Valacyclovir: 7 yam koj yuav tsum paub

1. Nws ua haujlwm li cas

  • Valacyclovir yog ib qho tshuaj tiv thaiv kab mob uas tau hloov mus rau hauv acyclovir sai sai hauv lub cev. Acyclovir muaj cov haujlwm tiv thaiv ntau yam kab mob xws li herpes simplex virus type 1 (HSV-1), 2 (HSV-2), thiab varicella-zoster virus (VZV). Cov kab mob no ua rau muaj mob xws li mob khaub thuas, qhov chaw mos herpes, thiab shingles.
  • Valacyclovir ua haujlwm ntau txoj hauv kev los tiv thaiv cov kab mob no los ntawm kev rov ua dua. Inhibits tus kab mob DNA replication los ntawm inhibiting viral DNA polymerase, kev koom ua ke, thiab txiav tawm ntawm cov kab mob DNA loj hlob, thiab inactivation ntawm tus kab mob DNA polymerase.
  • Kev xaiv ntau heev rau thymidine kinase encoded los ntawm HSV thiab VZV cov kab mob uas hloov acyclovir mus rau acyclovir monophosphate, uas tom qab ntawd hloov mus rau diphosphate, tom qab ntawd mus rau active triphosphate. Kev tawm tsam tiv thaiv HSV ntau dua li kev tawm tsam VZV. Kuj tseem nthuav tawm cov haujlwm tawm tsam lwm cov kab mob uas tsis yog code rau cov enzyme no.
  • Valacyclovir belongs rau pab pawg ntawm cov tshuaj hu ua antivirals.

2. Upsides

  • Valacyclovir yog siv los kho cov kab mob uas tshwm sim los ntawm herpes thiab varicella-zoster viruses, xws li qhov chaw mos herpes, mob khaub thuas, shingles, thiab kab mob qhua pias.
  • Active tiv thaiv kab mob herpesviridae xws li herpes simplex virus type 1 (HSV-1), 2 (HSV-2), thiab varicella-zoster virus (VZV), thiab cytomegalovirus.
  • Pom zoo los kho mob khaub thuas hauv cov menyuam yaus hnub nyoog qis dua 12 xyoos thiab kho cov kab mob khaub thuas rau cov menyuam yaus hnub nyoog 2 txog 18 xyoo.
  • Valacyclovir tsis kho qhov chaw mos herpes lossis tshem tawm tag nrho lub cev ntawm herpes lossis varicella zoster virus.
  • Valacyclovir yog ib ntsiav tshuaj ntawm qhov ncauj uas tsuas yog yuav tsum tau noj ob zaug ib hnub, piv rau tsib zaug ib hnub rau acyclovir. Qhov no ua rau nws yooj yim dua rau cov neeg siv. Kev kho mob yuav kav li ntawm ib mus rau 14 hnub nyob ntawm seb tus mob tau kho thiab kev tiv thaiv kab mob ntawm tus neeg raug kho. Kev kho mob khaub thuas yuav tsum tsis pub tshaj ib hnub.
  • Tej zaum yuav noj nrog lossis tsis muaj zaub mov.
  • Valacyclovir yog absorbed zoo dua li acyclovir. Qhov no ua rau cov concentrations hauv lub cev uas piv rau cov ua tiav nrog IV acyclovir.
  • Tsis pom tias muaj cov tshuaj tseem ceeb hauv tsev kho mob-tshuaj yeeb lossis tshuaj-khoom noj khoom haus sib cuam tshuam.
  • Tsis metabolized los ntawm CYP enzymes.
  • Generic valacyclovir muaj.

3. Kev poob qis

Yog tias koj muaj hnub nyoog ntawm 18 thiab 60 xyoo, tsis noj lwm yam tshuaj lossis tsis muaj lwm yam mob, cov kev mob tshwm sim uas koj yuav muaj xws li:

lyrica cov kev mob tshwm sim mus sij hawm ntev
  • Mob taub hau, xeev siab, ntuav, thiab mob plab yog qhov tshwm sim feem ntau tshwm sim.
  • Tsis tshua muaj, tej zaum yuav cuam tshuam rau lub raum los yog ua rau los ntshav. Hauv cov menyuam yaus hnub nyoog qis dua 12 xyoos, raws plab, ua npaws, lub cev qhuav dej, mob khaub thuas, thiab hnoos qeev ntau dua.
  • Tej zaum yuav tsis haum rau txhua tus, suav nrog cov neeg uas muaj tus kab mob HIV siab heev, hloov cov pob txha pob txha allogenic, teeb meem raum, noj qee yam tshuaj, lossis hauv cov neeg uas lub cev qhuav dej. Cov neeg laus tuaj yeem nkag siab ntau dua rau qee qhov kev mob tshwm sim ntawm valacyclovir.
  • Tsis tshua muaj, tej zaum yuav ua rau muaj kev phiv xws li ntxhov siab, hnov ​​​​lus, tsis meej pem, lossis qaug dab peg. Qhov kev pheej hmoo siab dua rau cov neeg mob raum thiab cov neeg tau txais ntau dua li qhov pom zoo noj ntawm valacyclovir.
  • Valacyclovir tsis yog tshuaj kho rau qhov chaw mos los yog herpes labialis (qhov mob khaub thuas).
  • Kev noj tshuaj valacyclovir xav tau txo qis hauv cov neeg mob raum.
  • Cov tshuaj tiv thaiv kab mob HSV thiab VZV tau tshaj tawm.
  • Kev ywg dej kom txaus yuav tsum tau khaws cia txwv tsis pub acyclovir tuaj yeem ua rau hauv lub raum tubules yog tias nws cov dej solubility ntau dhau hauv cov kua dej intratubular.
  • Ntsuas qhov txaus ntshai piv rau cov txiaj ntsig ntawm kev kho mob vim tias acyclovir (daim ntawv nquag ntawm valacyclovir) hla cov placenta rau hauv tus menyuam hauv plab. Acyclovir kuj kis mus rau hauv cov kua mis.

Nco tseg: Feem ntau, cov neeg laus lossis cov menyuam yaus, cov neeg uas muaj qee yam mob (xws li mob siab lossis mob raum, kab mob plawv, ntshav qab zib, qaug dab peg) lossis cov neeg noj lwm cov tshuaj muaj kev pheej hmoo ntau dua ntawm cov kev mob tshwm sim. Saib daim ntawv teev tag nrho cov kev mob tshwm sim



4. Kab hauv qab

Valacyclovir yog ib qho tshuaj tiv thaiv kab mob uas tau hloov mus rau hauv acyclovir sai sai hauv lub cev. Nws yuav tsum tau pib ntawm thawj lub cim ntawm qhov chaw mos herpes lossis cov tsos mob mob khaub thuas tab sis tsis yog kev kho rau cov mob no. Valacyclovir tsuas yog yuav tsum tau noj ob zaug hauv ib hnub piv nrog acyclovir uas yuav tsum tau noj tsib zaug hauv ib hnub.

5. Cov lus qhia

  • Noj valacyclovir raws nraim li koj tus kws kho mob qhia thiab raws li lub sijhawm tau teem tseg, txawm tias koj cov tsos mob zoo dua.
  • Tej zaum yuav noj nrog lossis tsis muaj zaub mov.
  • Kev kho mob Valacyclovir yog qhov zoo tshaj plaws pib hauv 24 teev ntawm cov tsos mob tshwm sim (piv txwv li, pob khaus, hlwv, tingling, kub hnyiab). Cov ntaub ntawv qhia tias valacyclovir yog qhov zoo tshaj plaws yog tias pib hauv lub sijhawm no.
  • Khaws valacyclovir ncua kev kawm ntawv nyob rau hauv lub tub yees thiab co zoo ua ntej siv. Muab pov tseg ib qho uas tsis siv tom qab 28 hnub.
  • Haus dej kom ntau thaum noj valacyclovir thiab tsis txhob cia koj tus kheej ua kom lub cev qhuav dej.
  • Txawm hais tias valacyclovir kho cov kab mob, nws tsis zoo tiv thaiv kab mob khaub thuas lossis mob khaub thuas.
  • Yog tias koj muaj pob khaus khaus lossis mob khaub thuas, sim ua kom huv thiab qhuav li sai tau. Ceev faj tsis txhob kis tus kab mob mus rau lwm tus; xyuas kom koj tsis txhob muab cov ntaub pua chaw, xws li phuam. Kev hnav khaub ncaws xoob tuaj yeem pab tiv thaiv kom tsis txhob ua pob khaus khaus khaus.
  • Yog tias koj noj valacyclovir rau qhov chaw mos herpes lossis mob khaub thuas, zam kev sib deev kom txog thaum koj tau ua tiav cov kev kho mob. Lwm lub sij hawm, ib txwm siv hnab looj tes, vim tias herpes tuaj yeem kis tau thaum tsis muaj tsos mob.
  • Nrhiav kev kho mob sai yog tias koj muaj cov tsos mob ntawm kev ua xua (xws li khaus khaus; ua pa nyuaj; lub ntsej muag lossis caj pas o).
  • Cov kab mob Herpes kis tau zoo heev thiab koj yuav tsum npog koj cov pob khaus thiab tsis txhob sib cuag. Tsis tas li ntawd, tsis txhob kov cov pob khaus thiab tom qab ntawd koj ob lub qhov muag. Ntxuav koj ob txhais tes tsis tu ncua. Yog tias koj tau kho koj tus kheej rau qhov chaw mos herpes thiab nws rov tshwm sim, ces nrhiav kev tawm kom sai li sai tau.
  • Yog tias koj muaj mob khaub thuas, pib kho sai li sai tau tom qab pib cov tsos mob (tingling, kub hnyiab, lossis khaus).
  • Tham nrog koj tus kws kho mob yog tias koj cev xeeb tub lossis npaj cev xeeb tub vim tias acyclovir (daim ntawv nquag ntawm valacyclovir) hla cov placenta rau hauv tus menyuam hauv plab. Acyclovir kuj kis mus rau hauv cov kua mis.

6. Teb thiab ua tau zoo

  • Valacyclovir yog ib qho tshuaj uas tau hloov mus rau acyclovir sai sai tom qab noj qhov ncauj. Qhov siab tshaj plaws ntawm acyclovir tau mus txog hauv ib mus rau peb teev.
  • Nws yuav siv sij hawm txog peb hnub ua ntej txo cov tsos mob tshwm sim. Txawm hais tias cov tsos mob tshwm sim tag nrho, valacyclovir yuav tsum tau noj kom txog thaum cov chav kawm tiav lawm. Qhov zoo tshaj plaws pib nyob rau hauv 24-48 teev ntawm cov tsos mob pib.
  • Rau qhov rov tshwm sim ntawm qhov chaw mos herpes, kev kho yuav tsum tau pib ua ntej 24 teev ntawm qhov pib tshwm sim lossis cov tsos mob tshwm sim; kev ua tau zoo tsis tau muaj pov thawj yog tias pib tom qab lub sijhawm no.

7. Kev sib tham

Cov tshuaj uas cuam tshuam nrog valacyclovir tuaj yeem txo qis nws cov txiaj ntsig, cuam tshuam ntev npaum li cas nws ua haujlwm rau, ua rau muaj kev phiv ntau ntxiv, lossis muaj kev cuam tshuam tsawg dua thaum noj nrog valacyclovir. Kev sib cuam tshuam ntawm ob cov tshuaj tsis yog ib txwm txhais tau tias koj yuav tsum tsis txhob noj ib yam tshuaj; txawm li cas los xij, qee zaum nws ua. Tham nrog koj tus kws kho mob txog yuav ua li cas kev sib cuam tshuam tshuaj yuav tsum tau tswj.

Cov tshuaj nquag uas tuaj yeem cuam tshuam nrog valacyclovir suav nrog:

  • cimetidine
  • clopidogrel
  • clozapine
  • Cov tshuaj kho kab mob siab B, xws li entecavir
  • Qee qhov tshuaj tiv thaiv, xws li kab mob varicella lossis tshuaj tiv thaiv kab mob zos
  • NSAIDs, xws li ibuprofen, diclofenac, lossis naproxen
  • Lwm cov tshuaj tiv thaiv kab mob, xws li acyclovir
  • probenecid
  • tenofovir
  • theophylline
  • warfarin, anticoagulant (ntshav thinner)
  • zidovudine.

Cawv yuav tsum tsis txhob haus cawv thaum noj valacyclovir vim tias nws ua rau lub cev tsis muaj zog thiab tuaj yeem ua rau muaj kev phiv ntawm valacyclovir.

Nco ntsoov tias daim ntawv teev npe no tsis suav nrog txhua yam thiab suav nrog tsuas yog cov tshuaj uas muaj feem cuam tshuam nrog valacyclovir. Koj yuav tsum xa mus rau cov ntaub ntawv sau tshuaj rau valacyclovir rau tag nrho cov npe ntawm kev sib cuam tshuam.

Cov ntaub ntawv

Valacyclovir. Kho tshiab 07/2020. AW DI. ahfs-di-monographsvalacyclovir.html#dosage

Cov ntaub ntawv ntxiv

Nco ntsoov, khaws cov tshuaj no thiab lwm yam tshuaj kom deb ntawm menyuam yaus, tsis txhob muab koj cov tshuaj rau lwm tus, thiab siv valacyclovir nkaus xwb rau cov lus qhia.

Nco ntsoov sab laj nrog koj tus kws kho mob kom paub meej tias cov ntaub ntawv uas tshwm sim hauv nplooj ntawv no siv tau rau koj tus kheej.

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