Rimadyl Txhaj

Lub npe dav: txhaj tshuaj carprofen
Dosage form: RAU NTAUB NTAWV SIV nkaus xwb

Ntawm nplooj ntawv no

• Kev piav qhia
• Clinical Pharmacology
• Contraindications
• Ceeb toom
• Cov kev ceev faj
• Cov Kev Phem Tsis Zoo/Sib Phem
• Dosage thiab Administration
• Kev tshawb fawb soj ntsuam
• Yuav Ua Li Cas Muab / Cia thiab tuav
• Cov ntaub ntawv

Non-steroidal anti-inflammatory tshuaj

Rau kev siv subcutaneous hauv cov dev xwb

CEEB TOOM

Tsoom Fwv Teb Chaws txoj cai txwv cov tshuaj no siv los ntawm lossis raws li kev txiav txim ntawm tus kws kho tsiaj muaj ntawv tso cai.

Rimadyl Txhaj Tshuaj Description

Rimadyl Injectable yog cov tshuaj tsis muaj tshuaj uas muaj carprofen, cov tshuaj uas tsis yog-steroidal anti-inflammatory tshuaj (NSAID) ntawm cov chav kawm propionic acid uas suav nrog ibuprofen, naproxen, thiab ketoprofen. Carprofen yog qhov tsis muaj npe rau kev hloov pauv carbazole, 6-chloro-α-methyl-9H-carbazole-2-acetic acid. Tus qauv empirical yog Ckaum tsibH12CINOobthiab molecular hnyav 273.72. Cov qauv tshuaj ntawm carprofen yog:

Txhua mL ntawm Rimadyl Injectable muaj 50.0 mg carprofen, 30.0 mg arginine, 88.5 mg glycocholic acid, 169.0 mg lecithin, 10.0 mg benzyl cawv, 6.17 mg sodium hydroxide, nrog ntxiv sodium hydroxide thiab hydrochloric acid raws li xav tau rau kev txhaj tshuaj pH. .

Rimadyl Txhaj Tshuaj - Chaw Kho Mob

Carprofen yog ib qho uas tsis yog-narcotic, nonsteroidal anti-inflammatory tus neeg sawv cev nrog cov yam ntxwv analgesic thiab antipyretic kev ua si kwv yees li equipotent rau indomethacin nyob rau hauv cov tsiaj qauv.ib

Cov txheej txheem ntawm kev ua ntawm carprofen, zoo li lwm cov NSAIDs, ntseeg tau tias muaj feem xyuam nrog inhibition ntawm cyclooxygenase kev ua haujlwm. Ob qhov tshwj xeeb cyclooxygenases tau piav qhia hauv cov tsiaj nyeg.obLub constitutive cyclooxygenase, COX-1, synthesizes prostaglandins tsim nyog rau lub plab zom mov thiab lub raum ua haujlwm. Lub inducible cyclooxygenase, COX-2, generates prostaglandins koom rau hauv o. Inhibition ntawm COX-1 yog xav tias yuav cuam tshuam nrog plab hnyuv thiab lub raum toxicity thaum inhibition ntawm COX-2 muab kev tiv thaiv kab mob. Qhov tshwj xeeb ntawm NSAID tshwj xeeb rau COX-2 piv rau COX-1 yuav txawv ntawm hom mus rau hom.3Hauv ibhauv vitrokawm siv cov kab lis kev cai ntawm tes, carprofen qhia kev xaiv inhibition ntawm COX-2 piv rau COX-1.4Kev soj ntsuam qhov tseeb ntawm cov ntaub ntawv no tsis tau qhia. Carprofen kuj tau pom tias inhibit qhov kev tso tawm ntawm ntau prostaglandins nyob rau hauv ob inflammatory cell systems: nas polymorphonuclear leukocytes (PMN) thiab tib neeg rheumatoid synovial hlwb, qhia inhibition ntawm mob (PMN system) thiab ntev (synovial cell system) inflammatory tshua.ib

Ntau qhov kev tshawb fawb tau pom tias carprofen muaj kev cuam tshuam rau ob qho tib si humoral thiab cellular tiv thaiv kab mob.5–9Cov ntaub ntawv tseem qhia tau tias carprofen inhibits qhov tsim ntawm osteoclastactivating factor (OAF), PGE.ib, thiab PGEoblos ntawm nws cov teebmeem inhibitory ntawm prostaglandin biosynthesis.ib

Raws li kev sib piv nrog cov ntaub ntawv tau txais los ntawm kev tswj hwm txoj hlab ntshav, carprofen tau nrawm thiab yuav luag tag nrho absorbed (ntau tshaj 90% bioavailable) thaum noj qhov ncauj.10Qhov siab tshaj plaws ntshav plasma concentration yog ua tiav hauv 1-3 teev tom qab noj qhov ncauj ntawm 1, 5, thiab 25 mg / kg rau dev.

Qhov nruab nrab nruab nrab ntawm lub neej ntawm carprofen yog kwv yees li 8 teev (ntau 4.5-9.8 teev) tom qab ib koob tshuaj ntawm qhov ncauj txawv ntawm 1-35 mg / kg ntawm lub cev hnyav. Tom qab 100 mg ib koob tshuaj bolus, qhov kev tshem tawm ib nrab ntawm lub neej yog kwv yees li 11.7 teev hauv tus dev. Rimadyl yog ntau dua 99% khi rau cov ntshav plasma protein thiab nthuav tawm qhov ntim me me ntawm kev faib tawm.

Kev sib piv ntawm ib koob tshuaj 25 mg ib zaug hauv Beagle dev tom qab kev tswj hwm subcutaneous thiab qhov ncauj qhia tau hais tias dorsoscapular subcutaneous kev tswj hwm tau ua rau qeeb qeeb ntawm cov tshuaj nkag (raws li kev cuam tshuam los ntawm qhov siab tshaj plaws pom qhov concentration) tab sis piv rau tag nrho cov tshuaj nqus dej hauv 12 teev sijhawm noj tshuaj ( raws li xav tau los ntawm cheeb tsam hauv qab qhov nkhaus ntawm teev xoom mus rau 12 postdose).

Carprofen raug tshem tawm hauv tus dev feem ntau los ntawm biotransformation hauv daim siab ua raws li kev tshem tawm sai ntawm cov metabolites (ester glucuronide ntawm carprofen thiab ether glucuronides ntawm 2 phenolic metabolites, 7-hydroxy carprofen thiab 8-hydroxy carprofen) hauv cov quav (70). -80%) thiab zis (10-20%). Qee qhov enterohepatic ncig ntawm cov tshuaj tau pom.

QHOV TSEEB

Rimadyl yog qhia rau kev kho mob thiab mob txuam nrog osteoarthritis thiab rau kev tswj cov mob postoperative cuam tshuam nrog cov nqaij mos thiab orthopedic phais nyob rau hauv dev.

levofloxacin rau kev siv ntau npaum li cas

Contraindications

Rimadyl yuav tsum tsis txhob siv rau hauv cov dev uas muaj qhov ua rau muaj kev phom sij rau carprofen yav dhau los.

Ceeb toom

Khaws kom deb ntawm cov menyuam yaus. Tsis yog siv rau tib neeg. Tham nrog tus kws kho mob thaum muaj xwm txheej tshwm sim rau tib neeg.Siv rau hauv cov dev xwb.Tsis txhob siv hauv miv.

Txhua tus dev yuav tsum tau ua tib zoo tshawb xyuas keeb kwm thiab kev kuaj lub cev ua ntej pib kho NSAID. Kev kuaj xyuas tsim nyog los tsim cov ntaub ntawv hematological thiab serum biochemical hauv paus ua ntej, thiab ib ntus, kev tswj hwm ntawm NSAID yuav tsum raug txiav txim siab.Cov tswv yuav tsum raug qhia kom saib xyuas cov cim qhia ntawm cov tshuaj toxicity (saib Kev Phem Tsis Zoo , Kev Nyab Xeeb Tsiaj thiab Tom qab kev pom zoo ).

Cov kev ceev faj

Raws li chav kawm, cyclooxygenase inhibitory NSAIDs tuaj yeem cuam tshuam nrog plab hnyuv, raum thiab mob siab toxicity. Cov teebmeem yuav tshwm sim los ntawm kev txo qis prostaglandin ntau lawm thiab inhibition ntawm enzyme cyclooxygenase uas yog lub luag haujlwm rau kev tsim cov prostaglandins los ntawm arachidonic acid.11–14 : kuvThaum NSAIDs inhibit prostaglandins uas ua rau mob, lawv kuj tuaj yeem cuam tshuam cov prostaglandins uas tswj hwm kev ua haujlwm ntawm homeostatic. Cov tshuaj tiv thaiv prostaglandin no tuaj yeem ua rau muaj kab mob tseem ceeb hauv cov neeg mob uas muaj kab mob hauv qab los yog ua ntej muaj feem ntau dua li cov neeg mob noj qab haus huv.12.14 NwsKev kho NSAID tuaj yeem tshem tawm cov kab mob occult uas yav dhau los tsis tau kuaj pom vim tsis muaj cov tsos mob tshwm sim. Piv txwv li, cov neeg mob uas muaj kab mob hauv lub raum, tej zaum yuav muaj exacerbation los yog decompensation ntawm lawv lub raum kab mob thaum kho NSAID.11–14 : kuvKev siv cov kua dej parenteral thaum phais yuav tsum tau txiav txim siab kom txo tau qhov muaj feem cuam tshuam ntawm lub raum teeb meem thaum siv NSAIDs perioperatively.

Carprofen yog ib qho NSAID, thiab ib yam li lwm tus hauv chav kawm, cov kev tsis zoo yuav tshwm sim nrog nws siv. Feem ntau tshaj tawm cov teebmeem yog cov tsos mob ntawm plab hnyuv. Cov xwm txheej uas xav tias lub raum, hematologic, neurologic, dermatological, thiab hepatic teebmeem kuj tau raug tshaj tawm. Cov neeg mob uas muaj kev pheej hmoo loj tshaj plaws rau lub raum toxicity yog cov uas lub cev qhuav dej, ntawm kev kho diuretic concomitant, lossis cov neeg muaj lub raum, lub plawv, thiab / lossis lub siab ua haujlwm tsis zoo. Kev tswj hwm ib txhij ntawm cov tshuaj muaj peev xwm nephrotoxic yuav tsum tau ua kom ceev faj, nrog kev saib xyuas tsim nyog. Kev siv Rimadyl nrog rau lwm cov tshuaj tiv thaiv kab mob, xws li lwm yam NSAIDs lossis corticosteroids, yuav tsum zam vim tias muaj peev xwm ua rau muaj kev cuam tshuam tsis zoo, suav nrog kev mob plab hnyuv thiab / lossis perforations. rhiab heev rau cov tshuaj uas cuam tshuam nrog kev phiv tshuaj txawv nrog tus neeg mob. Cov dev uas tau ntsib kev tsis zoo los ntawm ib qho NSAID tuaj yeem ntsib kev tsis zoo los ntawm lwm NSAID. Kev kho mob Rimadyl tsis cuam tshuam nrog rau lub raum toxicity lossis gastrointestinal ulceration nyob rau hauv kev tswj kev nyab xeeb kev tshawb fawb txog li kaum npaug ntawm koob tshuaj rau cov dev noj qab nyob zoo. Raws li nrog rau cov khoom siv tshuaj tua kab mob parenterally, cov txheej txheem tu cev zoo yuav tsum tau siv thaum siv Rimadyl Injectable. Nws raug nquahu kom siv cov chaw sib txawv rau kev txhaj tshuaj ntxiv.

Rimadyl tsis pom zoo siv rau hauv cov dev uas muaj cov kab mob los ntshav (piv txwv li, Von Willebrand tus kab mob), vim tias kev nyab xeeb tsis tau tsim nyob rau hauv cov dev uas muaj cov kab mob no. Kev nyab xeeb siv Rimadyl hauv cov tsiaj uas muaj hnub nyoog qis dua 6 lub lis piam, cov dev cev xeeb tub, dev siv rau kev yug me nyuam, lossis hauv lactating bitches tsis tau tsim. Kev nyab xeeb tsis tau tsim los rau IV lossis IM kev tswj hwm. Cov kev tshawb fawb los txiav txim siab txog kev ua haujlwm ntawm Rimadyl thaum siv nrog rau lwm cov protein-bound lossis cov tshuaj metabolized zoo sib xws tsis tau ua. Tshuaj compatibility yuav tsum tau saib xyuas nyob rau hauv cov neeg mob xav tau kev kho mob ntxiv. Xws li cov tshuaj feem ntau siv xws li mob plawv, tshuaj tiv thaiv kab mob thiab kev coj cwj pwm. Nws tau raug qhia tias kev kho mob nrog carprofen tuaj yeem txo qis cov tshuaj loog uas xav tau.kaum tsibYog tias cov tshuaj kho mob ntxiv tau lees paub tom qab kev tswj hwm ntawm tag nrho cov tshuaj niaj hnub ntawm Rimadyl, lwm txoj kev ua kom mob plab yuav tsum tau txiav txim siab. Tsis pom zoo siv lwm NSAID. Xav txog lub sijhawm ntxuav kom tsim nyog thaum hloov ntawm ib qho NSAID mus rau lwm qhov lossis thaum hloov los ntawm kev siv corticosteroid mus rau kev siv NSAID.

INFORMATION RAU DOG OWNERS

Rimadyl, zoo li lwm yam tshuaj ntawm nws cov chav kawm, tsis pub dawb los ntawm kev phiv tshuaj. Cov tswv yuav tsum tau qhia txog qhov muaj peev xwm ua rau muaj kev cuam tshuam tsis zoo thiab raug ceeb toom ntawm cov tsos mob tshwm sim cuam tshuam nrog kev tsis haum tshuaj. Cov tshuaj tiv thaiv tsis zoo yuav muaj xws li kev poob qab los noj mov, ntuav, raws plab, tsaus nti lossis tarry quav, noj dej ntau ntxiv, tso zis ntau ntxiv, cov pos hniav daj vim yog ntshav qab zib, yellowing ntawm cov pos hniav, tawv nqaij lossis dawb ntawm lub qhov muag vim jaundice, lethargy, incoordination, qaug dab peg, los yog kev hloov tus cwj pwm.Cov kev phiv loj heev uas cuam tshuam nrog chav kawm tshuaj no tuaj yeem tshwm sim yam tsis muaj kev ceeb toom thiab tsis tshua muaj xwm txheej ua rau tuag (saib Kev Phem Tsis Zoo ). Cov tswv yuav tsum raug qhia kom tsis txhob siv Rimadyl txoj kev kho thiab tiv tauj lawv tus kws kho tsiaj tam sim ntawd yog tias pom tias muaj kev tsis haum tshuaj.Feem coob ntawm cov neeg mob uas muaj cov tshuaj tiv thaiv tsis zoo tau rov zoo dua thaum pom cov tsos mob, cov tshuaj raug tshem tawm, thiab kev kho tsiaj, yog tias tsim nyog, pib. Cov tswv yuav tsum tau qhia txog qhov tseem ceeb ntawm kev saib xyuas txhua lub sijhawm rau txhua tus dev thaum tswj hwm NSAID.

Kev Phem Tsis Zoo

Thaum lub sij hawm soj ntsuam kev tshawb fawb rau caplet formulation, tsis muaj cov tshuaj tiv thaiv kab mob tseem ceeb tau qhia. Qee qhov kev kuaj mob tau pom thaum lub sijhawm kev tshawb fawb (n=297) uas zoo sib xws rau cov dev uas tau txais carprofen- thiab cov placebo. Cov xwm txheej hauv qab no tau pom nyob rau hauv ob pawg: ntuav (4%), raws plab (4%), kev hloov hauv qab los noj mov (3%), lethargy (1.4%), kev hloov cwj pwm (1%), thiab cem quav (0.3%). Cov khoom siv tsheb ua haujlwm tswj.

Tsis muaj qhov tshwm sim tsis zoo tshwm sim thaum lub sijhawm kev tshawb fawb soj ntsuam nrog kev tswj hwm qhov ncauj ib hnub ntawm 2 mg / lb. Cov pawg hauv qab no ntawm kev soj ntsuam kev noj qab haus huv txawv txav tau tshaj tawm. Cov khoom siv tsheb ua haujlwm tswj.

Clinical pathology parameters teev sawv cev cov lus ceeb toom ntawm qhov nce ntawm qhov kev kho mob ua ntej; kev siv cov kev txiav txim kho mob yog tsim nyog los txiav txim qhov tseeb ntawm kev kho mob (yog hais txog rooj hauv qab no).

Tsis muaj cov xwm txheej tsis zoo tshwm sim thaum lub sijhawm soj ntsuam kev tshawb fawb txog kev txhaj tshuaj. Cov pawg hauv qab no ntawm kev soj ntsuam kev noj qab haus huv txawv txav tau tshaj tawm. Saline tau siv los ua cov placebo tswj.

Tom qab kev pom zoo

Txawm hais tias tsis yog txhua qhov kev tshwm sim tsis zoo raug tshaj tawm, cov kev cuam tshuam tsis zoo hauv qab no yog ua raws li kev tso cai tom qab kev pom zoo tsis zoo rau kev tshaj tawm txog tshuaj. Cov pawg ntawm cov kev tsis zoo tshwm sim yog teev los ntawm lub cev.

plab hnyuv:ntuav, raws plab, cem quav, tsis qab los noj mov, melena, hematemesis, gastrointestinal ulceration, gastrointestinal los ntshav, pancreatitis.

Mob siab:Inappetence, ntuav, jaundice, mob hepatic toxicity, hepatic enzyme elevation, txawv txav daim siab ua hauj lwm (s), hyperbilirubinemia, bilirubinuria, hypoalbuminemia. Kwv yees li ib feem plaub ntawm cov kab mob siab tau nyob hauv Labrador Retrievers.

Neurological:Ataxia, paresis, tuag tes tuag taw, qaug dab peg, vestibular cim, disorientation.

tso zis:Hematuria, polyuria, polydipsia, urinary incontinence, urinary kab mob, azotemia, mob raum tsis ua hauj lwm, tubular abnormalities xws li mob tubular necrosis, raum tubular acidosis, glucosuria.

solu medrol cov kev mob tshwm sim

Kev coj cwj pwm:Sedation, lethargy, hyperactivity, nyob tsis tswm, aggressiveness.

Hematologic: Immune-mediated hemolytic anemia, tiv thaiv kab mob thrombocytopenia, ntshav poob anemia, epistaxis.

Dermatology:Pruritus, nce shedding, alopecia, pyotraumatic moist dermatitis (kub me ntsis), necrotizing panniculitis / vasculitis, ventral ecchymosis.

Hauv cov xwm txheej tsis tshua muaj, qhov chaw txhaj tshuaj xws li necrosis, abscess thiab seroma tsim, thiab granulomas tau tshaj tawm nrog cov tshuaj txhaj.

Immunologic lossis hypersensitivity:Lub ntsej muag o, khaus, erythema.

Nyob rau hauv cov xwm txheej tsis tshua muaj, kev tuag tau cuam tshuam nrog qee qhov kev tsis zoo uas tau teev tseg saum toj no.

lub sijhawm zoo tshaj plaws los noj zoloft

Yog xav paub ntxiv txog cov tshuaj tiv thaiv tsis zoo hu rau 1-800-366-5288.

Rimadyl Injection Dosage thiab Administration

Ua tib zoo xav txog cov txiaj ntsig thiab kev pheej hmoo ntawm Rimadyl thiab lwm yam kev kho mob ua ntej txiav txim siab siv Rimadyl. Siv cov koob tshuaj qis tshaj plaws rau lub sijhawm luv tshaj plaws raws li tus kheej cov lus teb. Cov koob tshuaj pom zoo rau kev tswj hwm subcutaneous rau dev yog 2 mg / lb (4.4 mg / kg) ntawm lub cev hnyav txhua hnub. Tag nrho cov koob tshuaj txhua hnub yuav raug muab coj los ua 2 mg / lb ntawm lub cev hnyav ib zaug ib hnub lossis muab faib thiab muab faib ua 1 mg / lb (2.2 mg / kg) ob zaug ib hnub. Txhawm rau tswj qhov mob tom qab phais, muab kwv yees li 2 teev ua ntej qhov txheej txheem.

TSEEM CEEB

Kev lees paub ntawm kev ua tau zoo ntawm Rimadyl rau kev txo qhov mob thiab mob txuam nrog osteoarthritis, thiab rau kev tswj cov mob tom qab phais cuam tshuam nrog cov ntaub so ntswg thiab orthopedic phais tau pom nyob rau hauv 7 placebo-tswj, npog cov kev tshawb fawb soj ntsuam cov tshuaj tiv thaiv thiab tshuaj tua kab mob ntawm cov tshuaj. Rimadyl caplets thiab txhaj rau hauv ntau hom dev.

Sib cais cov placebo-tswj, npog ntsej muag, ntau qhov kev tshawb fawb hauv cheeb tsam tau lees paub qhov kev tiv thaiv kab mob thiab tshuaj tua kab mob ntawm Rimadyl caplets thaum noj ntawm 2 mg / lb ib hnub ib zaug lossis thaum faib thiab muab tshuaj ntawm 1 mg / lb ob zaug ib hnub. Hauv ob qhov kev tshawb fawb no, cov dev tau kuaj mob osteoarthritis tau pom muaj kev txhim kho tseem ceeb tag nrho raws li kev ntsuam xyuas lameness los ntawm kws kho tsiaj thiab cov tswv kev soj ntsuam thaum muab Rimadyl ntawm cov tshuaj sau npe.

Raws li cov ntshav sib piv ntawm subcutaneous thiab qhov ncauj tswj hwm, Rimadyl cov txiaj ntsig zoo rau osteoarthritis tom qab dorsoscapular subcutaneous thiab qhov ncauj tswj hwm yuav tsum zoo sib xws, txawm hais tias yuav muaj kev ncua me ntsis ntawm qhov pib ntawm kev nyem tom qab txhaj tshuaj subcutaneous.

Sib cais cov placebo-tswj, npog ntsej muag, ntau qhov kev tshawb fawb hauv cheeb tsam tau lees paub qhov ua tau zoo ntawm Rimadyl txhaj rau kev tswj hwm ntawm qhov mob tom qab noj tshuaj thaum noj ntawm 2 mg / lb ib hnub ib zaug hauv ntau hom dev. Hauv cov kev tshawb fawb no, cov dev tau nthuav tawm rau ovariohysterectomy, kho cruciate thiab aural surgeries tau muab Rimadyl ua ntej thiab rau qhov siab tshaj plaws ntawm 3 hnub (cov ntaub so ntswg) lossis 4 hnub (orthopedic) postoperatively. Feem ntau, cov dev tswj hwm Rimadyl tau pom qhov kev txhim kho tseem ceeb hauv cov qhab nia mob piv rau kev tswj hwm.

TSEV KAWM NTAWV

Cov kev tshawb fawb hauv chav kuaj hauv cov dev uas tsis muaj tshuaj loog thiab kev tshawb fawb hauv chaw kho mob tau pom tias Rimadyl tau txais txiaj ntsig zoo hauv cov dev tom qab kev tswj hwm qhov ncauj thiab subcutaneous.

Hauv cov phiaj xwm kev tshawb fawb txog kev nyab xeeb tsiaj, Rimadyl tau hais lus rau cov dev noj qab haus huv Beagle ntawm 1, 3, thiab 5 mg / lb ob zaug ib hnub (1, 3 thiab 5 npaug ntawm qhov pom zoo tag nrho cov koob tshuaj txhua hnub) rau 42 hnub sib law liag uas tsis muaj qhov cuam tshuam loj heev. Serum albumin rau ib tus dev ib leeg tau txais 5 mg / lb ob zaug ib hnub poob qis rau 2.1 g / dL tom qab 2 lub lis piam ntawm kev kho mob, rov qab mus rau tus nqi kho mob ua ntej (2.6 g / dL) tom qab 4 lub lis piam kho, thiab yog 2.3 g / dL ntawm qhov kev ntsuam xyuas zaum kawg 6 lub lis piam. Tshaj li 6 lub lis piam kho mob, cov quav dub lossis ntshav tau pom hauv 1 tus dev (1 qhov xwm txheej) kho nrog 1 mg / lb ob zaug ib hnub thiab hauv 1 tus dev (2 qhov xwm txheej) kho nrog 3 mg / lb ob zaug ib hnub. Redness ntawm lub plab mucosa tau pom hauv 1 txiv neej uas tau txais 3 mg / lb ob zaug ib hnub.

Ob ntawm 8 tus dev tau txais 10 mg / lb ntawm qhov ncauj ob zaug hauv ib hnub (10 npaug ntawm qhov pom zoo tag nrho cov koob tshuaj txhua hnub) rau 14 hnub pom pom hypoalbuminemia. Qhov nruab nrab qib albumin hauv cov dev uas tau txais koob tshuaj no yog qis dua (2.38 g / dL) dua li txhua ntawm 2 pawg tswj hwm cov placebo (2.88 thiab 2.93 g / dL, feem). Peb qhov xwm txheej ntawm cov quav dub lossis ntshav tau pom hauv 1 tus dev. Tsib ntawm 8 tus dev tau nthuav tawm thaj chaw reddened ntawm duodenal mucosa ntawm tag nrho cov kab mob pathologic. Kev tshuaj xyuas histologic ntawm cov cheeb tsam no qhia tsis muaj pov thawj ntawm kev mob plab, tab sis tau pom tias muaj qhov paug tsawg ntawm lamina propria hauv 2 ntawm 5 tus dev.

Hauv kev tshawb fawb txog kev nyab xeeb sib cais ntev li 13 thiab 52 lub lis piam, raws li txoj cai, cov dev tau noj qhov ncauj mus txog 11.4 mg / lb / hnub (5.7 npaug ntawm qhov pom zoo txhua hnub koob tshuaj ntawm 2 mg / lb) ntawm carprofen. Hauv ob qho tib si kev tshawb fawb, cov tshuaj tau txais txiaj ntsig zoo los ntawm kev kho mob los ntawm txhua tus tsiaj. Tsis muaj tag nrho lossis kev hloov pauv histological tau pom hauv ib qho ntawm cov tsiaj kho. Hauv ob qho kev tshawb fawb, cov dev tau txais koob tshuaj ntau tshaj plaws tau nce qhov nruab nrab hauv cov ntshav L-alanine aminotransferase (ALT) ntawm kwv yees li 20 IU.

Hauv 52 lub lis piam txoj kev tshawb fawb, kev hloov pauv me me tshwm sim hauv cov dev hauv txhua pab pawg kho mob tab sis tsis nyob hauv cov dev tswj. Cov kev hloov pauv tau piav qhia me ntsis liab lossis pob liab liab thiab tau kuaj pom tias tsis yog dermatitis. Qhov muaj peev xwm tshwm sim tau tias cov kab mob me me no tau muaj kev kho mob, tab sis tsis muaj kev sib raug zoo ntawm koob tshuaj.

Cov kev tshawb fawb soj ntsuam tau ua nrog 549 tus dev ntawm ntau hom tsiaj ntawm qhov pom zoo koob tshuaj rau 14 hnub (297 dev tau suav nrog hauv kev tshawb fawb ntsuas 1 mg / lb ob zaug ib hnub thiab 252 dev tau suav nrog hauv kev tshawb fawb cais ntsuas 2 mg / lb ib hnub ib zaug. ). Hauv ob qho tib si kev tshawb fawb, cov tshuaj tau txais txiaj ntsig zoo thiab qhov tshwm sim ntawm cov tshuaj tiv thaiv tsis zoo rau Rimadyl-kho tsiaj tsis siab tshaj li cov placebo-kho tsiaj (cov placebo muaj cov khoom xyaw tsis muaj nyob hauv Rimadyl). Rau cov tsiaj tau txais 1 mg / lb ob zaug ib hnub, qhov nruab nrab tom qab kho cov ntshav qab zib ALT qhov tseem ceeb yog 11 IU ntau dua thiab 9 IU tsawg dua li qhov kev kho mob ua ntej rau cov dev uas tau txais Rimadyl thiab placebo, feem. Qhov sib txawv tsis yog qhov tseem ceeb. Rau cov tsiaj uas tau txais 2 mg / lb ib hnub ib zaug, qhov nruab nrab tom qab kho cov ntshav ALT qhov tseem ceeb yog 4.5 IU ntau dua thiab 0.9 IU tsawg dua qhov kev kho mob ua ntej rau cov dev uas tau txais Rimadyl thiab placebo, raws li. Nyob rau hauv txoj kev tshawb no tom kawg, 3 Rimadyl-kho dev tau tsim 3-fold los yog ntau dua ntawm (ALT) thiab / lossis (AST) thaum lub sijhawm kho. Ib tus dev uas tau txais placebo muaj ntau dua 2-fold nce hauv ALT. Tsis muaj ib qho ntawm cov tsiaj no pom cov tsos mob tshwm sim cuam tshuam nrog kev hloov pauv ntawm cov nqi kuaj. Kev hloov pauv hauv kev kuaj mob qhov tseem ceeb (hematology thiab chaw kho mob chemistry) tsis suav tias yog qhov tseem ceeb hauv kev kho mob. 1 mg / lb ob zaug ib hnub ntawm kev kho mob tau rov ua dua raws li qhov xav tau ntawm 2 lub lis piam nyob rau hauv 244 tus dev, qee qhov ntev li 5 xyoos.

Cov kev tshawb fawb soj ntsuam tau ua tiav ntawm 331 tus dev uas raug phais orthopedic lossis mos mos. Cov dev tau muab 2 mg / lb ntawm Rimadyl subcutaneously ob teev ua ntej kev phais thiab ib hnub tom qab ntawd, raws li xav tau, rau 2 hnub (mob phais) lossis 3 hnub (kev phais orthopedic). Rimadyl tau txais txiaj ntsig zoo thaum siv nrog rau ntau yam tshuaj loog hais txog tshuaj loog. Hom thiab qhov hnyav ntawm kev soj ntsuam kev noj qab haus huv tsis zoo hauv Rimadyl- thiab cov tsiaj kho placebo yog kwv yees li sib npaug thiab tsawg tus lej (saib Kev Phem Tsis Zoo ). Kev soj ntsuam kev noj qab haus huv ntau zaus yog ntuav thiab tau pom nyob ntawm kwv yees li tib zaus hauv Rimadyl- thiab cov tsiaj kho placebo. Kev hloov pauv hauv cov ntsuas ntsuas ntawm hematopoetic, lub raum, lub siab, thiab cov ntshav txhaws tsis yog qhov tseem ceeb hauv kev kho mob. Qhov nruab nrab tom qab kev kho mob ntshav qab zib ALT qhov tseem ceeb yog 8.4 IU thiab 7.0 IU tsawg dua li qhov kev kho mob ua ntej rau cov dev uas tau txais Rimadyl thiab placebo, feem. Qhov nruab nrab tom qab kev kho mob AST qhov tseem ceeb yog 1.5 IU thiab 0.7 IU ntau dua rau cov dev tau txais Rimadyl thiab placebo, feem.

Qhov o thiab sov sov tau cuam tshuam nrog qhov chaw txhaj tshuaj tom qab kev tswj hwm subcutaneous ntawm Rimadyl txhaj tshuaj. Cov kev tshawb pom no tsis tseem ceeb hauv kev kho mob. Kev siv lub sijhawm ntev ntawm kev txhaj tshuaj tsis tau kawm.

KHOOM

Khaws hauv tub yees 2°–8°C (36°–46°F). Thaum broached, cov khoom yuav khaws cia ntawm qhov kub txog 25 ° C (77 ° F) rau 28 hnub.

puas accutane pab nrog pob txuv

Rimadyl txhaj tshuaj li cas

Rimadyl Injectable yog nkag rau hauv 20-mL, amber, iav, tsis muaj menyuam, ntau koob tshuaj vials.

REFERENCES

1. Baruth H, thiab al: Hauv Tshuaj Tiv Thaiv Kab Mob thiab Tshuaj Tiv Thaiv Rheumatic, Vol. II, Newer Anti-Inflammatory Drugs, Rainsford KD, ed. CRC Xovxwm, Boca Raton, pp. 33–47, 1986.
2. Vane JR, Botting RM: Mechanism of action of anti-inflammatory drug.Scand J Rheumatol25:102, pp. 9–21.
3. Grossman CJ, Wiseman J, Lucas FS, et al: Inhibition of constitutive and inducible cyclooxygenase act in human platelets and mononuclear cells by NSAIDs and COX-2 inhibitors.Kev Tshawb Fawb Txog Kab Mob44: 253–257, 1995.
4. Ricketts AP, Lundy KM, Seibel SB: Kev ntsuam xyuas ntawm kev xaiv inhibition ntawm canine cyclooxgenase 1 thiab 2 los ntawm carprofen thiab lwm yam tshuaj uas tsis yog tshuaj steroidal.Am J Vet Res59:11 ,wb. 1441–1446, Nov 1998, nr.
5. Ceuppens JL.thiab al:Non-steroidal anti-inflammatory agents inhibit lub synthesis ntawm IgM rheumatoid yamhauv vitro. Phau Ntawv Nkauj 1:528, 1982.
6. Ceuppens JL, thiab al: Endogenous prostaglandin Eobtxhim kho polyclonal immunoglobulin ntau lawm los ntawm ionically inhibiting T suppressor cell kev ua.Cell ImmunolPeb 70:41, 1982.
7. Schleimer RP, thiab al: Cov teebmeem ntawm prostaglandin synthesis inhibition ntawm lub cev tiv thaiv kab mob.ImmunopharmacologyPeb 3:205, 1981.
8. Leung KH,thiab al:Modulation ntawm txoj kev loj hlob ntawm cell mediated kev tiv thaiv: ua tau lub luag hauj lwm ntawm cov khoom ntawm cyclooxgenase thiab lipoxygenase txoj kev ntawm arachidonic acid metabolism.Int J Immunopharmacology4:195, 1982, ib.
9. Veit BC: Immunoregulatory kev ua ntawm kab lis kev cai-induced suppressor macrophages.Cell ImmunolPeb 72:14, 1982.
10. Schmitt M, thiab al: Kev ntsuam xyuas biopharmaceutical ntawm carprofen tom qab txhaj tshuaj ib leeg, qhov ncauj, thiab qhov quav hauv dev.Biopharm Dispos11(7):585–94, 1990.
11. Kore AM: Toxicology ntawm nonsteriodal anti-inflammatory tshuaj. Veterinary Clinics ntawm North America,Me Tsiaj xyaumPeb Hlis 20, 1990.
12. Binns SH: Pathogenesis thiab pathophysiology ntawm ischemic raug mob thaum mob raum tsis ua haujlwm.Compend rau Cont EdPeb 16:1, 1994.
13. Boothe DM: Prostaglandins: Physiology thiab kev soj ntsuam cuam tshuam.Compend rau ContEd 6:11, Kaum Ib Hlis 1984.
14. Rubin SI: Nonsteroidal anti-inflammatory tshuaj, prostaglandins, thiab lub raum.JAVMA188:9, Peb 1986.
15. Ko CH, Lange DN, Mandsager RE, et al: Cov teebmeem ntawm butorphanol thiab carprofen ntawm qhov tsawg kawg nkaus alveolar concentration ntawm isoflurane hauv dev.JAVMA217: 1025–1028, 2000.

Rau ib daim ntawv theej ntawm Cov Ntaub Ntawv Kev Nyab Xeeb Cov Ntaub Ntawv (MSDS) lossis tshaj tawm cov kev cuam tshuam tsis zoo hu rau Pfizer Animal Health ntawm 1-800-366-5288.

NADA #141-199, Pom zoo los ntawm FDA

Muab faib los ntawm:
Pfizer Tsiaj Noj Qab Haus Huv
Div. ntawm Pfizer Inc
NY, NY 10017

Ua hauv Brazil

Lub Ib Hlis 2010

054577 - Zoo siab 360

PRINCIPAL DISPLAY PANEL - 50 mg/mL carton

RIMADYL®
(carprofen)

Kev txhaj tshuaj 50 mg / mL

Tsis-steroidal
tshuaj tiv thaiv kab mob

Rau kev siv subcutaneously
hauv dev xwb

Ceev faj:Tsoom fwv teb chaws txoj cai txwv qhov no
tshuaj siv los ntawm lossis ntawm qhov kev txiav txim ntawm a
tus kws kho tsiaj muaj ntawv tso cai.

Ntim: 20 mL

(TSI #141-199,
Pom zoo los ntawm FDA)

Pfizer