Teb chaws
los ntawm tshuaj.com- Cov tshuaj tshiab tshaj plaws (pom zoo Lub Ob Hlis 27, 2020) rau kev kho mob ntawm migraine yog Nurtec ODT (rimeegept).
- Cov tshuaj tshiab tshaj plaws (pom zoo Lub Ob Hlis 21, 2020) rau tiv thaiv ntawm migraine yog Vyepti (eptinezumab-jjmr). Nurtec ODT (rimegepant) kuj tau pom zoo rau kev tiv thaiv kev kho mob ntawm tus mob migraine thaum lub Tsib Hlis 27, 2021.
Cov Tshuaj Tshiab rau Kev Kho Mob Migraine
- Cov tshuaj tshiab tshaj plaws rau kev kho mob hnyav migraine yog Nurtec ODT (rimeegept) thiab Ubrelvy (ubrogepant), ob qho tib si ntawm qhov ncauj-administered calcitonin gene-related peptide (CGRP) receptor antagonists (gepants) .
- Lwm qhov tsis ntev los no pom zoo tshuaj rau tus mob hnyav kev kho mob ntawm migraine yog Reyvow (lasmiditan), thawj serotonin (5-HT)1 Ftus neeg sawv cev agonist.
- Lwm cov tshuaj tshiab rau kev kho mob mob migraine yog cov qauv tshiab ntawm sumatriptan , belongs rau chav kawm ntawm cov tshuaj hu ua serotonin (5-HT) receptor agonists (triptans). Sumatriptan yog ib qho kev kho mob migraine uas tau tsim muaj kev pom zoo thawj zaug hauv daim ntawv txhaj tshuaj subcutaneous raws li hom npe Imitrex xyoo 1992. Sumatriptan muaj ntau yam. noj cov ntawv , suav nrog kev txhaj tshuaj, ntsiav tshuaj ntawm qhov ncauj, tshuaj tsuag qhov ntswg, thiab tshuaj zawv plaub hau. Qee cov formulations kuj muaj raws li generics.
Cov tshuaj hauv qab no yog FDA pom zoo rau kho mob ntawm migraine nrog los yog tsis muaj aura nyob rau hauv cov neeg laus.
| Tshuaj npe | FDA pom zoo | Tuam txhab | Cov tshuaj | Daim ntawv tshuaj noj | Kev tswj hwm |
|---|---|---|---|---|---|
| Nurtec ODT (rimeegept) | Lub Ob Hlis 27, 2020 | Biohaven | calcitonin gene-related peptide (CGRP) receptor antagonist (gepant) | qhov ncauj disintegrating ntsiav tshuaj | raws li xav tau; Tsis pub ntau tshaj ib koob (75 mg) yuav tsum tau noj hauv 24 teev |
| Ubrelvy (ua tsis taus pa) | Kaum Ob Hlis 23, 2019 | Allergan Plc | calcitonin gene-related peptide (CGRP) receptor antagonist (gepant) | ntsiav tshuaj ntawm qhov ncauj | raws li qhov xav tau (ib koob thib ob tuaj yeem siv tsawg kawg 2 teev tom qab thawj koob tshuaj); tsis pub ntau tshaj 200 mg yuav tsum tau noj hauv 24 teev |
| Reyvow ( tav su) | Kaum Hli 11, 2019 | Eli Lilly thiab Co | serotonin (5-HT)1 FTus neeg sawv cev agonist (ditan) | ntsiav tshuaj ntawm qhov ncauj | raws li xav tau; tsis pub ntau tshaj ib koob tshuaj yuav tsum tau noj hauv 24 teev l-dopa noj tshuaj |
| qog (sumatriptan) | Lub Ib Hlis 25, 2019 | Dr. Reddy's Laboratories Limited | serotonin (5-HT)1B/1Dreceptor agonist (triptan) | tshuaj tsuag qhov ntswg | raws li xav tau; tsis pub ntau tshaj 30 mg yuav tsum tau noj hauv 24 teev (cov koob tshuaj sib cais tsawg kawg ib teev) |
| Zembrace SymTouch (sumatriptan) | Lub Ib Hlis 28, 2016 | Dr. Reddy's Laboratories Ltd. | serotonin (5-HT)1B/1Dreceptor agonist (triptan) | txhaj tshuaj subcutaneous | raws li xav tau; tsis pub ntau tshaj 12 mg yuav tsum tau noj hauv 24 teev (cov koob tshuaj sib cais tsawg kawg ib teev) robitussin ua xua & hnoos |
| Onzetra Xsail (sumatriptan) | Lub Ib Hlis 27, 2016 | Avanir Pharmaceuticals, Inc. | serotonin (5-HT)1B/1Dreceptor agonist (triptan) | hmoov hmoov | raws li xav tau; tsis pub ntau tshaj ob koob tshuaj (44 mg) yuav tsum tau noj nyob rau hauv 24 teev (cov koob tshuaj sib cais tsawg kawg yog ob teev) |
Cov Tshuaj Tshiab rau Kev Tiv Thaiv Migraine
Cov tshuaj tshiab tshaj plaws rau cov tiv thaiv ntawm migraine yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua calcitonin gene-related peptide (CGRP) antagonists thiab suav nrog Aimovig , Ajovy , Kev sib haum xeeb , thiab Vyepti .
Nurtec ODT (rimegepant) yog thawj qhov ncauj CGRP antagonist pom zoo los tiv thaiv mob taub hau.
Qhov ntev-acting monoclonal antibody CGRP antagonists ua haujlwm los ntawm kev thaiv cov haujlwm ntawm calcitonin gene-related peptide, ib qho neuropeptide uas tau cuam tshuam rau qhov mob thiab vasodilation txheej txheem cuam tshuam nrog migraine tawm tsam. Aimovig yog ib qho kev ua haujlwm ntawm tib neeg monoclonal antibody uas ua haujlwm los ntawm kev khi rau calcitonin noob ntsig txog peptide receptor. Ajovy, Emgality, thiab Vyepti yog humanized monoclonal antibodies uas tsom rau calcitonin noob ntsig txog peptide ligand. Aimovig, Ajovy, thiab Emgality yog txhua yam npaj rau kev txhaj tshuaj rau tus kheej uas siv ib koob txhaj tshuaj prefilled lossis autoinjector. Vyepti yog siv los ntawm kev txhaj tshuaj intravenous.
Nurtec ODT yog ib qho me me ntawm qhov ncauj CGRP antagonist uas ua haujlwm los ntawm kev thaiv cov CGRP receptor. Nws yog ob txoj kev kho mob siv rau ob qho tib si mob thiab tiv thaiv kev kho mob migraine. Nurtec ODT tau noj qhov ncauj txhua hnub rau kev tiv thaiv kev kho mob ntawm tus mob migraine. Nws tau noj raws li qhov xav tau rau kev kho mob migraine.
Cov tshuaj hauv qab no yog FDA pom zoo rau kev tiv thaiv kev kho mob migraine hauv cov neeg laus.
Emgality kuj pom zoo rau kev kho mob ntawm episodic pawg mob taub hau nyob rau hauv cov neeg laus.
| Tshuaj npe | FDA pom zoo | Tuam txhab | Cov tshuaj | Daim ntawv tshuaj noj | Kev tswj hwm |
|---|---|---|---|---|---|
| Nurtec ODT (rimeegept) | kuj pom zoo rau kev kho mob | Biohaven | calcitonin gene-related peptide (CGRP) receptor antagonist (gepant) | qhov ncauj disintegrating ntsiav tshuaj | txhua hnub guaifenesin thaum pub mis niam |
| Vyepti (eptinezumab-jjmr) | Lub Ob Hlis 21, 2020 | Lundbeck Inc. | calcitonin-gene ntsig txog peptide antagonist | txhaj tshuaj infusion | ib zaug txhua peb lub hlis |
| Kev sib haum xeeb (galcanezumab-gnlm) | Cuaj hlis 27, 2018 | Eli Lilly thiab Co | calcitonin-gene ntsig txog peptide antagonist | txhaj tshuaj subcutaneous | ib hlis ib zaug |
| Ajovy (fremanezumab-vfrm) | Cuaj hlis 14, 2018 | Teva Pharmaceutical Industries Ltd. | calcitonin gene-related peptide antagonist | txhaj tshuaj subcutaneous | ib hlis ib zaug LOSSIS ib zaug txhua peb lub hlis |
| Aimovig (ntxhais hmoob) | Lub Tsib Hlis 17, 2018 | Amgen Inc. | calcitonin gene-related peptide antagonist | txhaj tshuaj subcutaneous | ib hlis ib zaug |
Cov tshuaj tshiab hauv kev kho mob
Lwm tus CGRP antagonist hauv kev kho mob cov kav dej yog 'gepant' atogepant kev kho mob (Allergan).
Cov 'gepants' yog cov qauv me me CGRP receptor antagonists npaj rau kev tswj hwm qhov ncauj. Atogepant muaj lub zog siab thiab ntev ib nrab-lub neej, ua rau nws haum rau tiv thaiv kev kho mob ntawm migraine.
yog phenobarbital tshuaj tswj
Yog xav paub ntxiv, saib Kev Kho & Kev Tiv Thaiv Cov Lus Qhia rau Nyob Nrog Migraine Headaches
Rau ib daim ntawv teev tag nrho ntawm kev kho mob migraine, saib Cov tshuaj rau Migraine
Cov Lus Nug Txog Kev Kho Mob
Cov pab pawg txhawb nqa ntsig txog
- Ubrelvy (9 nqe lus nug, 5 tus tswv cuab)
- Aimovig (19 nqe lus nug, 65 tus tswv cuab)
- Kev sib haum xeeb (17 nqe lus nug, 35 tus tswv cuab)
- Sumatriptan (23 nqe lus nug, 52 tus tswv cuab)
- Erenumab (15 nqe lus nug, 3 tus tswv cuab)
- Ajovy (9 nqe lus nug, 13 tus tswv cuab)
- Fremanezumab (6 nqe lus nug, 3 tus tswv cuab)
- Galcanezumab (6 nqe lus nug, 3 tus tswv cuab)
- Ubrogeant (5 nqe lus nug, 3 tus tswv cuab)
- Onzetra Xsail (3 nqe lus nug, 3 tus tswv cuab)
- Nurtec ODT (3 nqe lus nug, 4 tus tswv cuab)
- Zembrace SymTouch (2 nqe lus nug, 3 tus tswv cuab)
- qog (2 nqe lus nug, 3 tus tswv cuab)
- Rimeegept (2 nqe lus nug, 3 tus tswv cuab)
- Eptinezumab (1 nqe lus nug, 3 tus tswv cuab)
- Reyvow (1 nqe lus nug, 3 tus tswv cuab)
- Vyepti (1 nqe lus nug, 3 tus tswv cuab)
- Lasmiditan (1 nqe lus nug, 3 tus tswv cuab)
- Mob taub hau (315 nqe lus nug, 1391 cov tswv cuab)
- Migraine (211 nqe lus nug, 1547 tus tswv cuab)
- Cluster Headaches (13 nqe lus nug, 104 tus tswv cuab)
