tshuam rau Cytochrome P450 Isoenzymes

Cov teebmeem ntawm kev siv sib xyaw lossis kev txiav tawm ntawm CYP3A4 inducers, 3A4 inhibitors, lossis 2D6 inhibitors nrog traMADol yog qhov nyuaj. Kev siv CYP3A4 inducers, 3A4 inhibitors, lossis 2D6 inhibitors nrog traMADol hydrochloride yuav tsum tau ua tib zoo xav txog cov teebmeem ntawm niam txiv cov tshuaj, traMADol, thiab cov metabolite nquag, M1.

Kev pheej hmoo los ntawm kev siv sib xyaw nrog benzodiazepines lossis lwm yam CNS Depressants

Concomitant siv tshuaj opioids nrog tshuaj benzodiazepines lossis lwm yam CNS kev nyuaj siab, suav nrog cawv, tuaj yeem ua rau muaj kev ntxhov siab, ua pa nyuaj, coma, thiab tuag. Reserve concomitant prescribing ntawm traMADol hydrochloride thiab tshuaj benzodiazepines los yog lwm yam CNS depressants siv rau cov neeg mob uas lwm txoj kev kho mob tsis txaus. Txwv ntau npaum li cas thiab ntev npaum li cas kom tsawg. Ua raws li cov neeg mob rau cov tsos mob thiab cov tsos mob ntawm kev nyuaj siab ua pa thiab sedation.

Kev mob tshwm sim yuav tsum tau mus kho mob tam sim

Nrog rau nws cov teebmeem xav tau, tramadol tuaj yeem ua rau qee qhov tsis xav tau. Txawm hais tias tsis yog tag nrho cov kev mob tshwm sim no tuaj yeem tshwm sim, yog tias lawv tshwm sim lawv yuav xav tau kev kho mob.

Nrog koj tus kws kho mob tham tam sim ntawd Yog tias ib qho ntawm cov kev mob tshwm sim hauv qab no tshwm sim thaum noj tramadol:

Tsawg dua

  • Qhov txawv txav lossis txo qhov kev xav kov
  • hlwv nyob rau hauv daim tawv nqaij
  • mob plab
  • ntshav nyob rau hauv cov zis
  • ntshav siab nce
  • qhov muag tsis pom kev
  • hloov hauv kev taug kev thiab sib npaug
  • mob hauv siab los yog tsis xis nyob
  • txias
  • tso zis tsaus
  • tso zis nyuaj
  • kiv taub hau los yog lightheadedness thaum sawv los ntawm ib qho chaw pw los yog zaum
  • ua tsis taus pa
  • lub plawv dhia ceev
  • nquag tso zis
  • gaseous mob plab
  • plab zom mov
  • lub plawv dhia tsis xwm yeem
  • poob ntawm kev nco
  • ua tsis taus pa thiab tingling ntawm lub ntsej muag, ntiv tes, lossis ntiv taw
  • mob ntawm caj npab, ceg, lossis sab nraub qaum, tshwj xeeb tshaj yog mob hauv plab los yog pob taws thaum ua haujlwm
  • mob lossis tsis xis nyob ntawm caj npab, puab tsaig, nraub qaum, lossis caj dab
  • mob hauv plab, sab, lossis plab, tejzaum nws tawg mus rau sab nraub qaum
  • daj ntseg, xiav-xim los yog tes txias los yog ko taw
  • rov ua npaws
  • pom, hnov, lossis hnov ​​tej yam uas tsis nyob ntawd
  • qaug dab peg
  • mob hnyav heev
  • mob hnyav xeev siab
  • redness heev, o, thiab khaus ntawm daim tawv nqaij
  • plab plab
  • tawm hws
  • o ntawm txhais tes, pob taws, ko taw, lossis ob txhais ceg
  • trembling thiab tuav tes los yog ko taw
  • teeb meem ua cov haujlwm niaj hnub
  • qaug zog los yog tsis muaj pulses nyob rau hauv ob txhais ceg
  • qhov muag daj lossis tawv nqaij

Qhov xwm txheej tsis paub

  • Kev ntxhov siab
  • tsis meej pem
  • hnoos
  • darkening ntawm daim tawv nqaij
  • raws plab
  • nyuaj nqos
  • kiv taub hau
  • ua npaws
  • khaus khaus , khaus, daim tawv nqaij ua pob
  • poob qab los noj mov
  • kev nyuaj siab
  • xeev siab
  • overactive reflexes
  • kev sib koom tes tsis zoo
  • puffiness los yog o ntawm daim tawv muag los yog ib ncig ntawm lub qhov muag, ntsej muag, daim di ncauj, los yog tus nplaig
  • kev ntxhov siab
  • tshee hnyo
  • tham lossis ua yeeb yam nrog kev zoo siab uas koj tswj tsis tau
  • nruj hauv siab
  • tshee
  • nkees nkees lossis qaug zog
  • ntuav

Tau txais kev pab thaum muaj xwm txheej ceev yog tias muaj cov tsos mob hauv qab no ntawm kev noj tshuaj ntau dhau thaum noj tramadol:

Cov tsos mob ntawm overdose

  • Hloov hauv kev nco qab
  • txo kev paub lossis kev ua haujlwm
  • nyuaj ua pa
  • tsis muaj leeg nqaij
  • lightheadedness
  • tsis nco qab
  • pinpointed cov menyuam kawm ntawv ntawm lub qhov muag
  • tsaug zog heev
  • qeeb lossis tsis meej lub plawv dhia
  • qaug zog txawv txawv

Kev mob tshwm sim tsis tas yuav tsum tau kho mob tam sim

Qee qhov kev mob tshwm sim ntawm tramadol tuaj yeem tshwm sim uas feem ntau tsis xav tau kev kho mob . Cov kev mob tshwm sim no yuav ploj mus thaum kho raws li koj lub cev hloov kho rau cov tshuaj. Tsis tas li ntawd, koj tus kws kho mob yuav tuaj yeem qhia koj txog txoj hauv kev los tiv thaiv lossis txo qee qhov kev mob tshwm sim.

Tshawb xyuas nrog koj tus kws kho mob yog tias muaj cov kev mob tshwm sim hauv qab no txuas ntxiv los yog thab plaub los yog koj muaj lus nug txog lawv:

Feem ntau

  • cem quav
  • kev poob siab
  • qaug zog
  • qhov ncauj qhuav
  • kev xav sov
  • xav tu siab los tsis muaj
  • hnov txias txias
  • kev xav tsis xis nyob los yog mob
  • mob taub hau
  • mob plawv
  • chim siab
  • khaus lossis pob khaus ntawm daim tawv nqaij
  • mob sib koom
  • tsis txaus siab lossis txaus siab
  • poob ntawm lub zog los yog tsis muaj zog
  • mob mob thiab mob
  • liab ntawm lub ntsej muag, caj dab, caj npab, thiab qee zaus, sab hauv siab
  • kua ntswg
  • pw tsaug zog los yog pw tsaug zog txawv txawv
  • mob caj pas
  • mob plab
  • qhov ntswg
  • nkees
  • teeb meem tsom
  • txawv txav ntawm excitement
  • qaug zog

Tsawg dua

  • Npau suav phem
  • qab los noj mov tsawg
  • mob nraub qaum
  • mob zais zis
  • blistering, crusting, irritation, khaus, los yog reddening ntawm daim tawv nqaij
  • ntshav los yog huab tso zis
  • mob lub cev los yog mob
  • hloov hauv kev hnov ​​lus
  • clamminess
  • hnoos ua paug
  • tawg, qhuav, los yog daim tawv nqaij scaly
  • txo kev txaus siab rau kev sib deev
  • nyuaj, kub hnyiab, lossis mob tso zis
  • nyuaj txav
  • cuam ​​tshuam hauv kev mloog
  • pob ntseg congestion
  • pob ntseg kua
  • pob ntseg los yog mob pob ntseg
  • roj ntau dhau
  • ntog
  • cuav lossis txawv txav ntawm kev noj qab haus huv
  • hnov kub
  • xav jittery
  • kev xav ntawm lub cev tsis xis nyob
  • goosebumps
  • mob taub hau, hnyav thiab throbbing
  • hnov lus
  • tsis muaj peev xwm muaj los yog ua kom erection
  • khaus, mob, liab, o, rhiab, los yog sov ntawm daim tawv nqaij
  • pob qij txha, txhav, los yog o
  • poob ntawm kev sib deev muaj peev xwm, muaj siab, tsav, lossis kev ua haujlwm
  • poob lub suab
  • sab nraub qaum lossis sab mob
  • nqaij mob los yog cramping
  • nqaij raug mob
  • mob nqaij, txhav, spasms, los yog twitching
  • qhov ntswg congestion
  • mob caj dab
  • hmo ntuj tawm hws
  • mob nyob rau hauv cov ceg
  • mob los yog rhiab nyob ib ncig ntawm lub qhov muag thiab cheekbones
  • mob, o, lossis liab ntawm pob qij txha
  • daim tawv nqaij discoloration
  • teeb meem tuav lossis tso zis
  • teeb meem pw tsaug zog
  • hnyav hloov

Rau Cov Kws Kho Mob

Siv rau tramadol: qhov ncauj capsule ncua kev tso tawm, qhov ncauj kua, qhov ncauj ntsiav tshuaj, qhov ncauj ntsiav tshuaj disintegrating, qhov ncauj ntsiav tshuaj ncua kev tso tawm

General

Cov kev phiv tshwm sim feem ntau muaj xws li xeev siab, cem quav, qhov ncauj qhuav, somnolence, kiv taub hau, thiab ntuav.[ Ref ]

Kev puas siab puas ntsws

CNS stimulation tau raug tshaj tawm raws li kev sib xyaw ntawm kev ntxhov siab, kev ntxhov siab , agitation, tshee, spasticity, euphoria, kev xav lability, thiab hallucinations. Thaum lub sij hawm soj ntsuam kev sim, kev kam rau siab txoj kev loj hlob yog me me thiab cov lus ceeb toom ntawm ib tug tshem tawm syndrome yog tsawg. Cov tsos mob ntawm kev tshem tawm syndrome muaj xws li: ceeb ntshai kev ntxhov siab heev, kev hnov ​​​​lus, paraesthesia, tinnitus thiab cov tsos mob CNS txawv txawv (piv txwv li tsis meej pem, delusions, personalization, derealization, thiab paranoia).[ Ref ]

cov npe tshuaj antiinflammatory

Feem ntau (10% lossis ntau dua): CNS stimulation (txog 14%)

Feem ntau (1% mus rau 10%): ntxhov siab vim, euphoria, nervousness, pw tsis tsaug zog, insomnia , kev nyuaj siab, ntxhov siab, apathy, depersonalization

Tsis tshua muaj (0.1% mus rau 1%): Emotional lability

Tsis tshua muaj (tsawg dua 0.1%): Hallucinations, npau suav phem , kev vam meej

Tsawg heev (tsawg dua 0.01%): Kev rho tawm syndrome[ Ref ]

Mob siab heev

Tsis tshua muaj (tsawg dua 0.1%): Anaphylaxis , kev tsis haum tshuaj xws li ua tsis taus pa bronchospasm, hawb pob, angioneurotic edema , daim tawv nqaij o[ Ref ]

plab hnyuv

Feem ntau (10% lossis ntau dua): xeev siab (txog 40%), cem quav (txog 46%), ntuav (txog 17%), dyspepsia (txog 13%)

Feem ntau (1% mus rau 10%): qhov ncauj qhuav, raws plab, mob plab , flatulence , mob qa, gastroenteritis kab mob

Tsis tshua muaj (0.1% mus rau 1%): Mob hniav kab mob appendicitis, pancreatitis [ Ref ]

Lub paj hlwb

Epileptiform qaug dab peg feem ntau tshwm sim tom qab kev tswj hwm ntawm koob tshuaj ntau lossis tom qab kev kho mob nrog tshuaj uas txo qis kev qaug dab peg lossis ua rau qaug dab peg.

Serotonin Syndrome tau tshaj tawm thaum siv cov tshuaj opioids nrog cov tshuaj serotonergic.[ Ref ]

Feem ntau (10% lossis ntau dua): kiv taub hau (txog 28%), somnolence (txog 25%), mob taub hau (txog 32%),

Feem ntau (1% mus rau 10%): Tsis meej pem, kev sib koom ua haujlwm cuam tshuam, tshee, paresthesia, hypoesthesia

Tsis tshua muaj (0.1% mus rau 1%): Migraine , kev nyuaj siab, syncope , cuam tshuam hauv kev mloog

Tsis tshua muaj (tsawg dua 0.1%): Epileptiform qaug dab peg

Postmarketing qhia : qaug dab peg

Opioids:

Postmarketing qhia : Serotonin Syndrome[ Ref ]

Dermatology

Feem ntau (10% lossis ntau dua): Pruritus (txog 11%)

Feem ntau (1% mus rau 10%): tawm hws, tawm pob, dermatitis

Tsis tshua muaj (0.1% mus rau 1%): Cellulitis , kev hlub , kev hlub , urticaria , tshuaj lom epidermal necrolysis , Stevens Johnson-sydrome, plaub hau tsis meej, tawv nqaij tsis meej[ Ref ]

Cov kab mob genitourinary

Feem ntau (1% mus rau 10%): Menopausal tsos mob, tso zis ntau zaus , tso zis , kab mob urinary ib ntsuj av

Tsis tshua muaj (0.1% mus rau 1%): Nyuaj hauv micturition, hematuria , dysuria , cystitis , kev ua haujlwm tsis zoo ntawm kev sib deev[ Ref ]

Mob plawv

Feem ntau (10% lossis ntau dua): Flushing (txog 15.8%)

Feem ntau (1% mus rau 10%): Vasodilation, postural hypotension , mob hauv siab

atorvastatin 20 mg tab

Tsis tshua muaj (0.1% mus rau 1%): Mob plawv , myocardial infarction, qis qis edema peripheral o, kub siab, nce plawv dhia, peripheral ischemia, EKG abnormality, hypotension, tachycardia

Tsis tshua muaj (tsawg dua 0.1%): Bradycardia

Postmarketing qhia : QT prolongation/torsade de pointes[ Ref ]

Cov ntawv ceeb toom ntawm QT ncua sij hawm thiab/los yog torsade de pointes tau txais. Feem ntau, cov neeg mob tau noj lwm cov tshuaj uas cuam tshuam nrog QT ncua ntev, muaj qhov pheej hmoo rau QT ncua ntev xws li hypokalemia , los yog nyob rau hauv qhov chaw overdose.[ Ref ]

Lwm yam

Feem ntau (10% lossis ntau dua): Asthenia (txog 12%)

Feem ntau (1% mus rau 10%): qaug zog, qaug zog, mob, kub cev, mob khaub thuas xws li mob, nruj, qaug zog , pyrexia

Tsis tshua muaj (0.1% mus rau 1%): Tinnitus, vertigo , mob pob ntseg[ Ref ]

Metabolic

Feem ntau (1% mus rau 10%): Anorexia, poob phaus, nce ntshav qabzib

Tsis tshua muaj (0.1% mus rau 1%): Gout

Tsis tshua muaj (tsawg dua 0.1%): Kev hloov hauv qab los noj mov[ Ref ]

Endocrine

Tsawg heev (tsawg dua 0.01%): Syndrome ntawm tsis tsim nyog antidiuretic hormone secretion

Opioids:

Postmarketing qhia : Adrenal tsis txaus ; androgen tsis muaj peev xwm[ Ref ]

Hematology

Tsis tshua muaj (0.1% mus rau 1%): anemia, ecchymosis[ Ref ]

Mob siab

Tsis tshua muaj (0.1% mus rau 1%): Cholelithiasis , cholecystitis , ALT thiab AST nce, txawv txav kuaj lub siab ua haujlwm [ Ref ]

Ocular

Feem ntau (1% mus rau 10%): Miosis, pom kev cuam tshuam, qhov muag tsis pom kev

Tsis tshua muaj (0.1% rau 1%): Lacrimation teeb meem

Zaus tsis qhia : Mydriasis[ Ref ]

Lub raum

Tsis tshua muaj (0.1% mus rau 1%): ntshav urea nitrogen nce[ Ref ]

Musculoskeletal

Feem ntau (1% mus rau 10%): Hypertonia, arthralgia, mob nraub qaum, mob caj dab, mob caj dab, mob pob qij txha, cov leeg pob txha, pob qij txha, leeg twitch , myalgia, aggravated osteoarthritis

Tsis tshua muaj (0.1% mus rau 1%): pob qij txha, pob qij txha, pob txha raug mob, ceg cramps

Tsis tshua muaj (tsawg dua 0.1%): Involuntary leeg contractions[ Ref ]

Cov ntaub ntawv

1. Cerner Multum, Inc. 'UK Summary of Product Characteristics.' O 0

2. Cerner Multum, Inc. 'Australian Product Information.' O 0

3. 'Cov ntaub ntawv khoom. Ultram ER (traMADol).' PriCara Pharmaceuticals, Raritan, NJ.

4. 'Cov ntaub ntawv khoom. Ultram (tramadol). McNeil Pharmaceutical, Raritan, NJ.

Cov ntaub ntawv ntxiv

Nco ntsoov sab laj nrog koj tus kws kho mob kom paub meej tias cov ntaub ntawv uas tshwm sim hauv nplooj ntawv no siv tau rau koj tus kheej.

Qee qhov kev mob tshwm sim yuav tsis qhia. Koj tuaj yeem qhia lawv mus rau lub FDA .