Puas yuav Victoza pab nrog kev poob phaus?

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Ntsiab Lus

  • Victoza (Lub npe nrov: liraglutide ) tuaj yeem pab txo qhov hnyav thaum siv los kho cov neeg mob ntshav qab zib hom 2, tab sis Victoza tsis tau pom zoo tshwj xeeb los ntawm FDA los siv rau kev poob phaus.
  • Saxenda , lwm hom ntawm liraglutide, tau pom zoo rau kev poob phaus ntxiv rau kev noj haus thiab kev tawm dag zog hauv cov neeg rog rog lossis rog rog uas muaj qee yam kev mob nkeeg, xws li ntshav siab, hom 2 mob ntshav qab zib mellitus, lossis cov roj (lipid) siab. Saxenda tsis siv rau kev kho mob ntshav qab zib.
  • Victoza thiab Saxenda ob leeg muaj liraglutide tab sis yog siv rau ntau lub hom phiaj thiab ntawm cov koob tshuaj sib txawv. Lawv yuav tsum tsis txhob siv ua ke.

Victoza (liraglutide), los ntawm Novo Nordisk, yog ib qho kev txhaj tshuaj siv ntxiv rau kev noj haus thiab kev tawm dag zog kom txo cov ntshav qab zib (qabzib) hauv cov neeg laus thiab cov menyuam yaus hnub nyoog 10 xyoo thiab laus dua nrog hom 2 mob ntshav qab zib mellitus. Nws raug cais raws li Glucagon-zoo li Peptide-1 (GLP-1) Receptor Agonist.

ip 145 ntsiav tshuaj dawb

Cov neeg mob uas muaj ntshav qab zib hom 2 kuj muaj kev pheej hmoo siab dua rau lub plawv nres lossis mob stroke. Victoza yog siv los txo cov kev pheej hmoo ntawm cov kab mob plawv loj xws li mob plawv, mob stroke lossis tuag rau cov neeg laus uas muaj ntshav qab zib hom 2 uas paub txog kab mob plawv.



Victoza muab ib hnub ib zaug los ntawm kev txhaj tshuaj subcutaneous (hauv qab daim tawv nqaij). Nws los nyob rau hauv ib tug prefilled cwj mem rau nws tus kheej txhaj tshuaj. Koj yuav tsum tsis txhob siv Victoza yog tias koj muaj ntshav qab zib hom 1 lossis ntshav qab zib ketoacidosis.

Poob poob nrog Victoza hauv kev tshawb fawb soj ntsuam

Victoza tsis pom zoo los ntawm FDA los siv rau kev poob phaus. Txawm li cas los xij, yog tias koj yog ib tus neeg laus siv Victoza rau hom 2 mob ntshav qab zib mellitus, koj yuav pom tias nws pab koj poob phaus. Hauv 26 mus rau 52-lub lim tiam ntev kev tshawb fawb soj ntsuam ntawm cov neeg laus uas muaj ntshav qab zib hom 2, ntau tus neeg mob poob qis dua qee qhov hnyav.

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Victoza ib leeg

Thaum Victoza tau siv ib leeg (monotherapy) hauv kev tshawb fawb 52 lub lis piam, qhov hnyav poob ntawm 5.5 lbs (2.5 kg) tshwm sim nrog 1.8 mg koob. Hauv pawg 1.2 mg, qhov hnyav poob ntawm 4.6 lbs (2.1 kg) tau tshaj tawm. Thaum piv rau monotherapy siv glimepiride (hom npe: Amaryl), qhov ncauj sulfonylureas siv rau kev kho mob ntshav qab zib hom 2, qhov poob phaus pom nrog Victoza yog qhov tseem ceeb. Qhov hnyav nce ntawm 2.4 lbs (1.1 kg) tau pom hauv pawg glimepiride.

Victoza ntxiv rau metformin

Hauv kev tshawb fawb 26 lub lis piam loj, thaum Victoza tau ntxiv rau kev kho metformin, cov neeg laus poob qhov nruab nrab txog li 5.7 lbs txog 6.2 lbs (2.6 kg txog 2.8 kg). Metformin nws tus kheej, thaum siv ib leeg nrog cov placebo tsis ua haujlwm, kuj ua rau poob phaus txog 3.3 lbs (1.5 kg). Metformin yog ib qho tshuaj noj hauv qhov ncauj uas nquag siv los ua thawj txoj kev kho mob ntshav qab zib hom 2.

dab tsi yog prometh dm phoov

Victoza ntxiv rau metformin thiab sitagliptin

Kev poob phaus kuj tau pom nyob rau hauv 26-lub lim tiam qhib-label sim ntawm Victoza piv rau sitagliptin (Hloov lub npe: Januvia ), ob qho tib si muab ua ke nrog metformin. Sitagliptin yog qhov ncauj dipeptidyl peptidase 4 (DPP-4) inhibitor kuj siv rau kev kho mob ntshav qab zib hom 2. Zuag qhia tag nrho, muaj qhov txo qis ntawm 5.9 lbs (2.7 kg) rau pawg Victoza 1.2 mg, 7.3 lbs (3.3 kg) rau pawg Victoza 1.8 mg, thiab 1.8 lbs (0.8 kg) rau cov neeg noj sitagliptin 100 mg.

Txawm li cas los xij, hauv Victoza kev tshawb fawb tsis yog txhua tus poob phaus, thiab qee tus neeg mob tau hnyav. Nws yog ib qho tseem ceeb kom nco ntsoov tias Victoza yog siv ntxiv rau kev noj haus thiab kev tawm dag zog rau kev kho mob ntshav qab zib hom 2.

Kab hauv qab

  • Victoza (liraglutide) tau pom tias ua rau poob phaus hauv kev tshawb fawb soj ntsuam; Txawm li cas los xij, nws tsis pom zoo los ntawm FDA rau kev siv no.
  • Saxenda yog lwm yam tshuaj uas tseem muaj liraglutide. Nws raug pom zoo tshwj xeeb rau kev poob phaus, ntxiv rau kev noj zaub mov thiab kev tawm dag zog, hauv cov neeg mob uas muaj kev pheej hmoo nrog qee yam mob. Tsis txhob siv Saxenda thiab Victoza tib lub sijhawm.
  • Hauv kev tshawb fawb soj ntsuam txij li 26 lub lis piam mus rau 52 lub lis piam, cov neeg mob poob ntau qhov hnyav. Piv txwv li, hauv kev tshawb fawb loj, thaum Victoza tau ntxiv rau kev kho mob metformin, cov neeg laus poob qhov nruab nrab mus txog 6.2 lbs (2.8 kg).

Qhov no tsis yog tag nrho cov ntaub ntawv koj xav paub txog Victoza kom muaj kev nyab xeeb thiab siv tau zoo. Saib xyuas lub tag nrho cov ntaub ntawv Victoza ntawm no , thiab tham txog cov ntaub ntawv no nrog koj tus kws kho mob lossis lwm tus kws kho mob.

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