Trobicin

Lub npe dav: tshuaj spectinomycin
Dosage form: txhaj tshuaj ncua
Chav kawm tshuaj: Lwm yam tshuaj tua kab mob

Txhawm rau txo qhov kev loj hlob ntawm cov kab mob tiv thaiv kab mob thiab tswj cov txiaj ntsig ntawm Trobicin Sterile Powder thiab lwm yam tshuaj tua kab mob, Trobicin Sterile Powder tsuas yog siv los kho lossis tiv thaiv kev kis kab mob uas muaj pov thawj lossis xav tias yuav tshwm sim los ntawm cov kab mob.

Rau kev txhaj tshuaj intramuscular

Ntawm nplooj ntawv no

• Kev piav qhia
• Clinical Pharmacology
• Indications thiab siv
• Contraindications
• Ceeb toom
• Cov kev ceev faj
• Cov Ntaub Ntawv Qhia Txog Tus Neeg Mob
• Cov Kev Phem Tsis Zoo/Sib Phem
• Kev noj ntau dhau
• Dosage thiab Administration
• Yuav Ua Li Cas Muab / Cia thiab tuav

Trobicin Description

Trobicin Sterile Powder muaj spectinomycin hydrochloride uas yog cov tshuaj tua kab mob aminocyclitol uas tsim los ntawm hom kab mob hauv av uas tau xaiv los uaStreptomyces spectabilis. Sterile spectinomycin hydrochloride yog pentahydrated dihydrochloride ntsev ntawm spectinomycin. Cov qauv tsim qauv yog sawv cev hauv qab no:

Spectinomycin hydrochloride yog cais raws li ib tug dawb mus rau daj ntseg buff crystalline dihydrochloride pentahydrate hmoov, molecular hnyav 495, thiab yog ruaj khov nyob rau hauv lub qhuav lub xeev rau 36 lub hlis.

Trobicin - Clinical Pharmacology

Trobicin Sterile Powder yog absorbed sai sai tom qab txhaj tshuaj intramuscular. Ib zaug, ob-gram txhaj tshuaj ua rau cov ntshav qab zib ntau tshaj qhov nruab nrab ntawm 100 mcg / mL ntawm ib teev; ib zaug, plaub-gram txhaj tshuaj ua rau cov ntshav siab siab tshaj plaws ntawm qhov nruab nrab ntawm 160 mcg / mL ntawm ob teev. Qhov nruab nrab ntawm cov ntshav qab zib ntau ntawm 15 mcg / mL rau ob-gram koob tshuaj thiab 31 mcg / mL rau plaub-gram koob muaj nyob yim teev tom qab noj.

Microbiology

Spectinomycin hydrochloride yog ib qho inhibitor ntawm protein synthesis nyob rau hauv cov kab mob ntawm tes; Qhov chaw ntawm kev ua yog 30S ribosomal subunit.

koj tso dab tsi rau hauv lub tshuab nqus dej

Hauv vitroCov kev tshawb fawb tau pom tias spectinomycin hydrochloride ua haujlwm tawm tsam feem ntau ntawm cov kab mobNeisseria gonorrhoeae muaj(yam tsawg kawg inhibitory concentration<7.5 to 20 mcg/mL).

Paub meejhauv vitrocov kev tshawb fawb tau pom tias tsis muaj qhov sib txawv ntawm qhov tsis zooN. gonorrhoeaenruab nrab ntawm spectinomycin hydrochloride thiab penicillin. Cov tshuaj tua kab mob tsis cuam tshuam rau plasma protein ntau.

Cov lus qhia thiab kev siv rau Trobicin

Trobicin Sterile Powder yog qhia nyob rau hauv kev kho mob ntawm tus kab mob gonorrheal urethritis thiab proctitis nyob rau hauv cov txiv neej thiab mob gonorrheal cervicitis thiab proctitis nyob rau hauv cov poj niam thaum vim muaj kab mob.Neisseria gonorrhoeae muaj. Cov txiv neej thiab cov poj niam uas paub tias muaj kab mob gonorrhea tsis ntev los no yuav tsum tau kho raws li cov neeg paub tias muaj kab mob gonorrhea.

Covhauv vitrosusceptibility ntawmNeisseria gonorrhoeae muajrau spectinomycin hydrochloride tuaj yeem kuaj los ntawm agar diluted txoj kev. Trobicin Susceptibility Powder muaj rau lub hom phiaj no thiab nws cov pob ntxig yuav tsum tau sab laj kom paub meej.

Txhawm rau txo qhov kev loj hlob ntawm cov kab mob uas tsis muaj tshuaj tiv thaiv thiab tswj xyuas cov txiaj ntsig ntawm Trobicin Sterile Powder thiab lwm yam tshuaj tua kab mob, Trobicin Sterile Powder tsuas yog siv los kho lossis tiv thaiv kev kis kab mob uas muaj pov thawj lossis xav tias yuav tshwm sim los ntawm cov kab mob raug mob. Thaum cov kab lis kev cai thiab cov ntaub ntawv cuam tshuam muaj, lawv yuav tsum tau txiav txim siab hauv kev xaiv lossis hloov kho cov kab mob tua kab mob. Thaum tsis muaj cov ntaub ntawv no, kev kis kab mob hauv zos thiab cov qauv kev puas tsuaj tuaj yeem ua rau muaj kev xaiv empiric ntawm kev kho.

indomethacin ntau npaum li cas rau gout

Contraindications

Kev siv Trobicin Sterile Powder yog contraindicated nyob rau hauv cov neeg mob yav tas los pom hypersensitive rau nws.

Ceeb toom

Spectinomycin hydrochloride tsis zoo rau kev kho mob syphilis. Cov tshuaj tua kab mob siv rau hauv cov koob tshuaj ntau rau lub sijhawm luv luv los kho tus kab mob gonorrhea tuaj yeem npog lossis ncua cov tsos mob ntawm incubating syphilis. Txij li thaum kev kho mob syphilis xav tau kev kho mob ntev nrog cov tshuaj tua kab mob zoo, cov neeg mob tau kho tus kab mob gonorrhea yuav tsum tau saib xyuas zoo. Txhua tus neeg mob gonorrhea yuav tsum tau kuaj serologic rau syphilis thaum lub sijhawm kuaj mob. Cov neeg mob kho nrog spectinomycin hydrochloride yuav tsum muaj kev soj ntsuam serologic kuaj mob syphilis tom qab peb lub hlis.

Muaj benzyl cawv. Benzyl cawv tau raug tshaj tawm tias muaj feem cuam tshuam nrog kev tuag 'Gasping Syndrome' hauv cov me nyuam mos ntxov ntxov thiab muaj kev cuam tshuam ntau ntxiv ntawm neurologic thiab lwm yam teeb meem.

Cov kev ceev faj

Kev ceev faj ib txwm yuav tsum tau soj ntsuam nrog cov neeg atopic.

Kev soj ntsuam kev ua tau zoo ntawm Trobicin Sterile Powder yuav tsum tau saib xyuas kom pom cov pov thawj ntawm kev txhim kho kev tiv thaiv los ntawmNeisseria gonorrhoeae muaj.

Kev sau tshuaj Trobicin Sterile Powder thaum tsis muaj pov thawj los yog xav tias muaj kab mob loj heev los yog cov tshuaj tiv thaiv kab mob tsis zoo yuav muab txiaj ntsig rau tus neeg mob thiab ua rau muaj kev pheej hmoo ntawm kev txhim kho cov kab mob tshuaj tiv thaiv kab mob.

Cov ntaub ntawv rau cov neeg mob

Cov neeg mob yuav tsum tau ntuas tias cov tshuaj tua kab mob xws li Trobicin Sterile Powder tsuas yog siv los kho cov kab mob. Lawv tsis kho cov kab mob kis kab mob (xws li mob khaub thuas). Thaum Trobicin Sterile Powder raug tshuaj los kho tus kab mob, cov neeg mob yuav tsum tau hais qhia tias txawm hais tias nws yog ib qho ua kom zoo dua thaum ntxov ntawm txoj kev kho, cov tshuaj yuav tsum tau noj raws nraim li qhia. Kev hla koob tshuaj lossis tsis ua tiav tag nrho cov kev kho mob tuaj yeem (1) txo cov txiaj ntsig ntawm kev kho tam sim ntawd thiab (2) ua kom cov kab mob tuaj yeem txhim kho thiab yuav tsis kho los ntawm Trobicin Sterile Powder lossis lwm yam tshuaj tua kab mob yav tom ntej.

polyvisol nrog hlau ntau npaum li cas

Carcinogenesis, Mutagenesis, Impairment of Fertility

Genotoxicity ntawm spectinomycin hydrochloride tau soj ntsuam nyob rau hauv 6 qhov kev xeem ntsuas suav nrog ob qhov kev sim Ames, ob qhov kev sim micronucleus hauv cov nas, tsis tau teem sijhawm DNA synthesis hauv nas thawj hepatocytes, thiab kuaj chromosomal aberration hauv Suav hamster zes qe menyuam. Spectinomycin tsis tau pom tias yog mutagenic lossis genotoxic hauv cov kev sim no.

Tsis muaj kev cuam tshuam tsis zoo rau kev xeeb tub lossis kev ua haujlwm ntawm kev ua menyuam yaus tau pom thaum spectinomycin tau muab tshuaj subcutaneously rau cov nas ntawm cov koob tshuaj txog li 300 mg / kg (sib npaug rau qhov pom zoo tshaj plaws tib neeg koob tshuaj raws li mg / m.ob). Ib txoj kev tshawb fawb peb-tiam luam tawm hauv cov nas tau tswj hwm spectinomycin hydrochloride ntawm qhov ncauj ntawm koob tshuaj txog li 400 mg / kg (sib npaug rau qhov pom zoo tshaj plaws tib neeg koob tshuaj raws li mg / m.ob) tsis muaj pov thawj ntawm cov tshuaj tiv thaiv toxicity thaum lub sij hawm loj hlob, cev xeeb tub, los yog lactation lub sij hawm ntawm ib tug niam txiv tiam. Cov poj niam cev xeeb tub ntawm 400 mg / kg / hnub pawg tau qis dua li cov pawg tswj hwm. Kev kuaj histopathological ntawm cov qog thiab zes qe menyuam ntawm cov tsiaj tiam thib peb yog qhov qub.

Kev xeeb tub

Cev xeeb tub qeb B

Spectinomycin tsis yog teratogenic lossis embryocidal thaum siv qhov ncauj lossis subcutaneously rau cov nas ntawm koob tshuaj 300 mg / kg / hnub (sib npaug rau qhov pom zoo tshaj plaws tib neeg koob tshuaj raws li mg / m.ob). Tsis muaj qhov cuam tshuam teratogenic tau pom thaum spectinomycin tau muab tshuaj rau hauv lub cev rau cov nas lossis nas ntawm cov koob tshuaj ntawm 400 lossis 1600 mg / kg / hnub, feem. Spectinomycin tau muab tshuaj intramuscularly lossis subcutaneously rau cov menyuam mos cev xeeb tub ntawm koob tshuaj txog li 300 mg / kg / hnub (sib npaug rau qhov pom zoo tshaj plaws tib neeg koob tshuaj raws li mg / m.ob). Kev loj hlob ntawm embryonic thiab fetal tsis cuam tshuam los ntawm kev kho mob. Txij li tsis muaj cov kev tshawb fawb tswj hwm ntawm spectinomycin hauv cov poj niam cev xeeb tub, thiab vim tias kev tshawb fawb txog kev yug tsiaj tsis yog ib txwm kwv yees ntawm tib neeg cov lus teb, spectinomycin yuav tsum tau siv thaum cev xeeb tub nkaus xwb yog tias xav tau kom meej.

Niam laus

Nws tsis paub tias cov tshuaj no puas tawm hauv tib neeg cov kua mis. Vim tias ntau cov tshuaj tau tawm hauv tib neeg cov kua mis, yuav tsum tau ceev faj thaum siv tshuaj spectinomycin rau tus poj niam laus.

Kev siv menyuam yaus

Kev nyab xeeb thiab kev ua tau zoo hauv cov menyuam yaus tsis tau tsim. (Saib CEEB TOOM .)

Kev Phem Tsis Zoo

Cov kev tshwm sim hauv qab no tau pom nyob rau hauv kev sim tshuaj ib zaug: mob ntawm qhov chaw txhaj tshuaj, urticaria, kiv taub hau, xeev siab, ua daus no, ua npaws thiab insomnia.

Thaum muaj ntau qhov kev tshawb fawb txog kev ua siab ntev ntev hauv cov neeg tuaj yeem pab dawb, cov hauv qab no tau sau tseg: txo qis hauv hemoglobin, hematocrit thiab creatinine tshem tawm; nce alkaline phosphatase, BUN thiab SGPT. Hauv kev tshawb fawb ib zaug thiab ntau koob hauv cov neeg tuaj yeem pab dawb, txo cov zis tso zis tau sau tseg. Kev tshawb fawb ntau lub raum ua haujlwm pom tau tias tsis muaj kev hloov pauv zoo ib yam qhia txog lub raum toxicity.

Ob peb kis ntawm anaphylaxis lossis anaphylactoid cov tshuaj tiv thaiv tau raug tshaj tawm. Yog tias muaj kev tsis haum tshuaj loj, cov tshuaj ib txwm muaj (epinephrine, corticosteroids, thiab / lossis tshuaj tiv thaiv kab mob) yuav tsum muaj rau kev siv thaum muaj xwm txheej ceev. Nyob rau hauv cov xwm txheej hnyav anaphylaxis, kev txhawb nqa pa thiab oxygen kuj yuav tsum tau.

Kev noj ntau dhau

Cov ntaub ntawv hais txog kev noj ntau dhau hauv tib neeg tsis muaj. Hemodialysis tau tshaj tawm los pab hauv kev tshem tawmtxhaj tshuaj intravenouslyspectinomycin los ntawm lub cev.

Kusumi R, Metzler C, Fas R; Pharmacokinetics ntawm Spectinomycin hauv cov neeg ua haujlwm pab dawb nrog rau lub raum tsis txaus,Tshuaj kho mob,27:95–98 (1981).

Trobicin Dosage thiab Administration

Kev npaj tshuaj rau kev txhaj tshuaj intramuscular

Trobicin Sterile Powder, 2 grams: rov ua dua nrog 3.2 mL ntawm cov khoom sib xyaw nrog. ib

cov tshuaj no yog dab tsi

Caw vials ceev nrooj tam sim ntawd tom qab ntxiv cov diluent thiab ua ntej rho tawm koob. Nws raug nquahu kom siv cov koob txhaj tshuaj thiab koob tshuaj pov tseg kom tsis txhob kis kab mob nrog penicillin residue, tshwj xeeb tshaj yog thaum kho cov neeg mob paub tias muaj kev nkag siab zoo rau penicillin.Pom zoo siv 20-gauge koob.

ib

Bacteriostatic Dej rau Txhaj Tshuaj nrog Benzyl Cawv 0.945% w/v ntxiv raws li preservative.

Kev noj tshuaj

Kev txhaj tshuaj intramuscular yuav tsum tau ua kom tob rau sab sauv sab sauv ntawm cov leeg gluteal.

Cov neeg laus (Txiv neej thiab poj niam) - Txhaj 5 mL intramuscularlyrau ib koob tshuaj 2 grams. Qhov no kuj yog qhov pom zoo koob tshuaj rau cov neeg mob tau kho tom qab ua tsis tiav ntawm kev kho tshuaj tua kab mob yav dhau los.

dab tsi yog lub voj diuretic

Hauv thaj chaw thaj chaw uas cov tshuaj tiv thaiv kab mob tau paub tias muaj ntau, kev kho thawj zaug nrog 4 grams (10 mL) intramuscularly yog nyiam. Kev txhaj tshuaj 10-mL tuaj yeem muab faib ua ob qhov chaw txhaj tshuaj gluteal.

KHOOM PLIG

Khaws cov khoom uas tsis tau hloov dua tshiab ntawm chav tswj qhov kub ntawm 20 ° txog 25 ° C (68 ° txog 77 ° F) [saib USP]. Khaws cov khoom raug tshem tawm ntawm qhov chaw tswj qhov kub ntawm 20 ° txog 25 ° C (68 ° txog 77 ° F) thiab siv hauv 24 teev.

Trobicin muab li cas

Muaj benzyl cawv. (Saib CEEB TOOM .)

Trobicin Sterile Powder muaj xws li:

Trobicin Sterile Powder, 2-gram vial NDC 0009-0566-01-nrog rau ib lub ampoule ntawm Bacteriostatic Dej rau Txhaj Tshuaj nrog Benzyl Cawv 0.945% w/v ntxiv raws li preservative.Thaum rov ua dua nrog 3.2 mL ntawm cov khoom sib txuas nrog, txhua lub vial ua rau muaj qhov txaus rau kev tshem tawm ntawm 5 mL ntawm kev ncua uas muaj 400 mg spectinomycin ib mL (raws li hydrochloride). Tsib mL muab 2 grams spectinomycin. Rau kev siv intramuscular nkaus xwb.

Trobicin Susceptibility Powder -100 mg. Saib pob ntxig rauhauv vitrocov txheej txheem kuaj.

Rx xwb

LAB-0230-3.0

Hloov kho Lub Yim Hli 2006